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The map label for this gene is cobQ

Identifier: 150005627

GI number: 150005627

Start: 3939721

End: 3941211

Strand: Direct

Name: cobQ

Synonym: BVU_3115

Alternate gene names: 150005627

Gene position: 3939721-3941211 (Clockwise)

Preceding gene: 150005626

Following gene: 150005628

Centisome position: 76.3

GC content: 44.8

Gene sequence:

>1491_bases
ATGAAAAAGAATTTACACCCGATTATGTTGGCAGGAACAGGCAGTGATGTTGGCAAAAGTGTCATCGCTGCTGCATTATG
CCGCATTTTTAAACAGGACGGTTATCGACCGGCACCTTTTAAGGCACAGAATATGGCACTGAATTCATATGCCACTCCGG
AAGGGTTGGAAATAGGGCGTGCACAAGCTGTACAGGCCGAAGCGGCTGGAGTCCCTTGTCATACGGACATGAATCCTTTG
TTGTTGAAACCCAGTTCCGATCATACTTCGCAAGTGGTATTAAACGGTCGTCCCATCGGTAATCGTAACGCTTTTGAGTA
TTTTCGCAAGGAGGGACGTGAAGAGCTGAGGCAGGAGGTAAACGCAGCCTTTGACCGTCTTGCCGCACGTTATAACCCTA
TTGTAATGGAGGGAGCAGGGAGTATTTCCGAAATAAATCTGCGGGATACTGATTTGGTGAATATGCCGATGGCCTGTTAT
GCGGATGCGGATGTGATTTTGGTAGCTGATATTGACCGGGGAGGAGTATTTGCCAGTGTCTATGGTTCGGTCATGTTACA
AACTCCTGAGGACAAGAAACGTATAAAAGGAGTAATCATTAATAAATTCAGAGGGGATATCCGTTTGTTTGAGTCTGGTG
TGAAGATGATGGAGGATTTATGTGGTATTCCTGTCTTGGGAATAATACCTTATTATAGAAATATACATATTGAGGAAGAG
GATTCCGTAGGCTTGGACTATAAACGGATGCAAGCCGTGGAAGGCAAAATAAACATAGCAGTTGTTCTGTTGCGTCATCT
CTCAAACTTTACAGATTTCAACAGATTGGAACGGGATGAACGGGTGCACCTTTATTATACCAATAATACGGAAGATCTGG
CCAAAGCTGATATTATTCTGCTTCCTGGCAGCAAAAGCACTTTGGATGACTTGTATGAGTTGAGACGGAACGGGGTGGCG
CAAGCTGTCCTACGTGCGCATAGGGAAGGGGTTACTGTAATGGGAATTTGTGGGGGATACCAATTGATGGGACTTGAGAT
TCACGATCCGGAAGGAGTGGAGGGAGAGATCCGTCAATTGCCGGGACTGGGACTGCTTCCCGTCATTACTACGATGCAAG
GGGAGAAGGTGACGCGGCAGGTGAATTTTCATTTTCTTGAGAATGCGGAAACTTGCCAAGGATATGAAATACACATGGGA
GAAACCCGCCCGGTTCCGGGGGAGGCTGTAGTTCCTTTGAATAAACTGGAAGACGGTGGAGAGGACGGTTGTTTTGTAAA
CCAAAAATGTATGGGAAGTTATATTCATGGAATATTGGATAATCAGGCATTTATAGATTATTTGCTGGAACCATACGCAG
AAAAACTGGAGTGTCATACGGTGTTGGATTACCGGACTTATAAAGAAGAACAATATGATAAATTGGCAGAGCATGTACGC
AGTCATCTTAATCTGCCTTTGTTGTACCAAATAATGAGTGGGAATGATTGA

Upstream 100 bases:

>100_bases
CCGATTTGTTTTTTGTTATGGCCCGTTATGAGATGCAACAACAGAACTGGACGGAAGAAAAGTGGCAGTCCTTTGCATAT
AAAAGAAAGAAGAAAGAGTG

Downstream 100 bases:

>100_bases
AGGACATGGTGATGATGCTTATAAGTATAAAGCAATAAAGATAAATTTCAGTTCAAACGTATATAATCATGTAGACCATA
GCGGATTACATCAACATTTG

Product: cobyric acid synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MKKNLHPIMLAGTGSDVGKSVIAAALCRIFKQDGYRPAPFKAQNMALNSYATPEGLEIGRAQAVQAEAAGVPCHTDMNPL
LLKPSSDHTSQVVLNGRPIGNRNAFEYFRKEGREELRQEVNAAFDRLAARYNPIVMEGAGSISEINLRDTDLVNMPMACY
ADADVILVADIDRGGVFASVYGSVMLQTPEDKKRIKGVIINKFRGDIRLFESGVKMMEDLCGIPVLGIIPYYRNIHIEEE
DSVGLDYKRMQAVEGKINIAVVLLRHLSNFTDFNRLERDERVHLYYTNNTEDLAKADIILLPGSKSTLDDLYELRRNGVA
QAVLRAHREGVTVMGICGGYQLMGLEIHDPEGVEGEIRQLPGLGLLPVITTMQGEKVTRQVNFHFLENAETCQGYEIHMG
ETRPVPGEAVVPLNKLEDGGEDGCFVNQKCMGSYIHGILDNQAFIDYLLEPYAEKLECHTVLDYRTYKEEQYDKLAEHVR
SHLNLPLLYQIMSGND

Sequences:

>Translated_496_residues
MKKNLHPIMLAGTGSDVGKSVIAAALCRIFKQDGYRPAPFKAQNMALNSYATPEGLEIGRAQAVQAEAAGVPCHTDMNPL
LLKPSSDHTSQVVLNGRPIGNRNAFEYFRKEGREELRQEVNAAFDRLAARYNPIVMEGAGSISEINLRDTDLVNMPMACY
ADADVILVADIDRGGVFASVYGSVMLQTPEDKKRIKGVIINKFRGDIRLFESGVKMMEDLCGIPVLGIIPYYRNIHIEEE
DSVGLDYKRMQAVEGKINIAVVLLRHLSNFTDFNRLERDERVHLYYTNNTEDLAKADIILLPGSKSTLDDLYELRRNGVA
QAVLRAHREGVTVMGICGGYQLMGLEIHDPEGVEGEIRQLPGLGLLPVITTMQGEKVTRQVNFHFLENAETCQGYEIHMG
ETRPVPGEAVVPLNKLEDGGEDGCFVNQKCMGSYIHGILDNQAFIDYLLEPYAEKLECHTVLDYRTYKEEQYDKLAEHVR
SHLNLPLLYQIMSGND
>Mature_496_residues
MKKNLHPIMLAGTGSDVGKSVIAAALCRIFKQDGYRPAPFKAQNMALNSYATPEGLEIGRAQAVQAEAAGVPCHTDMNPL
LLKPSSDHTSQVVLNGRPIGNRNAFEYFRKEGREELRQEVNAAFDRLAARYNPIVMEGAGSISEINLRDTDLVNMPMACY
ADADVILVADIDRGGVFASVYGSVMLQTPEDKKRIKGVIINKFRGDIRLFESGVKMMEDLCGIPVLGIIPYYRNIHIEEE
DSVGLDYKRMQAVEGKINIAVVLLRHLSNFTDFNRLERDERVHLYYTNNTEDLAKADIILLPGSKSTLDDLYELRRNGVA
QAVLRAHREGVTVMGICGGYQLMGLEIHDPEGVEGEIRQLPGLGLLPVITTMQGEKVTRQVNFHFLENAETCQGYEIHMG
ETRPVPGEAVVPLNKLEDGGEDGCFVNQKCMGSYIHGILDNQAFIDYLLEPYAEKLECHTVLDYRTYKEEQYDKLAEHVR
SHLNLPLLYQIMSGND

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_BACV8 (A6L4Y5)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001300371.1
- ProteinModelPortal:   A6L4Y5
- STRING:   A6L4Y5
- GeneID:   5304076
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_3115
- NMPDR:   fig|435590.6.peg.2915
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   AHTDLNP
- ProtClustDB:   PRK00784
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: NA

Molecular weight: Translated: 55364; Mature: 55364

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 337-337 ACT_SITE 436-436

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNLHPIMLAGTGSDVGKSVIAAALCRIFKQDGYRPAPFKAQNMALNSYATPEGLEIGR
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHCEEECCCCCCCCCCCCC
AQAVQAEAAGVPCHTDMNPLLLKPSSDHTSQVVLNGRPIGNRNAFEYFRKEGREELRQEV
HHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
NAAFDRLAARYNPIVMEGAGSISEINLRDTDLVNMPMACYADADVILVADIDRGGVFASV
HHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCHHEECCCCEEEEEECCCCCEEHEE
YGSVMLQTPEDKKRIKGVIINKFRGDIRLFESGVKMMEDLCGIPVLGIIPYYRNIHIEEE
CCCEEEECCCHHHHHHHHEEEHHCCHHHHHHHHHHHHHHHHCCCHHHHHCHHHEEEECCC
DSVGLDYKRMQAVEGKINIAVVLLRHLSNFTDFNRLERDERVHLYYTNNTEDLAKADIIL
CCCCCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCHHHCCCCEEE
LPGSKSTLDDLYELRRNGVAQAVLRAHREGVTVMGICGGYQLMGLEIHDPEGVEGEIRQL
ECCCCCHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCEEEEEEEEECCCCCCHHHHHC
PGLGLLPVITTMQGEKVTRQVNFHFLENAETCQGYEIHMGETRPVPGEAVVPLNKLEDGG
CCCCHHHHHHCCCCCHHHHEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHCCCCC
EDGCFVNQKCMGSYIHGILDNQAFIDYLLEPYAEKLECHTVLDYRTYKEEQYDKLAEHVR
CCCCEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHH
SHLNLPLLYQIMSGND
HHCCCCEEEEEECCCC
>Mature Secondary Structure
MKKNLHPIMLAGTGSDVGKSVIAAALCRIFKQDGYRPAPFKAQNMALNSYATPEGLEIGR
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHCEEECCCCCCCCCCCCC
AQAVQAEAAGVPCHTDMNPLLLKPSSDHTSQVVLNGRPIGNRNAFEYFRKEGREELRQEV
HHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
NAAFDRLAARYNPIVMEGAGSISEINLRDTDLVNMPMACYADADVILVADIDRGGVFASV
HHHHHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCHHEECCCCEEEEEECCCCCEEHEE
YGSVMLQTPEDKKRIKGVIINKFRGDIRLFESGVKMMEDLCGIPVLGIIPYYRNIHIEEE
CCCEEEECCCHHHHHHHHEEEHHCCHHHHHHHHHHHHHHHHCCCHHHHHCHHHEEEECCC
DSVGLDYKRMQAVEGKINIAVVLLRHLSNFTDFNRLERDERVHLYYTNNTEDLAKADIIL
CCCCCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCEEEEEECCCCHHHCCCCEEE
LPGSKSTLDDLYELRRNGVAQAVLRAHREGVTVMGICGGYQLMGLEIHDPEGVEGEIRQL
ECCCCCHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCEEEEEEEEECCCCCCHHHHHC
PGLGLLPVITTMQGEKVTRQVNFHFLENAETCQGYEIHMGETRPVPGEAVVPLNKLEDGG
CCCCHHHHHHCCCCCHHHHEEEEEEECCCCCCCCEEEECCCCCCCCCCCCCCHHHCCCCC
EDGCFVNQKCMGSYIHGILDNQAFIDYLLEPYAEKLECHTVLDYRTYKEEQYDKLAEHVR
CCCCEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHH
SHLNLPLLYQIMSGND
HHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA