Click here to switch to the map view.

The map label for this gene is atoB [H]

Identifier: 148827961

GI number: 148827961

Start: 1364603

End: 1365784

Strand: Reverse

Name: atoB [H]

Synonym: CGSHiGG_07350

Alternate gene names: 148827961

Gene position: 1365784-1364603 (Counterclockwise)

Preceding gene: 148827962

Following gene: 148827957

Centisome position: 72.37

GC content: 40.36

Gene sequence:

>1182_bases
ATGGAAAATGTTGTTATTGTTAGTGCAGTTAGAACACCGATCGGCAGCTTTAATGGTGCATTATCTTCCGTAAGTGCGGT
TGATTTAGGTGCAATTGTGATACAAGAAGCCATCAAACGTGCCAACATTGAAAGTGCATTAGTTAATGAAGTCATCATGG
GGAACGTATTACAAGCAGGACTAGGGCAAAATCCAGCCCGTCAAGCAGCATTAAAAGCAGGAATAGAGAAAGAAATCCCT
TCTTTAACAATCAATAAAGTATGTGGATCTGGTCTAAAAAGTGTCGCATTAGGTGCACAGTCTATTATCAGTGGTGATGC
TGATATTGTTGTTGTGGGTGGCATGGAAAATATGAGCCAAGCACCTTATCTTTTAGATAGCAAAGTACGACAAGGCGTCA
AAATGGGTAATCTCACATTAAGGGACACAATGATTGAAGACGGACTAACTTGTGCTAGCAATCACTATCATATGGGGATT
ACTGCCGAAAATATTGCGGAACAATATGGTATTAGCCGCCAAGCACAAGATGAACTCGCATTACGTTCACAAACCTTAGC
ATCTCAAGCCGTGCAATTAGGTGTATTTGATAAGGAAATTGTCCCTGTTATGGTAAAAACTCGCAAAGGTGACATTATTG
TTTCACGAGACGAGTATCCTAAAGCAGATACTACAGCCGAAGGTTTAGCTAAATTAAAACCTGCTTTCAAAAAAGAGGGT
ACTGTCTCCGCAGGTAACGCTTCTGGCATTAATGATGGTGCTGCAGCACTTATTTTAGTTAGCGAAAGCAAAGCTCATGC
ACTTGGATTAAAAGCCATTGCAAAAATTAGAAGCTATGCCAGCGGTGGGGTAGATCCATCTGTTATGGGATTAGGTCCAG
TTCCAGCAACGCAAAAAGCATTGAAAAAAGCAGGAATAAATCTTGATGATATCGATCTGATAGAAGCAAATGAAGCCTTT
GCCTCACAGTTCTTAGGTGTTGGCAAAGATCTCAATTTGGATATGAATAAAACCAATATTCATGGTGGAGCTATCGCACT
TGGGCATCCAATCGGCGCGAGTGGTGCAAGGATTTTAGTAACGTTATTGCACAATCTTATCGAAAAAGATAAAAAACTTG
GACTTGCTACACTTTGTATTGGCGGTGGTCAAGGTATTTCTATGATTGTAGAACGCTTATAA

Upstream 100 bases:

>100_bases
TTGGCGTGAGAGATATTATGGGCTTCTGTATGACCGCACTTATCTTCACCGCACCAATTTTTATTATTGGTTTATATTTC
TTATAGAAAAGGAGTTAAAA

Downstream 100 bases:

>100_bases
CTATTTACTTCCTAAACTACAACAGCGAAATATTTCACTTCTAACTAAAAAAGCGAATTTCTTTTAAGAAATTCGCTTTT
CTTTTGATATCCAATTATTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MENVVIVSAVRTPIGSFNGALSSVSAVDLGAIVIQEAIKRANIESALVNEVIMGNVLQAGLGQNPARQAALKAGIEKEIP
SLTINKVCGSGLKSVALGAQSIISGDADIVVVGGMENMSQAPYLLDSKVRQGVKMGNLTLRDTMIEDGLTCASNHYHMGI
TAENIAEQYGISRQAQDELALRSQTLASQAVQLGVFDKEIVPVMVKTRKGDIIVSRDEYPKADTTAEGLAKLKPAFKKEG
TVSAGNASGINDGAAALILVSESKAHALGLKAIAKIRSYASGGVDPSVMGLGPVPATQKALKKAGINLDDIDLIEANEAF
ASQFLGVGKDLNLDMNKTNIHGGAIALGHPIGASGARILVTLLHNLIEKDKKLGLATLCIGGGQGISMIVERL

Sequences:

>Translated_393_residues
MENVVIVSAVRTPIGSFNGALSSVSAVDLGAIVIQEAIKRANIESALVNEVIMGNVLQAGLGQNPARQAALKAGIEKEIP
SLTINKVCGSGLKSVALGAQSIISGDADIVVVGGMENMSQAPYLLDSKVRQGVKMGNLTLRDTMIEDGLTCASNHYHMGI
TAENIAEQYGISRQAQDELALRSQTLASQAVQLGVFDKEIVPVMVKTRKGDIIVSRDEYPKADTTAEGLAKLKPAFKKEG
TVSAGNASGINDGAAALILVSESKAHALGLKAIAKIRSYASGGVDPSVMGLGPVPATQKALKKAGINLDDIDLIEANEAF
ASQFLGVGKDLNLDMNKTNIHGGAIALGHPIGASGARILVTLLHNLIEKDKKLGLATLCIGGGQGISMIVERL
>Mature_393_residues
MENVVIVSAVRTPIGSFNGALSSVSAVDLGAIVIQEAIKRANIESALVNEVIMGNVLQAGLGQNPARQAALKAGIEKEIP
SLTINKVCGSGLKSVALGAQSIISGDADIVVVGGMENMSQAPYLLDSKVRQGVKMGNLTLRDTMIEDGLTCASNHYHMGI
TAENIAEQYGISRQAQDELALRSQTLASQAVQLGVFDKEIVPVMVKTRKGDIIVSRDEYPKADTTAEGLAKLKPAFKKEG
TVSAGNASGINDGAAALILVSESKAHALGLKAIAKIRSYASGGVDPSVMGLGPVPATQKALKKAGINLDDIDLIEANEAF
ASQFLGVGKDLNLDMNKTNIHGGAIALGHPIGASGARILVTLLHNLIEKDKKLGLATLCIGGGQGISMIVERL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=53.9440203562341, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=45.7070707070707, Blast_Score=345, Evalue=3e-95,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=44.9494949494949, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=42.1717171717172, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=33.6470588235294, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI194353979, Length=397, Percent_Identity=29.7229219143577, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=66.6666666666667, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=54.5918367346939, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=44.139650872818, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=44.139650872818, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=33.9622641509434, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=45.7800511508951, Blast_Score=347, Evalue=9e-96,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=40.2035623409669, Blast_Score=293, Evalue=9e-80,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=37.8172588832487, Blast_Score=264, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=32.2352941176471, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=32.741116751269, Blast_Score=194, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=45.7286432160804, Blast_Score=313, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=37.9746835443038, Blast_Score=227, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=57.7608142493639, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=45.4081632653061, Blast_Score=321, Evalue=4e-88,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=43.9897698209719, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=34.5882352941176, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40788; Mature: 40788

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVVIVSAVRTPIGSFNGALSSVSAVDLGAIVIQEAIKRANIESALVNEVIMGNVLQAG
CCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
LGQNPARQAALKAGIEKEIPSLTINKVCGSGLKSVALGAQSIISGDADIVVVGGMENMSQ
CCCCHHHHHHHHHCHHHHCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APYLLDSKVRQGVKMGNLTLRDTMIEDGLTCASNHYHMGITAENIAEQYGISRQAQDELA
CCHHHHHHHHCCCHHCCEEEHHHHHHCCCEECCCCEEECCCHHHHHHHHCCCHHHHHHHH
LRSQTLASQAVQLGVFDKEIVPVMVKTRKGDIIVSRDEYPKADTTAEGLAKLKPAFKKEG
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHCHHHHCCC
TVSAGNASGINDGAAALILVSESKAHALGLKAIAKIRSYASGGVDPSVMGLGPVPATQKA
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHH
LKKAGINLDDIDLIEANEAFASQFLGVGKDLNLDMNKTNIHGGAIALGHPIGASGARILV
HHHCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHH
TLLHNLIEKDKKLGLATLCIGGGQGISMIVERL
HHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCC
>Mature Secondary Structure
MENVVIVSAVRTPIGSFNGALSSVSAVDLGAIVIQEAIKRANIESALVNEVIMGNVLQAG
CCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
LGQNPARQAALKAGIEKEIPSLTINKVCGSGLKSVALGAQSIISGDADIVVVGGMENMSQ
CCCCHHHHHHHHHCHHHHCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APYLLDSKVRQGVKMGNLTLRDTMIEDGLTCASNHYHMGITAENIAEQYGISRQAQDELA
CCHHHHHHHHCCCHHCCEEEHHHHHHCCCEECCCCEEECCCHHHHHHHHCCCHHHHHHHH
LRSQTLASQAVQLGVFDKEIVPVMVKTRKGDIIVSRDEYPKADTTAEGLAKLKPAFKKEG
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHCHHHHCCC
TVSAGNASGINDGAAALILVSESKAHALGLKAIAKIRSYASGGVDPSVMGLGPVPATQKA
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHH
LKKAGINLDDIDLIEANEAFASQFLGVGKDLNLDMNKTNIHGGAIALGHPIGASGARILV
HHHCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHH
TLLHNLIEKDKKLGLATLCIGGGQGISMIVERL
HHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]