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The map label for this gene is serS [H]

Identifier: 150006127

GI number: 150006127

Start: 4503778

End: 4505052

Strand: Direct

Name: serS [H]

Synonym: BVU_3638

Alternate gene names: 150006127

Gene position: 4503778-4505052 (Clockwise)

Preceding gene: 150006124

Following gene: 150006128

Centisome position: 87.23

GC content: 43.84

Gene sequence:

>1275_bases
ATGCTTACCATTAAACAAATTACAGAGAATACGGAAGAGGTAATCCGCGGACTGGAAAAGAAGCATTTTAAAGATGCAAA
AGCAACGATAGAACAAGTGCTTGCATTCAATGACAAAAGACGTAGCACGCAGAATCAATTAGATAAAAACCTGGCAGAAG
TGAACTCGCTCTCCAAATCTATCGGGCAACTGATGAAAGAAGGGAAAAAAGAAGATGCTGAAACAGCTAAAGCACGTGTA
GCCGAAATCAAAGAAACCAGCAAAGCTTTACAAGCAGAAATGGACAAAGCACAGGAAGACATGACCAACCTGCTTTACAC
CATTCCCAATGTTCCTTATGACAGTGTGCCCGAAGGTGTAAGCGCTGAAGACAATGTGGTGGAAAAAATGGGCGGTATGG
AAACCGAACTCCCCAAGAATGCGCTTCCCCATTGGGAACTTGCCAAAAAATACGACTTGATAGATTTTGACCTGGGCGTG
AAAATCACAGGGGCAGGTTTTCCTGTATATAAAGGTAAAGGGGCACGTCTTCAACGCGCATTAATCAATTTCTTCCTGGA
TGAAGCCCGCGCTTCCGGTTACGAAGAAATCATGCCACCGACGGTAGTAAACACCGCATCGGGCTACGGAACAGGACAAC
TTCCCGACAAAGAAGGACAAATGTATCATTGTGAAGTAGATGATTTGTACTTGATTCCAACCGCAGAAGTTCCTGTAACC
AATATCTATCGTGACGTGATTTTGGACGAAAAACAATTGCCTATCAAGAATTGCGCATATACTCAATGTTTCCGTCGTGA
AGCCGGATCTTACGGCAAAGACGTACGTGGGTTGAACCGTTTGCACGAATTCTCAAAAGTAGAACTGGTACGCATTGACA
AACCCGAACATTCCAAACAGTCACATCAGGAAATGTTGGACCATGTAGAAGGCCTGTTGAAGAAATTAGAACTCCCCTAT
CGCATTCTCCGCCTTTGCGGTGGTGATATGAGTTTTACAGCTGCACTTTGCTTTGACTTTGAGGTTTATTCGGAAGCACA
ACAGCGTTGGCTGGAAGTAAGTTCTGTATCCAATTTCGATACGTATCAGGCTAATCGCCTGAAATGCCGTTACCGTTCTG
CCGAAAAGAAAACAGAATTATGCCATACTTTGAACGGTTCCGCACTGGCTTTGCCGCGTATTGTTGCAGCCTTATTAGAA
AATAATCAGACTCCGGAAGGTATCCGTATCCCTAAAGCATTAGTTCCTTATTGCGGATTCGAGATGATTGACTAA

Upstream 100 bases:

>100_bases
CTAATCCGGATGCAAAAGTAACGAATAACTCATACACCTTACCATTTTTTTATCTATCTTTGTCCATTAATTCAAGAAAT
ATCAAAAAGACTGAAAAGAT

Downstream 100 bases:

>100_bases
TAACAGCTAATTACATATATTGAATGTCATTCTGAGTATTATTCAGAATCCGATCTTTCCCGACAGATTCTGTCTTGTAT
GCAGAATGACATTCTTTTTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLTIKQITENTEEVIRGLEKKHFKDAKATIEQVLAFNDKRRSTQNQLDKNLAEVNSLSKSIGQLMKEGKKEDAETAKARV
AEIKETSKALQAEMDKAQEDMTNLLYTIPNVPYDSVPEGVSAEDNVVEKMGGMETELPKNALPHWELAKKYDLIDFDLGV
KITGAGFPVYKGKGARLQRALINFFLDEARASGYEEIMPPTVVNTASGYGTGQLPDKEGQMYHCEVDDLYLIPTAEVPVT
NIYRDVILDEKQLPIKNCAYTQCFRREAGSYGKDVRGLNRLHEFSKVELVRIDKPEHSKQSHQEMLDHVEGLLKKLELPY
RILRLCGGDMSFTAALCFDFEVYSEAQQRWLEVSSVSNFDTYQANRLKCRYRSAEKKTELCHTLNGSALALPRIVAALLE
NNQTPEGIRIPKALVPYCGFEMID

Sequences:

>Translated_424_residues
MLTIKQITENTEEVIRGLEKKHFKDAKATIEQVLAFNDKRRSTQNQLDKNLAEVNSLSKSIGQLMKEGKKEDAETAKARV
AEIKETSKALQAEMDKAQEDMTNLLYTIPNVPYDSVPEGVSAEDNVVEKMGGMETELPKNALPHWELAKKYDLIDFDLGV
KITGAGFPVYKGKGARLQRALINFFLDEARASGYEEIMPPTVVNTASGYGTGQLPDKEGQMYHCEVDDLYLIPTAEVPVT
NIYRDVILDEKQLPIKNCAYTQCFRREAGSYGKDVRGLNRLHEFSKVELVRIDKPEHSKQSHQEMLDHVEGLLKKLELPY
RILRLCGGDMSFTAALCFDFEVYSEAQQRWLEVSSVSNFDTYQANRLKCRYRSAEKKTELCHTLNGSALALPRIVAALLE
NNQTPEGIRIPKALVPYCGFEMID
>Mature_424_residues
MLTIKQITENTEEVIRGLEKKHFKDAKATIEQVLAFNDKRRSTQNQLDKNLAEVNSLSKSIGQLMKEGKKEDAETAKARV
AEIKETSKALQAEMDKAQEDMTNLLYTIPNVPYDSVPEGVSAEDNVVEKMGGMETELPKNALPHWELAKKYDLIDFDLGV
KITGAGFPVYKGKGARLQRALINFFLDEARASGYEEIMPPTVVNTASGYGTGQLPDKEGQMYHCEVDDLYLIPTAEVPVT
NIYRDVILDEKQLPIKNCAYTQCFRREAGSYGKDVRGLNRLHEFSKVELVRIDKPEHSKQSHQEMLDHVEGLLKKLELPY
RILRLCGGDMSFTAALCFDFEVYSEAQQRWLEVSSVSNFDTYQANRLKCRYRSAEKKTELCHTLNGSALALPRIVAALLE
NNQTPEGIRIPKALVPYCGFEMID

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=445, Percent_Identity=30.1123595505618, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI8923421, Length=437, Percent_Identity=26.3157894736842, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI225579074, Length=325, Percent_Identity=29.8461538461538, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1787120, Length=416, Percent_Identity=43.0288461538462, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17539260, Length=444, Percent_Identity=29.0540540540541, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17542084, Length=299, Percent_Identity=27.4247491638796, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320226, Length=437, Percent_Identity=30.6636155606407, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6321799, Length=423, Percent_Identity=27.4231678486998, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24581334, Length=448, Percent_Identity=28.5714285714286, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI17737985, Length=278, Percent_Identity=31.6546762589928, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47882; Mature: 47882

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIKQITENTEEVIRGLEKKHFKDAKATIEQVLAFNDKRRSTQNQLDKNLAEVNSLSKS
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IGQLMKEGKKEDAETAKARVAEIKETSKALQAEMDKAQEDMTNLLYTIPNVPYDSVPEGV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SAEDNVVEKMGGMETELPKNALPHWELAKKYDLIDFDLGVKITGAGFPVYKGKGARLQRA
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCEEECCCEEEECCCCCCCCCCCHHHHHH
LINFFLDEARASGYEEIMPPTVVNTASGYGTGQLPDKEGQMYHCEVDDLYLIPTAEVPVT
HHHHHHHHHHHCCHHHHCCCCCEECCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCHH
NIYRDVILDEKQLPIKNCAYTQCFRREAGSYGKDVRGLNRLHEFSKVELVRIDKPEHSKQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHH
SHQEMLDHVEGLLKKLELPYRILRLCGGDMSFTAALCFDFEVYSEAQQRWLEVSSVSNFD
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TYQANRLKCRYRSAEKKTELCHTLNGSALALPRIVAALLENNQTPEGIRIPKALVPYCGF
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
EMID
CCCC
>Mature Secondary Structure
MLTIKQITENTEEVIRGLEKKHFKDAKATIEQVLAFNDKRRSTQNQLDKNLAEVNSLSKS
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
IGQLMKEGKKEDAETAKARVAEIKETSKALQAEMDKAQEDMTNLLYTIPNVPYDSVPEGV
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SAEDNVVEKMGGMETELPKNALPHWELAKKYDLIDFDLGVKITGAGFPVYKGKGARLQRA
CCHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCEEECCCEEEECCCCCCCCCCCHHHHHH
LINFFLDEARASGYEEIMPPTVVNTASGYGTGQLPDKEGQMYHCEVDDLYLIPTAEVPVT
HHHHHHHHHHHCCHHHHCCCCCEECCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCHH
NIYRDVILDEKQLPIKNCAYTQCFRREAGSYGKDVRGLNRLHEFSKVELVRIDKPEHSKQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEECCCCCHHH
SHQEMLDHVEGLLKKLELPYRILRLCGGDMSFTAALCFDFEVYSEAQQRWLEVSSVSNFD
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TYQANRLKCRYRSAEKKTELCHTLNGSALALPRIVAALLENNQTPEGIRIPKALVPYCGF
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCC
EMID
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA