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The map label for this gene is norM [H]

Identifier: 150006246

GI number: 150006246

Start: 4645431

End: 4646720

Strand: Direct

Name: norM [H]

Synonym: BVU_3757

Alternate gene names: 150006246

Gene position: 4645431-4646720 (Clockwise)

Preceding gene: 150006245

Following gene: 150006252

Centisome position: 89.97

GC content: 38.84

Gene sequence:

>1290_bases
ATGAATTATACATATAAAAACATATGGCTCATCAACTTTCCGGTTATGATGAGCATCCTTATCGAACAACTTATTAATAT
AACTGATGCTATCTTCTTAGGTCATGTTGGTGAAATAGAATTAGGGGCATCTGCACTTGCCGGAATCTGGTACCTTGCCA
TTTATATGCTCGGTTTCGGATTCAGTATAGGTTTACAGGTTGTCATTGCACGGCGTAATGGCGAGCGGCAATATTCAGAA
ACAGGTAGGACATTCTTTCAGGGGTTACTTTTTCTGTCTGGCTTAGCAGCTCTACTGTGCACTATTTCTAAAATATTATC
TCCCATGATTCTGAGCAATCTGATTGTATCAGAGAAAGTATATTCTGCTGTTATTGACTATCTGGACTGGCGCATTTGGG
GATTAATGTTTTCTTTCCCATTTCTTGCGTTGCGGTCTTTCCTGGTCGGTATCACACTTACAAAGCCCTTGAACAAAGCT
GCCTTCACTGCAGTATTGGTGAATATACCTTGTAATTGGCTTTTCATATTTTATTTCGATATGGGAATAGCAGGTGCTGC
AATAGCGTCATCTTTTGCTGAATTATGCTCATTGATAATATTGTCTATCCATGTTTTACGAAAAATGGACAGAAAGGTTT
ATGGTCTGAACTGGCAGTTTAATAAAAACATATTCCATCATGTCTGCCGTGTATCTATCTGGAGCATGTTCAATCCGTTT
ATTGGTGTGGCCTCATGGTTTGCCTTCTTCGTAGCCATTGAGCATTTAGGCGAATTGGAACTGGCAGCGACAAATGTAAT
ACGTAGCATATCTACCTTGTTTTTTGTTATTGTCAATTCATTGGCAGCAACTACCGGCTCATTGGTAAGTAATCTGTTGG
GAGCAGGACAAAAGAATCAGATTTTCCCGTTATGTAACCGGGTTATCCGTTTGGGATATGCCGTGGGATTCCCACTTATT
ATTCTTTCTATAATCTGTTTCAATCCACTTTTTAATATTTACTCGGATAATGAGGGCCTAATGCAAATAGCACAGCTGCC
ATTTACAGTAGCGTTGTTGAATTATGCCTTTGCCTTACCTGGTTATGTATATATGAATGCTGTCACAGGGACAGGTGCCA
CACGTACAACCTTCATTTTTCAGACTGTAACCATTATAGCCTACCAGATTTATTTATGGACGATAAGCAATTTAAGCTCC
TCCCTGTCTGTATATTGGACAGCAGAATACTTATATGTGATATTGCTTGGAATGCTTTCCATTATATATCTTAAATGCAA
AAACCATTAA

Upstream 100 bases:

>100_bases
GGTCTGTACTTCTTTATTTTGCCATTATATCAAATAATTACCTTACAAATAAGTTATGTCACTAGTTGACAGGACTTGTT
GTATTTTATCATGTTGAACA

Downstream 100 bases:

>100_bases
TCATTTGAATCCCATGATGGAAAAAGACCTGTCTATCGAAGTCGGCGATTACACTTTCAAGTGAATAAAATACTTTTCAA
CCATATCTTTAAGCTGATTC

Product: BexA, putative cation effux pump

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter; Na(+)/drug antiporter [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNYTYKNIWLINFPVMMSILIEQLINITDAIFLGHVGEIELGASALAGIWYLAIYMLGFGFSIGLQVVIARRNGERQYSE
TGRTFFQGLLFLSGLAALLCTISKILSPMILSNLIVSEKVYSAVIDYLDWRIWGLMFSFPFLALRSFLVGITLTKPLNKA
AFTAVLVNIPCNWLFIFYFDMGIAGAAIASSFAELCSLIILSIHVLRKMDRKVYGLNWQFNKNIFHHVCRVSIWSMFNPF
IGVASWFAFFVAIEHLGELELAATNVIRSISTLFFVIVNSLAATTGSLVSNLLGAGQKNQIFPLCNRVIRLGYAVGFPLI
ILSIICFNPLFNIYSDNEGLMQIAQLPFTVALLNYAFALPGYVYMNAVTGTGATRTTFIFQTVTIIAYQIYLWTISNLSS
SLSVYWTAEYLYVILLGMLSIIYLKCKNH

Sequences:

>Translated_429_residues
MNYTYKNIWLINFPVMMSILIEQLINITDAIFLGHVGEIELGASALAGIWYLAIYMLGFGFSIGLQVVIARRNGERQYSE
TGRTFFQGLLFLSGLAALLCTISKILSPMILSNLIVSEKVYSAVIDYLDWRIWGLMFSFPFLALRSFLVGITLTKPLNKA
AFTAVLVNIPCNWLFIFYFDMGIAGAAIASSFAELCSLIILSIHVLRKMDRKVYGLNWQFNKNIFHHVCRVSIWSMFNPF
IGVASWFAFFVAIEHLGELELAATNVIRSISTLFFVIVNSLAATTGSLVSNLLGAGQKNQIFPLCNRVIRLGYAVGFPLI
ILSIICFNPLFNIYSDNEGLMQIAQLPFTVALLNYAFALPGYVYMNAVTGTGATRTTFIFQTVTIIAYQIYLWTISNLSS
SLSVYWTAEYLYVILLGMLSIIYLKCKNH
>Mature_429_residues
MNYTYKNIWLINFPVMMSILIEQLINITDAIFLGHVGEIELGASALAGIWYLAIYMLGFGFSIGLQVVIARRNGERQYSE
TGRTFFQGLLFLSGLAALLCTISKILSPMILSNLIVSEKVYSAVIDYLDWRIWGLMFSFPFLALRSFLVGITLTKPLNKA
AFTAVLVNIPCNWLFIFYFDMGIAGAAIASSFAELCSLIILSIHVLRKMDRKVYGLNWQFNKNIFHHVCRVSIWSMFNPF
IGVASWFAFFVAIEHLGELELAATNVIRSISTLFFVIVNSLAATTGSLVSNLLGAGQKNQIFPLCNRVIRLGYAVGFPLI
ILSIICFNPLFNIYSDNEGLMQIAQLPFTVALLNYAFALPGYVYMNAVTGTGATRTTFIFQTVTIIAYQIYLWTISNLSS
SLSVYWTAEYLYVILLGMLSIIYLKCKNH

Specific function: Multidrug efflux pump that functions as a Na(+)/drug antiporter [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48111; Mature: 48111

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYTYKNIWLINFPVMMSILIEQLINITDAIFLGHVGEIELGASALAGIWYLAIYMLGFG
CCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
FSIGLQVVIARRNGERQYSETGRTFFQGLLFLSGLAALLCTISKILSPMILSNLIVSEKV
HHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSAVIDYLDWRIWGLMFSFPFLALRSFLVGITLTKPLNKAAFTAVLVNIPCNWLFIFYFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCHHHHHHHHH
MGIAGAAIASSFAELCSLIILSIHVLRKMDRKVYGLNWQFNKNIFHHVCRVSIWSMFNPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEECHHHHHHHHHHHHHHHHHHH
IGVASWFAFFVAIEHLGELELAATNVIRSISTLFFVIVNSLAATTGSLVSNLLGAGQKNQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IFPLCNRVIRLGYAVGFPLIILSIICFNPLFNIYSDNEGLMQIAQLPFTVALLNYAFALP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
GYVYMNAVTGTGATRTTFIFQTVTIIAYQIYLWTISNLSSSLSVYWTAEYLYVILLGMLS
CHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHH
IIYLKCKNH
HHHHHCCCC
>Mature Secondary Structure
MNYTYKNIWLINFPVMMSILIEQLINITDAIFLGHVGEIELGASALAGIWYLAIYMLGFG
CCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
FSIGLQVVIARRNGERQYSETGRTFFQGLLFLSGLAALLCTISKILSPMILSNLIVSEKV
HHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSAVIDYLDWRIWGLMFSFPFLALRSFLVGITLTKPLNKAAFTAVLVNIPCNWLFIFYFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEECCCHHHHHHHHH
MGIAGAAIASSFAELCSLIILSIHVLRKMDRKVYGLNWQFNKNIFHHVCRVSIWSMFNPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEECHHHHHHHHHHHHHHHHHHH
IGVASWFAFFVAIEHLGELELAATNVIRSISTLFFVIVNSLAATTGSLVSNLLGAGQKNQ
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IFPLCNRVIRLGYAVGFPLIILSIICFNPLFNIYSDNEGLMQIAQLPFTVALLNYAFALP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
GYVYMNAVTGTGATRTTFIFQTVTIIAYQIYLWTISNLSSSLSVYWTAEYLYVILLGMLS
CHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHH
IIYLKCKNH
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA