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The map label for this gene is gyaR [H]

Identifier: 150398569

GI number: 150398569

Start: 3580661

End: 3581734

Strand: Direct

Name: gyaR [H]

Synonym: Smed_3380

Alternate gene names: 150398569

Gene position: 3580661-3581734 (Clockwise)

Preceding gene: 150398567

Following gene: 150398571

Centisome position: 94.68

GC content: 63.04

Gene sequence:

>1074_bases
TTGCGGCTGTGGGGAGAACTATCACCCGACTTGGTTAAGGACCCGTCAACGGGGGCGCCGCTCATAGCAATGACAAGCAA
GAAAAAGCCAACGGTCTACATCACCCGGAAACTGCCGGATGTCGTCGAAACAAGGATGCGCGAACTTTTCGATGCGGAAT
TGAACATCGATGACACGCCGCGCAGCCAACCGGAGCTGGTTGCCGCGCTCAAGCGCGCGGACGTGCTCGTGCCGACGGTG
ACGGATCGGATCGACGCCGCGCTGATCGAGCAGGCTGGGCCGCAACTGAAGCTCATTGCCGCCTTTTCGAATGGCGTCGA
CAACATCGATGTGGATGCAGCAGCGCGCAAGGGCATCACCGTTACCAATACGCCTAACGTTCTGACCGAGGACACGGCCG
ATATGACCATGGCGCTGATCCTCGCGGTGCCGCGCCGCCTTGCCGAGGGAGCGCAGGTGCTGACCGATCGCAAGGGCGAA
TGGGCGGGCTGGTCTCCAACCTGGATGCTCGGCCGGCGCATTGCCGGCAAGCGCATCGGCATCGTCGGCATGGGGCGCAT
CGGCACGGCCGTTGCCCGCCGCGCCAAGGCCTTCGGGCTTTCGATCCACTACCATAATCGCCATAGGGTCAAGCCGGAAA
CCGAGGAGATGCTGGAGGCGACCTATTGGGACAGCCTCGACCAGATGCTCGCCCGCGTCGATATCGTCTCCGTCAACTGC
CCCTCGACCCCGGCGACCTATCATCTGCTCTCGGCCCGGCGGCTGGCGCTGATGCGGCCCGAGAGCTACATCGTCAACAC
CGCGCGCGGCGGCATTATCGACGAGACGGCGCTTATCAAGAGCCTTCGCGAAGGGAAGATCGCCGGTGCAGGGCTCGACG
TTTTCGAGAACGAACCGTCCGTCAATCCGAAGCTCATCAAACTTGCCGGTGAGGGAAAGGTCGTGCTCCTGCCGCATATG
AGCTCGGCGACGCTGGAAGGCCGTATCGACATGGGCGAGAAGGTGGTGATCAACATCCGCACCTTCTTCGACGGCCACCG
TCCGCCCGACCGGGTGCTGCCGGGGCGGGATTGA

Upstream 100 bases:

>100_bases
TTGGTGCTGACCGGCCAGCCGCTCGCAAATCCCCGCAGCTTTCAAATCCCGCATGGGGGCGGCGACTTTCAATTGTGTTC
CCCACCGGGTCTGGTAGAAA

Downstream 100 bases:

>100_bases
ACCTCTGCGCGTCTGATAAGGCGCGCGGCGCTGCAGGAAACGTATCGGAGCCCTGCAATCACTCCTCTTCTCCTCGCCTC
TGCGCTTGTGTCACGGTGAT

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRLWGELSPDLVKDPSTGAPLIAMTSKKKPTVYITRKLPDVVETRMRELFDAELNIDDTPRSQPELVAALKRADVLVPTV
TDRIDAALIEQAGPQLKLIAAFSNGVDNIDVDAAARKGITVTNTPNVLTEDTADMTMALILAVPRRLAEGAQVLTDRKGE
WAGWSPTWMLGRRIAGKRIGIVGMGRIGTAVARRAKAFGLSIHYHNRHRVKPETEEMLEATYWDSLDQMLARVDIVSVNC
PSTPATYHLLSARRLALMRPESYIVNTARGGIIDETALIKSLREGKIAGAGLDVFENEPSVNPKLIKLAGEGKVVLLPHM
SSATLEGRIDMGEKVVINIRTFFDGHRPPDRVLPGRD

Sequences:

