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The map label for this gene is mepA [H]

Identifier: 150006082

GI number: 150006082

Start: 4454601

End: 4455752

Strand: Direct

Name: mepA [H]

Synonym: BVU_3591

Alternate gene names: 150006082

Gene position: 4454601-4455752 (Clockwise)

Preceding gene: 150006081

Following gene: 150006083

Centisome position: 86.28

GC content: 41.75

Gene sequence:

>1152_bases
ATGAAGAGTAATTTTCAGAAAATTGCGGTCCTGTGTACATGCACAGGATTGCTATGCTCTTGTGGTCAATCGGACAACAA
GCAGGAACATCACAAAGAATTCATTCCCATCACCATTCTTCACCCCACAACCATTGAGTTTCCACGCTCATATGTAGCTG
ATGTGCAAGCTATACAGTTTGTAGAAATTAAGCCCAAAGTGGAAGGATTTGTTCAACAAATATATGTAGACGAAGGACAG
AAAGTCAAAAAAGGACAGCCCCTATTCCAACTCAGTTCCGACCAATATAGCGAAACGGTAAAAGAGGCGCAAGCCAATTA
CAAACAAGCACAGGCACAATATGAAATGGCAAATTATGAAGCCGAAAGAATAGGCCGGCTGGTTGACAAACAAATCTTAT
CAAAAATCCGACTCGACCAAGCCAATAAAGAAAAAGAAGTAGCCCAAATGAAAGTGGAACAGGCAAAAGCACAAATGCAA
CGTTCACAGATGGATTATTCTTACACCACTATCACTGCCCCTTTTGACGGCTACATAGACCGTATTCCTTATAAGACGGG
AAGTCTGGTAAATCCGCAAAGCTTACTGACTACCGTAAGTGATATTTCCGAGATCTTTGCTTACTATAAAGTGAACGAAA
GCGAGTATCTGGAATACAAGCGCCAACAACTTAGCGGACAAAAACAGCACGAAGAAAATAATGTGGAACTGATTTTGTCA
GACGGTTCCATCTACTCCCACAAAGGCACATTAGAAACTGTAGAAGGTGACTTTGAACGAGGAACCGGCTCCATTGCCTT
CCGTGTCCGTTTTCCGAACCCGGACGGACTGCTGAAACATGGAGTGACTGGAAAAGTACGTATGATGACCCAAATGGACA
ACATCTGCCTAGTTCCCCAGAAATCAACATTCGAAATTCAAGATTTCACCTATGTATATACCGTTGATAGTGCCAGTGTA
GTAAAAGTACGCAGCTTCCAACCGCTGGAACGCTATAATAATTACTATGTGACACAAGACTTCTCTCCTAACACTGCCAT
CGTATACGAGGGAGTGCAAATGATGAAGGATGGCATTACCATCAAGACTGATACCATTGATATGGAAGCAATCAGAAAAG
AAGTTGAATTAAAACAACCTATCGTAAAATAA

Upstream 100 bases:

>100_bases
ATACATATTGGCCTTGTATTCTGAAAGATTTGAATGCAAGCCGGATCTTTTATTTACTCAAACTCAATTATTAATCTTTT
TAAATTGTATTCGTAATTTC

Downstream 100 bases:

>100_bases
AACGGACAGTTTATGTTTAAGCTATTTATAAAAAGACCGATACTTTCAGGAGTAATCTCCGTCATTATCGTCTGCTTGGG
CGTACTGTCTATTTTGACAC

Product: multidrug resistance protein MexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKSNFQKIAVLCTCTGLLCSCGQSDNKQEHHKEFIPITILHPTTIEFPRSYVADVQAIQFVEIKPKVEGFVQQIYVDEGQ
KVKKGQPLFQLSSDQYSETVKEAQANYKQAQAQYEMANYEAERIGRLVDKQILSKIRLDQANKEKEVAQMKVEQAKAQMQ
RSQMDYSYTTITAPFDGYIDRIPYKTGSLVNPQSLLTTVSDISEIFAYYKVNESEYLEYKRQQLSGQKQHEENNVELILS
DGSIYSHKGTLETVEGDFERGTGSIAFRVRFPNPDGLLKHGVTGKVRMMTQMDNICLVPQKSTFEIQDFTYVYTVDSASV
VKVRSFQPLERYNNYYVTQDFSPNTAIVYEGVQMMKDGITIKTDTIDMEAIRKEVELKQPIVK

Sequences:

>Translated_383_residues
MKSNFQKIAVLCTCTGLLCSCGQSDNKQEHHKEFIPITILHPTTIEFPRSYVADVQAIQFVEIKPKVEGFVQQIYVDEGQ
KVKKGQPLFQLSSDQYSETVKEAQANYKQAQAQYEMANYEAERIGRLVDKQILSKIRLDQANKEKEVAQMKVEQAKAQMQ
RSQMDYSYTTITAPFDGYIDRIPYKTGSLVNPQSLLTTVSDISEIFAYYKVNESEYLEYKRQQLSGQKQHEENNVELILS
DGSIYSHKGTLETVEGDFERGTGSIAFRVRFPNPDGLLKHGVTGKVRMMTQMDNICLVPQKSTFEIQDFTYVYTVDSASV
VKVRSFQPLERYNNYYVTQDFSPNTAIVYEGVQMMKDGITIKTDTIDMEAIRKEVELKQPIVK
>Mature_383_residues
MKSNFQKIAVLCTCTGLLCSCGQSDNKQEHHKEFIPITILHPTTIEFPRSYVADVQAIQFVEIKPKVEGFVQQIYVDEGQ
KVKKGQPLFQLSSDQYSETVKEAQANYKQAQAQYEMANYEAERIGRLVDKQILSKIRLDQANKEKEVAQMKVEQAKAQMQ
RSQMDYSYTTITAPFDGYIDRIPYKTGSLVNPQSLLTTVSDISEIFAYYKVNESEYLEYKRQQLSGQKQHEENNVELILS
DGSIYSHKGTLETVEGDFERGTGSIAFRVRFPNPDGLLKHGVTGKVRMMTQMDNICLVPQKSTFEIQDFTYVYTVDSASV
VKVRSFQPLERYNNYYVTQDFSPNTAIVYEGVQMMKDGITIKTDTIDMEAIRKEVELKQPIVK

Specific function: The periplasmic linker protein component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786668, Length=387, Percent_Identity=25.5813953488372, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789929, Length=360, Percent_Identity=25.2777777777778, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789665, Length=364, Percent_Identity=25.2747252747253, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87081796, Length=283, Percent_Identity=26.5017667844523, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789637, Length=134, Percent_Identity=32.8358208955224, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082036, Length=323, Percent_Identity=21.0526315789474, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43840; Mature: 43840

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNFQKIAVLCTCTGLLCSCGQSDNKQEHHKEFIPITILHPTTIEFPRSYVADVQAIQF
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEECCCCCCCCHHHHHHHHHEEE
VEIKPKVEGFVQQIYVDEGQKVKKGQPLFQLSSDQYSETVKEAQANYKQAQAQYEMANYE
EEECHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCC
AERIGRLVDKQILSKIRLDQANKEKEVAQMKVEQAKAQMQRSQMDYSYTTITAPFDGYID
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
RIPYKTGSLVNPQSLLTTVSDISEIFAYYKVNESEYLEYKRQQLSGQKQHEENNVELILS
HCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHCCCHHCCCCCEEEEEE
DGSIYSHKGTLETVEGDFERGTGSIAFRVRFPNPDGLLKHGVTGKVRMMTQMDNICLVPQ
CCCEEECCCCEEECCCCCCCCCCEEEEEEECCCCCCHHHCCCCCEEEEEEECCCEEEECC
KSTFEIQDFTYVYTVDSASVVKVRSFQPLERYNNYYVTQDFSPNTAIVYEGVQMMKDGIT
CCCEEEEEEEEEEEECCCCEEEEECCCCHHHCCCEEEEECCCCCEEEEECCHHHHHCCCE
IKTDTIDMEAIRKEVELKQPIVK
EEECCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKSNFQKIAVLCTCTGLLCSCGQSDNKQEHHKEFIPITILHPTTIEFPRSYVADVQAIQF
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEECCCCCCCCHHHHHHHHHEEE
VEIKPKVEGFVQQIYVDEGQKVKKGQPLFQLSSDQYSETVKEAQANYKQAQAQYEMANYE
EEECHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCC
AERIGRLVDKQILSKIRLDQANKEKEVAQMKVEQAKAQMQRSQMDYSYTTITAPFDGYID
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
RIPYKTGSLVNPQSLLTTVSDISEIFAYYKVNESEYLEYKRQQLSGQKQHEENNVELILS
HCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHCCCHHCCCCCEEEEEE
DGSIYSHKGTLETVEGDFERGTGSIAFRVRFPNPDGLLKHGVTGKVRMMTQMDNICLVPQ
CCCEEECCCCEEECCCCCCCCCCEEEEEEECCCCCCHHHCCCCCEEEEEEECCCEEEECC
KSTFEIQDFTYVYTVDSASVVKVRSFQPLERYNNYYVTQDFSPNTAIVYEGVQMMKDGIT
CCCEEEEEEEEEEEECCCCEEEEECCCCHHHCCCEEEEECCCCCEEEEECCHHHHHCCCE
IKTDTIDMEAIRKEVELKQPIVK
EEECCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9827328 [H]