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The map label for this gene is wecA [H]

Identifier: 150008055

GI number: 150008055

Start: 1646295

End: 1647437

Strand: Reverse

Name: wecA [H]

Synonym: BDI_1418

Alternate gene names: 150008055

Gene position: 1647437-1646295 (Counterclockwise)

Preceding gene: 150008056

Following gene: 150008054

Centisome position: 34.24

GC content: 49.69

Gene sequence:

>1143_bases
ATGAGTGAGGTGCAAATTCTATTATTGTTATTACTGTCCGGATATCTGATCTCCGTGTCTTTGGGCATGGTGATCATCCC
GAGGATCTTGGTGATCTCCCACAAGAAAAGACTGTATGATGTCCCGGATTCTCGAAAGGTACACACGACCCCGGTTCCCC
GCTTGGGTGGCCTGTCGTTTTTTCCCGTGGTCTTGATGTCGTTTGCCTTGGTGATAGGCTTTCGCCTTTATCTGTGGCCC
TCGGATCTGTCTAGCTTCTCGATCGAGATGCTCCATGAGTATCTTTTCTTGTTCGTGGGCATGACACTTCTTTATCTGGT
GGGTGTCTGCGATGACTTGGTCGGGGTGGGTTACCGCTACAAGTTCATCGTACAAGTCGTGTCGGCCCTCCTGCTGGTGT
TGTCCGGCAATTGGCTCGATACGCTGGGAGGCCTATTCGGGATCTATTCGGTCCCGGCCTTGCTGGGTGTGCCAGTCACG
GTTTTCGCCGTGGTTTATGTGACAAACGCTATCAACCTGATTGACGGGATCGATGGTCTGGCCTCCGGTTTGTGCTGTAT
CGCCTTATCGGTCTTGAGCGTGTTCTTTTTCATTCAAGATCAATGTGTTTATGCCTTGCTCGCTATCTGTACGCTGGGAA
TCCTCATGCCTTTCTGGTGCTACAATGTCTTTGGCAATGCCAACTGCGGGCATAAGCTCTTCATGGGCGATGCTGGGAGT
TTGACGTTGGGCTACGTGATCAGTTTCCTGATCATTCATTTATGCGTATCGAATAGTACCTCTACGGAGCGTTCGAATCC
TTATTTGGTGATTGCCTTTTCCACGGTCTTGGTACCGTTGCTGGACGTGGTACGTGTGGTGCTGCGCCGCCTTCGTGAGC
ACAAGAACCCGTTCTTGCCGGACAAGAACCATTTCCATCATAAGTTGTTGCGCACGGGTATGCGGGTGCGGATGGTGATG
GTGACGATCATTTGCGTGTCCGTTTTCTTTATCGCATTGAATATTGTATTGGCTAATCATTTGAATGTCAATTGTATATT
ATTTTTAAACCTGTCTCTATGGACGGTTCTTCACTTGGTGATCGATTGGCTGATCGCCCGGAATCGGCAGAAGAGGGAAT
CGGCATTCGACAAGAGGTTCTAG

Upstream 100 bases:

>100_bases
TAGATTACAAATTATTAACAGCATCCCAACTCTCCCATGAGGACTACCAAGCGTGGCATGCCGGCGAGGTGAAGGGGTTG
CCTTCATTAAGTGAGATCGT

Downstream 100 bases:

>100_bases
ACAAGGAAAGCCGGGAAGGGCAATTCCGTCCTTCCTATAAATCAAAATACCATGAAGAAAGTATTGAAAGGCTGGCTCAT
CGATAATGCGGTGACCACCG

Product: putative LPS biosynthesis glycosyltransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSEVQILLLLLLSGYLISVSLGMVIIPRILVISHKKRLYDVPDSRKVHTTPVPRLGGLSFFPVVLMSFALVIGFRLYLWP
SDLSSFSIEMLHEYLFLFVGMTLLYLVGVCDDLVGVGYRYKFIVQVVSALLLVLSGNWLDTLGGLFGIYSVPALLGVPVT
VFAVVYVTNAINLIDGIDGLASGLCCIALSVLSVFFFIQDQCVYALLAICTLGILMPFWCYNVFGNANCGHKLFMGDAGS
LTLGYVISFLIIHLCVSNSTSTERSNPYLVIAFSTVLVPLLDVVRVVLRRLREHKNPFLPDKNHFHHKLLRTGMRVRMVM
VTIICVSVFFIALNIVLANHLNVNCILFLNLSLWTVLHLVIDWLIARNRQKRESAFDKRF

Sequences:

>Translated_380_residues
MSEVQILLLLLLSGYLISVSLGMVIIPRILVISHKKRLYDVPDSRKVHTTPVPRLGGLSFFPVVLMSFALVIGFRLYLWP
SDLSSFSIEMLHEYLFLFVGMTLLYLVGVCDDLVGVGYRYKFIVQVVSALLLVLSGNWLDTLGGLFGIYSVPALLGVPVT
VFAVVYVTNAINLIDGIDGLASGLCCIALSVLSVFFFIQDQCVYALLAICTLGILMPFWCYNVFGNANCGHKLFMGDAGS
LTLGYVISFLIIHLCVSNSTSTERSNPYLVIAFSTVLVPLLDVVRVVLRRLREHKNPFLPDKNHFHHKLLRTGMRVRMVM
VTIICVSVFFIALNIVLANHLNVNCILFLNLSLWTVLHLVIDWLIARNRQKRESAFDKRF
>Mature_379_residues
SEVQILLLLLLSGYLISVSLGMVIIPRILVISHKKRLYDVPDSRKVHTTPVPRLGGLSFFPVVLMSFALVIGFRLYLWPS
DLSSFSIEMLHEYLFLFVGMTLLYLVGVCDDLVGVGYRYKFIVQVVSALLLVLSGNWLDTLGGLFGIYSVPALLGVPVTV
FAVVYVTNAINLIDGIDGLASGLCCIALSVLSVFFFIQDQCVYALLAICTLGILMPFWCYNVFGNANCGHKLFMGDAGSL
TLGYVISFLIIHLCVSNSTSTERSNPYLVIAFSTVLVPLLDVVRVVLRRLREHKNPFLPDKNHFHHKLLRTGMRVRMVMV
TIICVSVFFIALNIVLANHLNVNCILFLNLSLWTVLHLVIDWLIARNRQKRESAFDKRF

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55) [H]

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=295, Percent_Identity=28.8135593220339, Blast_Score=131, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715
- InterPro:   IPR018480 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 42566; Mature: 42435

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVQILLLLLLSGYLISVSLGMVIIPRILVISHKKRLYDVPDSRKVHTTPVPRLGGLSF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCHH
FPVVLMSFALVIGFRLYLWPSDLSSFSIEMLHEYLFLFVGMTLLYLVGVCDDLVGVGYRY
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KFIVQVVSALLLVLSGNWLDTLGGLFGIYSVPALLGVPVTVFAVVYVTNAINLIDGIDGL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASGLCCIALSVLSVFFFIQDQCVYALLAICTLGILMPFWCYNVFGNANCGHKLFMGDAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
LTLGYVISFLIIHLCVSNSTSTERSNPYLVIAFSTVLVPLLDVVRVVLRRLREHKNPFLP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DKNHFHHKLLRTGMRVRMVMVTIICVSVFFIALNIVLANHLNVNCILFLNLSLWTVLHLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHH
IDWLIARNRQKRESAFDKRF
HHHHHHCCCHHHHHHHCCCC
>Mature Secondary Structure 
SEVQILLLLLLSGYLISVSLGMVIIPRILVISHKKRLYDVPDSRKVHTTPVPRLGGLSF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCHH
FPVVLMSFALVIGFRLYLWPSDLSSFSIEMLHEYLFLFVGMTLLYLVGVCDDLVGVGYRY
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KFIVQVVSALLLVLSGNWLDTLGGLFGIYSVPALLGVPVTVFAVVYVTNAINLIDGIDGL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASGLCCIALSVLSVFFFIQDQCVYALLAICTLGILMPFWCYNVFGNANCGHKLFMGDAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
LTLGYVISFLIIHLCVSNSTSTERSNPYLVIAFSTVLVPLLDVVRVVLRRLREHKNPFLP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DKNHFHHKLLRTGMRVRMVMVTIICVSVFFIALNIVLANHLNVNCILFLNLSLWTVLHLV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHH
IDWLIARNRQKRESAFDKRF
HHHHHHCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]