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The map label for this gene is relA [H]

Identifier: 150005289

GI number: 150005289

Start: 3524101

End: 3526314

Strand: Reverse

Name: relA [H]

Synonym: BVU_2761

Alternate gene names: 150005289

Gene position: 3526314-3524101 (Counterclockwise)

Preceding gene: 150005292

Following gene: 150005288

Centisome position: 68.3

GC content: 46.7

Gene sequence:

>2214_bases
ATGGAAGAAAAAGCATTTTTCACAGCCAAAGAGCGTGAGCAACTGTTCGCCCTCTATAAACGATTGCTGCAATTATCCGG
CGACACCTTGCAGAAGGGTGATTGCCATAAGTTAAAAATACACCTCATAAAAGCAGTTGCCGAAGGTAACCTGCCACGAA
ATTGTTTCGGAATGAATCCTATCATCAAAGATATGCAGACCGCTGTCATCGTGGCCGAGGAAATTGGGATGAAACGGGCT
TCCATCCTGGGGATCATGCTGCACGAATCGGTAAAGAACCATTTATGCACCTTAGCATCTGTACAACAGGAATATGGAGA
GGATGTAGCGGGGATCATACGCGGTCTTGTGAAAATCAATGAGCTATACTCCAAAAGCCCTACCATAGAATCGGAAAATT
TCCGCAACCTGCTACTCTCCTTTGCCGAAGACATGCGTGTTATTCTGATCATCATTGCAGACCGCGTGAACCTGATGAGA
CAGATAAAGGAGACTCCCAATATAGAAGCACGCACCCAAGTAGCCAACGAAGCTGCCTATCTGTACGCACCACTGGCACA
CAAGCTGGGGCTATACAAACTGAAATCGGAACTGGAAGACCTTTCCTTGAAATATACCGAACACGACGTATATTATCATA
TAAAGGACAAACTGAACGAAACGAAAGCCTCCCGTGACAAATACATAGCCGCCTTTATCGAACCGATACAGCATAAGCTG
GAAGAAGCAGGATTGAAGTTCCACATGAAAGGGCGTACCAAGTCCATCCATTCCATCTATCAGAAAATGAAGAAACAGAA
ATGTCCCTTCGAAGGAGTGTATGACTTGTTTGCCATCCGAATCATTCTGGACTCTCCCGTCGACAAGGAAAAACAAGAAT
GCTGGCAGGTATATTCCATTGTGACCGATATGTATATGCCCAATCCCAAACGTCTGCGCGACTGGCTCTCCGTACCCAAA
AGTAACGGATACGAATCCTTGCATACCACTGTAATGGGGCCTGAAGGCAAATGGGTGGAAGTACAGATACGCACCGAACG
CATGGACGAGATAGCGGAACGTGGTCTGGCAGCCCACTGGCGTTACAAAGGCGTAAAAGGAGAAAGCGGTCTGGATGAAT
GGCTGACCTCCATCCGGGAAACACTGGAGAACGCCGACAGTGACCTGGAAGTGATGGACCAGTTCAAACTGGAATTATAC
GAAGACGAAGTATTCGTATTCACCCCCAAAGGTGACTTGTACAAGATGCCGAAAGGAGCGACCGTACTGGACTTTGCTTT
CGCCATCCACAGCAAACTGGGGTCCAAGTGTATCGGAGCAAAGGTGAACGGAAAGAACGCACAATTAAAGCAAACGCTGA
ACAGCGGTGACCAGGTAGAAGTCATGACTTCAAACACCCAGACACCCAAACGCGACTGGCTGAACATCGTCACCACTTCG
AAGGCAAGAACCAAAATACGCCAGGCCATCAAAGAGATAGAAGCCCGCCAGACAGAGTTCGCCAAAGAAACCATAGAACG
TAAATTCAAGAACCGCAAACTGGAATACGATGAAGCAGTGATGATGCGCCTGATAAAAAAGCTGGGATACAAAACCGTAA
CCGAGTTCTACCAGGACATAGCCAACGAGACAAGAGATGCGAACGACATCATCGAAAAATACCTGGAACTGAAGAAAAAG
GAAACGGAAAACCGGGAAGATATTGTCTATCGCAGCGCCGAGAATTTCAGCATGCAGACAGCACAGGACGACAAGACCTT
CAAAGAGGACGTACTGGTCATTGATCAGAATTTGAAAGGACTGGACTTCAAATTAGCCAAATGCTGTAACCCTATCTATG
GCGATGATGTATTCGGATTTGTAACCATCAGCGGAGGAATCAAAATACACCGTACCGACTGTCCTAACGCACGGGAGTTG
CAATCACGTTTCGCCTACCGTATCGTAAAGGCGCGTTGGGCTGGGAAAAGCCACGGCAAACAATACCCCATCACGCTGCG
CATCGTTGGCCATGACGATATAGGAATTGTGACAAATATCACCTCCATTATCAATAAGGAAAACGATATCCTGCTCCGTT
CCATCAGTATCGACTCGCACGACGGGCTGTTCAGCGGCATGATGACCGTAATGGTAGATGATACTTCAAAGCTGGAATCA
TTAGTAAAAAAGATAAAGACAGTAAAAGGAGTAAAACAGGTAAACAGAGGATAA

Upstream 100 bases:

>100_bases
CTTTCACTATTAATTGCCCAAAAATACAAAAAAATGCGAGAACACTACCTAATAAATAAAGAAAAAAACTACCTTTACCC
TCGAAAAGATTTCACGTGTT

Downstream 100 bases:

>100_bases
ACTCACCCCAAACTTAAAAAAATGAATGAACTGCATAAACGACTAAAAAGCTTTACATACGCCTGGAAAGGCGTATGTAG
TTTTTTAAGCAAGGAACACA

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 737; Mature: 737

Protein sequence:

>737_residues
MEEKAFFTAKEREQLFALYKRLLQLSGDTLQKGDCHKLKIHLIKAVAEGNLPRNCFGMNPIIKDMQTAVIVAEEIGMKRA
SILGIMLHESVKNHLCTLASVQQEYGEDVAGIIRGLVKINELYSKSPTIESENFRNLLLSFAEDMRVILIIIADRVNLMR
QIKETPNIEARTQVANEAAYLYAPLAHKLGLYKLKSELEDLSLKYTEHDVYYHIKDKLNETKASRDKYIAAFIEPIQHKL
EEAGLKFHMKGRTKSIHSIYQKMKKQKCPFEGVYDLFAIRIILDSPVDKEKQECWQVYSIVTDMYMPNPKRLRDWLSVPK
SNGYESLHTTVMGPEGKWVEVQIRTERMDEIAERGLAAHWRYKGVKGESGLDEWLTSIRETLENADSDLEVMDQFKLELY
EDEVFVFTPKGDLYKMPKGATVLDFAFAIHSKLGSKCIGAKVNGKNAQLKQTLNSGDQVEVMTSNTQTPKRDWLNIVTTS
KARTKIRQAIKEIEARQTEFAKETIERKFKNRKLEYDEAVMMRLIKKLGYKTVTEFYQDIANETRDANDIIEKYLELKKK
ETENREDIVYRSAENFSMQTAQDDKTFKEDVLVIDQNLKGLDFKLAKCCNPIYGDDVFGFVTISGGIKIHRTDCPNAREL
QSRFAYRIVKARWAGKSHGKQYPITLRIVGHDDIGIVTNITSIINKENDILLRSISIDSHDGLFSGMMTVMVDDTSKLES
LVKKIKTVKGVKQVNRG

Sequences:

>Translated_737_residues
MEEKAFFTAKEREQLFALYKRLLQLSGDTLQKGDCHKLKIHLIKAVAEGNLPRNCFGMNPIIKDMQTAVIVAEEIGMKRA
SILGIMLHESVKNHLCTLASVQQEYGEDVAGIIRGLVKINELYSKSPTIESENFRNLLLSFAEDMRVILIIIADRVNLMR
QIKETPNIEARTQVANEAAYLYAPLAHKLGLYKLKSELEDLSLKYTEHDVYYHIKDKLNETKASRDKYIAAFIEPIQHKL
EEAGLKFHMKGRTKSIHSIYQKMKKQKCPFEGVYDLFAIRIILDSPVDKEKQECWQVYSIVTDMYMPNPKRLRDWLSVPK
SNGYESLHTTVMGPEGKWVEVQIRTERMDEIAERGLAAHWRYKGVKGESGLDEWLTSIRETLENADSDLEVMDQFKLELY
EDEVFVFTPKGDLYKMPKGATVLDFAFAIHSKLGSKCIGAKVNGKNAQLKQTLNSGDQVEVMTSNTQTPKRDWLNIVTTS
KARTKIRQAIKEIEARQTEFAKETIERKFKNRKLEYDEAVMMRLIKKLGYKTVTEFYQDIANETRDANDIIEKYLELKKK
ETENREDIVYRSAENFSMQTAQDDKTFKEDVLVIDQNLKGLDFKLAKCCNPIYGDDVFGFVTISGGIKIHRTDCPNAREL
QSRFAYRIVKARWAGKSHGKQYPITLRIVGHDDIGIVTNITSIINKENDILLRSISIDSHDGLFSGMMTVMVDDTSKLES
LVKKIKTVKGVKQVNRG
>Mature_737_residues
MEEKAFFTAKEREQLFALYKRLLQLSGDTLQKGDCHKLKIHLIKAVAEGNLPRNCFGMNPIIKDMQTAVIVAEEIGMKRA
SILGIMLHESVKNHLCTLASVQQEYGEDVAGIIRGLVKINELYSKSPTIESENFRNLLLSFAEDMRVILIIIADRVNLMR
QIKETPNIEARTQVANEAAYLYAPLAHKLGLYKLKSELEDLSLKYTEHDVYYHIKDKLNETKASRDKYIAAFIEPIQHKL
EEAGLKFHMKGRTKSIHSIYQKMKKQKCPFEGVYDLFAIRIILDSPVDKEKQECWQVYSIVTDMYMPNPKRLRDWLSVPK
SNGYESLHTTVMGPEGKWVEVQIRTERMDEIAERGLAAHWRYKGVKGESGLDEWLTSIRETLENADSDLEVMDQFKLELY
EDEVFVFTPKGDLYKMPKGATVLDFAFAIHSKLGSKCIGAKVNGKNAQLKQTLNSGDQVEVMTSNTQTPKRDWLNIVTTS
KARTKIRQAIKEIEARQTEFAKETIERKFKNRKLEYDEAVMMRLIKKLGYKTVTEFYQDIANETRDANDIIEKYLELKKK
ETENREDIVYRSAENFSMQTAQDDKTFKEDVLVIDQNLKGLDFKLAKCCNPIYGDDVFGFVTISGGIKIHRTDCPNAREL
QSRFAYRIVKARWAGKSHGKQYPITLRIVGHDDIGIVTNITSIINKENDILLRSISIDSHDGLFSGMMTVMVDDTSKLES
LVKKIKTVKGVKQVNRG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=657, Percent_Identity=32.2678843226788, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI1790082, Length=687, Percent_Identity=30.1310043668122, Blast_Score=352, Evalue=5e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84508; Mature: 84508

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKAFFTAKEREQLFALYKRLLQLSGDTLQKGDCHKLKIHLIKAVAEGNLPRNCFGMNP
CCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCH
IIKDMQTAVIVAEEIGMKRASILGIMLHESVKNHLCTLASVQQEYGEDVAGIIRGLVKIN
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ELYSKSPTIESENFRNLLLSFAEDMRVILIIIADRVNLMRQIKETPNIEARTQVANEAAY
HHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LYAPLAHKLGLYKLKSELEDLSLKYTEHDVYYHIKDKLNETKASRDKYIAAFIEPIQHKL
HHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
EEAGLKFHMKGRTKSIHSIYQKMKKQKCPFEGVYDLFAIRIILDSPVDKEKQECWQVYSI
HHCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
VTDMYMPNPKRLRDWLSVPKSNGYESLHTTVMGPEGKWVEVQIRTERMDEIAERGLAAHW
HHHHCCCCHHHHHHHHCCCCCCCCCHHHHEEECCCCCEEEEEEEHHHHHHHHHCCCHHHH
RYKGVKGESGLDEWLTSIRETLENADSDLEVMDQFKLELYEDEVFVFTPKGDLYKMPKGA
EECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEECEEEEECCCCCCEECCCCC
TVLDFAFAIHSKLGSKCIGAKVNGKNAQLKQTLNSGDQVEVMTSNTQTPKRDWLNIVTTS
HHHHHHHHHHHHHCCHHCCCEECCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCH
KARTKIRQAIKEIEARQTEFAKETIERKFKNRKLEYDEAVMMRLIKKLGYKTVTEFYQDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHH
ANETRDANDIIEKYLELKKKETENREDIVYRSAENFSMQTAQDDKTFKEDVLVIDQNLKG
HHHCCCHHHHHHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCHHHHHCEEEEECCCCC
LDFKLAKCCNPIYGDDVFGFVTISGGIKIHRTDCPNARELQSRFAYRIVKARWAGKSHGK
CCHHHHHHCCCCCCCCCEEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCC
QYPITLRIVGHDDIGIVTNITSIINKENDILLRSISIDSHDGLFSGMMTVMVDDTSKLES
CCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCCCCEEECCHHHHHH
LVKKIKTVKGVKQVNRG
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEEKAFFTAKEREQLFALYKRLLQLSGDTLQKGDCHKLKIHLIKAVAEGNLPRNCFGMNP
CCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCH
IIKDMQTAVIVAEEIGMKRASILGIMLHESVKNHLCTLASVQQEYGEDVAGIIRGLVKIN
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ELYSKSPTIESENFRNLLLSFAEDMRVILIIIADRVNLMRQIKETPNIEARTQVANEAAY
HHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LYAPLAHKLGLYKLKSELEDLSLKYTEHDVYYHIKDKLNETKASRDKYIAAFIEPIQHKL
HHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
EEAGLKFHMKGRTKSIHSIYQKMKKQKCPFEGVYDLFAIRIILDSPVDKEKQECWQVYSI
HHCCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
VTDMYMPNPKRLRDWLSVPKSNGYESLHTTVMGPEGKWVEVQIRTERMDEIAERGLAAHW
HHHHCCCCHHHHHHHHCCCCCCCCCHHHHEEECCCCCEEEEEEEHHHHHHHHHCCCHHHH
RYKGVKGESGLDEWLTSIRETLENADSDLEVMDQFKLELYEDEVFVFTPKGDLYKMPKGA
EECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEECEEEEECCCCCCEECCCCC
TVLDFAFAIHSKLGSKCIGAKVNGKNAQLKQTLNSGDQVEVMTSNTQTPKRDWLNIVTTS
HHHHHHHHHHHHHCCHHCCCEECCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCH
KARTKIRQAIKEIEARQTEFAKETIERKFKNRKLEYDEAVMMRLIKKLGYKTVTEFYQDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHH
ANETRDANDIIEKYLELKKKETENREDIVYRSAENFSMQTAQDDKTFKEDVLVIDQNLKG
HHHCCCHHHHHHHHHHHHHHCCCCCHHHEEECCCCCCCCCCCCCHHHHHCEEEEECCCCC
LDFKLAKCCNPIYGDDVFGFVTISGGIKIHRTDCPNARELQSRFAYRIVKARWAGKSHGK
CCHHHHHHCCCCCCCCCEEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCC
QYPITLRIVGHDDIGIVTNITSIINKENDILLRSISIDSHDGLFSGMMTVMVDDTSKLES
CCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCCCCEEECCHHHHHH
LVKKIKTVKGVKQVNRG
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]