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The map label for this gene is pip [H]

Identifier: 150395941

GI number: 150395941

Start: 768355

End: 769317

Strand: Direct

Name: pip [H]

Synonym: Smed_0717

Alternate gene names: 150395941

Gene position: 768355-769317 (Clockwise)

Preceding gene: 150395940

Following gene: 150395942

Centisome position: 20.32

GC content: 63.55

Gene sequence:

>963_bases
GTGAGTTCTCCATTGCGTACTCTCTATCCGGAAATCGAGCCCTACGCCTCGGGTCGACTCGATGTGGGCGACGGCCATTC
GATCTACTGGGAGCGGGTGGGCACGCCCGGAGCGAAGCCGGCGGTCTTCCTGCACGGTGGCCCGGGCGGTACGATTTCGC
CGAACCACCGGCGGCTCTTCGATCCGGCGCTCTACGACGTGACGCTGTTCGACCAGCGCGGCTGCGGCAAGTCGGAGCCG
CATGCCGGGATCGAGGCGAACACGACCTGGCATCTCGTCGCCGATATCGAGCGGCTGAGGGAAGCGGCCGGCGCGGACAA
ATGGCTGGTTTTCGGCGGTTCCTGGGGTTCGACGCTGGCGCTTGCCTATACCGAAACCCATCCCGGGCGGGTCTCCGAAC
TCGTCGTCAGGGGCATTTACACGCTGACCAGGGCCGAGCTCGACTGGTACTATCAGTTCGGCGTTTCGGAACTCTTCCCC
GACAAGTGGGAACGCTTCATCGCCCCGATCCCGCCGGAAGAGCGCCATGAGATGATGCGCGCCTACCATCGCCGCCTCAC
GAGCGATGACCGTGCGATACGGCTTGCAGCGGCACGCGCCTGGAGCATATGGGAGGGCGAGACGATAACGCTTCTGCCGG
AGCCGGCCACCAGCACGCCCTTCGAGGAAGACGAATACGCGCTCGCCTTTGCCCGCATCGAGAACCATTTCTTCGTCAAT
GCCGGATGGCTGGAAGAGGGCCAATTGCTGCGCGATGCGCATAAGCTCCGCGGCATTCCGGGTGTGATCGTGCACGGCCG
CTACGATATGCCGTGCCCGGCGAAATATGCATGGCAATTGCACAAGGCTTGGCCGGAAGCGGAATTCCATCTGATCGAGG
GGGCCGGGCACGCCTATTCGGAGCCCGGCATTCTCGATCGGCTGATCCGATCGACCGACAAATTCGCCGGCAAGGCCGAA
TAA

Upstream 100 bases:

>100_bases
GCAGTGATGCGGCTGCCGAGCGACACCTGCTTGTTCTTGAAACCAATCGCCAGCATCCCGACTACGACACGGTGCACTGG
CCGCCCGAGGAAGATCTATC

Downstream 100 bases:

>100_bases
GGAGCGGGCCGAAAAGCCCACCATCGATGTACTGATCCATACGTTGGGACCGAGATATGACCAGGCAACGCATCTACCTC
TTCGACACGACTCTTCGAGA

Product: proline iminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSSPLRTLYPEIEPYASGRLDVGDGHSIYWERVGTPGAKPAVFLHGGPGGTISPNHRRLFDPALYDVTLFDQRGCGKSEP
HAGIEANTTWHLVADIERLREAAGADKWLVFGGSWGSTLALAYTETHPGRVSELVVRGIYTLTRAELDWYYQFGVSELFP
DKWERFIAPIPPEERHEMMRAYHRRLTSDDRAIRLAAARAWSIWEGETITLLPEPATSTPFEEDEYALAFARIENHFFVN
AGWLEEGQLLRDAHKLRGIPGVIVHGRYDMPCPAKYAWQLHKAWPEAEFHLIEGAGHAYSEPGILDRLIRSTDKFAGKAE

Sequences:

>Translated_320_residues
MSSPLRTLYPEIEPYASGRLDVGDGHSIYWERVGTPGAKPAVFLHGGPGGTISPNHRRLFDPALYDVTLFDQRGCGKSEP
HAGIEANTTWHLVADIERLREAAGADKWLVFGGSWGSTLALAYTETHPGRVSELVVRGIYTLTRAELDWYYQFGVSELFP
DKWERFIAPIPPEERHEMMRAYHRRLTSDDRAIRLAAARAWSIWEGETITLLPEPATSTPFEEDEYALAFARIENHFFVN
AGWLEEGQLLRDAHKLRGIPGVIVHGRYDMPCPAKYAWQLHKAWPEAEFHLIEGAGHAYSEPGILDRLIRSTDKFAGKAE
>Mature_319_residues
SSPLRTLYPEIEPYASGRLDVGDGHSIYWERVGTPGAKPAVFLHGGPGGTISPNHRRLFDPALYDVTLFDQRGCGKSEPH
AGIEANTTWHLVADIERLREAAGADKWLVFGGSWGSTLALAYTETHPGRVSELVVRGIYTLTRAELDWYYQFGVSELFPD
KWERFIAPIPPEERHEMMRAYHRRLTSDDRAIRLAAARAWSIWEGETITLLPEPATSTPFEEDEYALAFARIENHFFVNA
GWLEEGQLLRDAHKLRGIPGVIVHGRYDMPCPAKYAWQLHKAWPEAEFHLIEGAGHAYSEPGILDRLIRSTDKFAGKAE

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 36092; Mature: 35961

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPLRTLYPEIEPYASGRLDVGDGHSIYWERVGTPGAKPAVFLHGGPGGTISPNHRRLF
CCCCHHHHCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCEEC
DPALYDVTLFDQRGCGKSEPHAGIEANTTWHLVADIERLREAAGADKWLVFGGSWGSTLA
CCHHEEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEEEECCCCCEEE
LAYTETHPGRVSELVVRGIYTLTRAELDWYYQFGVSELFPDKWERFIAPIPPEERHEMMR
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHCHHHHHHHCCCCCCHHHHHHHH
AYHRRLTSDDRAIRLAAARAWSIWEGETITLLPEPATSTPFEEDEYALAFARIENHFFVN
HHHHHCCCCCCEEEEEEHHEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEECCEEEEE
AGWLEEGQLLRDAHKLRGIPGVIVHGRYDMPCPAKYAWQLHKAWPEAEFHLIEGAGHAYS
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCC
EPGILDRLIRSTDKFAGKAE
CCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSPLRTLYPEIEPYASGRLDVGDGHSIYWERVGTPGAKPAVFLHGGPGGTISPNHRRLF
CCCHHHHCCCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCEEC
DPALYDVTLFDQRGCGKSEPHAGIEANTTWHLVADIERLREAAGADKWLVFGGSWGSTLA
CCHHEEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCEEEEEECCCCCEEE
LAYTETHPGRVSELVVRGIYTLTRAELDWYYQFGVSELFPDKWERFIAPIPPEERHEMMR
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHCHHHHHHHCCCCCCHHHHHHHH
AYHRRLTSDDRAIRLAAARAWSIWEGETITLLPEPATSTPFEEDEYALAFARIENHFFVN
HHHHHCCCCCCEEEEEEHHEEEEECCCEEEEECCCCCCCCCCCCCCEEEEEEECCEEEEE
AGWLEEGQLLRDAHKLRGIPGVIVHGRYDMPCPAKYAWQLHKAWPEAEFHLIEGAGHAYS
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCC
EPGILDRLIRSTDKFAGKAE
CCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]