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The map label for this gene is uvrA [H]

Identifier: 150008060

GI number: 150008060

Start: 1653432

End: 1655675

Strand: Reverse

Name: uvrA [H]

Synonym: BDI_1423

Alternate gene names: 150008060

Gene position: 1655675-1653432 (Counterclockwise)

Preceding gene: 150008061

Following gene: 150008058

Centisome position: 34.41

GC content: 50.49

Gene sequence:

>2244_bases
ATGTCAAATCAAGAATATATCAAGATCGAGGGAGCTTATGAGAATAACTTGAAACATATCTCTCTGGATATTCCGAAGAA
GCAAATCACTATATTCACCGGGGTCTCGGGTTCTGGGAAATCGTCGTTGGTATTGGATACCATCGCCGCCAGTTCACGCC
GGGAGTTGAATGAGACGTTCCCCAGTTTCGTGCAGCAATACCTGCCCAAATATGGCCGTCCGCATGTAGACCGGATCGGG
AATCTGCCGGTCGCTATCGTGATAGACCAGCGGAAGCCCGCTCCCAACGCCCGTTCTACGGTGGGGACTTATACGGATAT
CTATTCATTGCTCCGTCTCTTGTTCTCACGGGTGGGCAAACCCTTTGTCGGATATTCGGATACATTCTCCTTTAATCATC
CGCAAGGCCGTTGTACCCGTTGTGACGGATTGGGGGAGATTCGTGAGCTGGACGTGCATAAGCTGGTTGATTTTGATAAA
TGCCTGAACGATGAGGACGTGATCCATTACGTCACCTTCCAGCCCGGCCAATGGCGATGGATACGTTATGCTTGCAGCGG
CCTTTTCGATCTGGATAAGAAGATCCGGGATTATACGCCGGAGGAGTTGCGCTTATTCCTTTATTCCCCGCAAATCCGTT
TGAAGAATCCTCCTGCCGACTGGCCGAAGACGGCGAAATATGAGGGCTTGGTAACCCGTATGTATCGCAGCATCATCAAT
TCCGAGGAAGGGAAGATCCATCAAAAGGTCTTGGAACCGATGGTTACGATGGGAATCTGCCCGGATTGCGGTGGGACCCG
CTTGAACGATAAGGTACTTTCTTGCCGGATCAACGGGAGAAATATAGCCGAAGTAACTCATATGGCGATCCCCGAGATAA
TCGCTTGGCTTCGGGAGATTGATGACCCGTTGGCGAAAGACATGAAGCAGGCGATCGGAGGCCGGTTATCCGCCTTATTG
GAGATCGGTTTGGGGTATTTGACGCTGGATCGCTCCATGGAAACCCTTTCCGGCGGGGAGGCGCAACGCTGTAAGATCGC
TAAATATATCAACTCATCTCTTTCCGATATGCTTTATGTGTTGGATGAGCCGAGCGTGGGCTTGCATAGCCACGATATCC
ATTTATTGAAAGCCTCGGTCCGAAAGTTGCGGGATCATGGGAATACGGTCTTGCTGGTGGAACATCATAAGGAAATGATA
CAGATCGCCGATCATATCGTGGATATGGGGCCGGGTTCGGGTATGGAGGGCGGCCGTATCTTGTACGAGGGAGATTATGC
GGGCTTACTCCGTAGCGATACCTTGACCGGCCGTATGCTAGGAGAAAATACCCCTCTGAAGGAAAGCCTCCGGATCCCGT
CCGGTTGGTTTACGGTAAAGCATGCCCGTCTTCATAACTTGAAGGACGTGACGGTAGATCTTCCTATGGGAGTACTGGCG
GTGATCGCCGGTGTAGCCGGTTCAGGGAAAAGCTCGTTGATGGAATGCTTCCGCCGGGATTTCCCCGAGGAGGTGATTTA
TATCAGCCAAAAGAATATCGGGATCAGCTTGCGTTCCACTCCGGCCACTTATCTGGGAGTTGCGGATGATATTCGTAAAC
TTTTCGCTAAGGAAAGTAAGGCTGGGCTTAGTATGTTCACGTTTAACGGAAAAGGCGGTTGCCCGGTTTGTGGGGGAAAA
GGCGTGATCGTGTCTGATATGGCTTTTATGGATTCGATCGAGACCGTTTGTGAGGCTTGTGGAGGATTGCGTTATTCCCC
GGAAGCCTTGCGGTATACAGTGGATGGTCTTACGATCGCTGAGGTGATGGACTTGACAGTCCGCAAGGCTTCCCTTCGTT
TTGCGGGAACGGTGATAGCGGAGAAACTCCGTCCGCTTATGCTGGTTGGTCTGGGGTATTTGCATTTGAACCAAGCCTTA
TCCACATTATCGGGAGGTGAGTTGCAACGGGTGAAACTGGCGTCTTATCTAGGAACCCAAAGCAAGGTCTTTGTCTTGGA
TGAGCCGACGGATGGCTTGCACGTGAAAGATGTCAGGCATATTATCTCCTTATTCGATTCTATGGTAGATCAAGGCAATA
GTGTCTTTTTGATCGAACATAATCTGGATGTCTTGAAAGCGGCGGACTATGTGATCGAGATAGGTCCTGGAGGCGGACTA
ATGGGGGGTGAGATCTTGTTTAGTGGTACTCCCAAGGAGTTACTATCCTGCGAGCGTTCCGTTACGAAAGACTATCTTGT
TTGA

Upstream 100 bases:

>100_bases
AACCTCTCTCAAAAGGTAGTGTTACAAGATACGCTTTATATCTATTAAAAAGACAGGATTAGATCGTATCTTTGTCATTC
GTTCATTAAGGTCATTGGTT

Downstream 100 bases:

>100_bases
TGATTATGAATATTATAGGGAAAGAGACGCAGCGTGCTGCGTCTCTATGTGAATATACGTCAAAAGTGAGGTCGCTTACT
CATCATACGAGATATTCCCT

Product: excinuclease ABC subunit A, daunorubicin resistance protein

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MSNQEYIKIEGAYENNLKHISLDIPKKQITIFTGVSGSGKSSLVLDTIAASSRRELNETFPSFVQQYLPKYGRPHVDRIG
NLPVAIVIDQRKPAPNARSTVGTYTDIYSLLRLLFSRVGKPFVGYSDTFSFNHPQGRCTRCDGLGEIRELDVHKLVDFDK
CLNDEDVIHYVTFQPGQWRWIRYACSGLFDLDKKIRDYTPEELRLFLYSPQIRLKNPPADWPKTAKYEGLVTRMYRSIIN
SEEGKIHQKVLEPMVTMGICPDCGGTRLNDKVLSCRINGRNIAEVTHMAIPEIIAWLREIDDPLAKDMKQAIGGRLSALL
EIGLGYLTLDRSMETLSGGEAQRCKIAKYINSSLSDMLYVLDEPSVGLHSHDIHLLKASVRKLRDHGNTVLLVEHHKEMI
QIADHIVDMGPGSGMEGGRILYEGDYAGLLRSDTLTGRMLGENTPLKESLRIPSGWFTVKHARLHNLKDVTVDLPMGVLA
VIAGVAGSGKSSLMECFRRDFPEEVIYISQKNIGISLRSTPATYLGVADDIRKLFAKESKAGLSMFTFNGKGGCPVCGGK
GVIVSDMAFMDSIETVCEACGGLRYSPEALRYTVDGLTIAEVMDLTVRKASLRFAGTVIAEKLRPLMLVGLGYLHLNQAL
STLSGGELQRVKLASYLGTQSKVFVLDEPTDGLHVKDVRHIISLFDSMVDQGNSVFLIEHNLDVLKAADYVIEIGPGGGL
MGGEILFSGTPKELLSCERSVTKDYLV

Sequences:

>Translated_747_residues
MSNQEYIKIEGAYENNLKHISLDIPKKQITIFTGVSGSGKSSLVLDTIAASSRRELNETFPSFVQQYLPKYGRPHVDRIG
NLPVAIVIDQRKPAPNARSTVGTYTDIYSLLRLLFSRVGKPFVGYSDTFSFNHPQGRCTRCDGLGEIRELDVHKLVDFDK
CLNDEDVIHYVTFQPGQWRWIRYACSGLFDLDKKIRDYTPEELRLFLYSPQIRLKNPPADWPKTAKYEGLVTRMYRSIIN
SEEGKIHQKVLEPMVTMGICPDCGGTRLNDKVLSCRINGRNIAEVTHMAIPEIIAWLREIDDPLAKDMKQAIGGRLSALL
EIGLGYLTLDRSMETLSGGEAQRCKIAKYINSSLSDMLYVLDEPSVGLHSHDIHLLKASVRKLRDHGNTVLLVEHHKEMI
QIADHIVDMGPGSGMEGGRILYEGDYAGLLRSDTLTGRMLGENTPLKESLRIPSGWFTVKHARLHNLKDVTVDLPMGVLA
VIAGVAGSGKSSLMECFRRDFPEEVIYISQKNIGISLRSTPATYLGVADDIRKLFAKESKAGLSMFTFNGKGGCPVCGGK
GVIVSDMAFMDSIETVCEACGGLRYSPEALRYTVDGLTIAEVMDLTVRKASLRFAGTVIAEKLRPLMLVGLGYLHLNQAL
STLSGGELQRVKLASYLGTQSKVFVLDEPTDGLHVKDVRHIISLFDSMVDQGNSVFLIEHNLDVLKAADYVIEIGPGGGL
MGGEILFSGTPKELLSCERSVTKDYLV
>Mature_746_residues
SNQEYIKIEGAYENNLKHISLDIPKKQITIFTGVSGSGKSSLVLDTIAASSRRELNETFPSFVQQYLPKYGRPHVDRIGN
LPVAIVIDQRKPAPNARSTVGTYTDIYSLLRLLFSRVGKPFVGYSDTFSFNHPQGRCTRCDGLGEIRELDVHKLVDFDKC
LNDEDVIHYVTFQPGQWRWIRYACSGLFDLDKKIRDYTPEELRLFLYSPQIRLKNPPADWPKTAKYEGLVTRMYRSIINS
EEGKIHQKVLEPMVTMGICPDCGGTRLNDKVLSCRINGRNIAEVTHMAIPEIIAWLREIDDPLAKDMKQAIGGRLSALLE
IGLGYLTLDRSMETLSGGEAQRCKIAKYINSSLSDMLYVLDEPSVGLHSHDIHLLKASVRKLRDHGNTVLLVEHHKEMIQ
IADHIVDMGPGSGMEGGRILYEGDYAGLLRSDTLTGRMLGENTPLKESLRIPSGWFTVKHARLHNLKDVTVDLPMGVLAV
IAGVAGSGKSSLMECFRRDFPEEVIYISQKNIGISLRSTPATYLGVADDIRKLFAKESKAGLSMFTFNGKGGCPVCGGKG
VIVSDMAFMDSIETVCEACGGLRYSPEALRYTVDGLTIAEVMDLTVRKASLRFAGTVIAEKLRPLMLVGLGYLHLNQALS
TLSGGELQRVKLASYLGTQSKVFVLDEPTDGLHVKDVRHIISLFDSMVDQGNSVFLIEHNLDVLKAADYVIEIGPGGGLM
GGEILFSGTPKELLSCERSVTKDYLV

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=703, Percent_Identity=36.9843527738265, Blast_Score=372, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 82712; Mature: 82580

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQEYIKIEGAYENNLKHISLDIPKKQITIFTGVSGSGKSSLVLDTIAASSRRELNETF
CCCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHH
PSFVQQYLPKYGRPHVDRIGNLPVAIVIDQRKPAPNARSTVGTYTDIYSLLRLLFSRVGK
HHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PFVGYSDTFSFNHPQGRCTRCDGLGEIRELDVHKLVDFDKCLNDEDVIHYVTFQPGQWRW
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEE
IRYACSGLFDLDKKIRDYTPEELRLFLYSPQIRLKNPPADWPKTAKYEGLVTRMYRSIIN
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHC
SEEGKIHQKVLEPMVTMGICPDCGGTRLNDKVLSCRINGRNIAEVTHMAIPEIIAWLREI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
DDPLAKDMKQAIGGRLSALLEIGLGYLTLDRSMETLSGGEAQRCKIAKYINSSLSDMLYV
CCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHEEE
LDEPSVGLHSHDIHLLKASVRKLRDHGNTVLLVEHHKEMIQIADHIVDMGPGSGMEGGRI
ECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCEE
LYEGDYAGLLRSDTLTGRMLGENTPLKESLRIPSGWFTVKHARLHNLKDVTVDLPMGVLA
EEECCCCCCEECCCCCCCCCCCCCCCHHHCCCCCCCEEEEHHHHCCCCCEEEECCHHHHH
VIAGVAGSGKSSLMECFRRDFPEEVIYISQKNIGISLRSTPATYLGVADDIRKLFAKESK
HHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCHHHCCHHHHHHHHHHHCC
AGLSMFTFNGKGGCPVCGGKGVIVSDMAFMDSIETVCEACGGLRYSPEALRYTVDGLTIA
CCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCEEHH
EVMDLTVRKASLRFAGTVIAEKLRPLMLVGLGYLHLNQALSTLSGGELQRVKLASYLGTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
SKVFVLDEPTDGLHVKDVRHIISLFDSMVDQGNSVFLIEHNLDVLKAADYVIEIGPGGGL
CEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHEECCEEEEECCCCCC
MGGEILFSGTPKELLSCERSVTKDYLV
CCCEEEECCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNQEYIKIEGAYENNLKHISLDIPKKQITIFTGVSGSGKSSLVLDTIAASSRRELNETF
CCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHH
PSFVQQYLPKYGRPHVDRIGNLPVAIVIDQRKPAPNARSTVGTYTDIYSLLRLLFSRVGK
HHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
PFVGYSDTFSFNHPQGRCTRCDGLGEIRELDVHKLVDFDKCLNDEDVIHYVTFQPGQWRW
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEE
IRYACSGLFDLDKKIRDYTPEELRLFLYSPQIRLKNPPADWPKTAKYEGLVTRMYRSIIN
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHC
SEEGKIHQKVLEPMVTMGICPDCGGTRLNDKVLSCRINGRNIAEVTHMAIPEIIAWLREI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
DDPLAKDMKQAIGGRLSALLEIGLGYLTLDRSMETLSGGEAQRCKIAKYINSSLSDMLYV
CCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHEEE
LDEPSVGLHSHDIHLLKASVRKLRDHGNTVLLVEHHKEMIQIADHIVDMGPGSGMEGGRI
ECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCEE
LYEGDYAGLLRSDTLTGRMLGENTPLKESLRIPSGWFTVKHARLHNLKDVTVDLPMGVLA
EEECCCCCCEECCCCCCCCCCCCCCCHHHCCCCCCCEEEEHHHHCCCCCEEEECCHHHHH
VIAGVAGSGKSSLMECFRRDFPEEVIYISQKNIGISLRSTPATYLGVADDIRKLFAKESK
HHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCHHHCCHHHHHHHHHHHCC
AGLSMFTFNGKGGCPVCGGKGVIVSDMAFMDSIETVCEACGGLRYSPEALRYTVDGLTIA
CCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHEEEECCEEHH
EVMDLTVRKASLRFAGTVIAEKLRPLMLVGLGYLHLNQALSTLSGGELQRVKLASYLGTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
SKVFVLDEPTDGLHVKDVRHIISLFDSMVDQGNSVFLIEHNLDVLKAADYVIEIGPGGGL
CEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHEECCEEEEECCCCCC
MGGEILFSGTPKELLSCERSVTKDYLV
CCCEEEECCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8675016 [H]