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The map label for this gene is cobB [H]

Identifier: 150394707

GI number: 150394707

Start: 2370072

End: 2370803

Strand: Direct

Name: cobB [H]

Synonym: SaurJH1_2267

Alternate gene names: 150394707

Gene position: 2370072-2370803 (Clockwise)

Preceding gene: 150394691

Following gene: 150394711

Centisome position: 81.54

GC content: 35.93

Gene sequence:

>732_bases
TTGAGAAATGATTTAGAGACATTAAAACATATTATAGATAGTTCGAATCGTATTACATTTTTCACAGGTGCTGGTGTATC
TGTCGCAAGTGGCGTTCCAGATTTCCGTTCAATGGGTGGCTTATTTGATGAAATTTCAAAAGATGGACTTTCGCCAGAAT
ACTTGTTAAGCCGTGATTATTTAGAAGATGATCCTGAAGGTTTTATCAATTTCTGCCATAAGCGTTTACTATTTGTCGAT
ACGAAGCCTAATATCGTTCATGATTGGATTGCAAAATTAGAACGTAATCAACAATCTTTAGGTGTCATCACGCAAAATAT
CGATGGTTTGCACTCAGACGCTGGAAGTCAACATGTTGATGAATTACATGGCACGTTAAATCGTTTTTATTGTAATGCAT
GTCATAAATCTTATACGAAGTCAGATGTTATTGATAGAACTTTGAAACATTGTGATAATTGTGGTGGTGCCATTCGACCG
GACATCGTATTATACGGTGAAATGTTAGATCAACCTACCATCATAAGGGCATTAAATAAAATTGAACATGCTGACACCCT
TGTTGTACTAGGTTCATCACTCGTTGTACAACCTGCCGCAGGATTAATATCACATTTTAAAGGCGACAATTTAATTATTA
TCAATAAAGATCGAACACCTTATGATAGCGACGCTACTTTGGTCATACATGACGACATGGTTTCCGTTGTAAAATCATTA
ATGACAGAGTAA

Upstream 100 bases:

>100_bases
GAACTGTTTAAACTGCGCTTTTGATAATCGTAAAATGAATATACTATAATAAAAGCAAAAGACGTTATAAATCATTCATT
ATTTTGATGGGGTGTTTATT

Downstream 100 bases:

>100_bases
TCAGTAGGTAAAAAGCATTTCCCGAGTAACAGGGAGATGCTTTTAATTTTGGAGTTGCGTTTTTGGAATTTGGAGTTTGG
TTTTCGGAATTCGACATTTG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MRNDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFINFCHKRLLFVD
TKPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVDELHGTLNRFYCNACHKSYTKSDVIDRTLKHCDNCGGAIRP
DIVLYGEMLDQPTIIRALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSL
MTE

Sequences:

>Translated_243_residues
MRNDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFINFCHKRLLFVD
TKPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVDELHGTLNRFYCNACHKSYTKSDVIDRTLKHCDNCGGAIRP
DIVLYGEMLDQPTIIRALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSL
MTE
>Mature_243_residues
MRNDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFINFCHKRLLFVD
TKPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVDELHGTLNRFYCNACHKSYTKSDVIDRTLKHCDNCGGAIRP
DIVLYGEMLDQPTIIRALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSL
MTE

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912660, Length=213, Percent_Identity=32.3943661971831, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI63054862, Length=205, Percent_Identity=33.1707317073171, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI300795542, Length=231, Percent_Identity=31.1688311688312, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI13775602, Length=218, Percent_Identity=33.0275229357798, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI7657575, Length=233, Percent_Identity=29.6137339055794, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI13775600, Length=215, Percent_Identity=33.4883720930233, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI13787215, Length=249, Percent_Identity=29.3172690763052, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI6912664, Length=249, Percent_Identity=29.3172690763052, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI300797705, Length=199, Percent_Identity=32.1608040201005, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI300797577, Length=251, Percent_Identity=27.4900398406374, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI7706712, Length=263, Percent_Identity=28.1368821292776, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI300797597, Length=238, Percent_Identity=27.3109243697479, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI215982798, Length=174, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI308199517, Length=201, Percent_Identity=34.3283582089552, Blast_Score=90, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17541892, Length=236, Percent_Identity=32.6271186440678, Blast_Score=119, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17567771, Length=284, Percent_Identity=26.4084507042254, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71990482, Length=284, Percent_Identity=26.4084507042254, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71990487, Length=286, Percent_Identity=26.2237762237762, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325242, Length=211, Percent_Identity=32.2274881516588, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324599, Length=278, Percent_Identity=29.4964028776978, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324504, Length=278, Percent_Identity=26.6187050359712, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320163, Length=257, Percent_Identity=25.2918287937743, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320397, Length=252, Percent_Identity=24.2063492063492, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17137536, Length=252, Percent_Identity=30.1587301587302, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24648389, Length=211, Percent_Identity=32.7014218009479, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28571445, Length=216, Percent_Identity=25, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24645650, Length=244, Percent_Identity=26.6393442622951, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27026; Mature: 27026

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDY
CCCHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHC
LEDDPEGFINFCHKRLLFVDTKPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVD
CCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCCHHHHH
ELHGTLNRFYCNACHKSYTKSDVIDRTLKHCDNCGGAIRPDIVLYGEMLDQPTIIRALNK
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHCCCHHHHHHHH
IEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSL
HHHHHHEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHH
MTE
HCC
>Mature Secondary Structure
MRNDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDY
CCCHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHC
LEDDPEGFINFCHKRLLFVDTKPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVD
CCCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCCHHHHH
ELHGTLNRFYCNACHKSYTKSDVIDRTLKHCDNCGGAIRPDIVLYGEMLDQPTIIRALNK
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHCCCHHHHHHHH
IEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSL
HHHHHHEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHH
MTE
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2163387 [H]