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The map label for this gene is fcl [H]

Identifier: 150005181

GI number: 150005181

Start: 3369629

End: 3370711

Strand: Reverse

Name: fcl [H]

Synonym: BVU_2651

Alternate gene names: 150005181

Gene position: 3370711-3369629 (Counterclockwise)

Preceding gene: 150005182

Following gene: 150005180

Centisome position: 65.28

GC content: 48.75

Gene sequence:

>1083_bases
ATGGAGAAATCAGCCAAAATTTATATAGCAGGGCACCACGGACTCGTGGGCTCCGCTATTTGGCGTAACCTGCAAGAAAA
AGGCTACACCAACCTGACCGGCAGAAGCCACAAGGAACTGGACTTGCTGGACGGAGTTGCCGTAAAGGACTTCTTTGACC
AAGAAAGACCGGAATATGTAATCCTTGCCGCCGCCCACGTGGGAGGTATCATGGCAAACAGCACATACAGGGCGGACTTT
ATCTACAAGAACCTGCAAATACAGCAGAACGTGATAGGGGAAAGCTTCCGTCACGGAGTGAAAAAATTATTGTTTCTGGG
AAGTACCTGCATTTATCCCAGAGATGCACAGCAGCCGATGAAGGAGGATGCTCTCCTCACCTCCCCGCTGGAATATACGA
ATGAGCCATACGCCATCGCCAAAATAGCGGGGCTGAAAATGTGCGAGAGTTTCAACCTGCAATATGGTACCAACTATATC
GCTGTAATGCCTACGAACCTGTATGGCCCCAATGATAACTTCGACCTGGAACGCAGCCATGTGCTGCCTGCCATGATCAG
GAAAATACATCTTGCCAAATGCTTGAACGAAGATAACTGGGAGAACATACGCTATGATCTGGATATGCGCCCGGTGGAAG
GTATAAACGGGGAGAGCAGAACAGAGGAGATACTGGCTGTCCTGAAAAGCTACGGCATCAGCAAGGACGGGGTGGAACTG
TGGGGAACAGGCACGCCGCTGCGCGAATTCTTATGGAGTGAGGAGATGGCGGATGCCAGTGTTTTCATCATGGAGCATGT
GGACTTTAAAGATACTTACCGTCCCGGCACAAAAGAGATACGCAACTGCCACATCAACATCGGCACGGGAAAAGAAATAT
CCATCGCCGACCTGGCTCATCTGATAGTAAAGGAAACGGGATATAAAGGCAGCATTACATTCAATCCGGAGAAACCGGAC
GGAACCATGCGCAAACTGACTGATGTGACCAAATTGCATGAACTGGGATGGCATCACAAAATAGACATAGAGGAAGGGGT
GCACAAGATGTACCAATGGTATCTGGAATATAAAAAGAAATAA

Upstream 100 bases:

>100_bases
CATTCGAGGAACTGGTGAAAATCATGGTGAAACACGATATGAAATTCGTGAAGAAACTTCATCTCAAAGCAAGCTGTTAA
ATCATTAGTCAAGAATTTCA

Downstream 100 bases:

>100_bases
AGAGCATACGTGTTATGGAAACTCATATCGTTATCATGGCAGGCGGCATAGGAAGCCGCTTCTGGCCCATGAGTACGCCG
GAATGTCCCAAACAGTTCAT

Product: GDP-4-keto-6-deoxy-D-mannose-3, 5-epimerase-4-reductase

Products: NA

Alternate protein names: GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MEKSAKIYIAGHHGLVGSAIWRNLQEKGYTNLTGRSHKELDLLDGVAVKDFFDQERPEYVILAAAHVGGIMANSTYRADF
IYKNLQIQQNVIGESFRHGVKKLLFLGSTCIYPRDAQQPMKEDALLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYI
AVMPTNLYGPNDNFDLERSHVLPAMIRKIHLAKCLNEDNWENIRYDLDMRPVEGINGESRTEEILAVLKSYGISKDGVEL
WGTGTPLREFLWSEEMADASVFIMEHVDFKDTYRPGTKEIRNCHINIGTGKEISIADLAHLIVKETGYKGSITFNPEKPD
GTMRKLTDVTKLHELGWHHKIDIEEGVHKMYQWYLEYKKK

Sequences:

>Translated_360_residues
MEKSAKIYIAGHHGLVGSAIWRNLQEKGYTNLTGRSHKELDLLDGVAVKDFFDQERPEYVILAAAHVGGIMANSTYRADF
IYKNLQIQQNVIGESFRHGVKKLLFLGSTCIYPRDAQQPMKEDALLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYI
AVMPTNLYGPNDNFDLERSHVLPAMIRKIHLAKCLNEDNWENIRYDLDMRPVEGINGESRTEEILAVLKSYGISKDGVEL
WGTGTPLREFLWSEEMADASVFIMEHVDFKDTYRPGTKEIRNCHINIGTGKEISIADLAHLIVKETGYKGSITFNPEKPD
GTMRKLTDVTKLHELGWHHKIDIEEGVHKMYQWYLEYKKK
>Mature_360_residues
MEKSAKIYIAGHHGLVGSAIWRNLQEKGYTNLTGRSHKELDLLDGVAVKDFFDQERPEYVILAAAHVGGIMANSTYRADF
IYKNLQIQQNVIGESFRHGVKKLLFLGSTCIYPRDAQQPMKEDALLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYI
AVMPTNLYGPNDNFDLERSHVLPAMIRKIHLAKCLNEDNWENIRYDLDMRPVEGINGESRTEEILAVLKSYGISKDGVEL
WGTGTPLREFLWSEEMADASVFIMEHVDFKDTYRPGTKEIRNCHINIGTGKEISIADLAHLIVKETGYKGSITFNPEKPD
GTMRKLTDVTKLHELGWHHKIDIEEGVHKMYQWYLEYKKK

Specific function: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=336, Percent_Identity=29.1666666666667, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1788365, Length=357, Percent_Identity=47.8991596638655, Blast_Score=337, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17554428, Length=356, Percent_Identity=25.561797752809, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI19922778, Length=356, Percent_Identity=26.123595505618, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.271 [H]

Molecular weight: Translated: 41107; Mature: 41107

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKSAKIYIAGHHGLVGSAIWRNLQEKGYTNLTGRSHKELDLLDGVAVKDFFDQERPEYV
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHCCCCCEE
ILAAAHVGGIMANSTYRADFIYKNLQIQQNVIGESFRHGVKKLLFLGSTCIYPRDAQQPM
EEEEHHHCCCCCCCCEEHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
KEDALLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYIAVMPTNLYGPNDNFDLERSH
HHCCCCCCCHHHCCCCEEHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCCCCCHHH
VLPAMIRKIHLAKCLNEDNWENIRYDLDMRPVEGINGESRTEEILAVLKSYGISKDGVEL
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
WGTGTPLREFLWSEEMADASVFIMEHVDFKDTYRPGTKEIRNCHINIGTGKEISIADLAH
EECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHCEEEEEECCCCEEHHHHHHH
LIVKETGYKGSITFNPEKPDGTMRKLTDVTKLHELGWHHKIDIEEGVHKMYQWYLEYKKK
HHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKSAKIYIAGHHGLVGSAIWRNLQEKGYTNLTGRSHKELDLLDGVAVKDFFDQERPEYV
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHCCCCCEE
ILAAAHVGGIMANSTYRADFIYKNLQIQQNVIGESFRHGVKKLLFLGSTCIYPRDAQQPM
EEEEHHHCCCCCCCCEEHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCH
KEDALLTSPLEYTNEPYAIAKIAGLKMCESFNLQYGTNYIAVMPTNLYGPNDNFDLERSH
HHCCCCCCCHHHCCCCEEHHHHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCCCCCHHH
VLPAMIRKIHLAKCLNEDNWENIRYDLDMRPVEGINGESRTEEILAVLKSYGISKDGVEL
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
WGTGTPLREFLWSEEMADASVFIMEHVDFKDTYRPGTKEIRNCHINIGTGKEISIADLAH
EECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHCEEEEEECCCCEEHHHHHHH
LIVKETGYKGSITFNPEKPDGTMRKLTDVTKLHELGWHHKIDIEEGVHKMYQWYLEYKKK
HHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7815923; 8759852; 9097040; 9278503; 9473059; 9862812 [H]