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The map label for this gene is disA [H]

Identifier: 152973931

GI number: 152973931

Start: 99855

End: 100928

Strand: Direct

Name: disA [H]

Synonym: Bcer98_0078

Alternate gene names: 152973931

Gene position: 99855-100928 (Clockwise)

Preceding gene: 152973930

Following gene: 152973932

Centisome position: 2.44

GC content: 36.5

Gene sequence:

>1074_bases
ATGGAAGAAAACAAGCAACGTGTGAAAAGTATGCTTAATATTTTACAGCTTGTTGCACCAGGTACACCGCTACGTGAAGG
GATAGATAATGTACTTCGTGCACAGACTGGTGGATTAATTGTTCTTGGGTACAATGAACAAATAAAAAGTATTGTGGATG
GAGGGTTCCATATTAATTGTGGATTTTCTCCTGCTAGTTTATACGAATTAGCAAAAATGGACGGTGCACTCATTTTAAAT
GAAACAGGAAGCAAAATCTTAATTGCAAATGCTCAATTAGTTCCTGAATCAGCTATTGACTCTATTGAAACAGGAATGCG
TCACCGTACGGCGGAGCGTGTAGCAAAACAAACAGGTAGTCTTGTTATAGCGATTTCACAAAGACGTAATGTAATTACGT
TATATCAAGGGAATTTACGTTATACATTAAAAGATATAGGTGTTATTTTAACTAAGGCGAATCAAGCGATTCAAACTTTA
GAAAAATATAAAGCAGTCTGGAATGACGGTATTACGAATTTGGGTATTCTAGAATTTGAAGAGGTTGTTACGTTATCTGA
GGTAGTTCACGTTTTACATAGTGTTGAGATGGTACTTCGTATTAAGAATGAGATTTTGAGCTATATTCATGAATTAGGAA
CAGAAGGCAGGCTCATTCGTTTACAATTAACGGAGTTACTGGCGGATTTAGAGGCGGAGGCCGCTTTATTAATAAAAGAT
TACTATCAAGAAAAAACGCAAGATCATTATCAAATATTGAAAAAACTACAAGATCTTGCAAATGCACAGCTTTTAGAAGA
TAGTGACTTAGTCAAATTGCTCGGTTACCCAGGACAAACAAGCTTGGAGGAAAGTGTCACACCAAGGGGATATCGCATTA
CAAGTAAAATATCGAGAGTGCCACCTCTCATTATTGAAAATTTGATCAATCGTTTTAAAACATTGCAAGGTGTCTGTCGA
GCATCGATTGATGAACTCGATGATGTGGAAGGAATTGGGGAAGTTCGAGCGAAAAAAATACGAGAAGGTTTAAAACGAAT
CCAAGAACATCTTTATATGAGTAGACACAACTAA

Upstream 100 bases:

>100_bases
GCGGAAAAATTTAGGTGGATGGACAATTCCTGAGGGGATTGAAGTGGTTGGTGTTTCCAATTTAGGCGAGGCGCTGCGAT
TGACATTAGGAGGCTAGGCT

Downstream 100 bases:

>100_bases
GAATATTACATTGAATATACAATATAACAAGGCGAGAACATTTTTAATATATGATATGATATATTGGTAAATAAAACGAT
TTATGAAAAAAGCACGTCCG

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MEENKQRVKSMLNILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCGFSPASLYELAKMDGALILN
ETGSKILIANAQLVPESAIDSIETGMRHRTAERVAKQTGSLVIAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTL
EKYKAVWNDGITNLGILEFEEVVTLSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
YYQEKTQDHYQILKKLQDLANAQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCR
ASIDELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN

Sequences:

>Translated_357_residues
MEENKQRVKSMLNILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCGFSPASLYELAKMDGALILN
ETGSKILIANAQLVPESAIDSIETGMRHRTAERVAKQTGSLVIAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTL
EKYKAVWNDGITNLGILEFEEVVTLSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
YYQEKTQDHYQILKKLQDLANAQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCR
ASIDELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
>Mature_357_residues
MEENKQRVKSMLNILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINCGFSPASLYELAKMDGALILN
ETGSKILIANAQLVPESAIDSIETGMRHRTAERVAKQTGSLVIAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTL
EKYKAVWNDGITNLGILEFEEVVTLSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
YYQEKTQDHYQILKKLQDLANAQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRVPPLIIENLINRFKTLQGVCR
ASIDELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN

Specific function: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, disA pauses at

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR003583
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N [H]

EC number: NA

Molecular weight: Translated: 40031; Mature: 40031

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00389 ATPASE_DELTA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEENKQRVKSMLNILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINC
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEC
GFSPASLYELAKMDGALILNETGSKILIANAQLVPESAIDSIETGMRHRTAERVAKQTGS
CCCHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
LVIAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFE
EEEEEECCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EVVTLSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
YYQEKTQDHYQILKKLQDLANAQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHCCCCCCEEHHHHHHHC
PPLIIENLINRFKTLQGVCRASIDELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEENKQRVKSMLNILQLVAPGTPLREGIDNVLRAQTGGLIVLGYNEQIKSIVDGGFHINC
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEC
GFSPASLYELAKMDGALILNETGSKILIANAQLVPESAIDSIETGMRHRTAERVAKQTGS
CCCHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
LVIAISQRRNVITLYQGNLRYTLKDIGVILTKANQAIQTLEKYKAVWNDGITNLGILEFE
EEEEEECCCCEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EVVTLSEVVHVLHSVEMVLRIKNEILSYIHELGTEGRLIRLQLTELLADLEAEAALLIKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHH
YYQEKTQDHYQILKKLQDLANAQLLEDSDLVKLLGYPGQTSLEESVTPRGYRITSKISRV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHCCCCCCEEHHHHHHHC
PPLIIENLINRFKTLQGVCRASIDELDDVEGIGEVRAKKIREGLKRIQEHLYMSRHN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA