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The map label for this gene is lldD2 [H]

Identifier: 150398700

GI number: 150398700

Start: 3717420

End: 3718565

Strand: Direct

Name: lldD2 [H]

Synonym: Smed_3514

Alternate gene names: 150398700

Gene position: 3717420-3718565 (Clockwise)

Preceding gene: 150398692

Following gene: 150398705

Centisome position: 98.29

GC content: 61.69

Gene sequence:

>1146_bases
ATGCGACTGCAAGACTGCCACAATTTCCATGATTTTCGCCGCCTTGCCCGCAGAAGGCTGCCGGGCCCGATTTTCAACTA
CATTGACGGCGCAGCGGACGACGAAGTGACTTTGCGGCGCAATGCCGCCGCCTTCGAGGCCTGCGATCTGGTTCCCAACG
TCCTGTGCGGCGTGGCCGAAGTGGACATGTCCGTCACCGTCATGGGCCAGAAGCTCGCTATGCCCGTCTATTGCTCACCA
ACCGCGCTGCAGCGGCTGTTCCACCATCAGGGTGAACGCGCGGTCGCCGCCGCCGCCAGCAAAACGGGGACGATGTTCGG
CGTCTCGTCGCTGGGAACGGTGAGCCTCGAAGAAGCGCGGCGGATCGGCCAGGGCCCTCAGGTGTACCAGTTTTATTTCC
ACAAGGATCGCGGCCTCAATCGTGCGATGATGCAGCGGGCCAAGGAAGCCGGCGTCGAGGCGATGATGCTGACCGTTGAC
AGCATCACAGGCGGCAACCGTGAGCGTGACAAGCGCACCGGATTTTCAATTCCTTTCCGGCTCAACCTTGCCGGTATCAC
GCAATTCGCACTGAAGCCGGCCTGGGCGATCAACTATCTGACACATGAACGCTTCGCCCTGCCGCAGCTCGATGGCCATG
TCGACATGGGCGGCGGCACCATGTCGATCAGCCGCTATTTCACCGAAATGCTGGATCCGGCGTTGCATTGGGACGATGTC
GCCGAAATGGTCGGCGAATGGGGCGGTCCGTTCTGCCTAAAAGGGGTGATGTCGGTTGCGGACGCCAAAAGGGCCGTCGA
CATAGGGTGCGCGGGTCTGGTGCTTTCGAACCATGGTGGACGGCAGCTCGATGGCTCCCGCACGGCATTCGACCAGCTCG
CCGAGATCGTTGACGCTGTCGGCGATCGCATCGATGTGATGATGGACGGCGGCGTCCAGCGCGGCACGCACGTGATCAAG
GCGCTGTCTCTGGGAGCGAAGGCGGTGGGTTTGGGCCGCTATTACCTCTTTCCGCTCGCAGCGGCAGGGCAGGCTGGCGT
CGAGCGCGCGCTCGACCTGATGCGCCTTGAGATCGAGCGAAGCATGAAACTCATGGGATGCAAATGCGTTGATGACCTGA
CGCGAAGCAATCTGAGGTTTCGCTAG

Upstream 100 bases:

>100_bases
GATCGTCGGCATCGGTACTCCCTCCACCGCCCGAGAGTGGATTTTTCCGGGTGGGGCGGCTACACCCGTTCGAACCGCGC
TCTCTCACGGGAAACCAAGC

Downstream 100 bases:

>100_bases
AGCGCCATGACATCAGTCGCCGGCGACCTCAGGTCGGTACCCGGCACTCTCATCAGCAGGGGGTCGGCATCTCCGACGAA
GAAGGTTAGCGTCGTCATCA

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MRLQDCHNFHDFRRLARRRLPGPIFNYIDGAADDEVTLRRNAAAFEACDLVPNVLCGVAEVDMSVTVMGQKLAMPVYCSP
TALQRLFHHQGERAVAAAASKTGTMFGVSSLGTVSLEEARRIGQGPQVYQFYFHKDRGLNRAMMQRAKEAGVEAMMLTVD
SITGGNRERDKRTGFSIPFRLNLAGITQFALKPAWAINYLTHERFALPQLDGHVDMGGGTMSISRYFTEMLDPALHWDDV
AEMVGEWGGPFCLKGVMSVADAKRAVDIGCAGLVLSNHGGRQLDGSRTAFDQLAEIVDAVGDRIDVMMDGGVQRGTHVIK
ALSLGAKAVGLGRYYLFPLAAAGQAGVERALDLMRLEIERSMKLMGCKCVDDLTRSNLRFR

Sequences:

>Translated_381_residues
MRLQDCHNFHDFRRLARRRLPGPIFNYIDGAADDEVTLRRNAAAFEACDLVPNVLCGVAEVDMSVTVMGQKLAMPVYCSP
TALQRLFHHQGERAVAAAASKTGTMFGVSSLGTVSLEEARRIGQGPQVYQFYFHKDRGLNRAMMQRAKEAGVEAMMLTVD
SITGGNRERDKRTGFSIPFRLNLAGITQFALKPAWAINYLTHERFALPQLDGHVDMGGGTMSISRYFTEMLDPALHWDDV
AEMVGEWGGPFCLKGVMSVADAKRAVDIGCAGLVLSNHGGRQLDGSRTAFDQLAEIVDAVGDRIDVMMDGGVQRGTHVIK
ALSLGAKAVGLGRYYLFPLAAAGQAGVERALDLMRLEIERSMKLMGCKCVDDLTRSNLRFR
>Mature_381_residues
MRLQDCHNFHDFRRLARRRLPGPIFNYIDGAADDEVTLRRNAAAFEACDLVPNVLCGVAEVDMSVTVMGQKLAMPVYCSP
TALQRLFHHQGERAVAAAASKTGTMFGVSSLGTVSLEEARRIGQGPQVYQFYFHKDRGLNRAMMQRAKEAGVEAMMLTVD
SITGGNRERDKRTGFSIPFRLNLAGITQFALKPAWAINYLTHERFALPQLDGHVDMGGGTMSISRYFTEMLDPALHWDDV
AEMVGEWGGPFCLKGVMSVADAKRAVDIGCAGLVLSNHGGRQLDGSRTAFDQLAEIVDAVGDRIDVMMDGGVQRGTHVIK
ALSLGAKAVGLGRYYLFPLAAAGQAGVERALDLMRLEIERSMKLMGCKCVDDLTRSNLRFR

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=372, Percent_Identity=35.2150537634409, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI54234014, Length=371, Percent_Identity=33.4231805929919, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI7705393, Length=371, Percent_Identity=33.4231805929919, Blast_Score=202, Evalue=5e-52,
Organism=Escherichia coli, GI1790033, Length=372, Percent_Identity=34.9462365591398, Blast_Score=225, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI193208036, Length=368, Percent_Identity=33.4239130434783, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI32566217, Length=279, Percent_Identity=31.8996415770609, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323587, Length=384, Percent_Identity=35.15625, Blast_Score=210, Evalue=3e-55,
Organism=Drosophila melanogaster, GI78707188, Length=368, Percent_Identity=35.5978260869565, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI281363140, Length=368, Percent_Identity=35.5978260869565, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI78707190, Length=368, Percent_Identity=35.5978260869565, Blast_Score=225, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41808; Mature: 41808

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLQDCHNFHDFRRLARRRLPGPIFNYIDGAADDEVTLRRNAAAFEACDLVPNVLCGVAE
CCCHHHCCHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
VDMSVTVMGQKLAMPVYCSPTALQRLFHHQGERAVAAAASKTGTMFGVSSLGTVSLEEAR
CCCEEEEECHHHCCCEEECHHHHHHHHHHCCCHHHHHHHHCCCCEEECCCCCCEEHHHHH
RIGQGPQVYQFYFHKDRGLNRAMMQRAKEAGVEAMMLTVDSITGGNRERDKRTGFSIPFR
HCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCEE
LNLAGITQFALKPAWAINYLTHERFALPQLDGHVDMGGGTMSISRYFTEMLDPALHWDDV
EEHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCHHHH
AEMVGEWGGPFCLKGVMSVADAKRAVDIGCAGLVLSNHGGRQLDGSRTAFDQLAEIVDAV
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GDRIDVMMDGGVQRGTHVIKALSLGAKAVGLGRYYLFPLAAAGQAGVERALDLMRLEIER
CCCEEEEECCCCHHHHHHHHHHHCCCHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SMKLMGCKCVDDLTRSNLRFR
HHHHHCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MRLQDCHNFHDFRRLARRRLPGPIFNYIDGAADDEVTLRRNAAAFEACDLVPNVLCGVAE
CCCHHHCCHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
VDMSVTVMGQKLAMPVYCSPTALQRLFHHQGERAVAAAASKTGTMFGVSSLGTVSLEEAR
CCCEEEEECHHHCCCEEECHHHHHHHHHHCCCHHHHHHHHCCCCEEECCCCCCEEHHHHH
RIGQGPQVYQFYFHKDRGLNRAMMQRAKEAGVEAMMLTVDSITGGNRERDKRTGFSIPFR
HCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCEE
LNLAGITQFALKPAWAINYLTHERFALPQLDGHVDMGGGTMSISRYFTEMLDPALHWDDV
EEHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCCHHHH
AEMVGEWGGPFCLKGVMSVADAKRAVDIGCAGLVLSNHGGRQLDGSRTAFDQLAEIVDAV
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GDRIDVMMDGGVQRGTHVIKALSLGAKAVGLGRYYLFPLAAAGQAGVERALDLMRLEIER
CCCEEEEECCCCHHHHHHHHHHHCCCHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SMKLMGCKCVDDLTRSNLRFR
HHHHHCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]