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The map label for this gene is sdaC [H]

Identifier: 152969521

GI number: 152969521

Start: 1093672

End: 1094961

Strand: Direct

Name: sdaC [H]

Synonym: KPN_00964

Alternate gene names: 152969521

Gene position: 1093672-1094961 (Clockwise)

Preceding gene: 152969520

Following gene: 152969522

Centisome position: 20.58

GC content: 52.09

Gene sequence:

>1290_bases
ATGAATACTGAAAATATAATTATCAATAAAGGATATTCCGATCCCGCAAAGTGGCATAGCGAAGATACCGTTTGGGTCCT
TGGCCTGTTCGGTACCGCCATTGGCGCTGGGGTGCTGTTTCTGCCGATTAATGCCGGAATTGGCGGCTTCTGGCCGCTGC
TGATTGTTTTTGTCCTCGCTTTTCCTATTACTTATCTGGCTCACCGCGGTCTGGCGAGATTCATTTACTCTTCCAATACG
CCGGAAAGCAGTATTACCGATGTTATTGGCGAGCATTTTGGCGCGCTGGCGGGAAAAGTATTTACCGTCATCTATTTCTT
CGCCGTCTATACCATTCTGATTATGTATGCGGTGGCTATCACCAACACCGCGCAGAGCTTTATCACCCACCAGTTGGCAA
TGGCCGAGCCTCCCCGGTCGCTGGTGGCCATCGTTCTGATCCTCGGGCTGATGTTTATCGTCCGTTTCGGACAGCGTTTG
ATAATGCGGGTGATGAGCACCCTGGTTTATCCCTTCATCATCTCGCTTATTTTTATGGCACTTTTTCTGATTCCGCACTG
GAACGGCGCAATTTTGCAAACCGTAAGCTTCAGCGCCGCGGGCGATGGGCAGGGGATCATGTTATCCCTGTGGATGACCT
TCCCGGTACTGGTGATGTCGTTTAACCACTATCCCATCATTTCGCCGATGGTGGTGCGCCAGAAGCAGCGTTACGGTCTG
GCGCTCGCTGAGGGTAAATGTGCGCAGATCCAGCGCTACGGTATCCTGCTCATGACGGTGGTGGTGCTGTTTTTTGTTCT
CAGCTGCGTGTTAAGCCTGTCGCCGCAGCAACTGGCGGAAGCCAAAGCCCAGAATCTGTCGATTTTGTCCTATCTTGCCA
ATCAGTACGATACACCGATTATTGCCTGGCTATCGCCGATTATCGCCTTTGTCGCTATTACTAAATCATTTCTTGGCCAC
TACATCGGCGCCTATGAATCGCTGCGCGACCTGATTCTGGAGGCCGCCGCCGCACGCGGGAAAAAACCTGGTATTCGCCT
CGTCGACGCGGTCATCCTGGTGTTTATGGTGCTTACCTGCTGGTTCGCCGCGTACAAGAACCCCAGTATCCTCGGTATTA
TCGAATGCATCAGCGGTCCCACCGGGGCGGCAATTCTGCTGCTGTTGCCTATGTACGCCATTCATAAATTACCGGTGCTT
GCCCCCTGGCGCGGTAAAGCGAGCAACGTTTTCGTCACCCTGATCGGTCTTATCACCGTATCTGCCATTTTTTACGGCAT
GTTCCAATAA

Upstream 100 bases:

>100_bases
GGCCATCTTACCTACCCTACAAGCCCTCGGTATGACAAGCGTTCTGACTCATAACGAAAACATACGCGCTTTCGCGTCAT
GCATAGAGAGAACCTGACCG

Downstream 100 bases:

>100_bases
CCACCATTATTAGCGAGATGTTATATGAGTCATTATCTGCAGATTAACGGCCAACGGCTTATCGATTCCCTGTATGCACT
TGGCGAACATGGTGCGCTGC

Product: putative transmembrane amino acid transporter protein

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNTENIIINKGYSDPAKWHSEDTVWVLGLFGTAIGAGVLFLPINAGIGGFWPLLIVFVLAFPITYLAHRGLARFIYSSNT
PESSITDVIGEHFGALAGKVFTVIYFFAVYTILIMYAVAITNTAQSFITHQLAMAEPPRSLVAIVLILGLMFIVRFGQRL
IMRVMSTLVYPFIISLIFMALFLIPHWNGAILQTVSFSAAGDGQGIMLSLWMTFPVLVMSFNHYPIISPMVVRQKQRYGL
ALAEGKCAQIQRYGILLMTVVVLFFVLSCVLSLSPQQLAEAKAQNLSILSYLANQYDTPIIAWLSPIIAFVAITKSFLGH
YIGAYESLRDLILEAAAARGKKPGIRLVDAVILVFMVLTCWFAAYKNPSILGIIECISGPTGAAILLLLPMYAIHKLPVL
APWRGKASNVFVTLIGLITVSAIFYGMFQ

Sequences:

>Translated_429_residues
MNTENIIINKGYSDPAKWHSEDTVWVLGLFGTAIGAGVLFLPINAGIGGFWPLLIVFVLAFPITYLAHRGLARFIYSSNT
PESSITDVIGEHFGALAGKVFTVIYFFAVYTILIMYAVAITNTAQSFITHQLAMAEPPRSLVAIVLILGLMFIVRFGQRL
IMRVMSTLVYPFIISLIFMALFLIPHWNGAILQTVSFSAAGDGQGIMLSLWMTFPVLVMSFNHYPIISPMVVRQKQRYGL
ALAEGKCAQIQRYGILLMTVVVLFFVLSCVLSLSPQQLAEAKAQNLSILSYLANQYDTPIIAWLSPIIAFVAITKSFLGH
YIGAYESLRDLILEAAAARGKKPGIRLVDAVILVFMVLTCWFAAYKNPSILGIIECISGPTGAAILLLLPMYAIHKLPVL
APWRGKASNVFVTLIGLITVSAIFYGMFQ
>Mature_429_residues
MNTENIIINKGYSDPAKWHSEDTVWVLGLFGTAIGAGVLFLPINAGIGGFWPLLIVFVLAFPITYLAHRGLARFIYSSNT
PESSITDVIGEHFGALAGKVFTVIYFFAVYTILIMYAVAITNTAQSFITHQLAMAEPPRSLVAIVLILGLMFIVRFGQRL
IMRVMSTLVYPFIISLIFMALFLIPHWNGAILQTVSFSAAGDGQGIMLSLWMTFPVLVMSFNHYPIISPMVVRQKQRYGL
ALAEGKCAQIQRYGILLMTVVVLFFVLSCVLSLSPQQLAEAKAQNLSILSYLANQYDTPIIAWLSPIIAFVAITKSFLGH
YIGAYESLRDLILEAAAARGKKPGIRLVDAVILVFMVLTCWFAAYKNPSILGIIECISGPTGAAILLLLPMYAIHKLPVL
APWRGKASNVFVTLIGLITVSAIFYGMFQ

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=415, Percent_Identity=53.0120481927711, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1789504, Length=446, Percent_Identity=43.9461883408072, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI1789211, Length=416, Percent_Identity=35.0961538461538, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI145693183, Length=409, Percent_Identity=25.4278728606357, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1789961, Length=389, Percent_Identity=25.1928020565553, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 47145; Mature: 47145

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTENIIINKGYSDPAKWHSEDTVWVLGLFGTAIGAGVLFLPINAGIGGFWPLLIVFVLA
CCCCCEEEECCCCCCHHHCCCCCEEHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPITYLAHRGLARFIYSSNTPESSITDVIGEHFGALAGKVFTVIYFFAVYTILIMYAVAI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNTAQSFITHQLAMAEPPRSLVAIVLILGLMFIVRFGQRLIMRVMSTLVYPFIISLIFMA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLIPHWNGAILQTVSFSAAGDGQGIMLSLWMTFPVLVMSFNHYPIISPMVVRQKQRYGL
HHHHCCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
ALAEGKCAQIQRYGILLMTVVVLFFVLSCVLSLSPQQLAEAKAQNLSILSYLANQYDTPI
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
IAWLSPIIAFVAITKSFLGHYIGAYESLRDLILEAAAARGKKPGIRLVDAVILVFMVLTC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
WFAAYKNPSILGIIECISGPTGAAILLLLPMYAIHKLPVLAPWRGKASNVFVTLIGLITV
HHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
SAIFYGMFQ
HHHHHHHCC
>Mature Secondary Structure
MNTENIIINKGYSDPAKWHSEDTVWVLGLFGTAIGAGVLFLPINAGIGGFWPLLIVFVLA
CCCCCEEEECCCCCCHHHCCCCCEEHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPITYLAHRGLARFIYSSNTPESSITDVIGEHFGALAGKVFTVIYFFAVYTILIMYAVAI
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNTAQSFITHQLAMAEPPRSLVAIVLILGLMFIVRFGQRLIMRVMSTLVYPFIISLIFMA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLIPHWNGAILQTVSFSAAGDGQGIMLSLWMTFPVLVMSFNHYPIISPMVVRQKQRYGL
HHHHCCCCCHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
ALAEGKCAQIQRYGILLMTVVVLFFVLSCVLSLSPQQLAEAKAQNLSILSYLANQYDTPI
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
IAWLSPIIAFVAITKSFLGHYIGAYESLRDLILEAAAARGKKPGIRLVDAVILVFMVLTC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
WFAAYKNPSILGIIECISGPTGAAILLLLPMYAIHKLPVLAPWRGKASNVFVTLIGLITV
HHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
SAIFYGMFQ
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]