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The map label for this gene is hisC [C]

Identifier: 150008052

GI number: 150008052

Start: 1642969

End: 1644780

Strand: Reverse

Name: hisC [C]

Synonym: BDI_1415

Alternate gene names: 150008052

Gene position: 1644780-1642969 (Counterclockwise)

Preceding gene: 150008053

Following gene: 150008051

Centisome position: 34.19

GC content: 37.97

Gene sequence:

>1812_bases
ATGCAAGCGATTATTTTAGCGGCGGGTATGGGAAAACGCCTCGGGGAATTGACTCGTAATAATACAAAGTGTATGGTGAA
AGTTAATGGTACTTCCTTGATAGATCGTATATTAACTCAGCTTTCCCTGTTGGATTTGTCGAAAGTAATAATAGTTATCG
GATATAAAGGGGATCTTCTACGTAACTATATTGGTCACAAATATAAAGGATTGAAGATAGAATATATAGAAAATCCAGTT
TATGATAAGACGAACAATATTTATTCGCTTTCCTTGGCAAAGAAAGAGCTGCAAAAAGATGATACATTATTGATAGAATC
AGATTTGATATTCGATGATACTCTTTTCCCGATGATTGTCTATAATCCATACCCTAATTTAGCGCTGGTAGCAAAGTACG
AGACTTGGATGGACGGAACAATGGTTCGCTTGGATGAGGAGAATAATATTGTCAATTTTATTCCTAAGAAAGCCTTTAAA
TACGGAGATGTAGATTATTATTACAAAACGGTTAATATCTACAAGTTCAGCAAAGAGTTCTCCACTACGAATTATGTTCC
CTTTTTGGAAGCGTATACTAAGGCTCTGGGCAATAATGAGTATTACGAGCAAGTGCTTCGGGTGATTACACTGTTGGATA
AATGTGAATTGAAAGCCTTGCCTTTGCAGGGGGAAAAGTGGTATGAGATAGACGATGTGCAGGACTTGGACATTGCGGAA
ACGATTTTTGCCACAGAAGAAGATCGCTTGTCGCTTTATCAAAAGCGCTATGGTGGTTATTGGCGTTTTCCGAACTTACT
AGACTTCTGTTATTTGGTCAATCCGTTTTTTCCACCTCAGAAGTTGAAGGATGAGTTGAAGGCTAATTTTGACGTGTTAT
TGGCTGAATATCCTTCTGGAATGCGTGTTAATTCGTTACTGATAGCTAGGTATTTTCATATTAAAAAAGAGTATGCCGTA
ATTGGGAATGGTGCGGCTGAGCTGATCAAGTCTCTTATGGAACAGATAGAGGGAAAGATTGGTGTCATATATCCGACGTT
TGAAGAGTACCCAAATCGTTGCGATAAGGAACAGCTAATTTGCTTTACGCCGGATAATAGGGATTTCTCTTATTCTGCTT
CCGATTTGAGAGCTTTCTTTTCTGATAAGCCTATTTCTACTTTGCTGTTGGTAAATCCTGACAATCCTTCTGGGAATTTC
ATTCCATACGCTGATTTGTTGGATTTGATAGCATGGGCACAACAAAGAAGAATCCGTATGGTGGTTGACGAATCATTTGT
CGATTTCAGCGTAGGTTATGAAAATAATACTTTGTTGTGTGATGATGTATTGGAACAATATGAGAATCTGGTAGTGATGA
AGAGTATTTCCAAGTCATACGGTGTTCCCGGTCTTCGTTTAGGCGTGTTGGCTTCGGGTAACATCGAGTTAATCAAGAAG
ATCAAAAGCGATATCTCTATTTGGAATATCAATTCGTTTGCCGAGTTCTATATGCAGATTTACGGGAAGTATGAGAGCGA
CTATAAGAAAGGTTGTGAAAAGTTTATCGCAGAACGCCAACGCTTTTATGAAGATTTGCGATCAATACCTTTCTTGCGTG
TGATACCCTCACAGGCTAATTATTTCTTATGCGAGGTGACAGATAAATATAAAGCTACAGAACTTACACAACTCCTTTTG
AAACATTGCAACATTCTTGTTAAAGACTGTAGCACAAAATCAGCCTTTGCTTGCAAACAGTATATTCGCTTGGCTATACG
CAACAGAATTGATAATGCTTATTTCATAAAAGCACTTAACGAACTTTTGTAA

Upstream 100 bases:

>100_bases
GTATGGTTCTGTGAGAAAGGAAGGTTAAAGTTTCCCTCTCTTTACTTGACCTTGAAACATCTTTTTGATAATTGAAATAT
AGACGTACAAACTAATTAAT

Downstream 100 bases:

>100_bases
TAGAAATTGTTGTTCCACTGATTATTGATATACGGGGAAAATGCAATATCTCCGATTTGGGTAAATATACTTAATATCTA
TAAAATGATTTCTTTCTTAA

Product: hemolysin erythrocyte lysis protein 2

Products: 2-Oxoglutarate; L-Histidinol phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MQAIILAAGMGKRLGELTRNNTKCMVKVNGTSLIDRILTQLSLLDLSKVIIVIGYKGDLLRNYIGHKYKGLKIEYIENPV
YDKTNNIYSLSLAKKELQKDDTLLIESDLIFDDTLFPMIVYNPYPNLALVAKYETWMDGTMVRLDEENNIVNFIPKKAFK
YGDVDYYYKTVNIYKFSKEFSTTNYVPFLEAYTKALGNNEYYEQVLRVITLLDKCELKALPLQGEKWYEIDDVQDLDIAE
TIFATEEDRLSLYQKRYGGYWRFPNLLDFCYLVNPFFPPQKLKDELKANFDVLLAEYPSGMRVNSLLIARYFHIKKEYAV
IGNGAAELIKSLMEQIEGKIGVIYPTFEEYPNRCDKEQLICFTPDNRDFSYSASDLRAFFSDKPISTLLLVNPDNPSGNF
IPYADLLDLIAWAQQRRIRMVVDESFVDFSVGYENNTLLCDDVLEQYENLVVMKSISKSYGVPGLRLGVLASGNIELIKK
IKSDISIWNINSFAEFYMQIYGKYESDYKKGCEKFIAERQRFYEDLRSIPFLRVIPSQANYFLCEVTDKYKATELTQLLL
KHCNILVKDCSTKSAFACKQYIRLAIRNRIDNAYFIKALNELL

Sequences:

>Translated_603_residues
MQAIILAAGMGKRLGELTRNNTKCMVKVNGTSLIDRILTQLSLLDLSKVIIVIGYKGDLLRNYIGHKYKGLKIEYIENPV
YDKTNNIYSLSLAKKELQKDDTLLIESDLIFDDTLFPMIVYNPYPNLALVAKYETWMDGTMVRLDEENNIVNFIPKKAFK
YGDVDYYYKTVNIYKFSKEFSTTNYVPFLEAYTKALGNNEYYEQVLRVITLLDKCELKALPLQGEKWYEIDDVQDLDIAE
TIFATEEDRLSLYQKRYGGYWRFPNLLDFCYLVNPFFPPQKLKDELKANFDVLLAEYPSGMRVNSLLIARYFHIKKEYAV
IGNGAAELIKSLMEQIEGKIGVIYPTFEEYPNRCDKEQLICFTPDNRDFSYSASDLRAFFSDKPISTLLLVNPDNPSGNF
IPYADLLDLIAWAQQRRIRMVVDESFVDFSVGYENNTLLCDDVLEQYENLVVMKSISKSYGVPGLRLGVLASGNIELIKK
IKSDISIWNINSFAEFYMQIYGKYESDYKKGCEKFIAERQRFYEDLRSIPFLRVIPSQANYFLCEVTDKYKATELTQLLL
KHCNILVKDCSTKSAFACKQYIRLAIRNRIDNAYFIKALNELL
>Mature_603_residues
MQAIILAAGMGKRLGELTRNNTKCMVKVNGTSLIDRILTQLSLLDLSKVIIVIGYKGDLLRNYIGHKYKGLKIEYIENPV
YDKTNNIYSLSLAKKELQKDDTLLIESDLIFDDTLFPMIVYNPYPNLALVAKYETWMDGTMVRLDEENNIVNFIPKKAFK
YGDVDYYYKTVNIYKFSKEFSTTNYVPFLEAYTKALGNNEYYEQVLRVITLLDKCELKALPLQGEKWYEIDDVQDLDIAE
TIFATEEDRLSLYQKRYGGYWRFPNLLDFCYLVNPFFPPQKLKDELKANFDVLLAEYPSGMRVNSLLIARYFHIKKEYAV
IGNGAAELIKSLMEQIEGKIGVIYPTFEEYPNRCDKEQLICFTPDNRDFSYSASDLRAFFSDKPISTLLLVNPDNPSGNF
IPYADLLDLIAWAQQRRIRMVVDESFVDFSVGYENNTLLCDDVLEQYENLVVMKSISKSYGVPGLRLGVLASGNIELIKK
IKSDISIWNINSFAEFYMQIYGKYESDYKKGCEKFIAERQRFYEDLRSIPFLRVIPSQANYFLCEVTDKYKATELTQLLL
KHCNILVKDCSTKSAFACKQYIRLAIRNRIDNAYFIKALNELL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To Rhizobium NGR234A y4qD [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322075, Length=301, Percent_Identity=25.5813953488372, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9 [C]

Molecular weight: Translated: 69888; Mature: 69888

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIILAAGMGKRLGELTRNNTKCMVKVNGTSLIDRILTQLSLLDLSKVIIVIGYKGDLL
CCEEEEECCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCHHHH
RNYIGHKYKGLKIEYIENPVYDKTNNIYSLSLAKKELQKDDTLLIESDLIFDDTLFPMIV
HHHHCCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHHCCCCCEEEECCCEECCCCCCEEE
YNPYPNLALVAKYETWMDGTMVRLDEENNIVNFIPKKAFKYGDVDYYYKTVNIYKFSKEF
ECCCCCEEEEEEEHHCCCCEEEEEECCCCEEECCCHHHHCCCCCEEEEEEEEEEEECCCC
STTNYVPFLEAYTKALGNNEYYEQVLRVITLLDKCELKALPLQGEKWYEIDDVQDLDIAE
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCEECCCCCCCCHHH
TIFATEEDRLSLYQKRYGGYWRFPNLLDFCYLVNPFFPPQKLKDELKANFDVLLAEYPSG
HHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCC
MRVNSLLIARYFHIKKEYAVIGNGAAELIKSLMEQIEGKIGVIYPTFEEYPNRCDKEQLI
CCHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCCCEE
CFTPDNRDFSYSASDLRAFFSDKPISTLLLVNPDNPSGNFIPYADLLDLIAWAQQRRIRM
EECCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEE
VVDESFVDFSVGYENNTLLCDDVLEQYENLVVMKSISKSYGVPGLRLGVLASGNIELIKK
EEECCCEEEEECCCCCCEEHHHHHHHHHCEEHHHHHHHHCCCCCEEEEEEECCCHHHHHH
IKSDISIWNINSFAEFYMQIYGKYESDYKKGCEKFIAERQRFYEDLRSIPFLRVIPSQAN
HHHCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
YFLCEVTDKYKATELTQLLLKHCNILVKDCSTKSAFACKQYIRLAIRNRIDNAYFIKALN
EEEEEECCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
ELL
HHC
>Mature Secondary Structure
MQAIILAAGMGKRLGELTRNNTKCMVKVNGTSLIDRILTQLSLLDLSKVIIVIGYKGDLL
CCEEEEECCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEECCHHHH
RNYIGHKYKGLKIEYIENPVYDKTNNIYSLSLAKKELQKDDTLLIESDLIFDDTLFPMIV
HHHHCCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHHCCCCCEEEECCCEECCCCCCEEE
YNPYPNLALVAKYETWMDGTMVRLDEENNIVNFIPKKAFKYGDVDYYYKTVNIYKFSKEF
ECCCCCEEEEEEEHHCCCCEEEEEECCCCEEECCCHHHHCCCCCEEEEEEEEEEEECCCC
STTNYVPFLEAYTKALGNNEYYEQVLRVITLLDKCELKALPLQGEKWYEIDDVQDLDIAE
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCEECCCCCCCCHHH
TIFATEEDRLSLYQKRYGGYWRFPNLLDFCYLVNPFFPPQKLKDELKANFDVLLAEYPSG
HHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCC
MRVNSLLIARYFHIKKEYAVIGNGAAELIKSLMEQIEGKIGVIYPTFEEYPNRCDKEQLI
CCHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCCCEE
CFTPDNRDFSYSASDLRAFFSDKPISTLLLVNPDNPSGNFIPYADLLDLIAWAQQRRIRM
EECCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEE
VVDESFVDFSVGYENNTLLCDDVLEQYENLVVMKSISKSYGVPGLRLGVLASGNIELIKK
EEECCCEEEEECCCCCCEEHHHHHHHHHCEEHHHHHHHHCCCCCEEEEEEECCCHHHHHH
IKSDISIWNINSFAEFYMQIYGKYESDYKKGCEKFIAERQRFYEDLRSIPFLRVIPSQAN
HHHCCEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
YFLCEVTDKYKATELTQLLLKHCNILVKDCSTKSAFACKQYIRLAIRNRIDNAYFIKALN
EEEEEECCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
ELL
HHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-Glutamate; 3-(Imidazol-4-yl)-2-oxopropyl phosphate [C]

Specific reaction: L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate --> 2-Oxoglutarate + L-Histidinol phosphate [C]

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]