>Translated_357_residues
MRLWGELSPDLVKDPSTGAPLIAMTSKKKPTVYITRKLPDVVETRMRELFDAELNIDDTPRSQPELVAALKRADVLVPTV
TDRIDAALIEQAGPQLKLIAAFSNGVDNIDVDAAARKGITVTNTPNVLTEDTADMTMALILAVPRRLAEGAQVLTDRKGE
WAGWSPTWMLGRRIAGKRIGIVGMGRIGTAVARRAKAFGLSIHYHNRHRVKPETEEMLEATYWDSLDQMLARVDIVSVNC
PSTPATYHLLSARRLALMRPESYIVNTARGGIIDETALIKSLREGKIAGAGLDVFENEPSVNPKLIKLAGEGKVVLLPHM
SSATLEGRIDMGEKVVINIRTFFDGHRPPDRVLPGRD
>Mature_357_residues
MRLWGELSPDLVKDPSTGAPLIAMTSKKKPTVYITRKLPDVVETRMRELFDAELNIDDTPRSQPELVAALKRADVLVPTV
TDRIDAALIEQAGPQLKLIAAFSNGVDNIDVDAAARKGITVTNTPNVLTEDTADMTMALILAVPRRLAEGAQVLTDRKGE
WAGWSPTWMLGRRIAGKRIGIVGMGRIGTAVARRAKAFGLSIHYHNRHRVKPETEEMLEATYWDSLDQMLARVDIVSVNC
PSTPATYHLLSARRLALMRPESYIVNTARGGIIDETALIKSLREGKIAGAGLDVFENEPSVNPKLIKLAGEGKVVLLPHM
SSATLEGRIDMGEKVVINIRTFFDGHRPPDRVLPGRD

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=324, Percent_Identity=32.0987654320988, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI23308577, Length=285, Percent_Identity=32.6315789473684, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI61743967, Length=266, Percent_Identity=35.3383458646617, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=35.3383458646617, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI145580578, Length=357, Percent_Identity=30.5322128851541, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI4557499, Length=357, Percent_Identity=30.5322128851541, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI145580575, Length=262, Percent_Identity=34.7328244274809, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI87082289, Length=329, Percent_Identity=38.9057750759878, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789279, Length=256, Percent_Identity=29.6875, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1787645, Length=336, Percent_Identity=26.7857142857143, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1788660, Length=304, Percent_Identity=24.6710526315789, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=291, Percent_Identity=31.2714776632302, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=341, Percent_Identity=29.3255131964809, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324055, Length=311, Percent_Identity=35.3697749196142, Blast_Score=165, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6320925, Length=293, Percent_Identity=27.9863481228669, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=320, Percent_Identity=27.5, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=262, Percent_Identity=30.1526717557252, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=263, Percent_Identity=29.277566539924, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=174, Percent_Identity=31.6091954022989, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=153, Percent_Identity=30.0653594771242, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571528, Length=329, Percent_Identity=36.1702127659575, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28574286, Length=277, Percent_Identity=33.9350180505415, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45552429, Length=287, Percent_Identity=33.7979094076655, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI28574284, Length=287, Percent_Identity=33.7979094076655, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24585514, Length=287, Percent_Identity=33.7979094076655, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI28574282, Length=287, Percent_Identity=33.7979094076655, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI45551003, Length=287, Percent_Identity=33.7979094076655, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24646446, Length=256, Percent_Identity=34.765625, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24646448, Length=256, Percent_Identity=34.765625, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24646452, Length=256, Percent_Identity=34.765625, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24646450, Length=256, Percent_Identity=34.765625, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI62472511, Length=256, Percent_Identity=34.765625, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24585516, Length=292, Percent_Identity=29.4520547945205, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI19921140, Length=271, Percent_Identity=31.3653136531365, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 39176; Mature: 39176

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLWGELSPDLVKDPSTGAPLIAMTSKKKPTVYITRKLPDVVETRMRELFDAELNIDDTP
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCC
RSQPELVAALKRADVLVPTVTDRIDAALIEQAGPQLKLIAAFSNGVDNIDVDAAARKGIT
CCCHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHCCEE
VTNTPNVLTEDTADMTMALILAVPRRLAEGAQVLTDRKGEWAGWSPTWMLGRRIAGKRIG
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEE
IVGMGRIGTAVARRAKAFGLSIHYHNRHRVKPETEEMLEATYWDSLDQMLARVDIVSVNC
EEECCHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECC
PSTPATYHLLSARRLALMRPESYIVNTARGGIIDETALIKSLREGKIAGAGLDVFENEPS
CCCCHHHHHHHHHHHHEECCCHHEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHCCCCCC
VNPKLIKLAGEGKVVLLPHMSSATLEGRIDMGEKVVINIRTFFDGHRPPDRVLPGRD
CCCEEEEEECCCCEEEEECCCCCEEECCCCCCCEEEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MRLWGELSPDLVKDPSTGAPLIAMTSKKKPTVYITRKLPDVVETRMRELFDAELNIDDTP
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCC
RSQPELVAALKRADVLVPTVTDRIDAALIEQAGPQLKLIAAFSNGVDNIDVDAAARKGIT
CCCHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHCCEE
VTNTPNVLTEDTADMTMALILAVPRRLAEGAQVLTDRKGEWAGWSPTWMLGRRIAGKRIG
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEE
IVGMGRIGTAVARRAKAFGLSIHYHNRHRVKPETEEMLEATYWDSLDQMLARVDIVSVNC
EEECCHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECC
PSTPATYHLLSARRLALMRPESYIVNTARGGIIDETALIKSLREGKIAGAGLDVFENEPS
CCCCHHHHHHHHHHHHEECCCHHEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHCCCCCC
VNPKLIKLAGEGKVVLLPHMSSATLEGRIDMGEKVVINIRTFFDGHRPPDRVLPGRD
CCCEEEEEECCCCEEEEECCCCCEEECCCCCCCEEEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA