| Definition | Klebsiella pneumoniae subsp. pneumoniae MGH 78578 chromosome, complete genome. |
|---|---|
| Accession | NC_009648 |
| Length | 5,315,120 |
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The map label for this gene is rlmL [H]
Identifier: 152969534
GI number: 152969534
Start: 1109223
End: 1111328
Strand: Direct
Name: rlmL [H]
Synonym: KPN_00977
Alternate gene names: 152969534
Gene position: 1109223-1111328 (Clockwise)
Preceding gene: 152969532
Following gene: 152969535
Centisome position: 20.87
GC content: 59.69
Gene sequence:
>2106_bases ATGAATTCTCTGTTTGCCAGTACGGCTCGTGGGCTGGAAGAGCTGTTAAAAACTGAACTGGAAGGGCTTGGCGCGACGGA CTGCCAGGTAGTCCAGGGCGGGGTCCATTTTCAGGGGGATACGCGCCTGCTGTATCAAAGCCTGATGTGGAGCCGGCTGG CTTCGCGCATCATGCTGCCGCTGGGCGAATGTCGCGTATACAGCGATCTGGATCTGTACCTCGGCGTACAGGCCATTCCG TGGACGGAGATGTTCAACCCTGGCGCCACCTTCGCGGTGCATTTTAGCGGCCTCAATGACGAGATCCGTAACAGCCAGTA CGGCGCGCTGAAGGTTAAAGACGCCATTGTCGACAGCTTCACCCGTAAGAATCTACCGCGCCCGAACGTCGATCGTGAGT CGCCCGATCTGCGGATCAACGTCTGGCTGAACAAAGAGACGGCGCACATCTCGCTGGATCTGAGCGGCGAAGGCCTGCAC CTGCGCGGCTATCGCGATGGTACCGGAATGGCGCCGATCAAAGAAAACCTCGCGGCGGCGATCGTCATGCGCTCTGGCTG GGTACCAGGTACGCCGCTGCTCGATCCGATGTGCGGCTCCGGTACCCTGCTGATTGAAGCGGCGATGCTGGCGACCGACC GCGCGCCGGGCCTGCACCGCGGCCACTGGGGCTTTGGCGGCTGGGCGCAGCACGATGACGCCATCTGGAAAGAGGTGAAG GCGGAAGCGCAAACCCGCGCTCGTCAGGGATTGGCAGCGTATGAGTCACGCTTCTACGGCTCAGACGTCGACGCGCGCGT AATCGAGCGCGCGCGCCGCAACGCCCGCCGCGCCGGCATTGGCGAGCTGATCGATTTTGACGTGAAAGACGTCGCCCAAC TGAACAACCCGCTGCCGAAAGGCCCGTACGGGACGGTGATCAGTAACCCGCCGTACGGCGAACGTCTGGAAAGCGAGCCA GCGCTGATCGCTCTGCACAGCCTGCTTGGCCGGATAATGAAAAGTCAGTTCGGCGGCTGGAACCTGTCGGTATTCAGCGC TTCGCCGGAGCTGCTGAGTTGCCTGCAGCTGCGTGCCGACAAGCAGTTTAAAGCCAAGAACGGCCCGCTGGACTGCGTGC AGAAGAATTATCACCTGGCGGAGAGCGAAGGCGGCAAGCCGGCGATGCTGGCGGAGGATTTTGCTAACCGTCTGCGTAAA AACCTGAAGAAGTTTGAAAAATGGGCCCGCCAGGAAGGAATCGAATGCTATCGCCTGTACGATGCTGATCTACCGGAATA CAACGTGGCCATTGACCGCTATGCCGACTGGGTGGTGGTCCAGGAGTATGCCCCGCCGAAAACCGTCGACGCGCATAAGG CGCGCCAGCGTCTGTTCGACATCATCGCTGCGACTATCGCCGTACTGGACATGGCGCCTAACAAGCTGGTGCTGAAAACC CGTGAACGGCAGAAGGGGAAAAACCAGTATCAGAAGATGGCGGAGAAGGGCGACTTTATTGAGGTACAGGAGTATAACGC GCGCCTGTGGGTCAACCTCACCGACTACCTGGATACCGGTCTGTTCCTCGACCACCGTATCGCCCGTCGCATGCTCGGCC AGATGAGTAAAGGTAAGGACTTCCTGAACCTGTTCTCCTATACCGGCAGCGCCAGCGTCCACGCAGGCCTCGGCGGTGCG CGATCCACCACCACGGTGGATATGTCACGCACCTACCTGGAGTGGGCGGAACGCAACCTGCGTCTCAATGGCCTGACCGG CCGCGCGCATCGCCTGATGCAGGCGGACGTGCTGGGTTGGCTGCGGGAGAGCACCGAGCAGTTCGATCTGATCTTTATCG ATCCGCCGACCTTTTCCAACTCCAAACGAATGGAAGATGCGTTTGACGTCCAGCGCGATCACATTCGCCTGATGACCGAT CTAAAACGTCTGCTGCGTAAAGGCGGCACCATTATGTTCTCGAATAACAAACGCGGTTTCCGTATGGATCATGACGGGCT GGCGGCGCTTGGCCTGAAGGCGCAAGAGATTTCGCAAAAAACGCTGTCGCAGGATTTTGCCCGCAACCGTCAGATCCACA ACTGCTGGCTGATTACCGCAGCCTGA
Upstream 100 bases:
>100_bases TACGCTGCCTCCGGGTTCCAAAAATAAGCCTATAACTTTATGACATAGGGCACATATTGGCTATAATGCGCACCAATTTT CTTTAAGTAAAAGTGACGAT
Downstream 100 bases:
>100_bases AAGGAATAAATAATGTCACTGATTAGTATGCACGGCGCCTGGCTTTCCTTCAGCGATGCGCCGCTGCTGGATAATGCCGA GCTGCATATTGAAGATAACG
Product: 23S rRNA m(2)G2445 methyltransferase
Products: NA
Alternate protein names: 23S rRNA m2G2445 methyltransferase; rRNA (guanine-N(2)-)-methyltransferase rlmL [H]
Number of amino acids: Translated: 701; Mature: 701
Protein sequence:
>701_residues MNSLFASTARGLEELLKTELEGLGATDCQVVQGGVHFQGDTRLLYQSLMWSRLASRIMLPLGECRVYSDLDLYLGVQAIP WTEMFNPGATFAVHFSGLNDEIRNSQYGALKVKDAIVDSFTRKNLPRPNVDRESPDLRINVWLNKETAHISLDLSGEGLH LRGYRDGTGMAPIKENLAAAIVMRSGWVPGTPLLDPMCGSGTLLIEAAMLATDRAPGLHRGHWGFGGWAQHDDAIWKEVK AEAQTRARQGLAAYESRFYGSDVDARVIERARRNARRAGIGELIDFDVKDVAQLNNPLPKGPYGTVISNPPYGERLESEP ALIALHSLLGRIMKSQFGGWNLSVFSASPELLSCLQLRADKQFKAKNGPLDCVQKNYHLAESEGGKPAMLAEDFANRLRK NLKKFEKWARQEGIECYRLYDADLPEYNVAIDRYADWVVVQEYAPPKTVDAHKARQRLFDIIAATIAVLDMAPNKLVLKT RERQKGKNQYQKMAEKGDFIEVQEYNARLWVNLTDYLDTGLFLDHRIARRMLGQMSKGKDFLNLFSYTGSASVHAGLGGA RSTTTVDMSRTYLEWAERNLRLNGLTGRAHRLMQADVLGWLRESTEQFDLIFIDPPTFSNSKRMEDAFDVQRDHIRLMTD LKRLLRKGGTIMFSNNKRGFRMDHDGLAALGLKAQEISQKTLSQDFARNRQIHNCWLITAA
Sequences:
>Translated_701_residues MNSLFASTARGLEELLKTELEGLGATDCQVVQGGVHFQGDTRLLYQSLMWSRLASRIMLPLGECRVYSDLDLYLGVQAIP WTEMFNPGATFAVHFSGLNDEIRNSQYGALKVKDAIVDSFTRKNLPRPNVDRESPDLRINVWLNKETAHISLDLSGEGLH LRGYRDGTGMAPIKENLAAAIVMRSGWVPGTPLLDPMCGSGTLLIEAAMLATDRAPGLHRGHWGFGGWAQHDDAIWKEVK AEAQTRARQGLAAYESRFYGSDVDARVIERARRNARRAGIGELIDFDVKDVAQLNNPLPKGPYGTVISNPPYGERLESEP ALIALHSLLGRIMKSQFGGWNLSVFSASPELLSCLQLRADKQFKAKNGPLDCVQKNYHLAESEGGKPAMLAEDFANRLRK NLKKFEKWARQEGIECYRLYDADLPEYNVAIDRYADWVVVQEYAPPKTVDAHKARQRLFDIIAATIAVLDMAPNKLVLKT RERQKGKNQYQKMAEKGDFIEVQEYNARLWVNLTDYLDTGLFLDHRIARRMLGQMSKGKDFLNLFSYTGSASVHAGLGGA RSTTTVDMSRTYLEWAERNLRLNGLTGRAHRLMQADVLGWLRESTEQFDLIFIDPPTFSNSKRMEDAFDVQRDHIRLMTD LKRLLRKGGTIMFSNNKRGFRMDHDGLAALGLKAQEISQKTLSQDFARNRQIHNCWLITAA >Mature_701_residues MNSLFASTARGLEELLKTELEGLGATDCQVVQGGVHFQGDTRLLYQSLMWSRLASRIMLPLGECRVYSDLDLYLGVQAIP WTEMFNPGATFAVHFSGLNDEIRNSQYGALKVKDAIVDSFTRKNLPRPNVDRESPDLRINVWLNKETAHISLDLSGEGLH LRGYRDGTGMAPIKENLAAAIVMRSGWVPGTPLLDPMCGSGTLLIEAAMLATDRAPGLHRGHWGFGGWAQHDDAIWKEVK AEAQTRARQGLAAYESRFYGSDVDARVIERARRNARRAGIGELIDFDVKDVAQLNNPLPKGPYGTVISNPPYGERLESEP ALIALHSLLGRIMKSQFGGWNLSVFSASPELLSCLQLRADKQFKAKNGPLDCVQKNYHLAESEGGKPAMLAEDFANRLRK NLKKFEKWARQEGIECYRLYDADLPEYNVAIDRYADWVVVQEYAPPKTVDAHKARQRLFDIIAATIAVLDMAPNKLVLKT RERQKGKNQYQKMAEKGDFIEVQEYNARLWVNLTDYLDTGLFLDHRIARRMLGQMSKGKDFLNLFSYTGSASVHAGLGGA RSTTTVDMSRTYLEWAERNLRLNGLTGRAHRLMQADVLGWLRESTEQFDLIFIDPPTFSNSKRMEDAFDVQRDHIRLMTD LKRLLRKGGTIMFSNNKRGFRMDHDGLAALGLKAQEISQKTLSQDFARNRQIHNCWLITAA
Specific function: Specifically methylates the guanosine in position 2445 (m2G2445) of 23S rRNA [H]
COG id: COG0116
COG function: function code L; Predicted N6-adenine-specific DNA methylase
Gene ontology:
Cell location: Cytoplasm (Potential) [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 THUMP domain [H]
Homologues:
Organism=Escherichia coli, GI1787181, Length=702, Percent_Identity=89.1737891737892, Blast_Score=1291, Evalue=0.0, Organism=Escherichia coli, GI145693111, Length=244, Percent_Identity=28.6885245901639, Blast_Score=86, Evalue=9e-18,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002052 - InterPro: IPR002296 - InterPro: IPR000241 - InterPro: IPR017244 - InterPro: IPR019614 - InterPro: IPR004114 [H]
Pfam domain/function: PF10672 Methyltrans_SAM; PF02926 THUMP; PF01170 UPF0020 [H]
EC number: =2.1.1.173 [H]
Molecular weight: Translated: 78912; Mature: 78912
Theoretical pI: Translated: 8.87; Mature: 8.87
Prosite motif: PS51165 THUMP ; PS00092 N6_MTASE ; PS01261 UPF0020
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 3.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNSLFASTARGLEELLKTELEGLGATDCQVVQGGVHFQGDTRLLYQSLMWSRLASRIMLP CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHHHHHCC LGECRVYSDLDLYLGVQAIPWTEMFNPGATFAVHFSGLNDEIRNSQYGALKVKDAIVDSF CCCCEEECCCHHHCCCEECCHHHHCCCCCEEEEEECCCCHHHCCCCCCEEEHHHHHHHHH TRKNLPRPNVDRESPDLRINVWLNKETAHISLDLSGEGLHLRGYRDGTGMAPIKENLAAA HHCCCCCCCCCCCCCCEEEEEEEECCEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHH IVMRSGWVPGTPLLDPMCGSGTLLIEAAMLATDRAPGLHRGHWGFGGWAQHDDAIWKEVK HHHCCCCCCCCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH AEAQTRARQGLAAYESRFYGSDVDARVIERARRNARRAGIGELIDFDVKDVAQLNNPLPK HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCCCC GPYGTVISNPPYGERLESEPALIALHSLLGRIMKSQFGGWNLSVFSASPELLSCLQLRAD CCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCC KQFKAKNGPLDCVQKNYHLAESEGGKPAMLAEDFANRLRKNLKKFEKWARQEGIECYRLY CCCCCCCCCHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE DADLPEYNVAIDRYADWVVVQEYAPPKTVDAHKARQRLFDIIAATIAVLDMAPNKLVLKT CCCCCCCCEEHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC RERQKGKNQYQKMAEKGDFIEVQEYNARLWVNLTDYLDTGLFLDHRIARRMLGQMSKGKD HHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHCCHH FLNLFSYTGSASVHAGLGGARSTTTVDMSRTYLEWAERNLRLNGLTGRAHRLMQADVLGW HHHHHHCCCCCCEECCCCCCCCCEEEHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHH LRESTEQFDLIFIDPPTFSNSKRMEDAFDVQRDHIRLMTDLKRLLRKGGTIMFSNNKRGF HHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC RMDHDGLAALGLKAQEISQKTLSQDFARNRQIHNCWLITAA EECCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEC >Mature Secondary Structure MNSLFASTARGLEELLKTELEGLGATDCQVVQGGVHFQGDTRLLYQSLMWSRLASRIMLP CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHHHHHCC LGECRVYSDLDLYLGVQAIPWTEMFNPGATFAVHFSGLNDEIRNSQYGALKVKDAIVDSF CCCCEEECCCHHHCCCEECCHHHHCCCCCEEEEEECCCCHHHCCCCCCEEEHHHHHHHHH TRKNLPRPNVDRESPDLRINVWLNKETAHISLDLSGEGLHLRGYRDGTGMAPIKENLAAA HHCCCCCCCCCCCCCCEEEEEEEECCEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHH IVMRSGWVPGTPLLDPMCGSGTLLIEAAMLATDRAPGLHRGHWGFGGWAQHDDAIWKEVK HHHCCCCCCCCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH AEAQTRARQGLAAYESRFYGSDVDARVIERARRNARRAGIGELIDFDVKDVAQLNNPLPK HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHCCCCCC GPYGTVISNPPYGERLESEPALIALHSLLGRIMKSQFGGWNLSVFSASPELLSCLQLRAD CCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCC KQFKAKNGPLDCVQKNYHLAESEGGKPAMLAEDFANRLRKNLKKFEKWARQEGIECYRLY CCCCCCCCCHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE DADLPEYNVAIDRYADWVVVQEYAPPKTVDAHKARQRLFDIIAATIAVLDMAPNKLVLKT CCCCCCCCEEHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC RERQKGKNQYQKMAEKGDFIEVQEYNARLWVNLTDYLDTGLFLDHRIARRMLGQMSKGKD HHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHCCHH FLNLFSYTGSASVHAGLGGARSTTTVDMSRTYLEWAERNLRLNGLTGRAHRLMQADVLGW HHHHHHCCCCCCEECCCCCCCCCEEEHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHH LRESTEQFDLIFIDPPTFSNSKRMEDAFDVQRDHIRLMTDLKRLLRKGGTIMFSNNKRGF HHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC RMDHDGLAALGLKAQEISQKTLSQDFARNRQIHNCWLITAA EECCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA