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The map label for this gene is lon [H]

Identifier: 150396097

GI number: 150396097

Start: 933551

End: 935971

Strand: Direct

Name: lon [H]

Synonym: Smed_0874

Alternate gene names: 150396097

Gene position: 933551-935971 (Clockwise)

Preceding gene: 150396096

Following gene: 150396098

Centisome position: 24.68

GC content: 60.26

Gene sequence:

>2421_bases
ATGACGAACAAAACGTCTCCGGCGACTGAAAGCGCGACCTATCCGGTTCTGCCGCTGCGTGACATCGTGGTCTTCCCCCA
CATGATCGTGCCGCTCTTCGTCGGCCGGGAGAAGTCGATCCGTGCACTCGAAGAGGTCATGGGTACCGACAAGCAGATCA
TGCTCGTGACCCAGATCAACGCTACGGACGACGATCCGGAACCCTCCGCCATTTACAAAGTCGGCACCATCGCCAATGTG
CTGCAGCTCCTGAAGCTTCCCGACGGAACCGTCAAGGTTCTGGTCGAAGGCCGTTCGCGTGCCGAGATCGAGCGCTATAC
GCCGCGCGACGATTTTTACGAGGCAATGGCTCATGCACTGCCCGAACCGGACGAGGACCCGGTTGAGATCGAGGCGCTGA
GCCGCTCGGTCGTTTCCGAATTCGAGAGCTATGTAAAGCTCAACAAGAAGATTTCGCCGGAAGTGGTCGGAGTTGCAAGC
CAGATCGAAGACTATTCGAAGCTTGCCGATACCGTTGCGTCCCATCTTTCCATCAAGATCGTCGAAAAGCAGGAAATGCT
GGAGACGACGAGCGTGAAGATGCGCCTCGAAAAGGCGCTCGGCTTCATGGAAGGAGAGATTTCGGTTCTTCAGGTCGAAA
AGCGTATCCGTTCGCGCGTCAAGCGCCAGATGGAGAAGACGCAGCGTGAGTACTACCTGAATGAGCAGATGAAGGCCATT
CAGAAGGAACTCGGCGATAGCGAGGACGGCCGCGACGAAATGGCCGAACTCGAAGAGCGCATCTCCAAGACGAAGCTCTC
CAAGGAAGCCCGTGAAAAGGCCGATGCGGAGTTGAAGAAGCTGCGCCAGATGAGCCCGATGTCGGCGGAAGCGACTGTCG
TCCGCAACTATCTCGACTGGCTGCTGGGCCTGCCCTGGGGCAAGAAGTCGAAGATCAAGACCGACCTCAATCACGCCGAA
AAGGTGCTCGACACCGATCACTTCGGTCTGGACAAGGTAAAGGAACGCATCGTCGAGTACCTGGCGGTGCAGGCCCGTTC
GTCCAAGATCAAGGGGCCGATCCTGTGCCTCGTGGGCCCTCCGGGCGTCGGCAAGACCTCGCTTGCGAAGTCGATCGCGA
AGGCGACCGGGCGTGAATATATCCGCATGGCACTGGGCGGTGTTCGCGACGAGGCCGAAATCCGCGGCCACCGGCGGACC
TATATCGGCTCCATGCCGGGTAAGGTCGTCCAGTCGATGAAGAAGGCCAAGAAGTCCAACCCGCTCTTCCTGCTCGACGA
GATCGACAAGATGGGCCAGGACTTCCGGGGAGATCCGTCTTCGGCGCTTTTGGAGGTGCTCGATCCGGAACAGAACTCGA
CCTTCATGGATCACTATCTGGAGGTTGAATATGACCTCTCGAACGTGATGTTCATCACCACGGCGAACACGCTCAACATC
CCGCCGCCGCTGATGGACCGTATGGAAGTCATCCGCATCGCCGGCTACACCGAAGAGGAAAAGCTGGAGATTGCCAAGCG
GCACCTGCTGCCGAAGGCGATCCGGGACCATGCGCTCCAGACGAACGAGTTCTCCGTAACGGATGGCGCTCTGACCGCGA
TCATCCAGAACTACACGCGAGAGGCGGGCGTGCGCAACTTCGAGCGCGAGCTGATGAAGCTTGCGCGCAAGGCGGTGACG
GAAATCCTCAAGGGCAAGACCAAAAAGGTCGAAGTCTCGGCCGAGAACATCAACGACTATCTCGGCGTACCGCGCTTCCG
CCATGGTGAAGCCGAACGCGACGATCAGGTCGGGGTGGTCACCGGTCTCGCCTGGACCGAGGTCGGCGGCGAACTGCTGA
CGATCGAGGGCGTGATGATGCCCGGCAAGGGCCGCATGACGGTGACCGGCAACCTGCGTGACGTGATGAAGGAATCCATT
TCGGCAGCGGCATCCTATGTCCGCTCGCGCGCGATCGATTTCGGCATCGAGCCGCCGCTGTTCGACAAGCGCGACATTCA
CGTCCACGTACCCGAGGGCGCAACCCCGAAGGACGGTCCGTCCGCCGGTGTTGCCATGGCGACGGCGATCGTGTCGGTGA
TGACCGGCATCCCGATCTCCAAGGATGTGGCGATGACGGGCGAAATCACCCTGCGTGGCCGTGTCCTGCCGATCGGCGGC
CTGAAGGAGAAGTTGCTTGCGGCTCTGCGCGGCGGCATCAAGAAGGTGCTGATCCCCGAGGAGAATGCCAAGGACCTCGC
CGACATCCCCGACAACGTCAAGAACAGCCTCGAAATCATCCCCGTTTCGCGGATGGGCGAGGTGATCGCGCATGCCTTGC
TGCGGCTTCCGGAGCCCATTGAATGGGATCCGGCCAGCCAGCCAGCCGCTCTGCCGTCCGTCGATTCGCAGGACGAAGCG
GGCACTTCGATTGCCCACTGA

