Click here to switch to the map view.

The map label for this gene is gluD [H]

Identifier: 153936267

GI number: 153936267

Start: 1860053

End: 1861318

Strand: Reverse

Name: gluD [H]

Synonym: CLC_1753

Alternate gene names: 153936267

Gene position: 1861318-1860053 (Counterclockwise)

Preceding gene: 153935531

Following gene: 153937519

Centisome position: 49.5

GC content: 35.07

Gene sequence:

>1266_bases
ATGGCAAAAGAAAATTTAAATCCATTTGAAAATGCGCAAAAACAAGTTAAAACAGCTTGTGACAAATTAGGTATGGAACC
AGCAGTATATGAGTTATTAAAAGAACCTCAAAGAGTAATTGAAGTTTCAATTCCAGTTAAAATGGACGACGGCTCAGTAA
AGGTTTTCAAAGGTTATAGATCTCAACATAATGATGCAGTAGGTCCAACAAAAGGTGGAGTAAGATTCCATCCAAATGTT
TCTTTAGACGAAGTGAAAGCGTTATCAATCTGGATGACATTTAAATGTTCAGTAACAGGAATTCCATATGGTGGTGGAAA
AGGTGGAATCATAGTTGATCCAAAAACTTTATCTAAAGGAGAACTTGAAAGATTAAGCAGAGGATACATAGACGGTATTC
ACAAATTAATAGGCGAAAAAGTGGATGTTCCAGCTCCAGATGTAAACACAAATGGACAAATAATGGCTTGGATGGTAGAC
GAATATAATAAATTAGTAGGAAGAAGTGCTATCGGCGTTATAACTGGTAAACCAGTTGAGTTTGGTGGTTCTTTAGGAAG
AAATGCAGCTACAGGTTTTGGTGTTGCAGTAACTGCAAGAGAAGCAGCTGCTAAATTAGGAATAGATATGAAAAAAGCTA
AATTAGCTATCCAAGGTATAGGTAACGTTGGAAGTCACACAGTATTAAATTGCGAAAAATTAGGTGGAACAGTTGTAGCT
TTAGCTGAATGGTGCAAAGAAGAAGGAACTTATGCTATCTATAACGAAAACGGTTTAGATGGAAAAGCTATGATAGAATA
TGTTAAAGAAAATGGAAATTTATTAGGTTATCCAGGAGCTAAGAAAATATCTTTAGATGAGTTCTGGGCATTAAATGTAG
ATATATTAATCCCAGCAGCACTTGAAAATGCTATAACTCATGAAAACGCTTCATCAATCAATGCAAAACTTGTTTGTGAA
GCTGCAAATGGCCCTATAACTCCAGATGCAGATGCTATATTAAAAGAAAAAGGAATAACAGTTACTCCAGACATATTAAC
TAATGCTGGTGGTGTTACAGTTTCTTACTTCGAATGGGTACAAAACTTATATGGCTACTATTGGACAGAAGCAGAAGTAG
AAGCTAAAGAAGAAGAAGCTATGGTAAAAGCTTTCGAATCAATTTGGGCTATAAAAGAAGAATATAGCGTTACAATGAGA
GAAGCAGCTTACATGCACTCAATTAAGAAAGTAGCAGGAGCTATGAAATTAAGAGGTTGGTATTAA

Upstream 100 bases:

>100_bases
ATAGAATACATATATTATAAAAGCAATTAAAAACAAAATTTTAAATGTAAAATTGCAAAATTTGTTGCAATATTATATTC
ACTATTGGGAGGTAATCAAT

Downstream 100 bases:

>100_bases
TCTTAAATATAAATAAAAAAAGAGGTTTGAGTTATCAAGCCTCTTTTTCGTTTTTAGTATATTTTTATAAATTTTAATCT
AAAAAATTCTTAAATATTTA

Product: glutamate dehydrogenase, NAD-specific

Products: NA

Alternate protein names: NAD-GDH [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MAKENLNPFENAQKQVKTACDKLGMEPAVYELLKEPQRVIEVSIPVKMDDGSVKVFKGYRSQHNDAVGPTKGGVRFHPNV
SLDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPKTLSKGELERLSRGYIDGIHKLIGEKVDVPAPDVNTNGQIMAWMVD
EYNKLVGRSAIGVITGKPVEFGGSLGRNAATGFGVAVTAREAAAKLGIDMKKAKLAIQGIGNVGSHTVLNCEKLGGTVVA
LAEWCKEEGTYAIYNENGLDGKAMIEYVKENGNLLGYPGAKKISLDEFWALNVDILIPAALENAITHENASSINAKLVCE
AANGPITPDADAILKEKGITVTPDILTNAGGVTVSYFEWVQNLYGYYWTEAEVEAKEEEAMVKAFESIWAIKEEYSVTMR
EAAYMHSIKKVAGAMKLRGWY

Sequences:

>Translated_421_residues
MAKENLNPFENAQKQVKTACDKLGMEPAVYELLKEPQRVIEVSIPVKMDDGSVKVFKGYRSQHNDAVGPTKGGVRFHPNV
SLDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPKTLSKGELERLSRGYIDGIHKLIGEKVDVPAPDVNTNGQIMAWMVD
EYNKLVGRSAIGVITGKPVEFGGSLGRNAATGFGVAVTAREAAAKLGIDMKKAKLAIQGIGNVGSHTVLNCEKLGGTVVA
LAEWCKEEGTYAIYNENGLDGKAMIEYVKENGNLLGYPGAKKISLDEFWALNVDILIPAALENAITHENASSINAKLVCE
AANGPITPDADAILKEKGITVTPDILTNAGGVTVSYFEWVQNLYGYYWTEAEVEAKEEEAMVKAFESIWAIKEEYSVTMR
EAAYMHSIKKVAGAMKLRGWY
>Mature_420_residues
AKENLNPFENAQKQVKTACDKLGMEPAVYELLKEPQRVIEVSIPVKMDDGSVKVFKGYRSQHNDAVGPTKGGVRFHPNVS
LDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPKTLSKGELERLSRGYIDGIHKLIGEKVDVPAPDVNTNGQIMAWMVDE
YNKLVGRSAIGVITGKPVEFGGSLGRNAATGFGVAVTAREAAAKLGIDMKKAKLAIQGIGNVGSHTVLNCEKLGGTVVAL
AEWCKEEGTYAIYNENGLDGKAMIEYVKENGNLLGYPGAKKISLDEFWALNVDILIPAALENAITHENASSINAKLVCEA
ANGPITPDADAILKEKGITVTPDILTNAGGVTVSYFEWVQNLYGYYWTEAEVEAKEEEAMVKAFESIWAIKEEYSVTMRE
AAYMHSIKKVAGAMKLRGWY

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=348, Percent_Identity=40.2298850574713, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4885281, Length=348, Percent_Identity=39.9425287356322, Blast_Score=261, Evalue=8e-70,
Organism=Escherichia coli, GI1788059, Length=368, Percent_Identity=33.1521739130435, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17544676, Length=361, Percent_Identity=41.2742382271468, Blast_Score=253, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319256, Length=437, Percent_Identity=30.4347826086957, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6324951, Length=427, Percent_Identity=30.4449648711944, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI45549226, Length=345, Percent_Identity=42.0289855072464, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI45553475, Length=345, Percent_Identity=42.0289855072464, Blast_Score=266, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24649283, Length=349, Percent_Identity=39.8280802292264, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24649460, Length=285, Percent_Identity=41.4035087719298, Blast_Score=207, Evalue=7e-54,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.2 [H]

Molecular weight: Translated: 45614; Mature: 45483

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKENLNPFENAQKQVKTACDKLGMEPAVYELLKEPQRVIEVSIPVKMDDGSVKVFKGYR
CCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHEEEEEEEEEECCCCEEEEECHH
SQHNDAVGPTKGGVRFHPNVSLDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPKTLSKG
HCCCCCCCCCCCCEEECCCCCHHHEEEEEEEEEEEEEEEECCCCCCCCCEEECCCCCCHH
ELERLSRGYIDGIHKLIGEKVDVPAPDVNTNGQIMAWMVDEYNKLVGRSAIGVITGKPVE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCEEEEECCCHH
FGGSLGRNAATGFGVAVTAREAAAKLGIDMKKAKLAIQGIGNVGSHTVLNCEKLGGTVVA
CCCCCCCCCCCCCEEEEEHHHHHHHHCCCHHHHHEEEEECCCCCCCEEEEHHHHCCHHHH
LAEWCKEEGTYAIYNENGLDGKAMIEYVKENGNLLGYPGAKKISLDEFWALNVDILIPAA
HHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCEEECCCCCCCCHHHEEEEEEEEEEHHH
LENAITHENASSINAKLVCEAANGPITPDADAILKEKGITVTPDILTNAGGVTVSYFEWV
HHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEECHHHHCCCCCCEEHHHHHH
QNLYGYYWTEAEVEAKEEEAMVKAFESIWAIKEEYSVTMREAAYMHSIKKVAGAMKLRGW
HHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
Y
C
>Mature Secondary Structure 
AKENLNPFENAQKQVKTACDKLGMEPAVYELLKEPQRVIEVSIPVKMDDGSVKVFKGYR
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHEEEEEEEEEECCCCEEEEECHH
SQHNDAVGPTKGGVRFHPNVSLDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPKTLSKG
HCCCCCCCCCCCCEEECCCCCHHHEEEEEEEEEEEEEEEECCCCCCCCCEEECCCCCCHH
ELERLSRGYIDGIHKLIGEKVDVPAPDVNTNGQIMAWMVDEYNKLVGRSAIGVITGKPVE
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCCCEEEEECCCHH
FGGSLGRNAATGFGVAVTAREAAAKLGIDMKKAKLAIQGIGNVGSHTVLNCEKLGGTVVA
CCCCCCCCCCCCCEEEEEHHHHHHHHCCCHHHHHEEEEECCCCCCCEEEEHHHHCCHHHH
LAEWCKEEGTYAIYNENGLDGKAMIEYVKENGNLLGYPGAKKISLDEFWALNVDILIPAA
HHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCEEECCCCCCCCHHHEEEEEEEEEEHHH
LENAITHENASSINAKLVCEAANGPITPDADAILKEKGITVTPDILTNAGGVTVSYFEWV
HHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEECHHHHCCCCCCEEHHHHHH
QNLYGYYWTEAEVEAKEEEAMVKAFESIWAIKEEYSVTMREAAYMHSIKKVAGAMKLRGW
HHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1774279 [H]