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The map label for this gene is alaS [H]

Identifier: 152976803

GI number: 152976803

Start: 3141004

End: 3143646

Strand: Reverse

Name: alaS [H]

Synonym: Bcer98_3101

Alternate gene names: 152976803

Gene position: 3143646-3141004 (Counterclockwise)

Preceding gene: 152976804

Following gene: 152976802

Centisome position: 76.92

GC content: 38.71

Gene sequence:

>2643_bases
ATGAAACAATTAACAGGCGCACAAATTCGTCAAATGTTTTTAGATTTTTTTAAGGAAAAAGGGCATGCGATTGAACCGAG
TGCATCATTAGTTCCACATGAAGATCCATCTCTTTTATGGATCAATAGTGGCGTAGCGACATTAAAAAAATACTTTGATG
GACGTGTTATTCCACAAAATCCACGTATTACAAATGCACAAAAATCAATTCGTACCAACGATATTGAAAACGTTGGGAAA
ACAGCTCGTCACCATACATTCTTTGAAATGCTAGGAAACTTTTCAATCGGTGATTATTTTAAAGAAGAGGCAATTACATG
GGCTTGGGAATTTTTAACGAGCGACAAATGGATTGGATTCGATAAAGAATTATTATCTGTTACAATTCACCCAGAAGATG
AAGAAGCCTTTACAATTTGGCATGAAAAAATAGGTGTTCCGAAAGAACGTATTATTCGTTTAGAAGAAAACTTCTGGGAT
ATTGGTGAAGGACCAAGTGGACCGAATACTGAGATTTTCTATGATCGCGGTGAAGCTTATGGTAATGATCCAAGTGATCC
AGAATTATATCCTGGTGGTGAAAATGAGCGATACTTAGAAGTATGGAACCTTGTGTTCTCTCAATTTAACCATAACCCAG
ACGGTTCTTATACACCACTTCCAAAGAAAAACATCGATACAGGAATGGGCCTAGAGCGTATGACATCTATCGTTCAAAAC
GTGCCTACAAACTTTGATACAGATTTATTCATGCCGATGATTGGTGCAACAGAATCAATCTCTGGTGAGAAGTATCGTAG
TGGCGACGCAGAGAAAGATATGGCATTTAAAGTGATTGCAGACCATATTCGTACTGTAACATTTGCTGTTGGTGATGGGG
CTCTTCCTTCTAACGAAGGTCGTGGTTATGTATTACGTCGTTTATTACGTCGCGCTGTTCGTTATGCGAAAAAATTAAAC
ATGAACCGTCCATTTATGTATGAATTAGTACCCGTTGTTGGAGAAGTGATGAAAGACTTTTATCCAGAAGTTCTTGAAAA
GAAAGATTTCATTGCAAAAGTTGTGAAAAATGAAGAAGAGCGTTTCCATGAAACACTTCATGACGGTGAAGCGATTTTAG
CAGAAGTAATTGCAAAAGCGAAAGAAGAAAAAACAACCGTTATTTCTGGAGTAGATGCATTCCGTCTATATGACACATAT
GGATTCCCGGTTGAATTAACAGAAGAATATGCTGAAGAAGCTGGTATGACAGTTGATCATGCAGGATTTGAAGCAGAGAT
GGAAAAACAACGTGAACGTGCACGTGCGGCTCGTCAAGATGTTGATTCTATGCAAGTTCAAGGCGGTGTTCTTGGGGAAA
TTAAAGTAGCAAGTGAATTCGTTGGTTACGGCACTGTTGCAACAGAAAGCAATGTAGTGGCACTTGTGAAAAATGGTGAG
TATACAGACAGCTTACAAGCAGGTGAAGAAGGACAATTAATGCTTGATGTAACGCCATTCTACGCTGAAAGCGGTGGGCA
AATTGCAGACAGTGGTTACCTTCTTACAGACGGTGTGAAAGTTCTTGTAAAAGATGTACAAAAAGCACCAAATGGTCAAA
ACTTACACAAAGTAGTTGTGGAAGAAGGAGTATTAACGAAAGATGCAACTGTGAAAGCTGTGATTGATACGAAAAATCGC
AGTAGCATTGTGAAGAACCATACAGCAACTCACCTGTTGCATCAAGCTTTAAAAGATGTGCTTGGAACACATGTTAACCA
AGCGGGTTCTCTTGTTACAGCAGAACGTTTACGCTTTGATTTCTCTCACTTCGGTCAAGTACAAGCTGATGAATTAGAAA
AAATTGAGCGTATTGTAAACGAGAAAATTTGGGAAAGTATTGATGTGGAAATTTCTCAAAAGGCAATTGAAGAAGCAAAA
GAAATGGGTGCAATGGCATTATTCGGTGAAAAATATGGAGATGTTGTTCGCGTTGTTCAAGTTGGTGATTACAGCTTAGA
ACTTTGTGGTGGTTGCCATGTTGATAACACAGCTTCTATCGGTATTTTCAAAATTGTTGCTGAGTCTGGTATCGGTGCAG
GAACACGTCGTATCGAAGCAGTAACTGGTAAAGCGGCATACGAATTAATGAACGATCAAGTAAGTTTATTAAAAGAGGCT
GCAGGGAAAATGAAAACAAATCCGAAAGATATTTTAACAAGAGTGGATGGTTTATTTGCTGAGGTGAAACAACTTCAAAA
AGAAAATGAATCTCTTGCTGCTAAGTTAAGTAATATTGAAGCTGGAAATTTAACAGATGCAGTTGTCTCAGTGGATGGGA
TTAATGTATTAGCGACGAAAGTAAATGTTGCAGATATGAATAACTTACGTACAATGATGGATGACTTGAAAAATAAGTTA
GAATCTGCAGTAATTGTATTAGCAGCTGTAAATGATGATAAAGTAAATATCTTAGCAGGTGTAACGAAAGATCTAGTTGG
TCAAGGATATCACGCGGGAAAACTTGTAAAAGAAGTTGCCTCTCGCTGCGGTGGCGGCGGTGGTGGCCGTCCTGATATGG
CTCAAGCGGGCGGTAAAAATCCAGCGCAAGTAGACGAAGCTCTAGCTTTTGTACAAGAGTACGTTAAATCTGTTTCAAAA
TAA

Upstream 100 bases:

>100_bases
TTATTTCATAATTAGGGTGGTATCGCGAGTTAACTCTCGTCCCTTTTATAGGGGCGAGAGTTTTTTGTTTTTATGGAATT
TTTTAAAGGAGGAAATGTAG

Downstream 100 bases:

>100_bases
AGAGAGAGTAGTGTACAATAGTAGGGAGAGGAAATAGTCTTCTCCCTATATTTACTACTTGATAAGTGAGGTGCTTTAAA
TGGACGGTTTTGATAAAACA

Product: alanyl-tRNA synthetase

Products: NA

Alternate protein names: Alanine--tRNA ligase; AlaRS [H]

Number of amino acids: Translated: 880; Mature: 880

Protein sequence:

>880_residues
MKQLTGAQIRQMFLDFFKEKGHAIEPSASLVPHEDPSLLWINSGVATLKKYFDGRVIPQNPRITNAQKSIRTNDIENVGK
TARHHTFFEMLGNFSIGDYFKEEAITWAWEFLTSDKWIGFDKELLSVTIHPEDEEAFTIWHEKIGVPKERIIRLEENFWD
IGEGPSGPNTEIFYDRGEAYGNDPSDPELYPGGENERYLEVWNLVFSQFNHNPDGSYTPLPKKNIDTGMGLERMTSIVQN
VPTNFDTDLFMPMIGATESISGEKYRSGDAEKDMAFKVIADHIRTVTFAVGDGALPSNEGRGYVLRRLLRRAVRYAKKLN
MNRPFMYELVPVVGEVMKDFYPEVLEKKDFIAKVVKNEEERFHETLHDGEAILAEVIAKAKEEKTTVISGVDAFRLYDTY
GFPVELTEEYAEEAGMTVDHAGFEAEMEKQRERARAARQDVDSMQVQGGVLGEIKVASEFVGYGTVATESNVVALVKNGE
YTDSLQAGEEGQLMLDVTPFYAESGGQIADSGYLLTDGVKVLVKDVQKAPNGQNLHKVVVEEGVLTKDATVKAVIDTKNR
SSIVKNHTATHLLHQALKDVLGTHVNQAGSLVTAERLRFDFSHFGQVQADELEKIERIVNEKIWESIDVEISQKAIEEAK
EMGAMALFGEKYGDVVRVVQVGDYSLELCGGCHVDNTASIGIFKIVAESGIGAGTRRIEAVTGKAAYELMNDQVSLLKEA
AGKMKTNPKDILTRVDGLFAEVKQLQKENESLAAKLSNIEAGNLTDAVVSVDGINVLATKVNVADMNNLRTMMDDLKNKL
ESAVIVLAAVNDDKVNILAGVTKDLVGQGYHAGKLVKEVASRCGGGGGGRPDMAQAGGKNPAQVDEALAFVQEYVKSVSK

Sequences:

>Translated_880_residues
MKQLTGAQIRQMFLDFFKEKGHAIEPSASLVPHEDPSLLWINSGVATLKKYFDGRVIPQNPRITNAQKSIRTNDIENVGK
TARHHTFFEMLGNFSIGDYFKEEAITWAWEFLTSDKWIGFDKELLSVTIHPEDEEAFTIWHEKIGVPKERIIRLEENFWD
IGEGPSGPNTEIFYDRGEAYGNDPSDPELYPGGENERYLEVWNLVFSQFNHNPDGSYTPLPKKNIDTGMGLERMTSIVQN
