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The map label for this gene is hemA

Identifier: 152976883

GI number: 152976883

Start: 3233440

End: 3234774

Strand: Reverse

Name: hemA

Synonym: Bcer98_3182

Alternate gene names: 152976883

Gene position: 3234774-3233440 (Counterclockwise)

Preceding gene: 152976884

Following gene: 152976882

Centisome position: 79.15

GC content: 37.38

Gene sequence:

>1335_bases
GTGCATATTCTTGTTGTTGGTGTAAATTATCGAACAGTCCCTGTAGAGATTCGTGAGAAACTCACATTTCAGGAAACAGA
ACTAAAACGAGCAATGACGACATTACAAAGTCAAAAAAGCGTGTTAGAGAATGTCATTGTATCAACGTGCAATCGTACGG
AGATTTATGCTGTTGTTGATCAATTACACACGGGACGATATTACATTAAGAAATTTTTAGCTGATTGGTTTCAGCTTGAG
ATAGAAGAAATCTCACCATACTTGTCTATTTTTGAGCAAGATGGTGCAATTGAGCATTTATTCCGTGTTACGTGCGGATT
AGATTCTATGGTAGTTGGGGAAACACAGATTTTAGGTCAAATTCGAAATAGCTTTTTAACAGCCCAGGAGGTAAAGACAA
CAGGAACCATTTTTAACGAATTGTTGAAACAGGTTATTACGTTAGCAAAGCGTGCACATTCAGAAACGACAATTGGTGAA
AGTGCAATGTCCGTTAGCTATGCTGCTGTTGAACTTGGAAAGAAAATTTTTGGTGATTTAACAGACTGTCACGTTTTAAT
TCTTGGTGCTGGAAAAATGGGGGAGCTTGCACTGCAAAACTTATATGGGAGTGGAGTTCAAAAAGTTACTGTTATGAATC
GTACATTTACAAAAGCGGAAACAATGGCAGAAAAATATATGGGACATGCGAAGCCGTTAAGTGAACTACAATGTGCTTTG
TTAGAAGCGGACATTTTGATCAGTTCAACAGGATCCTCGAATTATGTCATTACGAAAGAAATGATGAAAAAGGTAGAACG
CATGCGCAGTGGTCGCCCATTATTTATGGTTGATATTGCGGTACCTCGTGATATTGATCCAGAAATCAATGAATTAGAGG
GTTCTTTCTTGTACGATATCGATGATTTACAAGATGTAGTGGAAGCGAATCGTGCTGAGCGTTTAAAAGAAGCGGAAAAG
ATTCAATTTATGATTGAAGAAGAAATCGTTTTATTTAAAAATTGGTTAAACACGCTAGGTGTTGTACCTTTAATATCGGC
TCTTCGAGAGAAAGCGCTAGGAATTCAAAGTGAGACGATGAGAAGTTTAGAACGAAAAATTCCAACGTTAAGTGATCGGG
AGAAAAAGGTTATTAGTAAGCATACAAAAAGTATTATTAATCAATTGCTGAAGGATCCAATCTTGGTAGCAAAAGAGCTA
GCTGCAGAAGAGAAAGCAACGGAAAAGCTTGCTTTATTTGCGAAAATTTTTGATTTAGAAGTACAAGAAGAGGTTGAACA
TACGGAAGAACTGGAACATAAACGAGCGTGGACACCATCCGTTTCATCTTTATAA

Upstream 100 bases:

>100_bases
TAAAAAATTTCGTTGTTCACACGATTGTTAGATTCATAAGAGGAAAGTTGTATTATGATAGTAGATAAGGTGATAAAACG
GGTGAAGGGGGACATGCTGC

Downstream 100 bases:

>100_bases
TACGAAAGGATGATCGGATGAGCTTTTTAAATAATAGTATTATTTATCATATCACAATTATTTTATATGCTTGTAGCATT
AGTTTATATTTTATAGATTA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MHILVVGVNYRTVPVEIREKLTFQETELKRAMTTLQSQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLE
IEEISPYLSIFEQDGAIEHLFRVTCGLDSMVVGETQILGQIRNSFLTAQEVKTTGTIFNELLKQVITLAKRAHSETTIGE
SAMSVSYAAVELGKKIFGDLTDCHVLILGAGKMGELALQNLYGSGVQKVTVMNRTFTKAETMAEKYMGHAKPLSELQCAL
LEADILISSTGSSNYVITKEMMKKVERMRSGRPLFMVDIAVPRDIDPEINELEGSFLYDIDDLQDVVEANRAERLKEAEK
IQFMIEEEIVLFKNWLNTLGVVPLISALREKALGIQSETMRSLERKIPTLSDREKKVISKHTKSIINQLLKDPILVAKEL
AAEEKATEKLALFAKIFDLEVQEEVEHTEELEHKRAWTPSVSSL

Sequences:

>Translated_444_residues
MHILVVGVNYRTVPVEIREKLTFQETELKRAMTTLQSQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLE
IEEISPYLSIFEQDGAIEHLFRVTCGLDSMVVGETQILGQIRNSFLTAQEVKTTGTIFNELLKQVITLAKRAHSETTIGE
SAMSVSYAAVELGKKIFGDLTDCHVLILGAGKMGELALQNLYGSGVQKVTVMNRTFTKAETMAEKYMGHAKPLSELQCAL
LEADILISSTGSSNYVITKEMMKKVERMRSGRPLFMVDIAVPRDIDPEINELEGSFLYDIDDLQDVVEANRAERLKEAEK
IQFMIEEEIVLFKNWLNTLGVVPLISALREKALGIQSETMRSLERKIPTLSDREKKVISKHTKSIINQLLKDPILVAKEL
AAEEKATEKLALFAKIFDLEVQEEVEHTEELEHKRAWTPSVSSL
>Mature_444_residues
MHILVVGVNYRTVPVEIREKLTFQETELKRAMTTLQSQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLE
IEEISPYLSIFEQDGAIEHLFRVTCGLDSMVVGETQILGQIRNSFLTAQEVKTTGTIFNELLKQVITLAKRAHSETTIGE
SAMSVSYAAVELGKKIFGDLTDCHVLILGAGKMGELALQNLYGSGVQKVTVMNRTFTKAETMAEKYMGHAKPLSELQCAL
LEADILISSTGSSNYVITKEMMKKVERMRSGRPLFMVDIAVPRDIDPEINELEGSFLYDIDDLQDVVEANRAERLKEAEK
IQFMIEEEIVLFKNWLNTLGVVPLISALREKALGIQSETMRSLERKIPTLSDREKKVISKHTKSIINQLLKDPILVAKEL
AAEEKATEKLALFAKIFDLEVQEEVEHTEELEHKRAWTPSVSSL

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=358, Percent_Identity=35.7541899441341, Blast_Score=236, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_BACCN (A7GTE7)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001376400.1
- ProteinModelPortal:   A7GTE7
- SMR:   A7GTE7
- STRING:   A7GTE7
- EnsemblBacteria:   EBBACT00000037207
- GeneID:   5343752
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_3182
- eggNOG:   COG0373
- GeneTree:   EBGT00050000001402
- HOGENOM:   HBG732626
- OMA:   LLIDIAN
- ProtClustDB:   PRK00045
- BioCyc:   BCER315749:BCER98_3182-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 50176; Mature: 50176

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILVVGVNYRTVPVEIREKLTFQETELKRAMTTLQSQKSVLENVIVSTCNRTEIYAVVD
CEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QLHTGRYYIKKFLADWFQLEIEEISPYLSIFEQDGAIEHLFRVTCGLDSMVVGETQILGQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHH
IRNSFLTAQEVKTTGTIFNELLKQVITLAKRAHSETTIGESAMSVSYAAVELGKKIFGDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHHCCC
TDCHVLILGAGKMGELALQNLYGSGVQKVTVMNRTFTKAETMAEKYMGHAKPLSELQCAL
CCCEEEEECCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LEADILISSTGSSNYVITKEMMKKVERMRSGRPLFMVDIAVPRDIDPEINELEGSFLYDI
HHHHHEEECCCCCCEEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCCCEEECH
DDLQDVVEANRAERLKEAEKIQFMIEEEIVLFKNWLNTLGVVPLISALREKALGIQSETM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RSLERKIPTLSDREKKVISKHTKSIINQLLKDPILVAKELAAEEKATEKLALFAKIFDLE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQEEVEHTEELEHKRAWTPSVSSL
HHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHILVVGVNYRTVPVEIREKLTFQETELKRAMTTLQSQKSVLENVIVSTCNRTEIYAVVD
CEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
QLHTGRYYIKKFLADWFQLEIEEISPYLSIFEQDGAIEHLFRVTCGLDSMVVGETQILGQ
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHH
IRNSFLTAQEVKTTGTIFNELLKQVITLAKRAHSETTIGESAMSVSYAAVELGKKIFGDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHHCCC
TDCHVLILGAGKMGELALQNLYGSGVQKVTVMNRTFTKAETMAEKYMGHAKPLSELQCAL
CCCEEEEECCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LEADILISSTGSSNYVITKEMMKKVERMRSGRPLFMVDIAVPRDIDPEINELEGSFLYDI
HHHHHEEECCCCCCEEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCCCEEECH
DDLQDVVEANRAERLKEAEKIQFMIEEEIVLFKNWLNTLGVVPLISALREKALGIQSETM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
RSLERKIPTLSDREKKVISKHTKSIINQLLKDPILVAKELAAEEKATEKLALFAKIFDLE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQEEVEHTEELEHKRAWTPSVSSL
HHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA