| Definition | Klebsiella pneumoniae subsp. pneumoniae MGH 78578 chromosome, complete genome. |
|---|---|
| Accession | NC_009648 |
| Length | 5,315,120 |
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The map label for this gene is fabG [C]
Identifier: 152969384
GI number: 152969384
Start: 921793
End: 922542
Strand: Direct
Name: fabG [C]
Synonym: KPN_00827
Alternate gene names: 152969384
Gene position: 921793-922542 (Clockwise)
Preceding gene: 152969383
Following gene: 152969385
Centisome position: 17.34
GC content: 60.0
Gene sequence:
>750_bases ATGTTATTGAAAGATAAAGTCGCCATTATTACTGGCGCGGCCTCCGCACGCGGTTTGGGCTTCGCGACTGCGAAATTATT CGCCGAAAACGGCGCGAAAGTGGTCATTATCGACCTCAATGGCGAAGCCAGTAAAACCGCCGCGGCGGCATTAGGCGAAG ACCATCTCGGCCTGGCGGCCAACGTCGCTGATGAAGTGCAGGTGCAGGCGGCCATCGAACAGATCCTGGCGAAATACGGT CGGGTTGATGTACTGGTCAATAACGCCGGGATTACCCAGCCGCTGAAGCTGATGGATATCAAGCGCGCCAACTATGACGC GGTGCTTGATGTTAGCCTGCGCGGCACGCTGCTGATGTCGCAGGCGGTTATCCCCACCATGCGGGCGCAAAAATCCGGCA GCATCGTCTGCATCTCGTCCGTCTCCGCCCAGCGCGGCGGCGGTATTTTCGGCGGACCGCACTACAGCGCGGCAAAAGCC GGGGTGCTGGGTCTGGCGCGGGCGATGGCGCGCGAGCTTGGCCCGGATAACGTCCGCGTTAACTGCATCACCCCGGGGCT GATTCAGACCGACATTACCGCCGGCAAGCTGACTGATGACATGACGGCCAACATTCTTGCCGGCATTCCGATGAACCGCC TTGGCGACGCGATAGACATCGCGCGCGCCGCGCTGTTCCTCGGCAGCGATCTTTCCTCCTACTCCACCGGCATCACCCTG GACGTTAACGGCGGCATGTTAATTCACTAA
Upstream 100 bases:
>100_bases GCGCCGCCATTGGTTTGGTGGTGATTCTTTTCCTCGATGAACCACAATAACGGAAATATATCCTGTTAATTAATATGACG TAATGTCATGGAGTGAAACT
Downstream 100 bases:
>100_bases GCGAGGCAAACAGATGAAGATGACCGAATCACAAAAAGTCGCCGCGGCGGCGTGGCGTATTCGCCGTTACGCCCTGCAAA TGGGGGAAGTGCAGGGGCAG
Product: putative short-chain dehydrogenase/reductase SDR
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 249; Mature: 249
Protein sequence:
>249_residues MLLKDKVAIITGAASARGLGFATAKLFAENGAKVVIIDLNGEASKTAAAALGEDHLGLAANVADEVQVQAAIEQILAKYG RVDVLVNNAGITQPLKLMDIKRANYDAVLDVSLRGTLLMSQAVIPTMRAQKSGSIVCISSVSAQRGGGIFGGPHYSAAKA GVLGLARAMARELGPDNVRVNCITPGLIQTDITAGKLTDDMTANILAGIPMNRLGDAIDIARAALFLGSDLSSYSTGITL DVNGGMLIH
Sequences:
>Translated_249_residues MLLKDKVAIITGAASARGLGFATAKLFAENGAKVVIIDLNGEASKTAAAALGEDHLGLAANVADEVQVQAAIEQILAKYG RVDVLVNNAGITQPLKLMDIKRANYDAVLDVSLRGTLLMSQAVIPTMRAQKSGSIVCISSVSAQRGGGIFGGPHYSAAKA GVLGLARAMARELGPDNVRVNCITPGLIQTDITAGKLTDDMTANILAGIPMNRLGDAIDIARAALFLGSDLSSYSTGITL DVNGGMLIH >Mature_249_residues MLLKDKVAIITGAASARGLGFATAKLFAENGAKVVIIDLNGEASKTAAAALGEDHLGLAANVADEVQVQAAIEQILAKYG RVDVLVNNAGITQPLKLMDIKRANYDAVLDVSLRGTLLMSQAVIPTMRAQKSGSIVCISSVSAQRGGGIFGGPHYSAAKA GVLGLARAMARELGPDNVRVNCITPGLIQTDITAGKLTDDMTANILAGIPMNRLGDAIDIARAALFLGSDLSSYSTGITL DVNGGMLIH
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=37.603305785124, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=34.8837209302326, Blast_Score=129, Evalue=3e-30, Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=33.7349397590361, Blast_Score=125, Evalue=2e-29, Organism=Homo sapiens, GI10190704, Length=254, Percent_Identity=32.6771653543307, Blast_Score=113, Evalue=1e-25, Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=30.5019305019305, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI66933014, Length=225, Percent_Identity=31.5555555555556, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=30.5220883534137, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI4758504, Length=233, Percent_Identity=34.7639484978541, Blast_Score=101, Evalue=5e-22, Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=31.7460317460317, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI4504505, Length=189, Percent_Identity=37.037037037037, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=30.8695652173913, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=30.2788844621514, Blast_Score=96, Evalue=4e-20, Organism=Homo sapiens, GI126723191, Length=186, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=2e-19, Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=31.9796954314721, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI31542939, Length=207, Percent_Identity=32.8502415458937, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI83715985, Length=233, Percent_Identity=33.0472103004292, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI20149619, Length=207, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=9e-17, Organism=Homo sapiens, GI210032110, Length=225, Percent_Identity=24.4444444444444, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI4503817, Length=186, Percent_Identity=31.7204301075269, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI302344755, Length=107, Percent_Identity=37.3831775700935, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI4503301, Length=229, Percent_Identity=27.0742358078603, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI224922801, Length=183, Percent_Identity=31.6939890710383, Blast_Score=75, Evalue=4e-14, Organism=Homo sapiens, GI7706318, Length=216, Percent_Identity=28.2407407407407, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI40254986, Length=195, Percent_Identity=31.7948717948718, Blast_Score=72, Evalue=7e-13, Organism=Homo sapiens, GI109715829, Length=234, Percent_Identity=23.5042735042735, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI40807363, Length=200, Percent_Identity=28.5, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI157739938, Length=205, Percent_Identity=25.8536585365854, Blast_Score=64, Evalue=9e-11, Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=40.3225806451613, Blast_Score=175, Evalue=3e-45, Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=34.1176470588235, Blast_Score=137, Evalue=5e-34, Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=37.8486055776892, Blast_Score=137, Evalue=6e-34, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=34, Blast_Score=127, Evalue=6e-31, Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=33.7349397590361, Blast_Score=122, Evalue=2e-29, Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=35.7723577235772, Blast_Score=116, Evalue=1e-27, Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=29.9610894941634, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI1788459, Length=252, Percent_Identity=31.7460317460317, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI2367175, Length=255, Percent_Identity=31.3725490196078, Blast_Score=91, Evalue=7e-20, Organism=Escherichia coli, GI1789378, Length=253, Percent_Identity=27.6679841897233, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1787526, Length=254, Percent_Identity=27.9527559055118, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI1788891, Length=240, Percent_Identity=26.25, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI2367365, Length=230, Percent_Identity=28.2608695652174, Blast_Score=71, Evalue=9e-14, Organism=Escherichia coli, GI1787820, Length=190, Percent_Identity=30, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1787545, Length=260, Percent_Identity=26.5384615384615, Blast_Score=67, Evalue=1e-12, Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=38.1526104417671, Blast_Score=152, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17555706, Length=250, Percent_Identity=38.4, Blast_Score=147, Evalue=4e-36, Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=33.2, Blast_Score=130, Evalue=6e-31, Organism=Caenorhabditis elegans, GI71994600, Length=252, Percent_Identity=32.5396825396825, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=33.2089552238806, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=33.8345864661654, Blast_Score=104, Evalue=5e-23, Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=31.0756972111554, Blast_Score=103, Evalue=8e-23, Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=30.5019305019305, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=32.4528301886792, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17568967, Length=189, Percent_Identity=32.2751322751323, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=31.5589353612167, Blast_Score=94, Evalue=8e-20, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=32.5670498084291, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=27.8195488721804, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=32.4, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17565030, Length=267, Percent_Identity=31.4606741573034, Blast_Score=88, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=31.2977099236641, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=30.9160305343511, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17538182, Length=225, Percent_Identity=31.5555555555556, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=31.4176245210728, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17562904, Length=273, Percent_Identity=30.4029304029304, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=30.4182509505703, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17561272, Length=235, Percent_Identity=30.2127659574468, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=29.8850574712644, Blast_Score=80, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=30.3030303030303, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=31.1787072243346, Blast_Score=78, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17536025, Length=252, Percent_Identity=27.3809523809524, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=30.5343511450382, Blast_Score=77, Evalue=6e-15, Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=30.6513409961686, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=30.7984790874525, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17536651, Length=252, Percent_Identity=26.5873015873016, Blast_Score=73, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17567345, Length=194, Percent_Identity=29.8969072164948, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17508895, Length=197, Percent_Identity=27.4111675126904, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI71982365, Length=196, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=7e-13, Organism=Caenorhabditis elegans, GI193203115, Length=203, Percent_Identity=27.0935960591133, Blast_Score=67, Evalue=6e-12, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=8e-12, Organism=Caenorhabditis elegans, GI17564282, Length=199, Percent_Identity=26.6331658291457, Blast_Score=64, Evalue=1e-10, Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=38.860103626943, Blast_Score=112, Evalue=4e-26, Organism=Saccharomyces cerevisiae, GI6324126, Length=254, Percent_Identity=30.7086614173228, Blast_Score=101, Evalue=1e-22, Organism=Saccharomyces cerevisiae, GI6322227, Length=198, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=2e-11, Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=36.9477911646586, Blast_Score=142, Evalue=2e-34, Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=34.6613545816733, Blast_Score=138, Evalue=3e-33, Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=35.0597609561753, Blast_Score=129, Evalue=1e-30, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=36.3636363636364, Blast_Score=126, Evalue=2e-29, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=36.7588932806324, Blast_Score=125, Evalue=3e-29, Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=34.9019607843137, Blast_Score=115, Evalue=4e-26, Organism=Drosophila melanogaster, GI18859837, Length=210, Percent_Identity=38.0952380952381, Blast_Score=107, Evalue=1e-23, Organism=Drosophila melanogaster, GI24643142, Length=253, Percent_Identity=30.0395256916996, Blast_Score=99, Evalue=4e-21, Organism=Drosophila melanogaster, GI24644337, Length=233, Percent_Identity=29.6137339055794, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI17737361, Length=236, Percent_Identity=31.7796610169492, Blast_Score=91, Evalue=1e-18, Organism=Drosophila melanogaster, GI24641232, Length=237, Percent_Identity=29.1139240506329, Blast_Score=79, Evalue=3e-15, Organism=Drosophila melanogaster, GI21358495, Length=209, Percent_Identity=31.1004784688995, Blast_Score=78, Evalue=7e-15, Organism=Drosophila melanogaster, GI21357673, Length=189, Percent_Identity=29.1005291005291, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24581726, Length=176, Percent_Identity=27.8409090909091, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI281364892, Length=194, Percent_Identity=29.8969072164948, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24649181, Length=203, Percent_Identity=25.615763546798, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI221510726, Length=195, Percent_Identity=27.6923076923077, Blast_Score=65, Evalue=5e-11, Organism=Drosophila melanogaster, GI21355631, Length=223, Percent_Identity=25.5605381165919, Blast_Score=65, Evalue=6e-11, Organism=Drosophila melanogaster, GI24647931, Length=223, Percent_Identity=27.8026905829596, Blast_Score=64, Evalue=1e-10,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 25638; Mature: 25638
Theoretical pI: Translated: 7.51; Mature: 7.51
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLLKDKVAIITGAASARGLGFATAKLFAENGAKVVIIDLNGEASKTAAAALGEDHLGLAA CCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCCCCEEE NVADEVQVQAAIEQILAKYGRVDVLVNNAGITQPLKLMDIKRANYDAVLDVSLRGTLLMS CCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHEEECCCCCCEEEEEEECCEEEHH QAVIPTMRAQKSGSIVCISSVSAQRGGGIFGGPHYSAAKAGVLGLARAMARELGPDNVRV HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE NCITPGLIQTDITAGKLTDDMTANILAGIPMNRLGDAIDIARAALFLGSDLSSYSTGITL EEECCCEEEECCCCCCCCCCCHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCHHCCCCEEE DVNGGMLIH EECCCEEEC >Mature Secondary Structure MLLKDKVAIITGAASARGLGFATAKLFAENGAKVVIIDLNGEASKTAAAALGEDHLGLAA CCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCCCCEEE NVADEVQVQAAIEQILAKYGRVDVLVNNAGITQPLKLMDIKRANYDAVLDVSLRGTLLMS CCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHEEECCCCCCEEEEEEECCEEEHH QAVIPTMRAQKSGSIVCISSVSAQRGGGIFGGPHYSAAKAGVLGLARAMARELGPDNVRV HHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE NCITPGLIQTDITAGKLTDDMTANILAGIPMNRLGDAIDIARAALFLGSDLSSYSTGITL EEECCCEEEECCCCCCCCCCCHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCHHCCCCEEE DVNGGMLIH EECCCEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9163424 [H]