Click here to switch to the map view.

The map label for this gene is xasA [C]

Identifier: 153936839

GI number: 153936839

Start: 2452237

End: 2453682

Strand: Direct

Name: xasA [C]

Synonym: CLC_2322

Alternate gene names: 153936839

Gene position: 2452237-2453682 (Clockwise)

Preceding gene: 153934623

Following gene: 153936494

Centisome position: 65.21

GC content: 32.92

Gene sequence:

>1446_bases
ATGAAAAAGTCCTTGACATTCAAAGACATGGTTTTAATGACCATGACAGCTATTTTAGGATTAAGATGGGTAGCTGTTTC
AGCCAAGTATGGCGCCTCCTGTGCAGTATTATGGGGGATAGCAGCATTACTATTCTTTATTCCTAGTGCATTAGTAGCTG
CAGAATTAGGAGGTAAATATCCTGAGCAAGGCGGCTTAAGCGTATGGGTTACAAAAGCCTATGGTGAAAAAATGGGTTTT
TTAGTATCTTGGCTTAACTGGGTTAGTAAACTATTCTTTTATCCTGGATTTGTAACATATGCAGCAGTTACATTTGCATA
CGTTATAGATCCAAGTCTTGCAAACAATAAACTTTACAATTTATTTATGGTTTTAGGAATCTTCTGGTTTATAACTATAT
GGAGTTTTAGGGGCACTGGAAATAGTAAAATATTTGCAGTTATAGGTGGACTTGTAGGCAGTGTACTTCCTGCTTTATTA
ATTATAATATTAGGTTATGCATCTGCTTTTGTTCTTAAAAGACCTCTTGCAACAACTTATACCCTTCAAGGCATGATACC
AGACTTCACTAATATAGCTAATTTAGCATTACTATCTTCTGTAATGTTTGGATTAACAGGCGCTGAAGTAACAGCAGCCT
TTGCTGGAGAAGTTGAAGACGCAAAAAAAACAATTCCCAAAGCAATTATATTCTGTGCTATCTTTATAACTATTTTATAT
ATACTATGTTCATCTGCCATTACTTTTGTAGTATCGCCAGAAAAAATCGGTGCTGCAAATGGACTTATAGAAGCATTTAG
ATTAATAACAGAACAGTTTGGTATAGGACAATGGTTCCTAACTTTAATGGCAGTACTTATGACTATAGAAGCTTTGGGCG
GTGTTAGTTTATATATAATGTCTCCTATAACTATGTTATTTGAAACTAGTAAAAATGGTGTTTTACCACCATTCTTAACA
AAAACAAATAAAAATGGCGTACCAATTAATGCATTATTGGTACAAGGTATAGGTATTTCAATAGTAATAATAATTACAAC
TCTTTTACCAACAGTTAATGCTATATATTCAATACTTATAATAATGACGGCTATAACAGGCTTAATCCCTTACTTATTAA
TGTTTGCATCTTACATTAGATTAAAGAAAATGGAGAAATTACAAGCTAAGGGAGAATCCACAGAGGAATTTTACGAAATA
TCAAAATCAAAGCAATTTTCAACCTTTGTATCCATTGTAGGATTAATAAGTGTAATATTTGGAATTGTAACTTCATTCTT
CCCACCATCAGATTATACAACCACAGGACAAATTGTATTCTTTGAATTATTAAGTATCGGTGGACCAATTCTTCTAAGCT
GGATTGGTTGGAGAATGTTTAGCAAATATGAACAAAAAAGAGATACAGGCGAAATTCAATCCACAAATAATTCTTTATCA
GAATAA

Upstream 100 bases:

>100_bases
AAAAATGTCTTGATTTTGTTATAAAAATAACATAATATTAAATAGTATTTAACAATTTAACAATATTATCAAAAATTTTA
CAATAGGGGTGATTATTAAA

Downstream 100 bases:

>100_bases
ATTAATGAAAAAATCTATCTGATTATAAGTAAGAATCAGATAGATTTTTTTATTAATTTATAAATTTTTCCACAAATATA
AATTTTTTAAACAAAGATTA

Product: amino acid permease family protein

Products: L-glutamate [Cytoplasm]; 4-aminobutyrate [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKKSLTFKDMVLMTMTAILGLRWVAVSAKYGASCAVLWGIAALLFFIPSALVAAELGGKYPEQGGLSVWVTKAYGEKMGF
LVSWLNWVSKLFFYPGFVTYAAVTFAYVIDPSLANNKLYNLFMVLGIFWFITIWSFRGTGNSKIFAVIGGLVGSVLPALL
IIILGYASAFVLKRPLATTYTLQGMIPDFTNIANLALLSSVMFGLTGAEVTAAFAGEVEDAKKTIPKAIIFCAIFITILY
ILCSSAITFVVSPEKIGAANGLIEAFRLITEQFGIGQWFLTLMAVLMTIEALGGVSLYIMSPITMLFETSKNGVLPPFLT
KTNKNGVPINALLVQGIGISIVIIITTLLPTVNAIYSILIIMTAITGLIPYLLMFASYIRLKKMEKLQAKGESTEEFYEI
SKSKQFSTFVSIVGLISVIFGIVTSFFPPSDYTTTGQIVFFELLSIGGPILLSWIGWRMFSKYEQKRDTGEIQSTNNSLS
E

Sequences:

>Translated_481_residues
MKKSLTFKDMVLMTMTAILGLRWVAVSAKYGASCAVLWGIAALLFFIPSALVAAELGGKYPEQGGLSVWVTKAYGEKMGF
LVSWLNWVSKLFFYPGFVTYAAVTFAYVIDPSLANNKLYNLFMVLGIFWFITIWSFRGTGNSKIFAVIGGLVGSVLPALL
IIILGYASAFVLKRPLATTYTLQGMIPDFTNIANLALLSSVMFGLTGAEVTAAFAGEVEDAKKTIPKAIIFCAIFITILY
ILCSSAITFVVSPEKIGAANGLIEAFRLITEQFGIGQWFLTLMAVLMTIEALGGVSLYIMSPITMLFETSKNGVLPPFLT
KTNKNGVPINALLVQGIGISIVIIITTLLPTVNAIYSILIIMTAITGLIPYLLMFASYIRLKKMEKLQAKGESTEEFYEI
SKSKQFSTFVSIVGLISVIFGIVTSFFPPSDYTTTGQIVFFELLSIGGPILLSWIGWRMFSKYEQKRDTGEIQSTNNSLS
E
>Mature_481_residues
MKKSLTFKDMVLMTMTAILGLRWVAVSAKYGASCAVLWGIAALLFFIPSALVAAELGGKYPEQGGLSVWVTKAYGEKMGF
LVSWLNWVSKLFFYPGFVTYAAVTFAYVIDPSLANNKLYNLFMVLGIFWFITIWSFRGTGNSKIFAVIGGLVGSVLPALL
IIILGYASAFVLKRPLATTYTLQGMIPDFTNIANLALLSSVMFGLTGAEVTAAFAGEVEDAKKTIPKAIIFCAIFITILY
ILCSSAITFVVSPEKIGAANGLIEAFRLITEQFGIGQWFLTLMAVLMTIEALGGVSLYIMSPITMLFETSKNGVLPPFLT
KTNKNGVPINALLVQGIGISIVIIITTLLPTVNAIYSILIIMTAITGLIPYLLMFASYIRLKKMEKLQAKGESTEEFYEI
SKSKQFSTFVSIVGLISVIFGIVTSFFPPSDYTTTGQIVFFELLSIGGPILLSWIGWRMFSKYEQKRDTGEIQSTNNSLS
E

Specific function: Probable Amino Acid Transporter. Involved In Extreme Acid Resistance. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1787768, Length=435, Percent_Identity=23.6781609195402, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI87081798, Length=470, Percent_Identity=23.6170212765957, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI48994921, Length=446, Percent_Identity=24.8878923766816, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082380, Length=502, Percent_Identity=23.1075697211155, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87081708, Length=406, Percent_Identity=23.1527093596059, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786789, Length=378, Percent_Identity=23.8095238095238, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790575, Length=349, Percent_Identity=24.3553008595989, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357367, Length=315, Percent_Identity=26.984126984127, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52560; Mature: 52560

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSLTFKDMVLMTMTAILGLRWVAVSAKYGASCAVLWGIAALLFFIPSALVAAELGGKY
CCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEQGGLSVWVTKAYGEKMGFLVSWLNWVSKLFFYPGFVTYAAVTFAYVIDPSLANNKLYN
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHH
LFMVLGIFWFITIWSFRGTGNSKIFAVIGGLVGSVLPALLIIILGYASAFVLKRPLATTY
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TLQGMIPDFTNIANLALLSSVMFGLTGAEVTAAFAGEVEDAKKTIPKAIIFCAIFITILY
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
ILCSSAITFVVSPEKIGAANGLIEAFRLITEQFGIGQWFLTLMAVLMTIEALGGVSLYIM
HHHHHHHEEEECCHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHH
SPITMLFETSKNGVLPPFLTKTNKNGVPINALLVQGIGISIVIIITTLLPTVNAIYSILI
HHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IMTAITGLIPYLLMFASYIRLKKMEKLQAKGESTEEFYEISKSKQFSTFVSIVGLISVIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHH
GIVTSFFPPSDYTTTGQIVFFELLSIGGPILLSWIGWRMFSKYEQKRDTGEIQSTNNSLS
HHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCC
E
C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-aminobutyrate [Cytoplasm]; L-glutamate [Periplasm] [C]

Specific reaction: 4-aminobutyrate [Cytoplasm] + L-glutamate [Periplasm] = L-glutamate [Cytoplasm] + 4-aminobutyrate [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]