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The map label for this gene is fabF [H]

Identifier: 150395971

GI number: 150395971

Start: 800391

End: 801656

Strand: Direct

Name: fabF [H]

Synonym: Smed_0747

Alternate gene names: 150395971

Gene position: 800391-801656 (Clockwise)

Preceding gene: 150395970

Following gene: 150395972

Centisome position: 21.16

GC content: 62.24

Gene sequence:

>1266_bases
ATGAGACGTGTCGTTATCACCGGTACCGGCATGGTATCTCCTCTGGGTTGCGGAACCGAAGTCAGCTGGTCGCGCCTTCT
GGCCGGCGACAATGCAGCCCGCAGGGTCACCGAATTCGAGGTCGAGGACCTTCCCGCCAAGATAGCCTGCCGAATTCCTT
TCGGCGATGGTAGCGACGGTACGTTCAATGCCGACGACTGGATGGAGCCCAAGGAACAGCGCAAGGTCGACCCTTTCATC
GTCTACGCGATGGCCGCTGCCGACATGGCGCTTGCGGATGCGGGCTGGAACCCTGAAACAGACGAAGACCAGATTTCGAC
CGGCGTCCTGATCGGCTCCGGCATTGGCGGCCTGGAAGGTATTGTCGATGCGGGCTATACGTTGCGCGACAAGGGCCCGC
GCCGGATTTCACCATTCTTCATTCCCGGCCGGCTGATCAATCTCGCAGCAGGGCAGGTTTCCATCCGCCACAAGCTGCGC
GGTCCTAACCATTCCGTCGTGACGGCCTGTTCGACCGGCGCGCATGCGATCGGTGACGCCAGCCGGTTGATCGCGCTCGG
AGACGCGGACGTGATGGTGGCGGGTGGCACGGAATCGCCGATCTGCCGCATCTCGCTCGCAGGCTTCGCCGCCTGCAAGG
CGCTCTCGACCCAGCACAACGACAATCCGCAAAAGGCATCGCGGCCCTATGACGCCGATCGCGACGGCTTCGTCATGGGC
GAGGGCGCGGGTATCGTCATTCTGGAAGAGCTGGAGCACGCGAAGGCACGCGGCGCCAAGATCTACGCCGAGGTGATCGG
CTACGGTCTGTCCGGCGATGCCTTCCACATCACTGCTCCGTCCGAGAACGGCGAAGGCGCTTACCGATGCATGCAGATGG
CGATGAAGCGCGCCGGCATCTCGGCTGCGGACATCGACTATATCAACGCACACGGCACCTCGACAATGGCCGACACGATT
GAACTCGGCGCTGTCGAGCGATTGGTCGGAGACAGCGGTTCCAAAATTTCCATGTCCTCGACCAAATCGGCAATCGGCCA
TTTGCTCGGTGCGGCCGGCGCGGTCGAGGCGATCTTCTCGGCGCTCGCCATCAGGGACAATATCGCCCCTCCGACGCTTA
ACCTCGACAACCCTTCCGTCGAGACGAAGATCGACCTCGTGCCGCATTCCGCACGTAAGCGCGAGATCAATGTGGCCCTG
TCGAACTCGTTCGGATTCGGTGGCACCAACGCGTCGTTGATCCTGCGCCGTTACGCCGGCCATTAG

Upstream 100 bases:

>100_bases
GCGCGGCGCTGTAGCGAGATTTGCAATGTATTGCACGGGTCGCGATCGTCACGTGGTCCGGTCCGGCGGTTGAATTGAAC
AATCAGGGTGGGTCACGGGT

Downstream 100 bases:

>100_bases
ATCACGACGATTTAAGCACATCTTCATCGGTATCGATCCGCGGTCCCGCTTTTTGCCGCAATGCTCACTAAAAGCTGTCG
CCGGGGTGGCGACGACTCGG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRRVVITGTGMVSPLGCGTEVSWSRLLAGDNAARRVTEFEVEDLPAKIACRIPFGDGSDGTFNADDWMEPKEQRKVDPFI
VYAMAAADMALADAGWNPETDEDQISTGVLIGSGIGGLEGIVDAGYTLRDKGPRRISPFFIPGRLINLAAGQVSIRHKLR
GPNHSVVTACSTGAHAIGDASRLIALGDADVMVAGGTESPICRISLAGFAACKALSTQHNDNPQKASRPYDADRDGFVMG
EGAGIVILEELEHAKARGAKIYAEVIGYGLSGDAFHITAPSENGEGAYRCMQMAMKRAGISAADIDYINAHGTSTMADTI
ELGAVERLVGDSGSKISMSSTKSAIGHLLGAAGAVEAIFSALAIRDNIAPPTLNLDNPSVETKIDLVPHSARKREINVAL
SNSFGFGGTNASLILRRYAGH

Sequences:

>Translated_421_residues
MRRVVITGTGMVSPLGCGTEVSWSRLLAGDNAARRVTEFEVEDLPAKIACRIPFGDGSDGTFNADDWMEPKEQRKVDPFI
VYAMAAADMALADAGWNPETDEDQISTGVLIGSGIGGLEGIVDAGYTLRDKGPRRISPFFIPGRLINLAAGQVSIRHKLR
GPNHSVVTACSTGAHAIGDASRLIALGDADVMVAGGTESPICRISLAGFAACKALSTQHNDNPQKASRPYDADRDGFVMG
EGAGIVILEELEHAKARGAKIYAEVIGYGLSGDAFHITAPSENGEGAYRCMQMAMKRAGISAADIDYINAHGTSTMADTI
ELGAVERLVGDSGSKISMSSTKSAIGHLLGAAGAVEAIFSALAIRDNIAPPTLNLDNPSVETKIDLVPHSARKREINVAL
SNSFGFGGTNASLILRRYAGH
>Mature_421_residues
MRRVVITGTGMVSPLGCGTEVSWSRLLAGDNAARRVTEFEVEDLPAKIACRIPFGDGSDGTFNADDWMEPKEQRKVDPFI
VYAMAAADMALADAGWNPETDEDQISTGVLIGSGIGGLEGIVDAGYTLRDKGPRRISPFFIPGRLINLAAGQVSIRHKLR
GPNHSVVTACSTGAHAIGDASRLIALGDADVMVAGGTESPICRISLAGFAACKALSTQHNDNPQKASRPYDADRDGFVMG
EGAGIVILEELEHAKARGAKIYAEVIGYGLSGDAFHITAPSENGEGAYRCMQMAMKRAGISAADIDYINAHGTSTMADTI
ELGAVERLVGDSGSKISMSSTKSAIGHLLGAAGAVEAIFSALAIRDNIAPPTLNLDNPSVETKIDLVPHSARKREINVAL
SNSFGFGGTNASLILRRYAGH

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=50.7177033492823, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI223972627, Length=193, Percent_Identity=44.0414507772021, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI41872631, Length=361, Percent_Identity=26.3157894736842, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=49.4033412887828, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1788663, Length=419, Percent_Identity=37.708830548926, Blast_Score=258, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=38.4433962264151, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=42.8571428571429, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI212642053, Length=430, Percent_Identity=26.046511627907, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=321, Percent_Identity=24.9221183800623, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=41.5178571428571, Blast_Score=304, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=47.1563981042654, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI19920632, Length=364, Percent_Identity=25.5494505494505, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI221330659, Length=364, Percent_Identity=25.5494505494505, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24581345, Length=360, Percent_Identity=23.8888888888889, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44195; Mature: 44195

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGTGMVSPLGCGTEVSWSRLLAGDNAARRVTEFEVEDLPAKIACRIPFGDGSDG
CCEEEEECCCCCCCCCCCCCCCHHHHHCCCCHHHHEEEEECCCCCEEEEEEEECCCCCCC
TFNADDWMEPKEQRKVDPFIVYAMAAADMALADAGWNPETDEDQISTGVLIGSGIGGLEG
CCCCHHCCCCHHHCCCCCEEEEEEHHHHHHHCCCCCCCCCCHHHHHCCEEEECCCCCHHH
IVDAGYTLRDKGPRRISPFFIPGRLINLAAGQVSIRHKLRGPNHSVVTACSTGAHAIGDA
HHHCCCEEECCCCCCCCCEEECCEEEEEECCCEEEEECCCCCCCCEEEEECCCCCCCCCC
SRLIALGDADVMVAGGTESPICRISLAGFAACKALSTQHNDNPQKASRPYDADRDGFVMG
CEEEEECCCCEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCEEEE
EGAGIVILEELEHAKARGAKIYAEVIGYGLSGDAFHITAPSENGEGAYRCMQMAMKRAGI
CCCCEEEEECHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
SAADIDYINAHGTSTMADTIELGAVERLVGDSGSKISMSSTKSAIGHLLGAAGAVEAIFS
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHH
ALAIRDNIAPPTLNLDNPSVETKIDLVPHSARKREINVALSNSFGFGGTNASLILRRYAG
HHHHHCCCCCCEECCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHEECCC
H
C
>Mature Secondary Structure
MRRVVITGTGMVSPLGCGTEVSWSRLLAGDNAARRVTEFEVEDLPAKIACRIPFGDGSDG
CCEEEEECCCCCCCCCCCCCCCHHHHHCCCCHHHHEEEEECCCCCEEEEEEEECCCCCCC
TFNADDWMEPKEQRKVDPFIVYAMAAADMALADAGWNPETDEDQISTGVLIGSGIGGLEG
CCCCHHCCCCHHHCCCCCEEEEEEHHHHHHHCCCCCCCCCCHHHHHCCEEEECCCCCHHH
IVDAGYTLRDKGPRRISPFFIPGRLINLAAGQVSIRHKLRGPNHSVVTACSTGAHAIGDA
HHHCCCEEECCCCCCCCCEEECCEEEEEECCCEEEEECCCCCCCCEEEEECCCCCCCCCC
SRLIALGDADVMVAGGTESPICRISLAGFAACKALSTQHNDNPQKASRPYDADRDGFVMG
CEEEEECCCCEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCEEEE
EGAGIVILEELEHAKARGAKIYAEVIGYGLSGDAFHITAPSENGEGAYRCMQMAMKRAGI
CCCCEEEEECHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
SAADIDYINAHGTSTMADTIELGAVERLVGDSGSKISMSSTKSAIGHLLGAAGAVEAIFS
CCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHH
ALAIRDNIAPPTLNLDNPSVETKIDLVPHSARKREINVALSNSFGFGGTNASLILRRYAG
HHHHHCCCCCCEECCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHEECCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]