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The map label for this gene is ttdR [H]

Identifier: 152969636

GI number: 152969636

Start: 1230980

End: 1231915

Strand: Direct

Name: ttdR [H]

Synonym: KPN_01082

Alternate gene names: 152969636

Gene position: 1230980-1231915 (Clockwise)

Preceding gene: 152969634

Following gene: 152969638

Centisome position: 23.16

GC content: 61.65

Gene sequence:

>936_bases
ATGAAAAGACAAGAGCGTATAGACCGCATTGAGCTGATGCGCACCTATATCCGCATCGTAGAGGCCGGATCGCTCTCCGC
CGCCGCAGGGCAGATGGACACTACCCAGGCGACCGTCAGCCGCCGCCTGCAGTCCCTTGAAGGGCTGCTGGGGGTTAAGC
TGATCCTGCGCACCACCCATGCGATGAAGCTCACTGACGATGGCGAACGCTGTTATCGTCACGCCCGTCAGGTGGTGGAC
GCCTGGCTGGCGCTGGAGGATGACCTGCGTATTGCCGACGATCGGCCGGTGGGCGTTCTGCGAGTGCGGGCGCCCCACGC
GTTTGGCCAGCAGCAGCTGCTGGCGCCGCTGGTGGCATTTCTACAGCGCCATCCGCAGCTGTCGGTGGAGTGGATGCTAA
ACGATAATACCGTCGACTTCCTCAGCGATAATATCGACTGCGCTATTCGCGTGGGGGCGGAGGTGGATCCAGCAACGGTA
TCCGTACTGCTGGCGGAAGTGCCGCGCTGCGTAGTGGCTTCTCCTGAGCTGCTGGCGAAGTATCCGCCGTTAACCTCGCT
GGAGGCGTTATCGGGCCTGCCATGGATCGCCATTAATACCTTTTATCAGCATGAGGTACGGCTCAGGCATCAGGCAAGCG
GGCAGATTGTCTCTACAGCGATTACTCCCTGTCTGAGCACTGACAGTCTTTACGTCGCGCGCAACACCGCGCTGGCGGGG
CTGGGGGTGGCGATGGTGTCCAGCTGGACGGTCGTGGAGGATATTGCCGCCGGACGGCTGATTGAGCTGTTCCCGCAGTG
GCGACCCGCCTCGCTGCCGGTTCATCTGGTTTATCCCTGGGCGCGCTATTACCCGACACGCCTGCGTAAGTTCCTCGACC
TGATGCGGGAGATCATGCCGGATCTCGCCGGGATGCAGCGTCCGCAAAGCGCATAA

Upstream 100 bases:

>100_bases
CTCATAGATGCGATGGGGCTATTTTTCCCTGAACGCGACTGGCGCGGTAGCCGGGCTGGTGGTAAAACGGTTATACGTAG
CACGTATAGGCAAAAGGAAA

Downstream 100 bases:

>100_bases
AAAAACCGGCCAAAGGCCGGTTTTTTTATTAAGCACGCTTACTCGACGGGCTGTGGGCGAGTCGGTTCAGCGGTGGCTTT
ATGGGTCGCGCTATGACCAC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKRQERIDRIELMRTYIRIVEAGSLSAAAGQMDTTQATVSRRLQSLEGLLGVKLILRTTHAMKLTDDGERCYRHARQVVD
AWLALEDDLRIADDRPVGVLRVRAPHAFGQQQLLAPLVAFLQRHPQLSVEWMLNDNTVDFLSDNIDCAIRVGAEVDPATV
SVLLAEVPRCVVASPELLAKYPPLTSLEALSGLPWIAINTFYQHEVRLRHQASGQIVSTAITPCLSTDSLYVARNTALAG
LGVAMVSSWTVVEDIAAGRLIELFPQWRPASLPVHLVYPWARYYPTRLRKFLDLMREIMPDLAGMQRPQSA

Sequences:

>Translated_311_residues
MKRQERIDRIELMRTYIRIVEAGSLSAAAGQMDTTQATVSRRLQSLEGLLGVKLILRTTHAMKLTDDGERCYRHARQVVD
AWLALEDDLRIADDRPVGVLRVRAPHAFGQQQLLAPLVAFLQRHPQLSVEWMLNDNTVDFLSDNIDCAIRVGAEVDPATV
SVLLAEVPRCVVASPELLAKYPPLTSLEALSGLPWIAINTFYQHEVRLRHQASGQIVSTAITPCLSTDSLYVARNTALAG
LGVAMVSSWTVVEDIAAGRLIELFPQWRPASLPVHLVYPWARYYPTRLRKFLDLMREIMPDLAGMQRPQSA
>Mature_311_residues
MKRQERIDRIELMRTYIRIVEAGSLSAAAGQMDTTQATVSRRLQSLEGLLGVKLILRTTHAMKLTDDGERCYRHARQVVD
AWLALEDDLRIADDRPVGVLRVRAPHAFGQQQLLAPLVAFLQRHPQLSVEWMLNDNTVDFLSDNIDCAIRVGAEVDPATV
SVLLAEVPRCVVASPELLAKYPPLTSLEALSGLPWIAINTFYQHEVRLRHQASGQIVSTAITPCLSTDSLYVARNTALAG
LGVAMVSSWTVVEDIAAGRLIELFPQWRPASLPVHLVYPWARYYPTRLRKFLDLMREIMPDLAGMQRPQSA

Specific function: Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789440, Length=288, Percent_Identity=29.8611111111111, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1786401, Length=288, Percent_Identity=27.0833333333333, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI145693193, Length=301, Percent_Identity=29.9003322259136, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI87081978, Length=275, Percent_Identity=29.4545454545455, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789639, Length=290, Percent_Identity=26.551724137931, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787128, Length=303, Percent_Identity=23.7623762376238, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787589, Length=307, Percent_Identity=24.4299674267101, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786448, Length=256, Percent_Identity=25, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789173, Length=265, Percent_Identity=26.0377358490566, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787601, Length=124, Percent_Identity=26.6129032258064, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787806, Length=303, Percent_Identity=24.0924092409241, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1788481, Length=303, Percent_Identity=24.0924092409241, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34784; Mature: 34784

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRQERIDRIELMRTYIRIVEAGSLSAAAGQMDTTQATVSRRLQSLEGLLGVKLILRTTH
CCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKLTDDGERCYRHARQVVDAWLALEDDLRIADDRPVGVLRVRAPHAFGQQQLLAPLVAF
HEEECCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCCCHHHHHHHHHHH
LQRHPQLSVEWMLNDNTVDFLSDNIDCAIRVGAEVDPATVSVLLAEVPRCVVASPELLAK
HHCCCCCEEEEEECCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCHHHCCCHHHHHC
YPPLTSLEALSGLPWIAINTFYQHEVRLRHQASGQIVSTAITPCLSTDSLYVARNTALAG
CCCCCCHHHHCCCCEEEEHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCEEEEECCHHHH
LGVAMVSSWTVVEDIAAGRLIELFPQWRPASLPVHLVYPWARYYPTRLRKFLDLMREIMP
HHHHHHHCCHHHHHHHCCHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
DLAGMQRPQSA
HHHCCCCCCCC
>Mature Secondary Structure
MKRQERIDRIELMRTYIRIVEAGSLSAAAGQMDTTQATVSRRLQSLEGLLGVKLILRTTH
CCHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMKLTDDGERCYRHARQVVDAWLALEDDLRIADDRPVGVLRVRAPHAFGQQQLLAPLVAF
HEEECCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCCCHHHHHHHHHHH
LQRHPQLSVEWMLNDNTVDFLSDNIDCAIRVGAEVDPATVSVLLAEVPRCVVASPELLAK
HHCCCCCEEEEEECCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCHHHCCCHHHHHC
YPPLTSLEALSGLPWIAINTFYQHEVRLRHQASGQIVSTAITPCLSTDSLYVARNTALAG
CCCCCCHHHHCCCCEEEEHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCEEEEECCHHHH
LGVAMVSSWTVVEDIAAGRLIELFPQWRPASLPVHLVYPWARYYPTRLRKFLDLMREIMP
HHHHHHHCCHHHHHHHCCHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
DLAGMQRPQSA
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]