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The map label for this gene is wecC [H]

Identifier: 150008212

GI number: 150008212

Start: 1849237

End: 1850442

Strand: Reverse

Name: wecC [H]

Synonym: BDI_1578

Alternate gene names: 150008212

Gene position: 1850442-1849237 (Counterclockwise)

Preceding gene: 150008213

Following gene: 150008211

Centisome position: 38.46

GC content: 53.65

Gene sequence:

>1206_bases
ATGAAAGCATGTTTCATGGGGTTGGGCTATATTGGCCTGCCCACGGCTATTATTGCCGCAAAGCACGGGGTGGAGATCGC
CGGCGTGGATATTAACGCTCAAGTGGTGGAGGTTACCAACCAGGGGAAATTGCATATCATCGAGCCGGGTATGGAGGAGA
TGTTGCGGGAGGTACTGGCCTCCGGACATTTCAAGGCGTACACCGAGCCTCGGGTGAGCGACGCTTATTTCATGGTGGTA
CCCACTCCTTTCAAGGGGGATCATGAGCCGGACGTATCGTTCGTTGAGTCGGCTACCCGTATGGTGCTTCCTTTGTTGAA
GGAGGGGGATTTGTACGTGATCGAGTCTACATCGCCGGTGGGGACGACCGAACGGATGGCTAGGTTGATTTTCTCGGAGC
GGCCGGAACTGGAGGGCAAGATCTATATCGCTTATTGCCCGGAGCGGGTGCTTCCGGGTAACGTGATCCATGAGTTGGTG
CATAACGACCGGGTCATCGGCGGCATGGACGAGGCCTCCACCCGTAAGGCGATGGAGTTCTACGGCCAGTTCGTGAAGGG
TACGCTTCACCCAACGAATAGCAAGACGGCCGAGATGTGTAAATTGACCGAGAACTCAAGCCGGGACGTACAGATCGCTT
TCGCCAATGAGCTGTCGTTTATTTGTGATAAGGCCGGGATCAATGTGTGGGAGCTGATCGATTTGGCGAACAAGCATCCC
CGTGTGAATATCTTACGGCCGGGTTGCGGAGTTGGCGGTCATTGCATAGCGGTGGACCCTTATTTCATCACGGCGGAGTT
TCCGATGGAGAGCCGTATGATCTCGACGGCCCGTGAGACGAATAATTACAAGGCTTTCTGGTGCGCTGAGAAAGTGAGGA
ACGCCATGCTGCGGTTTGAGTTGAAGCATGGGCGTAAGCCGGCGGTGGCAATGATGGGCTTGGCTTTCAAGCCTGATATC
GATGACTTACGTGAATCGCCGGCCAAGGGAATAACGACGAAGGTGTTGCAATCGTGCAACAACGCTGATATCATGGTGGT
GGAGCCGAACGTTTCGGAGCATAAGTTGTTTAAGCTGACCCCTTATAAGGAGGCATACGAGAAGGCGGATATAGTGGTCT
TCTTGGTGAATCATAGGGAGTTTGCGGGGTTGAATTATCGGGATGACGTGGAGGTGCTGGACTTTTGCGGGACATTCAAG
AAATAA

Upstream 100 bases:

>100_bases
ATTCATTTTGTGAAGAGACTTTCTTATACAATCGGTTGATCGTTATTGGACCATTCTTGATCTGCCTAATATCTTACTTA
AAAAATAACACATATTTCTT

Downstream 100 bases:

>100_bases
TCGTTCGCTAAATAGAAGAATACGCAGTAATGAGAAAAATAATGTTAGTATTCGGGACCCGTCCCGAGGCGATCAAGATG
GCTCCGCTGGTGAAGGAGTT

Product: putative UDP-ManNAc dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKACFMGLGYIGLPTAIIAAKHGVEIAGVDINAQVVEVTNQGKLHIIEPGMEEMLREVLASGHFKAYTEPRVSDAYFMVV
PTPFKGDHEPDVSFVESATRMVLPLLKEGDLYVIESTSPVGTTERMARLIFSERPELEGKIYIAYCPERVLPGNVIHELV
HNDRVIGGMDEASTRKAMEFYGQFVKGTLHPTNSKTAEMCKLTENSSRDVQIAFANELSFICDKAGINVWELIDLANKHP
RVNILRPGCGVGGHCIAVDPYFITAEFPMESRMISTARETNNYKAFWCAEKVRNAMLRFELKHGRKPAVAMMGLAFKPDI
DDLRESPAKGITTKVLQSCNNADIMVVEPNVSEHKLFKLTPYKEAYEKADIVVFLVNHREFAGLNYRDDVEVLDFCGTFK
K

Sequences:

>Translated_401_residues
MKACFMGLGYIGLPTAIIAAKHGVEIAGVDINAQVVEVTNQGKLHIIEPGMEEMLREVLASGHFKAYTEPRVSDAYFMVV
PTPFKGDHEPDVSFVESATRMVLPLLKEGDLYVIESTSPVGTTERMARLIFSERPELEGKIYIAYCPERVLPGNVIHELV
HNDRVIGGMDEASTRKAMEFYGQFVKGTLHPTNSKTAEMCKLTENSSRDVQIAFANELSFICDKAGINVWELIDLANKHP
RVNILRPGCGVGGHCIAVDPYFITAEFPMESRMISTARETNNYKAFWCAEKVRNAMLRFELKHGRKPAVAMMGLAFKPDI
DDLRESPAKGITTKVLQSCNNADIMVVEPNVSEHKLFKLTPYKEAYEKADIVVFLVNHREFAGLNYRDDVEVLDFCGTFK
K
>Mature_401_residues
MKACFMGLGYIGLPTAIIAAKHGVEIAGVDINAQVVEVTNQGKLHIIEPGMEEMLREVLASGHFKAYTEPRVSDAYFMVV
PTPFKGDHEPDVSFVESATRMVLPLLKEGDLYVIESTSPVGTTERMARLIFSERPELEGKIYIAYCPERVLPGNVIHELV
HNDRVIGGMDEASTRKAMEFYGQFVKGTLHPTNSKTAEMCKLTENSSRDVQIAFANELSFICDKAGINVWELIDLANKHP
RVNILRPGCGVGGHCIAVDPYFITAEFPMESRMISTARETNNYKAFWCAEKVRNAMLRFELKHGRKPAVAMMGLAFKPDI
DDLRESPAKGITTKVLQSCNNADIMVVEPNVSEHKLFKLTPYKEAYEKADIVVFLVNHREFAGLNYRDDVEVLDFCGTFK
K

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=378, Percent_Identity=25.3968253968254, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI296040438, Length=279, Percent_Identity=24.3727598566308, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI48994968, Length=398, Percent_Identity=51.5075376884422, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1788340, Length=397, Percent_Identity=25.1889168765743, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560350, Length=428, Percent_Identity=25.4672897196262, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17136908, Length=368, Percent_Identity=26.9021739130435, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 44830; Mature: 44830

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKACFMGLGYIGLPTAIIAAKHGVEIAGVDINAQVVEVTNQGKLHIIEPGMEEMLREVLA
CCCEEEECCHHHHHHHHHHHHCCCEEEEEECCEEEEEEECCCCEEEECCCHHHHHHHHHH
SGHFKAYTEPRVSDAYFMVVPTPFKGDHEPDVSFVESATRMVLPLLKEGDLYVIESTSPV
CCCEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GTTERMARLIFSERPELEGKIYIAYCPERVLPGNVIHELVHNDRVIGGMDEASTRKAMEF
CHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCHHHHHHHHH
YGQFVKGTLHPTNSKTAEMCKLTENSSRDVQIAFANELSFICDKAGINVWELIDLANKHP
HHHHHCCEECCCCCCHHHHHHHCCCCCCEEEEEEECCHHHHHHHCCCCHHHHHHHHCCCC
RVNILRPGCGVGGHCIAVDPYFITAEFPMESRMISTARETNNYKAFWCAEKVRNAMLRFE
EEEEECCCCCCCCEEEEECCEEEEEECCHHHHHHHHHHHCCCEEEEEEHHHHHHHHEEEE
LKHGRKPAVAMMGLAFKPDIDDLRESPAKGITTKVLQSCNNADIMVVEPNVSEHKLFKLT
CCCCCCCCHHHCCEECCCCHHHHHCCCCCCHHHHHHHCCCCCCEEEECCCCCCCEEEEEC
PYKEAYEKADIVVFLVNHREFAGLNYRDDVEVLDFCGTFKK
CCHHHHCCCCEEEEEECCCEECCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MKACFMGLGYIGLPTAIIAAKHGVEIAGVDINAQVVEVTNQGKLHIIEPGMEEMLREVLA
CCCEEEECCHHHHHHHHHHHHCCCEEEEEECCEEEEEEECCCCEEEECCCHHHHHHHHHH
SGHFKAYTEPRVSDAYFMVVPTPFKGDHEPDVSFVESATRMVLPLLKEGDLYVIESTSPV
CCCEEEECCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GTTERMARLIFSERPELEGKIYIAYCPERVLPGNVIHELVHNDRVIGGMDEASTRKAMEF
CHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCHHHHHHHHH
YGQFVKGTLHPTNSKTAEMCKLTENSSRDVQIAFANELSFICDKAGINVWELIDLANKHP
HHHHHCCEECCCCCCHHHHHHHCCCCCCEEEEEEECCHHHHHHHCCCCHHHHHHHHCCCC
RVNILRPGCGVGGHCIAVDPYFITAEFPMESRMISTARETNNYKAFWCAEKVRNAMLRFE
EEEEECCCCCCCCEEEEECCEEEEEECCHHHHHHHHHHHCCCEEEEEEHHHHHHHHEEEE
LKHGRKPAVAMMGLAFKPDIDDLRESPAKGITTKVLQSCNNADIMVVEPNVSEHKLFKLT
CCCCCCCCHHHCCEECCCCHHHHHCCCCCCHHHHHHHCCCCCCEEEECCCCCCCEEEEEC
PYKEAYEKADIVVFLVNHREFAGLNYRDDVEVLDFCGTFKK
CCHHHHCCCCEEEEEECCCEECCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]