Upstream 100 bases:

>100_bases
CCTCTCTTGCACTCCACTTTCATGTACGAAATGTGACAGCCGGGAGTGCCGTAGAGGCTCCCGGATACGGGCCCGAAAAT
CGGGACGGAAAGGAAATGAA

Downstream 100 bases:

>100_bases
CGGAGCGCGAATGGGGCGGCAAGTGTGTCCCGCTTGCGCCCTTTGCCCAGAAAAACAAGGAAGACCGGCGCTTCGCCGGT
CTTTTTTGTTGTAAAAGCAC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MTNKTSPATESATYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGTDKQIMLVTQINATDDDPEPSAIYKVGTIANV
LQLLKLPDGTVKVLVEGRSRAEIERYTPRDDFYEAMAHALPEPDEDPVEIEALSRSVVSEFESYVKLNKKISPEVVGVAS
QIEDYSKLADTVASHLSIKIVEKQEMLETTSVKMRLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAI
QKELGDSEDGRDEMAELEERISKTKLSKEAREKADAELKKLRQMSPMSAEATVVRNYLDWLLGLPWGKKSKIKTDLNHAE
KVLDTDHFGLDKVKERIVEYLAVQARSSKIKGPILCLVGPPGVGKTSLAKSIAKATGREYIRMALGGVRDEAEIRGHRRT
YIGSMPGKVVQSMKKAKKSNPLFLLDEIDKMGQDFRGDPSSALLEVLDPEQNSTFMDHYLEVEYDLSNVMFITTANTLNI
PPPLMDRMEVIRIAGYTEEEKLEIAKRHLLPKAIRDHALQTNEFSVTDGALTAIIQNYTREAGVRNFERELMKLARKAVT
EILKGKTKKVEVSAENINDYLGVPRFRHGEAERDDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESI
SAAASYVRSRAIDFGIEPPLFDKRDIHVHVPEGATPKDGPSAGVAMATAIVSVMTGIPISKDVAMTGEITLRGRVLPIGG
LKEKLLAALRGGIKKVLIPEENAKDLADIPDNVKNSLEIIPVSRMGEVIAHALLRLPEPIEWDPASQPAALPSVDSQDEA
GTSIAH

Sequences:

>Translated_806_residues
MTNKTSPATESATYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGTDKQIMLVTQINATDDDPEPSAIYKVGTIANV
LQLLKLPDGTVKVLVEGRSRAEIERYTPRDDFYEAMAHALPEPDEDPVEIEALSRSVVSEFESYVKLNKKISPEVVGVAS
QIEDYSKLADTVASHLSIKIVEKQEMLETTSVKMRLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAI
QKELGDSEDGRDEMAELEERISKTKLSKEAREKADAELKKLRQMSPMSAEATVVRNYLDWLLGLPWGKKSKIKTDLNHAE
KVLDTDHFGLDKVKERIVEYLAVQARSSKIKGPILCLVGPPGVGKTSLAKSIAKATGREYIRMALGGVRDEAEIRGHRRT
YIGSMPGKVVQSMKKAKKSNPLFLLDEIDKMGQDFRGDPSSALLEVLDPEQNSTFMDHYLEVEYDLSNVMFITTANTLNI
PPPLMDRMEVIRIAGYTEEEKLEIAKRHLLPKAIRDHALQTNEFSVTDGALTAIIQNYTREAGVRNFERELMKLARKAVT
EILKGKTKKVEVSAENINDYLGVPRFRHGEAERDDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESI
SAAASYVRSRAIDFGIEPPLFDKRDIHVHVPEGATPKDGPSAGVAMATAIVSVMTGIPISKDVAMTGEITLRGRVLPIGG
LKEKLLAALRGGIKKVLIPEENAKDLADIPDNVKNSLEIIPVSRMGEVIAHALLRLPEPIEWDPASQPAALPSVDSQDEA
GTSIAH
>Mature_805_residues
TNKTSPATESATYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGTDKQIMLVTQINATDDDPEPSAIYKVGTIANVL
QLLKLPDGTVKVLVEGRSRAEIERYTPRDDFYEAMAHALPEPDEDPVEIEALSRSVVSEFESYVKLNKKISPEVVGVASQ
IEDYSKLADTVASHLSIKIVEKQEMLETTSVKMRLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAIQ
KELGDSEDGRDEMAELEERISKTKLSKEAREKADAELKKLRQMSPMSAEATVVRNYLDWLLGLPWGKKSKIKTDLNHAEK
VLDTDHFGLDKVKERIVEYLAVQARSSKIKGPILCLVGPPGVGKTSLAKSIAKATGREYIRMALGGVRDEAEIRGHRRTY
IGSMPGKVVQSMKKAKKSNPLFLLDEIDKMGQDFRGDPSSALLEVLDPEQNSTFMDHYLEVEYDLSNVMFITTANTLNIP
PPLMDRMEVIRIAGYTEEEKLEIAKRHLLPKAIRDHALQTNEFSVTDGALTAIIQNYTREAGVRNFERELMKLARKAVTE
ILKGKTKKVEVSAENINDYLGVPRFRHGEAERDDQVGVVTGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESIS
AAASYVRSRAIDFGIEPPLFDKRDIHVHVPEGATPKDGPSAGVAMATAIVSVMTGIPISKDVAMTGEITLRGRVLPIGGL
KEKLLAALRGGIKKVLIPEENAKDLADIPDNVKNSLEIIPVSRMGEVIAHALLRLPEPIEWDPASQPAALPSVDSQDEAG
TSIAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=659, Percent_Identity=42.9438543247344, Blast_Score=541, Evalue=1e-153,
Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=44.2273534635879, Blast_Score=505, Evalue=1e-143,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=63.6363636363636, Blast_Score=993, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=656, Percent_Identity=42.8353658536585, Blast_Score=517, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17556486, Length=792, Percent_Identity=32.7020202020202, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=713, Percent_Identity=40.3927068723703, Blast_Score=522, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221513036, Length=650, Percent_Identity=42.4615384615385, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24666867, Length=650, Percent_Identity=42.4615384615385, Blast_Score=528, Evalue=1e-150,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89381; Mature: 89250

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKTSPATESATYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGTDKQIMLVTQIN
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEC
ATDDDPEPSAIYKVGTIANVLQLLKLPDGTVKVLVEGRSRAEIERYTPRDDFYEAMAHAL
CCCCCCCCCHHEEHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHC
PEPDEDPVEIEALSRSVVSEFESYVKLNKKISPEVVGVASQIEDYSKLADTVASHLSIKI
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEE
VEKQEMLETTSVKMRLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAI
ECHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGDSEDGRDEMAELEERISKTKLSKEAREKADAELKKLRQMSPMSAEATVVRNYLDW
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LLGLPWGKKSKIKTDLNHAEKVLDTDHFGLDKVKERIVEYLAVQARSSKIKGPILCLVGP
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
PGVGKTSLAKSIAKATGREYIRMALGGVRDEAEIRGHRRTYIGSMPGKVVQSMKKAKKSN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHCCC
PLFLLDEIDKMGQDFRGDPSSALLEVLDPEQNSTFMDHYLEVEYDLSNVMFITTANTLNI
CEEEEHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHEEEEECCCCEEEEEECCCCCC
PPPLMDRMEVIRIAGYTEEEKLEIAKRHLLPKAIRDHALQTNEFSVTDGALTAIIQNYTR
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
EAGVRNFERELMKLARKAVTEILKGKTKKVEVSAENINDYLGVPRFRHGEAERDDQVGVV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEE
TGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESISAAASYVRSRAIDFGIEPPL
ECCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FDKRDIHVHVPEGATPKDGPSAGVAMATAIVSVMTGIPISKDVAMTGEITLRGRVLPIGG
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEEEEECCC
LKEKLLAALRGGIKKVLIPEENAKDLADIPDNVKNSLEIIPVSRMGEVIAHALLRLPEPI
HHHHHHHHHHCCCEEEECCCCCCCHHHCCCHHHHCCEEEEEHHHHHHHHHHHHHHCCCCC
EWDPASQPAALPSVDSQDEAGTSIAH
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TNKTSPATESATYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMGTDKQIMLVTQIN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEC
ATDDDPEPSAIYKVGTIANVLQLLKLPDGTVKVLVEGRSRAEIERYTPRDDFYEAMAHAL
CCCCCCCCCHHEEHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHC
PEPDEDPVEIEALSRSVVSEFESYVKLNKKISPEVVGVASQIEDYSKLADTVASHLSIKI
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEE
VEKQEMLETTSVKMRLEKALGFMEGEISVLQVEKRIRSRVKRQMEKTQREYYLNEQMKAI
ECHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGDSEDGRDEMAELEERISKTKLSKEAREKADAELKKLRQMSPMSAEATVVRNYLDW
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LLGLPWGKKSKIKTDLNHAEKVLDTDHFGLDKVKERIVEYLAVQARSSKIKGPILCLVGP
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
PGVGKTSLAKSIAKATGREYIRMALGGVRDEAEIRGHRRTYIGSMPGKVVQSMKKAKKSN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHCCC
PLFLLDEIDKMGQDFRGDPSSALLEVLDPEQNSTFMDHYLEVEYDLSNVMFITTANTLNI
CEEEEHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHEEEEECCCCEEEEEECCCCCC
PPPLMDRMEVIRIAGYTEEEKLEIAKRHLLPKAIRDHALQTNEFSVTDGALTAIIQNYTR
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
EAGVRNFERELMKLARKAVTEILKGKTKKVEVSAENINDYLGVPRFRHGEAERDDQVGVV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEE
TGLAWTEVGGELLTIEGVMMPGKGRMTVTGNLRDVMKESISAAASYVRSRAIDFGIEPPL
ECCHHHHCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
FDKRDIHVHVPEGATPKDGPSAGVAMATAIVSVMTGIPISKDVAMTGEITLRGRVLPIGG
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEEEEECCC
LKEKLLAALRGGIKKVLIPEENAKDLADIPDNVKNSLEIIPVSRMGEVIAHALLRLPEPI
HHHHHHHHHHCCCEEEECCCCCCCHHHCCCHHHHCCEEEEEHHHHHHHHHHHHHHCCCCC
EWDPASQPAALPSVDSQDEAGTSIAH
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10762258; 11481430 [H]