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The map label for this gene is lpxK

Identifier: 152969499

GI number: 152969499

Start: 1062788

End: 1063768

Strand: Direct

Name: lpxK

Synonym: KPN_00942

Alternate gene names: 152969499

Gene position: 1062788-1063768 (Clockwise)

Preceding gene: 152969498

Following gene: 152969500

Centisome position: 20.0

GC content: 63.71

Gene sequence:

>981_bases
ATGATCGCGCGCATCTGGTCCGGGGAATCGCCGCTGTGGCGCCTGCTGCTGCCGCTCTCCTGGCTGTATGGCCTGGTGAG
CGGGGTGATTCGCCTCAGCTATCAGCTGGGGTGGCAAAAAGCCTGGCGCGCGCCGGTGCCGGTGGTGGTGGTTGGTAACC
TGACCGCCGGCGGCAATGGCAAAACGCCGGTGGTGATCTGGCTGGTGGAGCAGCTGCAGCAGCGCGGTATTCGCGTTGGC
GTCGTGTCTCGCGGCTACGGCGGTAAAGCTGAACGCTATCCGCTGGTGTTGGACGACAGAACCAGTACGGCGCTGGCGGG
TGATGAACCGGTGTTGATCCATCAGCGTACCGGTGCCCCGGTCGCTGTCGCTCCGCTACGCAGCGACGCGGTAAAAGCAT
TGCTCAGCGCGCACGATCTGCAGATGATTGTGACCGACGACGGGTTGCAGCACTATAAGCTTGCGCGGGACAGAGAAATT
GTCGTTATTGACGGCGTGCGCCGCTTTGGCAACGGCTGGTGGCTGCCTGCCGGGCCGATGCGCGAGCGGGCGTCGCGCTT
GCAAAGCGTTGATGCGGTTATCGTTAACGGCGGCGTGGCGCGTCCGGGTGAGATCCCGATGCGGCTGCGCCCAGGGATGG
CGGTTAACCTGCTTACCGGCGAACGTCGCGATGTCTCCACCTTCACGAACGTAGTGGCGATGGCCGGCATCGGCCATCCG
CCGCGCTTCTTCGCCACCCTCGAAAGCTGCGGCGTCCAGCCGGTCAAAACCGTGGCGCTGGCGGACCATCAGGCGCTGAG
CCAGGCTGATGTCGCCGCCCTGGTGACCGCCGATCAGACGCTGCTGATGACCGAGAAAGATGCCGTGAAATGTCGCGATT
TCGCCGCTGCAAACTGGTGGTATTTACCGGTCGACGCCATAATGGCCGATGAACGCGCACAGCGGTTGCTTGCGGACTTA
GCGACGTTGGCGCAACGTTAA

Upstream 100 bases:

>100_bases
TGGTGGTTGAAGACGGGCGGATCGTGGAGCGCGGAACGCACCATGATCTGCTGGAGCATAAGGGCGTGTACGCCCAGCTG
CATAAGATGCAATTCGGCGA

Downstream 100 bases:

>100_bases
CTGACGCGCCGGCTTTGCTCGCCGCTGTGCTGGAATTCCTGACGGAGAACCTGCATGTCGGTATTGCAACTATCGCTTAA
CGAGGCGCGCCACCTCCATC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGVIRLSYQLGWQKAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQQRGIRVG
VVSRGYGGKAERYPLVLDDRTSTALAGDEPVLIHQRTGAPVAVAPLRSDAVKALLSAHDLQMIVTDDGLQHYKLARDREI
VVIDGVRRFGNGWWLPAGPMRERASRLQSVDAVIVNGGVARPGEIPMRLRPGMAVNLLTGERRDVSTFTNVVAMAGIGHP
PRFFATLESCGVQPVKTVALADHQALSQADVAALVTADQTLLMTEKDAVKCRDFAAANWWYLPVDAIMADERAQRLLADL
ATLAQR

Sequences:

>Translated_326_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGVIRLSYQLGWQKAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQQRGIRVG
VVSRGYGGKAERYPLVLDDRTSTALAGDEPVLIHQRTGAPVAVAPLRSDAVKALLSAHDLQMIVTDDGLQHYKLARDREI
VVIDGVRRFGNGWWLPAGPMRERASRLQSVDAVIVNGGVARPGEIPMRLRPGMAVNLLTGERRDVSTFTNVVAMAGIGHP
PRFFATLESCGVQPVKTVALADHQALSQADVAALVTADQTLLMTEKDAVKCRDFAAANWWYLPVDAIMADERAQRLLADL
ATLAQR
>Mature_326_residues
MIARIWSGESPLWRLLLPLSWLYGLVSGVIRLSYQLGWQKAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQQRGIRVG
VVSRGYGGKAERYPLVLDDRTSTALAGDEPVLIHQRTGAPVAVAPLRSDAVKALLSAHDLQMIVTDDGLQHYKLARDREI
VVIDGVRRFGNGWWLPAGPMRERASRLQSVDAVIVNGGVARPGEIPMRLRPGMAVNLLTGERRDVSTFTNVVAMAGIGHP
PRFFATLESCGVQPVKTVALADHQALSQADVAALVTADQTLLMTEKDAVKCRDFAAANWWYLPVDAIMADERAQRLLADL
ATLAQR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=325, Percent_Identity=77.8461538461538, Blast_Score=508, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_KLEP7 (A6T707)

Other databases:

- EMBL:   CP000647
- RefSeq:   YP_001334608.1
- STRING:   A6T707
- GeneID:   5339796
- GenomeReviews:   CP000647_GR
- KEGG:   kpn:KPN_00942
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- ProtClustDB:   PRK00652
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 35556; Mature: 35556

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARIWSGESPLWRLLLPLSWLYGLVSGVIRLSYQLGWQKAWRAPVPVVVVGNLTAGGNG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEEEECEECCCCC
KTPVVIWLVEQLQQRGIRVGVVSRGYGGKAERYPLVLDDRTSTALAGDEPVLIHQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCEECCCCCEEEEECCCCC
VAVAPLRSDAVKALLSAHDLQMIVTDDGLQHYKLARDREIVVIDGVRRFGNGWWLPAGPM
EEEECCCHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCEEEEEECHHHHCCCCCCCCCHH
RERASRLQSVDAVIVNGGVARPGEIPMRLRPGMAVNLLTGERRDVSTFTNVVAMAGIGHP
HHHHHHHHHCCEEEEECCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
PRFFATLESCGVQPVKTVALADHQALSQADVAALVTADQTLLMTEKDAVKCRDFAAANWW
HHHHHHHHHCCCCHHHHEEHHHHHHHHHHCEEEEEECCCEEEEECCCHHHHHHHCCCCEE
YLPVDAIMADERAQRLLADLATLAQR
EEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIARIWSGESPLWRLLLPLSWLYGLVSGVIRLSYQLGWQKAWRAPVPVVVVGNLTAGGNG
CEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCEEEEECEECCCCC
KTPVVIWLVEQLQQRGIRVGVVSRGYGGKAERYPLVLDDRTSTALAGDEPVLIHQRTGAP
CCCEEEEEHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCEECCCCCEEEEECCCCC
VAVAPLRSDAVKALLSAHDLQMIVTDDGLQHYKLARDREIVVIDGVRRFGNGWWLPAGPM
EEEECCCHHHHHHHHHHCCEEEEEECCCCHHHHHCCCCEEEEEECHHHHCCCCCCCCCHH
RERASRLQSVDAVIVNGGVARPGEIPMRLRPGMAVNLLTGERRDVSTFTNVVAMAGIGHP
HHHHHHHHHCCEEEEECCCCCCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
PRFFATLESCGVQPVKTVALADHQALSQADVAALVTADQTLLMTEKDAVKCRDFAAANWW
HHHHHHHHHCCCCHHHHEEHHHHHHHHHHCEEEEEECCCEEEEECCCHHHHHHHCCCCEE
YLPVDAIMADERAQRLLADLATLAQR
EEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA