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The map label for this gene is uppS [H]

Identifier: 150401559

GI number: 150401559

Start: 1180958

End: 1181749

Strand: Reverse

Name: uppS [H]

Synonym: Maeo_1136

Alternate gene names: 150401559

Gene position: 1181749-1180958 (Counterclockwise)

Preceding gene: 150401560

Following gene: 150401558

Centisome position: 75.29

GC content: 31.19

Gene sequence:

>792_bases
TTGTTGGTAGAAATTTACGATTTTATGACTAAATTGGGAATTTACAAATATTATGAAAAAATGCTTGAAAGAAAGTTAGA
TAAAAAAAATATCCCAAAACATATCGGAGTAATCATGGATGGAAATCGGAGAATGACTAAGACAATTGGAAGTAAATCCA
TGATTGGCCATAAAATCGGTGCTAAAAAAAGTTTGGAGTTTGTAGATTGGTGTGTTAATTTAGGGGTAAAAGTAATTACG
CTATATTCTTTTTCACAGGAGAATTTTAATAGGTCTAAGGAAGAAGTAGATTTTTTAATGGATTTGTTTGAACAAGAATT
TATGGCCACAGCAGACGACAGTATGGTTCATAAAAAAAAGATAAGAATAAAGGCGATAGGGCGAGTAGATTTGCTTCCCG
AGCGAGTTAGGAAAGCAATAGATTATGCAGAAGAAAGAACAAAAGACTATAATAATTATTATGTAAATGTTGCAATTGCC
TATGGCGGACAGCAGGAAATTGTAGATGCCATAAAAGATATAGCATATAAAATAAAAAACAATGAATTAAATGTTGAGGA
TATATCTGTTAATACAATATCTGAACGACTATATACTTCACATTTACCCCACCCTAATCCAGATTTAATAATTAGAACAT
CGGGCGAGGAGAGAATTAGTAATTTTTTAACATGGCAGTCCATATATTCAGAACTTTATTTTTGTGAAGTGTATTGGCCT
CAATTTAGAAAAATAGATTTTCTAAGAGCAATTCGGGATTATCAAAAGAGAAAAAGACGATATGGAAAGTAA

Upstream 100 bases:

>100_bases
GTGATTTTAAATGATAAAGATATAAAATTTATAGATACCAGTAGAAGCGGGGATTGGAAAAGATATTATAATGCCATAAA
ATTCTTAAATGGTGATTAAT

Downstream 100 bases:

>100_bases
AAATATAGTAAGTTCAATAACTGTCCCTTATCCGCCATATCGTAAAAATTCCTCTGGAATTTTGAGGTCCCCCCGAGATT
CAATAATCTCTGATTATTGC

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MLVEIYDFMTKLGIYKYYEKMLERKLDKKNIPKHIGVIMDGNRRMTKTIGSKSMIGHKIGAKKSLEFVDWCVNLGVKVIT
LYSFSQENFNRSKEEVDFLMDLFEQEFMATADDSMVHKKKIRIKAIGRVDLLPERVRKAIDYAEERTKDYNNYYVNVAIA
YGGQQEIVDAIKDIAYKIKNNELNVEDISVNTISERLYTSHLPHPNPDLIIRTSGEERISNFLTWQSIYSELYFCEVYWP
QFRKIDFLRAIRDYQKRKRRYGK

Sequences:

>Translated_263_residues
MLVEIYDFMTKLGIYKYYEKMLERKLDKKNIPKHIGVIMDGNRRMTKTIGSKSMIGHKIGAKKSLEFVDWCVNLGVKVIT
LYSFSQENFNRSKEEVDFLMDLFEQEFMATADDSMVHKKKIRIKAIGRVDLLPERVRKAIDYAEERTKDYNNYYVNVAIA
YGGQQEIVDAIKDIAYKIKNNELNVEDISVNTISERLYTSHLPHPNPDLIIRTSGEERISNFLTWQSIYSELYFCEVYWP
QFRKIDFLRAIRDYQKRKRRYGK
>Mature_263_residues
MLVEIYDFMTKLGIYKYYEKMLERKLDKKNIPKHIGVIMDGNRRMTKTIGSKSMIGHKIGAKKSLEFVDWCVNLGVKVIT
LYSFSQENFNRSKEEVDFLMDLFEQEFMATADDSMVHKKKIRIKAIGRVDLLPERVRKAIDYAEERTKDYNNYYVNVAIA
YGGQQEIVDAIKDIAYKIKNNELNVEDISVNTISERLYTSHLPHPNPDLIIRTSGEERISNFLTWQSIYSELYFCEVYWP
QFRKIDFLRAIRDYQKRKRRYGK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=246, Percent_Identity=39.0243902439024, Blast_Score=185, Evalue=3e-47,
Organism=Homo sapiens, GI45580742, Length=246, Percent_Identity=39.0243902439024, Blast_Score=185, Evalue=4e-47,
Organism=Escherichia coli, GI1786371, Length=234, Percent_Identity=38.034188034188, Blast_Score=164, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71993029, Length=241, Percent_Identity=36.9294605809129, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319474, Length=238, Percent_Identity=33.6134453781513, Blast_Score=118, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=249, Percent_Identity=31.7269076305221, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18857969, Length=244, Percent_Identity=37.7049180327869, Blast_Score=168, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 31192; Mature: 31192

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVEIYDFMTKLGIYKYYEKMLERKLDKKNIPKHIGVIMDGNRRMTKTIGSKSMIGHKIG
CEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEECCCCHHHHHCCCHHHHHHHCC
AKKSLEFVDWCVNLGVKVITLYSFSQENFNRSKEEVDFLMDLFEQEFMATADDSMVHKKK
CCHHHHHHHHHHHCCEEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IRIKAIGRVDLLPERVRKAIDYAEERTKDYNNYYVNVAIAYGGQQEIVDAIKDIAYKIKN
HEEEECCCHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHCC
NELNVEDISVNTISERLYTSHLPHPNPDLIIRTSGEERISNFLTWQSIYSELYFCEVYWP
CCCCEEEEEHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEEEECC
QFRKIDFLRAIRDYQKRKRRYGK
HHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLVEIYDFMTKLGIYKYYEKMLERKLDKKNIPKHIGVIMDGNRRMTKTIGSKSMIGHKIG
CEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEECCCCHHHHHCCCHHHHHHHCC
AKKSLEFVDWCVNLGVKVITLYSFSQENFNRSKEEVDFLMDLFEQEFMATADDSMVHKKK
CCHHHHHHHHHHHCCEEEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IRIKAIGRVDLLPERVRKAIDYAEERTKDYNNYYVNVAIAYGGQQEIVDAIKDIAYKIKN
HEEEECCCHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHCC
NELNVEDISVNTISERLYTSHLPHPNPDLIIRTSGEERISNFLTWQSIYSELYFCEVYWP
CCCCEEEEEHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEEEECC
QFRKIDFLRAIRDYQKRKRRYGK
HHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]