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The map label for this gene is pgm [C]

Identifier: 148827931

GI number: 148827931

Start: 1331928

End: 1333580

Strand: Direct

Name: pgm [C]

Synonym: CGSHiGG_07190

Alternate gene names: 148827931

Gene position: 1331928-1333580 (Clockwise)

Preceding gene: 148827928

Following gene: 148827933

Centisome position: 70.58

GC content: 41.68

Gene sequence:

>1653_bases
ATGACAACACTTTTTGAGGTTGCACAACATTGGTTAAACCAAGATCCTGACACAGAAACTCGTGCAGAATTAACCGCACT
TTTAGATGCAGCAAAAGGCGGAGATAAAGCGGCAGAAGCAGAATTACATGTGCGTTTTGATGGTCGTTTACAATTTGGTA
CGGCAGGTTTACGTGGTCGTTTACAAGCTGGCTCAATGGGAATGAACCGAGTGCTAGTTTCTCAAGCTGCTGGTGGTTTA
GCGGAATATTTAAAAGGTTACGATAAAGAACCCTCAATCGTCATTGGTTACGATGGCCGTAAAAACTCTGACGTTTTTGC
CCGTGACACCGCTGAAATTATGGCGGGTGCAGGCGTAAAAGCTTATTTATTACCACGCAAATTACCGACTCCAGTTTTAG
CCTATGCTATCCAATATTTTGATACCACTGCAGGTGTAATGGTAACAGCAAGCCATAACCCACCAGAAGATAATGGCTAC
AAAGTGTATTTAGGTAAAGCAAATGGTGGCGGTCAAATCGTTTCACCGGCAGATAAAGACATCGCAGCATTAATTGATAA
AGTTGCGGCTGGCAATATCCAAGATTTACCACGTAGCGATAATTATGTGGTGTTAAATGATGAAGTAGTAGATGCGTACA
TTACAAAAACTGCATCATTAGCTAAAGAGCCAGCTTGCGACATTAACTATGTTTATACCGCTATGCATGGTGTTGGCTAT
GAAGTTTTAAGTAAAACACTGGCAAAAGCAGGCTTACCACAACCCCACGTAGTCGCAGATCAAGTTTGGCCAGATGGCAG
ATTCCCAACGGTGAATTTCCCAAATCCAGAAGAAAAAGGCGCATTGGATTTAGCAATTAAAGTGGCAAAAGAAAAGAACG
CTGAATTTATCATTGCGAATGACCCAGATGCAGACCGTTTAGCCGTTGCTGTGCCTGATGCACAAGGCAACTGGAAATCA
CTACACGGCAACGTAGTAGGCTGTTTCTTAGGTTGGTACTTGGCAAAACAATATCAAGGTAAACAAGGCACATTGGCTTG
CTCACTTGTTTCTTCCCCAGCTCTTGCTGAAATTGCGAAAAAATACGGTTTCCAATCAGAAGAAACCTTAACTGGTTTCA
AATACATCGGTAAAGTATTTGGCTTATTGTTCGGTTTTGAAGAGGCATTAGGCTATTTAGTGGATCCAGACAAAGTACGC
GATAAAGACGGTATTTCTGCAGCAATCGTGTTCTTAGATCTTGTGCGTAACTTGAAAAAACAAGGCAAAACTTTAGCAGA
TTATGCTGATGAATTTACCAAAGAATTTGGTGCTTATGTGAGTGGACAAATCTCTATTCGAGTCAGCGAACTTTCAGAAA
TCGGAAAATTAATGACCGCACTTCGTAACAATCCACCAGCAGAAATCGCTGGCGTGAAAGTGGCACAATTTATCGACCAT
ATTAAAACAGATCGTCAAAGCGATATCCTTGTATTTAACTTGGAAAATGGCGGACGCTTAATTGCTCGTCCTTCAGGTAC
TGAACCAAAAATTAAATTCTACTTGGATGCGCGCGGTAAAGATCCAAAAGATGCAGATCGCGTATTGGCAGAATTTGATG
AAGGTGTTCGTCACATTCTTCGCCAAGATACTTATGGCAAACAAGACTGCTAA

Upstream 100 bases:

>100_bases
AAGTAGATCAAAAAATTGAGAATTATCCGTTTTCATTTTGTTAGATTTCCGCTAGTCTAACGGCGATTTTTTATTTATTT
CAACGAATAAGGATAACGCT

Downstream 100 bases:

>100_bases
TTGCAAAATAGTAAGAAAAGACACCGCTTGTAAAAGCGGTGTTTTTGCATTTAAGCACTTTTGCTTTTTAAAATTTTCCC
TAAATTCGTTTCCAACCAAT

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MTTLFEVAQHWLNQDPDTETRAELTALLDAAKGGDKAAEAELHVRFDGRLQFGTAGLRGRLQAGSMGMNRVLVSQAAGGL
AEYLKGYDKEPSIVIGYDGRKNSDVFARDTAEIMAGAGVKAYLLPRKLPTPVLAYAIQYFDTTAGVMVTASHNPPEDNGY
KVYLGKANGGGQIVSPADKDIAALIDKVAAGNIQDLPRSDNYVVLNDEVVDAYITKTASLAKEPACDINYVYTAMHGVGY
EVLSKTLAKAGLPQPHVVADQVWPDGRFPTVNFPNPEEKGALDLAIKVAKEKNAEFIIANDPDADRLAVAVPDAQGNWKS
LHGNVVGCFLGWYLAKQYQGKQGTLACSLVSSPALAEIAKKYGFQSEETLTGFKYIGKVFGLLFGFEEALGYLVDPDKVR
DKDGISAAIVFLDLVRNLKKQGKTLADYADEFTKEFGAYVSGQISIRVSELSEIGKLMTALRNNPPAEIAGVKVAQFIDH
IKTDRQSDILVFNLENGGRLIARPSGTEPKIKFYLDARGKDPKDADRVLAEFDEGVRHILRQDTYGKQDC

Sequences:

>Translated_550_residues
MTTLFEVAQHWLNQDPDTETRAELTALLDAAKGGDKAAEAELHVRFDGRLQFGTAGLRGRLQAGSMGMNRVLVSQAAGGL
AEYLKGYDKEPSIVIGYDGRKNSDVFARDTAEIMAGAGVKAYLLPRKLPTPVLAYAIQYFDTTAGVMVTASHNPPEDNGY
KVYLGKANGGGQIVSPADKDIAALIDKVAAGNIQDLPRSDNYVVLNDEVVDAYITKTASLAKEPACDINYVYTAMHGVGY
EVLSKTLAKAGLPQPHVVADQVWPDGRFPTVNFPNPEEKGALDLAIKVAKEKNAEFIIANDPDADRLAVAVPDAQGNWKS
LHGNVVGCFLGWYLAKQYQGKQGTLACSLVSSPALAEIAKKYGFQSEETLTGFKYIGKVFGLLFGFEEALGYLVDPDKVR
DKDGISAAIVFLDLVRNLKKQGKTLADYADEFTKEFGAYVSGQISIRVSELSEIGKLMTALRNNPPAEIAGVKVAQFIDH
IKTDRQSDILVFNLENGGRLIARPSGTEPKIKFYLDARGKDPKDADRVLAEFDEGVRHILRQDTYGKQDC
>Mature_549_residues
TTLFEVAQHWLNQDPDTETRAELTALLDAAKGGDKAAEAELHVRFDGRLQFGTAGLRGRLQAGSMGMNRVLVSQAAGGLA
EYLKGYDKEPSIVIGYDGRKNSDVFARDTAEIMAGAGVKAYLLPRKLPTPVLAYAIQYFDTTAGVMVTASHNPPEDNGYK
VYLGKANGGGQIVSPADKDIAALIDKVAAGNIQDLPRSDNYVVLNDEVVDAYITKTASLAKEPACDINYVYTAMHGVGYE
VLSKTLAKAGLPQPHVVADQVWPDGRFPTVNFPNPEEKGALDLAIKVAKEKNAEFIIANDPDADRLAVAVPDAQGNWKSL
HGNVVGCFLGWYLAKQYQGKQGTLACSLVSSPALAEIAKKYGFQSEETLTGFKYIGKVFGLLFGFEEALGYLVDPDKVRD
KDGISAAIVFLDLVRNLKKQGKTLADYADEFTKEFGAYVSGQISIRVSELSEIGKLMTALRNNPPAEIAGVKVAQFIDHI
KTDRQSDILVFNLENGGRLIARPSGTEPKIKFYLDARGKDPKDADRVLAEFDEGVRHILRQDTYGKQDC

Specific function: This Enzyme Participates In Both The Breakdown And Synthesis Of Glucose. [C]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=616, Percent_Identity=32.6298701298701, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI31377548, Length=590, Percent_Identity=32.7118644067797, Blast_Score=265, Evalue=6e-71,
Organism=Escherichia coli, GI1789566, Length=477, Percent_Identity=25.7861635220126, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71993870, Length=594, Percent_Identity=32.4915824915825, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71993878, Length=320, Percent_Identity=35.625, Blast_Score=175, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323934, Length=614, Percent_Identity=34.5276872964169, Blast_Score=270, Evalue=4e-73,
Organism=Drosophila melanogaster, GI20129809, Length=594, Percent_Identity=35.016835016835, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24651977, Length=433, Percent_Identity=39.7228637413395, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI24653722, Length=496, Percent_Identity=32.8629032258064, Blast_Score=218, Evalue=7e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.8 [H]

Molecular weight: Translated: 59733; Mature: 59602

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLFEVAQHWLNQDPDTETRAELTALLDAAKGGDKAAEAELHVRFDGRLQFGTAGLRGR
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEECCCCCCCC
LQAGSMGMNRVLVSQAAGGLAEYLKGYDKEPSIVIGYDGRKNSDVFARDTAEIMAGAGVK
CCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCEEEEECCCCCCCEEHHHHHHHHHCCCCE
AYLLPRKLPTPVLAYAIQYFDTTAGVMVTASHNPPEDNGYKVYLGKANGGGQIVSPADKD
EEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCHH
IAALIDKVAAGNIQDLPRSDNYVVLNDEVVDAYITKTASLAKEPACDINYVYTAMHGVGY
HHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCH
EVLSKTLAKAGLPQPHVVADQVWPDGRFPTVNFPNPEEKGALDLAIKVAKEKNAEFIIAN
HHHHHHHHHCCCCCCCEEHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEC
DPDADRLAVAVPDAQGNWKSLHGNVVGCFLGWYLAKQYQGKQGTLACSLVSSPALAEIAK
CCCCCEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
KYGFQSEETLTGFKYIGKVFGLLFGFEEALGYLVDPDKVRDKDGISAAIVFLDLVRNLKK
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHH
QGKTLADYADEFTKEFGAYVSGQISIRVSELSEIGKLMTALRNNPPAEIAGVKVAQFIDH
CCCHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IKTDRQSDILVFNLENGGRLIARPSGTEPKIKFYLDARGKDPKDADRVLAEFDEGVRHIL
HHCCCCCCEEEEEECCCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
RQDTYGKQDC
HCCCCCCCCC
>Mature Secondary Structure 
TTLFEVAQHWLNQDPDTETRAELTALLDAAKGGDKAAEAELHVRFDGRLQFGTAGLRGR
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCEEEECCCCCCCC
LQAGSMGMNRVLVSQAAGGLAEYLKGYDKEPSIVIGYDGRKNSDVFARDTAEIMAGAGVK
CCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCEEEEECCCCCCCEEHHHHHHHHHCCCCE
AYLLPRKLPTPVLAYAIQYFDTTAGVMVTASHNPPEDNGYKVYLGKANGGGQIVSPADKD
EEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCHH
IAALIDKVAAGNIQDLPRSDNYVVLNDEVVDAYITKTASLAKEPACDINYVYTAMHGVGY
HHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCH
EVLSKTLAKAGLPQPHVVADQVWPDGRFPTVNFPNPEEKGALDLAIKVAKEKNAEFIIAN
HHHHHHHHHCCCCCCCEEHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEC
DPDADRLAVAVPDAQGNWKSLHGNVVGCFLGWYLAKQYQGKQGTLACSLVSSPALAEIAK
CCCCCEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
KYGFQSEETLTGFKYIGKVFGLLFGFEEALGYLVDPDKVRDKDGISAAIVFLDLVRNLKK
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHH
QGKTLADYADEFTKEFGAYVSGQISIRVSELSEIGKLMTALRNNPPAEIAGVKVAQFIDH
CCCHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IKTDRQSDILVFNLENGGRLIARPSGTEPKIKFYLDARGKDPKDADRVLAEFDEGVRHIL
HHCCCCCCEEEEEECCCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
RQDTYGKQDC
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]