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The map label for this gene is pyrD [H]

Identifier: 152969531

GI number: 152969531

Start: 1106295

End: 1107305

Strand: Direct

Name: pyrD [H]

Synonym: KPN_00974

Alternate gene names: 152969531

Gene position: 1106295-1107305 (Clockwise)

Preceding gene: 152969525

Following gene: 152969532

Centisome position: 20.81

GC content: 51.83

Gene sequence:

>1011_bases
ATGTACTACCCCTTCGTTCGTAAAGCCCTTTTTCAGCTCGATCCTGAGCGCGCTCATGAAGTTACCTTTCAACAATTACG
CCGTGTCACCGGGACGCCGCTGGAAATGCTGGTTCGCCAGAAGGTACCGGCCAGGCCTGTCACCTGCATGGGGCTAACCT
TTAAAAACCCGCTGGGTCTGGCGGCCGGGCTGGATAAAAATGGGGAATGCATTGACGCGCTGGGCGCGATGGGGTTTGGT
TCGATTGAGATCGGCACCGTGACGCCGCGTCCGCAGCCGGGCAACGATAAGCCAAGGATCTTCCGTCTGGTTGATGCCGA
GGGATTGATCAACCGCATGGGCTTTAATAACCATGGCGTCGATAACCTGGTTGAGAATGTGAAAAAGGCGCATTTTGACG
GCGTGCTGGGTATCAATATCGGCAAAAATAAAGATACGCCGGTTGAGCACGGGAAAGATGATTACCTGATTTGTATGGAA
AAAGTCTATCCGTACGCCGGGTATATCGCCATTAATATCTCCTCGCCGAATACCCCAGGGCTGCGCACGCTGCAATACGG
CGAAGCGCTGGATGATTTACTCTCCGGTATTAAAAATAAGCAGCTCGAGCTGCAGCAGAAGCATCAAAAATATGTCCCGG
TCGCCATAAAGATCGCGCCGGATCTTTTGCCTGAGGAATTGATCCAGGTTGCCGATAGCCTCGTGCGTCATAATATTGAT
GGCGTGATTGCAACCAATACCACCCTCGATCGTTCCCTGGTTCAGGGAATGAAACATTGCGATGAGACCGGCGGGCTTAG
CGGTCGTCCATTACAATTAAAAAGCACTGAAATTATCCGTATGCTCTCCGCTGAGCTGAATGGCCGTTTGCCTATCATCG
GCGTGGGCGGCATTGATTCGGTGATTGCCGCGCGGGAAAAGATTGCCGCCGGGGCATCGCTGGTGCAGATCTATTCTGGA
TTTATTTTTAAAGGTCCGCCGCTGATTAAAGAAATTGTTACCCACATCTAA

Upstream 100 bases:

>100_bases
TGCGCTGATGGGGGATTTTTTGTCGCAGGTCAATTCCCTTTCCGCAACAGATCGCACATAATACGCCCCCGGTTTGCACA
CCGGGAATCCAGGAGAGTTC

Downstream 100 bases:

>100_bases
TCTTTTCCTCCTCTGAATCCCACCCAGGGCTTTATTTCCGGCCCTGGTTGTTTTATATTCCCTCACTGTTGCTTATTTAA
ACATTTTAGACTTTTCTTAA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MYYPFVRKALFQLDPERAHEVTFQQLRRVTGTPLEMLVRQKVPARPVTCMGLTFKNPLGLAAGLDKNGECIDALGAMGFG
SIEIGTVTPRPQPGNDKPRIFRLVDAEGLINRMGFNNHGVDNLVENVKKAHFDGVLGINIGKNKDTPVEHGKDDYLICME
KVYPYAGYIAINISSPNTPGLRTLQYGEALDDLLSGIKNKQLELQQKHQKYVPVAIKIAPDLLPEELIQVADSLVRHNID
GVIATNTTLDRSLVQGMKHCDETGGLSGRPLQLKSTEIIRMLSAELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG
FIFKGPPLIKEIVTHI

Sequences:

>Translated_336_residues
MYYPFVRKALFQLDPERAHEVTFQQLRRVTGTPLEMLVRQKVPARPVTCMGLTFKNPLGLAAGLDKNGECIDALGAMGFG
SIEIGTVTPRPQPGNDKPRIFRLVDAEGLINRMGFNNHGVDNLVENVKKAHFDGVLGINIGKNKDTPVEHGKDDYLICME
KVYPYAGYIAINISSPNTPGLRTLQYGEALDDLLSGIKNKQLELQQKHQKYVPVAIKIAPDLLPEELIQVADSLVRHNID
GVIATNTTLDRSLVQGMKHCDETGGLSGRPLQLKSTEIIRMLSAELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG
FIFKGPPLIKEIVTHI
>Mature_336_residues
MYYPFVRKALFQLDPERAHEVTFQQLRRVTGTPLEMLVRQKVPARPVTCMGLTFKNPLGLAAGLDKNGECIDALGAMGFG
SIEIGTVTPRPQPGNDKPRIFRLVDAEGLINRMGFNNHGVDNLVENVKKAHFDGVLGINIGKNKDTPVEHGKDDYLICME
KVYPYAGYIAINISSPNTPGLRTLQYGEALDDLLSGIKNKQLELQQKHQKYVPVAIKIAPDLLPEELIQVADSLVRHNID
GVIATNTTLDRSLVQGMKHCDETGGLSGRPLQLKSTEIIRMLSAELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG
FIFKGPPLIKEIVTHI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=333, Percent_Identity=44.4444444444444, Blast_Score=239, Evalue=2e-63,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=91.6666666666667, Blast_Score=632, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17509475, Length=303, Percent_Identity=45.8745874587459, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI281361352, Length=294, Percent_Identity=42.8571428571429, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI17137316, Length=294, Percent_Identity=42.8571428571429, Blast_Score=238, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36763; Mature: 36763

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYPFVRKALFQLDPERAHEVTFQQLRRVTGTPLEMLVRQKVPARPVTCMGLTFKNPLGL
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEEECCCCCC
AAGLDKNGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRIFRLVDAEGLINRMGFNNHGV
CCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEECHHHHHHHCCCCCCCH
DNLVENVKKAHFDGVLGINIGKNKDTPVEHGKDDYLICMEKVYPYAGYIAINISSPNTPG
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEHHHHCCCCCEEEEEECCCCCCC
LRTLQYGEALDDLLSGIKNKQLELQQKHQKYVPVAIKIAPDLLPEELIQVADSLVRHNID
CEEHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GVIATNTTLDRSLVQGMKHCDETGGLSGRPLQLKSTEIIRMLSAELNGRLPIIGVGGIDS
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHCCCCCEEECCCHHH
VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
HHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MYYPFVRKALFQLDPERAHEVTFQQLRRVTGTPLEMLVRQKVPARPVTCMGLTFKNPLGL
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEEEECCCCCC
AAGLDKNGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRIFRLVDAEGLINRMGFNNHGV
CCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEECHHHHHHHCCCCCCCH
DNLVENVKKAHFDGVLGINIGKNKDTPVEHGKDDYLICMEKVYPYAGYIAINISSPNTPG
HHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEHHHHCCCCCEEEEEECCCCCCC
LRTLQYGEALDDLLSGIKNKQLELQQKHQKYVPVAIKIAPDLLPEELIQVADSLVRHNID
CEEHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCC
GVIATNTTLDRSLVQGMKHCDETGGLSGRPLQLKSTEIIRMLSAELNGRLPIIGVGGIDS
CEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHCCCCCEEECCCHHH
VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI
HHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA