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The map label for this gene is comE [H]

Identifier: 150401641

GI number: 150401641

Start: 1289224

End: 1289787

Strand: Direct

Name: comE [H]

Synonym: Maeo_1219

Alternate gene names: 150401641

Gene position: 1289224-1289787 (Clockwise)

Preceding gene: 150401640

Following gene: 150401650

Centisome position: 82.14

GC content: 29.43

Gene sequence:

>564_bases
TTGGACAATACACTAAGAAGAATTGATATAATAAAAATATTAATGGAATATGTGAAAGATGAATTAATAATAAGCAATAT
AGGATTTCCCAGCAAGGAGCTCCACCACATAAAAGACAGAAATGAAAATTTTTATATGCTTGGCTCTATGGGGTTATGCT
CTTCGATAGGTTTAGGTTTGGCATTAAACACCGATAAAAAAGTAATTTCAATTGATGGAGACGGATCTGTTCTTATGAAT
TTGGGAACATTATCTACAATTGGACATACAAAACCTAATAATTTTATTTTGTTAATTGTGGATAATTCTGCCTATGGTTC
AACAGGAAACCAGAAAACACATACAAACAATACAGAATTAGATAAAATAGCTAAATCATGTGGATTACATACAATTAAAA
CTAAAAATGAAAAAGAGCTAAGAGATGCTTTAACTAAGGCACTAAAAGAAAATAAAACCACCGTAATAGTGGCAAAGGCA
AAGGCATATAATGAAAAAACAAAGAATATAAAAATTCCGCCAGTTGTAATAAAATATAGATTTATGAATTCTGTTAATGG
GTAA

Upstream 100 bases:

>100_bases
TAGTTTAAATGTAGATGGTGTTTTAATAGCCACTTCAATTCATAATGGAACGCTAAATTTAAAAGAAATAATTGAAAAAT
ATAAATAAATTGGTGATAAT

Downstream 100 bases:

>100_bases
TTACGATAGGACAAATAAGGACAGTTATTAAACTTACTAAATATGGGAGCTCCTAAATAATAGTTTGTTCGAGAACTTTT
TAAACGAAATATGCCATGAC

Product: thiamine pyrophosphate binding domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MDNTLRRIDIIKILMEYVKDELIISNIGFPSKELHHIKDRNENFYMLGSMGLCSSIGLGLALNTDKKVISIDGDGSVLMN
LGTLSTIGHTKPNNFILLIVDNSAYGSTGNQKTHTNNTELDKIAKSCGLHTIKTKNEKELRDALTKALKENKTTVIVAKA
KAYNEKTKNIKIPPVVIKYRFMNSVNG

Sequences:

>Translated_187_residues
MDNTLRRIDIIKILMEYVKDELIISNIGFPSKELHHIKDRNENFYMLGSMGLCSSIGLGLALNTDKKVISIDGDGSVLMN
LGTLSTIGHTKPNNFILLIVDNSAYGSTGNQKTHTNNTELDKIAKSCGLHTIKTKNEKELRDALTKALKENKTTVIVAKA
KAYNEKTKNIKIPPVVIKYRFMNSVNG
>Mature_187_residues
MDNTLRRIDIIKILMEYVKDELIISNIGFPSKELHHIKDRNENFYMLGSMGLCSSIGLGLALNTDKKVISIDGDGSVLMN
LGTLSTIGHTKPNNFILLIVDNSAYGSTGNQKTHTNNTELDKIAKSCGLHTIKTKNEKELRDALTKALKENKTTVIVAKA
KAYNEKTKNIKIPPVVIKYRFMNSVNG

Specific function: Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022494
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C [H]

EC number: =4.1.1.79 [H]

Molecular weight: Translated: 20763; Mature: 20763

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNTLRRIDIIKILMEYVKDELIISNIGFPSKELHHIKDRNENFYMLGSMGLCSSIGLGL
CCCHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCCEEEEECCCCHHHCCCCE
ALNTDKKVISIDGDGSVLMNLGTLSTIGHTKPNNFILLIVDNSAYGSTGNQKTHTNNTEL
EECCCCEEEEECCCCEEEEECCCHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHH
DKIAKSCGLHTIKTKNEKELRDALTKALKENKTTVIVAKAKAYNEKTKNIKIPPVVIKYR
HHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCEEEEEE
FMNSVNG
EHHCCCC
>Mature Secondary Structure
MDNTLRRIDIIKILMEYVKDELIISNIGFPSKELHHIKDRNENFYMLGSMGLCSSIGLGL
CCCHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCCEEEEECCCCHHHCCCCE
ALNTDKKVISIDGDGSVLMNLGTLSTIGHTKPNNFILLIVDNSAYGSTGNQKTHTNNTEL
EECCCCEEEEECCCCEEEEECCCHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHH
DKIAKSCGLHTIKTKNEKELRDALTKALKENKTTVIVAKAKAYNEKTKNIKIPPVVIKYR
HHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCEEEEEE
FMNSVNG
EHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10940029 [H]