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The map label for this gene is glyA [H]

Identifier: 150005845

GI number: 150005845

Start: 4175477

End: 4176757

Strand: Direct

Name: glyA [H]

Synonym: BVU_3341

Alternate gene names: 150005845

Gene position: 4175477-4176757 (Clockwise)

Preceding gene: 150005844

Following gene: 150005846

Centisome position: 80.87

GC content: 44.89

Gene sequence:

>1281_bases
ATGAAAAGAGACGATTTGATTTTCGACATTATCGAAAAAGAGCATCAACGCCAGCTCAAAGGTATCGAGCTGATCGCATC
CGAAAACTTTGTTAGTGACCAAGTAATGCAAGCCATGGGTTCTTGCCTTACCAACAAGTATGCTGAAGGGTATCCCGGCA
AGCGCTACTATGGCGGTTGCGAAGTGGTAGACCAGAGCGAACAAATCGCTATCGACAGACTGAAACAAATATTTGGAGCA
GAATGGGCTAATGTACAACCTCACTCCGGAGCACAGGCTAATGCTGCTGTATTTCTGGCCGTTTTGAATCCGGGTGATAA
ATTTATGGGATTAAATTTGGCCCATGGTGGTCACTTGTCACATGGTTCATTGGTAAACACATCCGGAATTATTTATACTC
CGTGTGAATACAACCTGAACAAAGAAACAGGTCGTGTAGATTACGATCAGATGGAAGAAATCGCATTACGTGAAAAACCC
AAAATGATTATCGGTGGCGGTTCTGCATATTCTCGCGAGTGGGACTACAAACGTATGCGTGAAATCGCAGATAAAGTGGG
AGCCATCCTGATGATTGATATGGCCCACCCTGCCGGACTGATTGCTGCCGGACTGTTGGACAACCCGGTTAAATATGCTC
ATATCGTCACTTCAACAACCCATAAAACCCTTCGTGGCCCTCGTGGCGGTGTCATCATGATGGGTAAAGACTTCCCTAAC
CCATGGGGCAAGAAAACTCCAAAAGGTGAAATCAAGATGATGTCACAACTTTTGGATTCTGCTGTATTCCCTGGTATACA
AGGTGGCCCGTTGGAACATGTCATCGCAGCCAAAGCTGTTGCATTCGGTGAATGTTTACAGCCGGAATACAAAGAATATC
AAACACAAGTAAAAAAGAATGCAGCCGTATTGGCACAGGCTTTGATTGACCGTGGCTTTACGATCGTTTCCGGTGGTACA
GACAACCACTCCATGCTGGTAGACCTGCGTACCAAATACCCTGATCTGACAGGCAAAGTAGCAGAAAAAGCATTGGTTGC
TGCTGATATCACTGTAAACAAGAACATGGTCCCATTTGACAGCCGTTCTGCTTTCCAAACTTCAGGTATCCGTTTGGGAA
CTCCCGCTATCACAACTCGCGGAGCAAAAGAAGACTTGATGTTGGAAATCGCCGAAATGATTGAGACAGTTCTTTCAAAC
GTAGACAATGAAGAAGTAATTGCACAAGTTCGTGCACGCGTAAACGAAACAATGAAGAAATATCCTATTTTCGCTTACTA
A

Upstream 100 bases:

>100_bases
CACCAAATATTTTCCTCTAAATAATTTCCTTATATTCTAAAATTACTTAACTTTGTGAACTCAGAATCGAATATCGCACA
TAAACTTATTATAAAAAGAA

Downstream 100 bases:

>100_bases
TCAACGACTTCTATCAATATACTCATAAAAGACTTTGGAGTTTTTGAAAAAGCTTTATCCTTCTTCAAGAACTTCAAAGT
TTTTTATAAAACATCCAGAC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKRDDLIFDIIEKEHQRQLKGIELIASENFVSDQVMQAMGSCLTNKYAEGYPGKRYYGGCEVVDQSEQIAIDRLKQIFGA
EWANVQPHSGAQANAAVFLAVLNPGDKFMGLNLAHGGHLSHGSLVNTSGIIYTPCEYNLNKETGRVDYDQMEEIALREKP
KMIIGGGSAYSREWDYKRMREIADKVGAILMIDMAHPAGLIAAGLLDNPVKYAHIVTSTTHKTLRGPRGGVIMMGKDFPN
PWGKKTPKGEIKMMSQLLDSAVFPGIQGGPLEHVIAAKAVAFGECLQPEYKEYQTQVKKNAAVLAQALIDRGFTIVSGGT
DNHSMLVDLRTKYPDLTGKVAEKALVAADITVNKNMVPFDSRSAFQTSGIRLGTPAITTRGAKEDLMLEIAEMIETVLSN
VDNEEVIAQVRARVNETMKKYPIFAY

Sequences:

>Translated_426_residues
MKRDDLIFDIIEKEHQRQLKGIELIASENFVSDQVMQAMGSCLTNKYAEGYPGKRYYGGCEVVDQSEQIAIDRLKQIFGA
EWANVQPHSGAQANAAVFLAVLNPGDKFMGLNLAHGGHLSHGSLVNTSGIIYTPCEYNLNKETGRVDYDQMEEIALREKP
KMIIGGGSAYSREWDYKRMREIADKVGAILMIDMAHPAGLIAAGLLDNPVKYAHIVTSTTHKTLRGPRGGVIMMGKDFPN
PWGKKTPKGEIKMMSQLLDSAVFPGIQGGPLEHVIAAKAVAFGECLQPEYKEYQTQVKKNAAVLAQALIDRGFTIVSGGT
DNHSMLVDLRTKYPDLTGKVAEKALVAADITVNKNMVPFDSRSAFQTSGIRLGTPAITTRGAKEDLMLEIAEMIETVLSN
VDNEEVIAQVRARVNETMKKYPIFAY
>Mature_426_residues
MKRDDLIFDIIEKEHQRQLKGIELIASENFVSDQVMQAMGSCLTNKYAEGYPGKRYYGGCEVVDQSEQIAIDRLKQIFGA
EWANVQPHSGAQANAAVFLAVLNPGDKFMGLNLAHGGHLSHGSLVNTSGIIYTPCEYNLNKETGRVDYDQMEEIALREKP
KMIIGGGSAYSREWDYKRMREIADKVGAILMIDMAHPAGLIAAGLLDNPVKYAHIVTSTTHKTLRGPRGGVIMMGKDFPN
PWGKKTPKGEIKMMSQLLDSAVFPGIQGGPLEHVIAAKAVAFGECLQPEYKEYQTQVKKNAAVLAQALIDRGFTIVSGGT
DNHSMLVDLRTKYPDLTGKVAEKALVAADITVNKNMVPFDSRSAFQTSGIRLGTPAITTRGAKEDLMLEIAEMIETVLSN
VDNEEVIAQVRARVNETMKKYPIFAY

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=450, Percent_Identity=43.5555555555556, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI261862352, Length=450, Percent_Identity=43.5555555555556, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI261862350, Length=450, Percent_Identity=43.5555555555556, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI261862348, Length=450, Percent_Identity=43.5555555555556, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI261862346, Length=450, Percent_Identity=42.4444444444444, Blast_Score=345, Evalue=6e-95,
Organism=Homo sapiens, GI22547186, Length=404, Percent_Identity=48.019801980198, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI22547189, Length=404, Percent_Identity=44.0594059405941, Blast_Score=298, Evalue=5e-81,
Organism=Escherichia coli, GI1788902, Length=422, Percent_Identity=56.1611374407583, Blast_Score=440, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI25144732, Length=432, Percent_Identity=43.75, Blast_Score=350, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=432, Percent_Identity=43.75, Blast_Score=349, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6319739, Length=433, Percent_Identity=42.7251732101617, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6323087, Length=402, Percent_Identity=46.5174129353234, Blast_Score=329, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24640005, Length=456, Percent_Identity=43.640350877193, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221329721, Length=456, Percent_Identity=43.640350877193, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46827; Mature: 46827

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRDDLIFDIIEKEHQRQLKGIELIASENFVSDQVMQAMGSCLTNKYAEGYPGKRYYGGC
CCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCC
EVVDQSEQIAIDRLKQIFGAEWANVQPHSGAQANAAVFLAVLNPGDKFMGLNLAHGGHLS
CEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCC
HGSLVNTSGIIYTPCEYNLNKETGRVDYDQMEEIALREKPKMIIGGGSAYSREWDYKRMR
CCCEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHH
EIADKVGAILMIDMAHPAGLIAAGLLDNPVKYAHIVTSTTHKTLRGPRGGVIMMGKDFPN
HHHHHCCEEEEEEECCCCHHHHHHHHCCCCCEEEEEECCHHHHHCCCCCCEEEECCCCCC
PWGKKTPKGEIKMMSQLLDSAVFPGIQGGPLEHVIAAKAVAFGECLQPEYKEYQTQVKKN
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AAVLAQALIDRGFTIVSGGTDNHSMLVDLRTKYPDLTGKVAEKALVAADITVNKNMVPFD
HHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHEEEEEEECCCCCCCC
SRSAFQTSGIRLGTPAITTRGAKEDLMLEIAEMIETVLSNVDNEEVIAQVRARVNETMKK
CCCCHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
YPIFAY
CCCCCC
>Mature Secondary Structure
MKRDDLIFDIIEKEHQRQLKGIELIASENFVSDQVMQAMGSCLTNKYAEGYPGKRYYGGC
CCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCC
EVVDQSEQIAIDRLKQIFGAEWANVQPHSGAQANAAVFLAVLNPGDKFMGLNLAHGGHLS
CEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCC
HGSLVNTSGIIYTPCEYNLNKETGRVDYDQMEEIALREKPKMIIGGGSAYSREWDYKRMR
CCCEEECCCEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHH
EIADKVGAILMIDMAHPAGLIAAGLLDNPVKYAHIVTSTTHKTLRGPRGGVIMMGKDFPN
HHHHHCCEEEEEEECCCCHHHHHHHHCCCCCEEEEEECCHHHHHCCCCCCEEEECCCCCC
PWGKKTPKGEIKMMSQLLDSAVFPGIQGGPLEHVIAAKAVAFGECLQPEYKEYQTQVKKN
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
AAVLAQALIDRGFTIVSGGTDNHSMLVDLRTKYPDLTGKVAEKALVAADITVNKNMVPFD
HHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHEEEEEEECCCCCCCC
SRSAFQTSGIRLGTPAITTRGAKEDLMLEIAEMIETVLSNVDNEEVIAQVRARVNETMKK
CCCCHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
YPIFAY
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA