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The map label for this gene is hsrA [H]

Identifier: 148828036

GI number: 148828036

Start: 1428159

End: 1429550

Strand: Direct

Name: hsrA [H]

Synonym: CGSHiGG_07775

Alternate gene names: 148828036

Gene position: 1428159-1429550 (Clockwise)

Preceding gene: 148828035

Following gene: 148828037

Centisome position: 75.68

GC content: 39.3

Gene sequence:

>1392_bases
ATGACTACTGAATCCAATGCCTATCGCGGTTTAGCTTGGGTAGCAGCAATGGCACTTTTTATGCAAAGCCTCGATGCGAC
CATTCTAAATACAGCTTTACCCGCGATATCTTCCGATTTACATAAACCCGCCTTTGAAATGCAAATGGCGATCATCGCTT
ATTCTTTAGCTGTTGCATTATTTATTCCTCTTACCGCTTGGGCTGCGGCAAAATTTGGGACATTGACCGTTTTTCGTAGT
GCAGTTTTCACGTTTATTTTAGGTTCAGTTGCTTGTGCCGCGGCCTCTAATTTAGAGAGCCTTATTTTAGCCCGAGTGAT
TCAGGGGATAGGCGGTGCCTTTATGATGCCGGTGGCACGTTTAGCTATTATTCAAGCTGTCCCCAAACAACAATTAGTGA
ATGCTTGGAATTTAATGGCAACTGCAGGTTTGATTGGGCCAATTCTAGGGCCTATTTTAGGTGGATGGTTAGTCATTCAC
GCCAGTTGGCACTGGATTTTTTTAATTAATATTCCAATTGGTGCGCTAGGAATTTTGGCATCGGGCAGCGTGATGAACAA
TATCAAGGGCGAGGCAGAGAAATTAGATTGGACAGGTTTTTTACTCTTTGCATTGGGGTTAGTTGGTATTACGCTTGGTT
TGGATTTACTCGGAGAAAGTCAGCATAATTCAAGTGTAACTTATAGCATATTAGTTGTTGGTATTCTGTTACTCGTAACT
TATTGTGGCTATGCTAAAAACAATGAAAATGCCATTTTACCTTTATCCCTTTTCCGCACTCGTACATTCAGATTAGGTAT
TATTGCCAATATTTTTATCCGATTATCTGCATCTGGCGTTCCCTTTTTATTGCCTTTGATGTTCCAATTATCTTTCGGTT
ACAGTGCTGAAATGTCTGGCTGGCTATTAGCACCGATTGCGTTAATTTCTGTGATGTTGAAAATATTAATTGGACGAATT
TTAAATCGTTGGGGTTATAAAACCACGTTAATTTCATCCGCACTTTTGATGGCAGGTTCTGTGATTTCAATGGCTTGGTT
AGATAAACAAAGTTCTCTAACTTGGATTATTTGTAATCTTATGTGGTATGGGGCTTGTATGTCGATCATTTTTACTTCAA
TTAATACGCTGGTTGTAGGCGATCTTTCAAAACAACAGTCTGGCACAGGCTCTACCGTATTAAGTATTGTGCAGCAAGTG
GGGATTGGATTTGGTATTGCTGTTTCATCAATAATCTTAAATCTTTATCGACATTTCTTTAGCGCAAATGATGGCTTACA
ACAGGCATTCAGCTATACTTTTTTAACTTCATCACTTTTTGCAATCGCCTTAGTTTGGTCGCTTATGAAATTACACAAAA
ATGATGGTGATCATTTACGAAAAATGCCTTAG

Upstream 100 bases:

>100_bases
ATTATTCCCTTGAAATTGACCGCACTTTGTTGGATATTAACCGCATTCCGCAAATTGCCGATTTTATTGAAAATTGGTTG
CACCATTTTCACGGAGCACG

Downstream 100 bases:

>100_bases
ATTAATTTGTTATAATCCATAGAATTTTTTTATTTAAAAAAAGGGAAATTTGCTTATATCTTATTGATATTTCTTGTTGG
TGGAGATAGCTCCATCGTTT

Product: hypothetical protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRS
AVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIH
ASWHWIFLINIPIGALGILASGSVMNNIKGEAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVT
YCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRI
LNRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLVVGDLSKQQSGTGSTVLSIVQQV
GIGFGIAVSSIILNLYRHFFSANDGLQQAFSYTFLTSSLFAIALVWSLMKLHKNDGDHLRKMP

Sequences:

>Translated_463_residues
MTTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRS
AVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIH
ASWHWIFLINIPIGALGILASGSVMNNIKGEAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVT
YCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRI
LNRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLVVGDLSKQQSGTGSTVLSIVQQV
GIGFGIAVSSIILNLYRHFFSANDGLQQAFSYTFLTSSLFAIALVWSLMKLHKNDGDHLRKMP
>Mature_462_residues
TTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVALFIPLTAWAAAKFGTLTVFRSA
VFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVARLAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHA
SWHWIFLINIPIGALGILASGSVMNNIKGEAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVTY
CGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSGWLLAPIALISVMLKILIGRIL
NRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNLMWYGACMSIIFTSINTLVVGDLSKQQSGTGSTVLSIVQQVG
IGFGIAVSSIILNLYRHFFSANDGLQQAFSYTFLTSSLFAIALVWSLMKLHKNDGDHLRKMP

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=459, Percent_Identity=44.4444444444444, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1788392, Length=444, Percent_Identity=36.2612612612613, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788710, Length=396, Percent_Identity=31.3131313131313, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1789042, Length=311, Percent_Identity=32.1543408360129, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI87081983, Length=402, Percent_Identity=25.8706467661692, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1788509, Length=167, Percent_Identity=28.1437125748503, Blast_Score=62, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322958, Length=359, Percent_Identity=26.1838440111421, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325455, Length=228, Percent_Identity=27.6315789473684, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49993; Mature: 49862

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGALGILA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECEEEEEEEECCHHHHHHHH
SGSVMNNIKGEAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVT
CCHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
YCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSG
HCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
WLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
MWYGACMSIIFTSINTLVVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNLYRHFF
HHHHHHHHHHHHHHHHHEEECCHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SANDGLQQAFSYTFLTSSLFAIALVWSLMKLHKNDGDHLRKMP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure 
TTESNAYRGLAWVAAMALFMQSLDATILNTALPAISSDLHKPAFEMQMAIIAYSLAVAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FIPLTAWAAAKFGTLTVFRSAVFTFILGSVACAAASNLESLILARVIQGIGGAFMMPVAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LAIIQAVPKQQLVNAWNLMATAGLIGPILGPILGGWLVIHASWHWIFLINIPIGALGILA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECEEEEEEEECCHHHHHHHH
SGSVMNNIKGEAEKLDWTGFLLFALGLVGITLGLDLLGESQHNSSVTYSILVVGILLLVT
CCHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
YCGYAKNNENAILPLSLFRTRTFRLGIIANIFIRLSASGVPFLLPLMFQLSFGYSAEMSG
HCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCC
WLLAPIALISVMLKILIGRILNRWGYKTTLISSALLMAGSVISMAWLDKQSSLTWIICNL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
MWYGACMSIIFTSINTLVVGDLSKQQSGTGSTVLSIVQQVGIGFGIAVSSIILNLYRHFF
HHHHHHHHHHHHHHHHHEEECCHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
SANDGLQQAFSYTFLTSSLFAIALVWSLMKLHKNDGDHLRKMP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]