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The map label for this gene is tmk [H]

Identifier: 152969650

GI number: 152969650

Start: 1246042

End: 1246683

Strand: Direct

Name: tmk [H]

Synonym: KPN_01096

Alternate gene names: 152969650

Gene position: 1246042-1246683 (Clockwise)

Preceding gene: 152969649

Following gene: 152969651

Centisome position: 23.44

GC content: 63.08

Gene sequence:

>642_bases
ATGCGCAGTAACTATATCGTCATCGAGGGGCTGGAGGGCGCCGGGAAGACCACCGCACGTCAACTGGTGGTGGAGACGCT
GCAGTCGGCGGGTATTCACGATATGGTGTTTACCCGCGAGCCGGGGGGCACAATCCTTGCCGAAAAACTGCGTAGCCTGG
TGCTGGATATCCAGTCCACGGGCGATGAAGTGATTAACGATAAAGCGGAAGTGCTGATGTTTTACGCGGCGCGCGTCCAG
TTGGTGGAGACCGTGATTAAGCCCGCGCTGGCCCGCGGCCAGTGGGTGATCGGCGATCGTCACGATCTGTCGACGCAGGC
CTATCAGGGCGGCGGCCGGGGAATTGACCGCACGATGCTGGCGACGCTGCGCGACGCGGTACTCGGTGATTTTCGCCCCA
ATCTGACGCTGTATCTCGACGTCACGCCGGAAGTGGGGCTGCAGCGCGCCCGGGCCCGCGGCGAGCTGGATCGCATTGAG
CAGGAGTCCATGAACTTTTTCAACCGTACCCGCGCGCGCTATCTTGAGCTGGCCGCCGCCGATCCTTCTATCCGCACGGT
TGACGCAACTCAGCCGCTGGATGCCGTGGCGCGCGACATTCGCGCCACGATCGCCCAGTGGATGGCGGAGCAAGCGGCAT
GA

Upstream 100 bases:

>100_bases
TATTTCGTCGCCGACGGGAAAGGGGGCCATACGTTTACCACAAACCTGGTCAGTCATAACCGTGCGGTGCAGGATTATCT
GAAAGTACTTAAGGAAAAAA

Downstream 100 bases:

>100_bases
AATGGTATCCGTGGCTGCGCCCCTCGTTCGAGCAACTGGTCGGTAGCTATCAGGCCGGACGAGGCCACCACGCCTTACTG
TTACAGTCCCTGAACGGGAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MRSNYIVIEGLEGAGKTTARQLVVETLQSAGIHDMVFTREPGGTILAEKLRSLVLDIQSTGDEVINDKAEVLMFYAARVQ
LVETVIKPALARGQWVIGDRHDLSTQAYQGGGRGIDRTMLATLRDAVLGDFRPNLTLYLDVTPEVGLQRARARGELDRIE
QESMNFFNRTRARYLELAAADPSIRTVDATQPLDAVARDIRATIAQWMAEQAA

Sequences:

>Translated_213_residues
MRSNYIVIEGLEGAGKTTARQLVVETLQSAGIHDMVFTREPGGTILAEKLRSLVLDIQSTGDEVINDKAEVLMFYAARVQ
LVETVIKPALARGQWVIGDRHDLSTQAYQGGGRGIDRTMLATLRDAVLGDFRPNLTLYLDVTPEVGLQRARARGELDRIE
QESMNFFNRTRARYLELAAADPSIRTVDATQPLDAVARDIRATIAQWMAEQAA
>Mature_213_residues
MRSNYIVIEGLEGAGKTTARQLVVETLQSAGIHDMVFTREPGGTILAEKLRSLVLDIQSTGDEVINDKAEVLMFYAARVQ
LVETVIKPALARGQWVIGDRHDLSTQAYQGGGRGIDRTMLATLRDAVLGDFRPNLTLYLDVTPEVGLQRARARGELDRIE
QESMNFFNRTRARYLELAAADPSIRTVDATQPLDAVARDIRATIAQWMAEQAA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=210, Percent_Identity=84.2857142857143, Blast_Score=358, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23556; Mature: 23556

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSNYIVIEGLEGAGKTTARQLVVETLQSAGIHDMVFTREPGGTILAEKLRSLVLDIQST
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCC
GDEVINDKAEVLMFYAARVQLVETVIKPALARGQWVIGDRHDLSTQAYQGGGRGIDRTML
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHCCCCCCHHHHHH
ATLRDAVLGDFRPNLTLYLDVTPEVGLQRARARGELDRIEQESMNFFNRTRARYLELAAA
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DPSIRTVDATQPLDAVARDIRATIAQWMAEQAA
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRSNYIVIEGLEGAGKTTARQLVVETLQSAGIHDMVFTREPGGTILAEKLRSLVLDIQST
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCC
GDEVINDKAEVLMFYAARVQLVETVIKPALARGQWVIGDRHDLSTQAYQGGGRGIDRTML
CHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHCCCCCCHHHHHH
ATLRDAVLGDFRPNLTLYLDVTPEVGLQRARARGELDRIEQESMNFFNRTRARYLELAAA
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
DPSIRTVDATQPLDAVARDIRATIAQWMAEQAA
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA