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The map label for this gene is dxs [C]

Identifier: 152969386

GI number: 152969386

Start: 923401

End: 924393

Strand: Direct

Name: dxs [C]

Synonym: KPN_00829

Alternate gene names: 152969386

Gene position: 923401-924393 (Clockwise)

Preceding gene: 152969385

Following gene: 152969387

Centisome position: 17.37

GC content: 60.42

Gene sequence:

>993_bases
ATGAGCCAGAGTCAACCCCGTTTAAAAACGTCGGCGATGATCGCCTCGATTGCTGATGAAGGCCAGGCGACCGTCCCTGC
GCCCTTCGGCGTCGCGCTGTCAAAACTGGCGGCGCAGCGCCCGGAAATCGTCGGCATGACTGCGGATCTGTCAAAATATA
CCGACCTGCATATTTTCGCCCAGGCCTTCCCGGATCGCTTTTTCCAGATGGGCATGGCCGAACAGCTGCTGATGGCGGCG
GCAGGGGGGATGGCGAAGGAGGGATTTATTCCTTTCGCCACCACCTATGCCGCCTTTGCAACCCGTCGCGCCTATGATTT
TATTCACCAGGTCATCGCCGAAGAGCATCTGAACGTGAAGATCTGCGCGGCGCTGCCGGGCCTGACGACCGGCTATGGCC
CCAGCCATCAGGCCACCGAAGATCTGGCGATCATGCGCGGTATCCCCGGGATGGTTATCGTCGATCCTTGCGATGCGCTG
GAGATAGAGCAGGCGGTACCGGCCATTGCCGATCACCAGGGGCCGGTGTATATGCGTCTGCTGCGCGGTAAGGTGCCGCT
GGTGCTGGATAAATATGACTATCAGTTCGAACTGGGTAAGGCGAAGCTGCTGGAGGACGGCAACGATGTGCTGATTATCT
CCTCCGGGCTGATGACCATGCGCGCGCTGGAGGCGGCTGAAAAGCTGCGGGCCGATAATATCGGCGTGGCGGTTCTGCAC
GTGCCGACCATCAAACCGCTGGATGAGAAAGCGATTATTGAACAGGCGTCGAAGCCGGGCCGCCTGGTGGTAACTGCGGA
GAACCACACCGCGGTCGGCGGCCTGGGGGAAGCGGTGGCCGCGCTGCTGATGCGTAAGGGCGTACGCTGTGAGCTGGATA
GCGTGGGGCTGCCCGACGCGTTCCTGTTAGCCGGCGCCCTGCCGACCCTCCACGATCGCTACGGCATCTCCACCGCGAAG
ATTGTCGAAAAAATTAAGTATCGTCTGCGTTAA

Upstream 100 bases:

>100_bases
TCGAAACCCGCGATAAAAACCATTTTATTCGCGTCGATGCCGACGAATGGCAAAAAGCGATCGCGGTGCTGGACGCTAAC
AAACCGGAAGGAGTGCTGTA

Downstream 100 bases:

>100_bases
CCGCACTGCTATGACCCACTGGCCGCTGAGCGCGCTCAGCGGCCTTCTCATGCCCGCCAGCCAGGCGCGGCATTCTTTTG
CAGATTTTATGCGGCCTGTC

Product: putative transketolase

Products: D-ribose 5-phosphate; D-xylulose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MSQSQPRLKTSAMIASIADEGQATVPAPFGVALSKLAAQRPEIVGMTADLSKYTDLHIFAQAFPDRFFQMGMAEQLLMAA
AGGMAKEGFIPFATTYAAFATRRAYDFIHQVIAEEHLNVKICAALPGLTTGYGPSHQATEDLAIMRGIPGMVIVDPCDAL
EIEQAVPAIADHQGPVYMRLLRGKVPLVLDKYDYQFELGKAKLLEDGNDVLIISSGLMTMRALEAAEKLRADNIGVAVLH
VPTIKPLDEKAIIEQASKPGRLVVTAENHTAVGGLGEAVAALLMRKGVRCELDSVGLPDAFLLAGALPTLHDRYGISTAK
IVEKIKYRLR

Sequences:

>Translated_330_residues
MSQSQPRLKTSAMIASIADEGQATVPAPFGVALSKLAAQRPEIVGMTADLSKYTDLHIFAQAFPDRFFQMGMAEQLLMAA
AGGMAKEGFIPFATTYAAFATRRAYDFIHQVIAEEHLNVKICAALPGLTTGYGPSHQATEDLAIMRGIPGMVIVDPCDAL
EIEQAVPAIADHQGPVYMRLLRGKVPLVLDKYDYQFELGKAKLLEDGNDVLIISSGLMTMRALEAAEKLRADNIGVAVLH
VPTIKPLDEKAIIEQASKPGRLVVTAENHTAVGGLGEAVAALLMRKGVRCELDSVGLPDAFLLAGALPTLHDRYGISTAK
IVEKIKYRLR
>Mature_329_residues
SQSQPRLKTSAMIASIADEGQATVPAPFGVALSKLAAQRPEIVGMTADLSKYTDLHIFAQAFPDRFFQMGMAEQLLMAAA
GGMAKEGFIPFATTYAAFATRRAYDFIHQVIAEEHLNVKICAALPGLTTGYGPSHQATEDLAIMRGIPGMVIVDPCDALE
IEQAVPAIADHQGPVYMRLLRGKVPLVLDKYDYQFELGKAKLLEDGNDVLIISSGLMTMRALEAAEKLRADNIGVAVLHV
PTIKPLDEKAIIEQASKPGRLVVTAENHTAVGGLGEAVAALLMRKGVRCELDSVGLPDAFLLAGALPTLHDRYGISTAKI
VEKIKYRLR

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=260, Percent_Identity=34.6153846153846, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI4507521, Length=260, Percent_Identity=34.6153846153846, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI225637463, Length=306, Percent_Identity=34.9673202614379, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI225637459, Length=306, Percent_Identity=34.9673202614379, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI225637461, Length=306, Percent_Identity=34.9673202614379, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI133778974, Length=306, Percent_Identity=32.6797385620915, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1786622, Length=325, Percent_Identity=28.9230769230769, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788808, Length=229, Percent_Identity=27.5109170305677, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539652, Length=311, Percent_Identity=36.6559485530547, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24666278, Length=299, Percent_Identity=32.7759197324415, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24645119, Length=308, Percent_Identity=32.1428571428571, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45551847, Length=308, Percent_Identity=32.1428571428571, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45550715, Length=308, Percent_Identity=32.1428571428571, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 2.2.1.1

Molecular weight: Translated: 35522; Mature: 35391

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSQPRLKTSAMIASIADEGQATVPAPFGVALSKLAAQRPEIVGMTADLSKYTDLHIFA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHH
QAFPDRFFQMGMAEQLLMAAAGGMAKEGFIPFATTYAAFATRRAYDFIHQVIAEEHLNVK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
ICAALPGLTTGYGPSHQATEDLAIMRGIPGMVIVDPCDALEIEQAVPAIADHQGPVYMRL
EEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHCCHHHCCCCCHHHHH
LRGKVPLVLDKYDYQFELGKAKLLEDGNDVLIISSGLMTMRALEAAEKLRADNIGVAVLH
HCCCCCEEEECCCCEEECCCHHEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEE
VPTIKPLDEKAIIEQASKPGRLVVTAENHTAVGGLGEAVAALLMRKGVRCELDSVGLPDA
ECCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCHH
FLLAGALPTLHDRYGISTAKIVEKIKYRLR
HHHHCCCCHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SQSQPRLKTSAMIASIADEGQATVPAPFGVALSKLAAQRPEIVGMTADLSKYTDLHIFA
CCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHH
QAFPDRFFQMGMAEQLLMAAAGGMAKEGFIPFATTYAAFATRRAYDFIHQVIAEEHLNVK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
ICAALPGLTTGYGPSHQATEDLAIMRGIPGMVIVDPCDALEIEQAVPAIADHQGPVYMRL
EEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHCCHHHCCCCCHHHHH
LRGKVPLVLDKYDYQFELGKAKLLEDGNDVLIISSGLMTMRALEAAEKLRADNIGVAVLH
HCCCCCEEEECCCCEEECCCHHEECCCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEEE
VPTIKPLDEKAIIEQASKPGRLVVTAENHTAVGGLGEAVAALLMRKGVRCELDSVGLPDA
ECCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCHH
FLLAGALPTLHDRYGISTAKIVEKIKYRLR
HHHHCCCCHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: sedoheptulose 7-phosphate; D-glyceraldehyde 3-phosphate

Specific reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]