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The map label for this gene is galM [H]

Identifier: 148828005

GI number: 148828005

Start: 1398924

End: 1399946

Strand: Reverse

Name: galM [H]

Synonym: CGSHiGG_07590

Alternate gene names: 148828005

Gene position: 1399946-1398924 (Counterclockwise)

Preceding gene: 148828006

Following gene: 148828004

Centisome position: 74.18

GC content: 38.81

Gene sequence:

>1023_bases
ATGTTAGAACAAACCACTTTTAATGCGCCTGATGGTGCACCTTATCAGCTTATAACCCTGCAAAATGAAAATGGGATGCG
TGTTCAATTTATGGATTGGGGCGCAACTTGGCTTTCTTGTAAAGTGCCAGTAAATGACACATTACGCGAGGTTTTATTGG
GTTGTAAGGTAGAGAATTATCCCACTCATCAAAGCTATTTAGGCGCAAGCGTAGGGCGTTATGCAAATCGTATTGCAAAT
GCACAATTTGAATTGAATGGCGAACTTATTAAATTAAGTAGTAATCAAGGAAAGCACCAGCTTCATGGTGGAGAGGGCTT
TGATAAACGCCGTTGGAAAATTCAAGAGTGCGGTGAAAATTTTGTGTGTTTTTCATTACATTCAGAGCATGGTGATCAAG
GTTTTCCTGGTAATGTGGATGTGTCTGTAACCTATATGCTAACAGATGATAATAGCGTAAAAATTGAATATGCAGGGATT
TGTGATAAGGATACCGCATTGAACTTAACGAATCATGCTTATTTCAATTTAGAAAATGCAGAGCAAGACAGTGACGTGCG
TGAACATACATTACGTTTAAATGCTGATTTTTATCTGCCTGTAGATAATGAGGGGATTCCTAATTCTCCATTAAAGCACG
TGGTGAATACAAGTTTTGACTTCCGTATTGCTAAACCCATCAAGCAAGATTTTTTACAAGGGGATCAGCAAGCAACAAAA
GGTTACGATCATTCCTTTATTGTCAATAAGGCTTGGCAAAAGCCTTGTGTGTTACTAACCTCTCCAACTGGCGATTTAAG
TTTGGAAGTAAGAACCTCGCAAGCTGCATTGCAGGTTTATACAGGTAATTATCTTGCAGGTACACCAACGAGAAATGGCG
AATTATATGCCGATTTTTCTGGCATAGCACTAGAAACCCAATGTTTACCAGATACGCCTAATCATCCTGAATGGCAAAAT
TACGGCGGAATTCAAAAAGCAGGCGAGCAATATTATCAATGGACGGAGTTTAAATTTAAATAA

Upstream 100 bases:

>100_bases
TAAAATTATTGCGGATAATTACGAGAAAACGACTGGTTTAAAAGAAACTTTTTATGTGTGTACCGCATCACAAGGTGTTC
GAGTGATTTAAGAGAAAATG

Downstream 100 bases:

>100_bases
GCCATTATTTATAATAAAAATGTCATTACAAGATCTATAAATTAGGTTCATTTCTAGCGTTAAAAGCTGTGACACACCAC
CAGCCTCTTAATCTAATTTA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVENYPTHQSYLGASVGRYANRIAN
AQFELNGELIKLSSNQGKHQLHGGEGFDKRRWKIQECGENFVCFSLHSEHGDQGFPGNVDVSVTYMLTDDNSVKIEYAGI
CDKDTALNLTNHAYFNLENAEQDSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFSGIALETQCLPDTPNHPEWQN
YGGIQKAGEQYYQWTEFKFK

Sequences:

>Translated_340_residues
MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVENYPTHQSYLGASVGRYANRIAN
AQFELNGELIKLSSNQGKHQLHGGEGFDKRRWKIQECGENFVCFSLHSEHGDQGFPGNVDVSVTYMLTDDNSVKIEYAGI
CDKDTALNLTNHAYFNLENAEQDSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFSGIALETQCLPDTPNHPEWQN
YGGIQKAGEQYYQWTEFKFK
>Mature_340_residues
MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVENYPTHQSYLGASVGRYANRIAN
AQFELNGELIKLSSNQGKHQLHGGEGFDKRRWKIQECGENFVCFSLHSEHGDQGFPGNVDVSVTYMLTDDNSVKIEYAGI
CDKDTALNLTNHAYFNLENAEQDSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFSGIALETQCLPDTPNHPEWQN
YGGIQKAGEQYYQWTEFKFK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=324, Percent_Identity=37.037037037037, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1786971, Length=345, Percent_Identity=51.0144927536232, Blast_Score=339, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17557428, Length=330, Percent_Identity=28.7878787878788, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI115533334, Length=330, Percent_Identity=28.7878787878788, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324399, Length=347, Percent_Identity=27.9538904899135, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322004, Length=357, Percent_Identity=28.0112044817927, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319493, Length=348, Percent_Identity=25.2873563218391, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24659048, Length=340, Percent_Identity=34.1176470588235, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24668278, Length=311, Percent_Identity=33.1189710610932, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24583720, Length=334, Percent_Identity=30.8383233532934, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24668282, Length=336, Percent_Identity=28.8690476190476, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24641876, Length=341, Percent_Identity=26.099706744868, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38325; Mature: 38325

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVENY
CCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCC
PTHQSYLGASVGRYANRIANAQFELNGELIKLSSNQGKHQLHGGEGFDKRRWKIQECGEN
CCHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCCEEECCCCCCHHHCEEHHHCCCC
FVCFSLHSEHGDQGFPGNVDVSVTYMLTDDNSVKIEYAGICDKDTALNLTNHAYFNLENA
EEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCEEEECCEEEEEECCC
EQDSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
CCCCCHHHEEEEECCEEEEECCCCCCCCCHHHHHHCCCCCEEECCHHHHHHHCCCHHHHC
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFS
CCCCEEEEECCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCEEECCCCCCCEEEEECC
GIALETQCLPDTPNHPEWQNYGGIQKAGEQYYQWTEFKFK
CEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHEEEEEEEC
>Mature Secondary Structure
MLEQTTFNAPDGAPYQLITLQNENGMRVQFMDWGATWLSCKVPVNDTLREVLLGCKVENY
CCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCC
PTHQSYLGASVGRYANRIANAQFELNGELIKLSSNQGKHQLHGGEGFDKRRWKIQECGEN
CCHHHHHHHHHHHHHHHHCCCEEEECCEEEEEECCCCCEEECCCCCCHHHCEEHHHCCCC
FVCFSLHSEHGDQGFPGNVDVSVTYMLTDDNSVKIEYAGICDKDTALNLTNHAYFNLENA
EEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCEEEECCEEEEEECCC
EQDSDVREHTLRLNADFYLPVDNEGIPNSPLKHVVNTSFDFRIAKPIKQDFLQGDQQATK
CCCCCHHHEEEEECCEEEEECCCCCCCCCHHHHHHCCCCCEEECCHHHHHHHCCCHHHHC
GYDHSFIVNKAWQKPCVLLTSPTGDLSLEVRTSQAALQVYTGNYLAGTPTRNGELYADFS
CCCCEEEEECCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCEEECCCCCCCEEEEECC
GIALETQCLPDTPNHPEWQNYGGIQKAGEQYYQWTEFKFK
CEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 1282642 [H]