VPTNFDTDLFMPMIGATESISGEKYRSGDAEKDMAFKVIADHIRTVTFAVGDGALPSNEGRGYVLRRLLRRAVRYAKKLN
MNRPFMYELVPVVGEVMKDFYPEVLEKKDFIAKVVKNEEERFHETLHDGEAILAEVIAKAKEEKTTVISGVDAFRLYDTY
GFPVELTEEYAEEAGMTVDHAGFEAEMEKQRERARAARQDVDSMQVQGGVLGEIKVASEFVGYGTVATESNVVALVKNGE
YTDSLQAGEEGQLMLDVTPFYAESGGQIADSGYLLTDGVKVLVKDVQKAPNGQNLHKVVVEEGVLTKDATVKAVIDTKNR
SSIVKNHTATHLLHQALKDVLGTHVNQAGSLVTAERLRFDFSHFGQVQADELEKIERIVNEKIWESIDVEISQKAIEEAK
EMGAMALFGEKYGDVVRVVQVGDYSLELCGGCHVDNTASIGIFKIVAESGIGAGTRRIEAVTGKAAYELMNDQVSLLKEA
AGKMKTNPKDILTRVDGLFAEVKQLQKENESLAAKLSNIEAGNLTDAVVSVDGINVLATKVNVADMNNLRTMMDDLKNKL
ESAVIVLAAVNDDKVNILAGVTKDLVGQGYHAGKLVKEVASRCGGGGGGRPDMAQAGGKNPAQVDEALAFVQEYVKSVSK
>Mature_880_residues
MKQLTGAQIRQMFLDFFKEKGHAIEPSASLVPHEDPSLLWINSGVATLKKYFDGRVIPQNPRITNAQKSIRTNDIENVGK
TARHHTFFEMLGNFSIGDYFKEEAITWAWEFLTSDKWIGFDKELLSVTIHPEDEEAFTIWHEKIGVPKERIIRLEENFWD
IGEGPSGPNTEIFYDRGEAYGNDPSDPELYPGGENERYLEVWNLVFSQFNHNPDGSYTPLPKKNIDTGMGLERMTSIVQN
VPTNFDTDLFMPMIGATESISGEKYRSGDAEKDMAFKVIADHIRTVTFAVGDGALPSNEGRGYVLRRLLRRAVRYAKKLN
MNRPFMYELVPVVGEVMKDFYPEVLEKKDFIAKVVKNEEERFHETLHDGEAILAEVIAKAKEEKTTVISGVDAFRLYDTY
GFPVELTEEYAEEAGMTVDHAGFEAEMEKQRERARAARQDVDSMQVQGGVLGEIKVASEFVGYGTVATESNVVALVKNGE
YTDSLQAGEEGQLMLDVTPFYAESGGQIADSGYLLTDGVKVLVKDVQKAPNGQNLHKVVVEEGVLTKDATVKAVIDTKNR
SSIVKNHTATHLLHQALKDVLGTHVNQAGSLVTAERLRFDFSHFGQVQADELEKIERIVNEKIWESIDVEISQKAIEEAK
EMGAMALFGEKYGDVVRVVQVGDYSLELCGGCHVDNTASIGIFKIVAESGIGAGTRRIEAVTGKAAYELMNDQVSLLKEA
AGKMKTNPKDILTRVDGLFAEVKQLQKENESLAAKLSNIEAGNLTDAVVSVDGINVLATKVNVADMNNLRTMMDDLKNKL
ESAVIVLAAVNDDKVNILAGVTKDLVGQGYHAGKLVKEVASRCGGGGGGRPDMAQAGGKNPAQVDEALAFVQEYVKSVSK

Specific function: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction:alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editin

COG id: COG0013

COG function: function code J; Alanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI109148542, Length=976, Percent_Identity=36.3729508196721, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI38569417, Length=964, Percent_Identity=31.9502074688797, Blast_Score=385, Evalue=1e-106,
Organism=Escherichia coli, GI1789048, Length=873, Percent_Identity=45.360824742268, Blast_Score=744, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17506981, Length=984, Percent_Identity=35.2642276422764, Blast_Score=511, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17536681, Length=765, Percent_Identity=34.7712418300654, Blast_Score=384, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324911, Length=789, Percent_Identity=40.8111533586819, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24582809, Length=975, Percent_Identity=34.7692307692308, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI45552267, Length=975, Percent_Identity=34.7692307692308, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24658214, Length=807, Percent_Identity=29.7397769516729, Blast_Score=302, Evalue=7e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002318
- InterPro:   IPR018162
- InterPro:   IPR018165
- InterPro:   IPR018164
- InterPro:   IPR023033
- InterPro:   IPR003156
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF02272 DHHA1; PF01411 tRNA-synt_2c; PF07973 tRNA_SAD [H]

EC number: =6.1.1.7 [H]

Molecular weight: Translated: 97157; Mature: 97157

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50860 AA_TRNA_LIGASE_II_ALA ; PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLTGAQIRQMFLDFFKEKGHAIEPSASLVPHEDPSLLWINSGVATLKKYFDGRVIPQN
CCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCC
PRITNAQKSIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKEEAITWAWEFLTSDKWIGF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
DKELLSVTIHPEDEEAFTIWHEKIGVPKERIIRLEENFWDIGEGPSGPNTEIFYDRGEAY
CHHHEEEEECCCCCCCEEEEHHHHCCCHHHHEEHHHCCCCCCCCCCCCCCCEEEECCCCC
GNDPSDPELYPGGENERYLEVWNLVFSQFNHNPDGSYTPLPKKNIDTGMGLERMTSIVQN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VPTNFDTDLFMPMIGATESISGEKYRSGDAEKDMAFKVIADHIRTVTFAVGDGALPSNEG
CCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCC
RGYVLRRLLRRAVRYAKKLNMNRPFMYELVPVVGEVMKDFYPEVLEKKDFIAKVVKNEEE
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
RFHETLHDGEAILAEVIAKAKEEKTTVISGVDAFRLYDTYGFPVELTEEYAEEAGMTVDH
HHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCHHHHHHHHHHCCCEEEC
AGFEAEMEKQRERARAARQDVDSMQVQGGVLGEIKVASEFVGYGTVATESNVVALVKNGE
CCCHHHHHHHHHHHHHHHHCHHHHHHCCCCEEHHHHHHHHHCCCCEECCCCEEEEEECCC
YTDSLQAGEEGQLMLDVTPFYAESGGQIADSGYLLTDGVKVLVKDVQKAPNGQNLHKVVV
CCCHHCCCCCCCEEEEECHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHH
EEGVLTKDATVKAVIDTKNRSSIVKNHTATHLLHQALKDVLGTHVNQAGSLVTAERLRFD
HCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FSHFGQVQADELEKIERIVNEKIWESIDVEISQKAIEEAKEMGAMALFGEKYGDVVRVVQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEE
VGDYSLELCGGCHVDNTASIGIFKIVAESGIGAGTRRIEAVTGKAAYELMNDQVSLLKEA
ECCCEEEECCCCCCCCCCCCHHEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGKMKTNPKDILTRVDGLFAEVKQLQKENESLAAKLSNIEAGNLTDAVVSVDGINVLATK
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCCEEEEEE
VNVADMNNLRTMMDDLKNKLESAVIVLAAVNDDKVNILAGVTKDLVGQGYHAGKLVKEVA
EEHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEHHHHHHHHCCCCHHHHHHHHHH
SRCGGGGGGRPDMAQAGGKNPAQVDEALAFVQEYVKSVSK
HHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQLTGAQIRQMFLDFFKEKGHAIEPSASLVPHEDPSLLWINSGVATLKKYFDGRVIPQN
CCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCC
PRITNAQKSIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKEEAITWAWEFLTSDKWIGF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
DKELLSVTIHPEDEEAFTIWHEKIGVPKERIIRLEENFWDIGEGPSGPNTEIFYDRGEAY
CHHHEEEEECCCCCCCEEEEHHHHCCCHHHHEEHHHCCCCCCCCCCCCCCCEEEECCCCC
GNDPSDPELYPGGENERYLEVWNLVFSQFNHNPDGSYTPLPKKNIDTGMGLERMTSIVQN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VPTNFDTDLFMPMIGATESISGEKYRSGDAEKDMAFKVIADHIRTVTFAVGDGALPSNEG
CCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCC
RGYVLRRLLRRAVRYAKKLNMNRPFMYELVPVVGEVMKDFYPEVLEKKDFIAKVVKNEEE
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
RFHETLHDGEAILAEVIAKAKEEKTTVISGVDAFRLYDTYGFPVELTEEYAEEAGMTVDH
HHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCHHHHHHHHHHCCCEEEC
AGFEAEMEKQRERARAARQDVDSMQVQGGVLGEIKVASEFVGYGTVATESNVVALVKNGE
CCCHHHHHHHHHHHHHHHHCHHHHHHCCCCEEHHHHHHHHHCCCCEECCCCEEEEEECCC
YTDSLQAGEEGQLMLDVTPFYAESGGQIADSGYLLTDGVKVLVKDVQKAPNGQNLHKVVV
CCCHHCCCCCCCEEEEECHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHH
EEGVLTKDATVKAVIDTKNRSSIVKNHTATHLLHQALKDVLGTHVNQAGSLVTAERLRFD
HCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FSHFGQVQADELEKIERIVNEKIWESIDVEISQKAIEEAKEMGAMALFGEKYGDVVRVVQ
HHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEE
VGDYSLELCGGCHVDNTASIGIFKIVAESGIGAGTRRIEAVTGKAAYELMNDQVSLLKEA
ECCCEEEECCCCCCCCCCCCHHEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGKMKTNPKDILTRVDGLFAEVKQLQKENESLAAKLSNIEAGNLTDAVVSVDGINVLATK
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCCEEEEEE
VNVADMNNLRTMMDDLKNKLESAVIVLAAVNDDKVNILAGVTKDLVGQGYHAGKLVKEVA
EEHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEHHHHHHHHCCCCHHHHHHHHHH
SRCGGGGGGRPDMAQAGGKNPAQVDEALAFVQEYVKSVSK
HHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA