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The map label for this gene is tyrR [H]

Identifier: 148827610

GI number: 148827610

Start: 954374

End: 955330

Strand: Direct

Name: tyrR [H]

Synonym: CGSHiGG_05235

Alternate gene names: 148827610

Gene position: 954374-955330 (Clockwise)

Preceding gene: 148827605

Following gene: 148827613

Centisome position: 50.57

GC content: 37.93

Gene sequence:

>957_bases
ATGACGATTTCTAAATTTAATCCACAAAAACCTTTCGAGTGTTTTATTGTACAAAGTGAAGCGATGAAAAGTGCGGTAGA
AAACGCGAAACGTTTTGCTATGTTTGATGTGCCTTTGTTAATTCAAGGCGAAACGGGGACAGGAAAGGATTTGTTAGCGA
AAGCCTGCCATTATCAGAGTTTACGTCGTGATAAAAAATTTATCGCAGTAAATTGTGCTGGGTTGCCTGATGAAGATGCC
GAAAGTGAAATGTTTGGTCGAAAAGTTGGCGACAGCGAAACCATTGGTTTTTTTGAATACGCAAATGAGGGTACAGTTTT
ACTCGATGGTATTGCTGAACTTTCATTGGGTTTGCAGGCTAAATTATTGCGTTTTTTAACGGATGGATCTTTCCGTCGAG
TAGGCGAAGAAAAGGAACATTATGCAAATGTACGTGTGATTTGCACATCACAGGTTCCACTCCATTTGCTTGTTGAGCAA
GGTAAAGTACGTGCTGATTTATTTCATCGCTTAAATGTTCTTACTCTTAATGTGCCGCCATTACGCGAACGCATGACTGA
TATTGAGCCACTGGCACAAGGTTTTTTACAGGAAATCAGCGAAGAATTAAAAATTGCAAAACCAACTTTCGATAAAGATT
TTCTTCTTTATTTGCAGAAATATGACTGGAAAGGGAATGTTCGTGAGCTTTATAACACCCTTTATCGTGCCTGCTCTCTG
GTACAAGATAATCATTTGACTATCGAAAGTTTAAATCTTGCTCCGCCACAAAGTGCAGTAATTTCTTTGGATGAATTTGG
AAATAAAACCTTAGATGAAATCATCGGTTCTTATGAGGCACAAGTTCTAAAATTATTTTATGCAGAATATCCAAGCACGA
GAAAATTGGCTCAACGTTTAGGCGTTTCCCATACTGCGATTGCGAATAAATTGAAACAATATGGAATTGGAAAATAA

Upstream 100 bases:

>100_bases
GTCAAAAATGGTCGCATTTTTACCTTATGTAAAATAATATTTACACTTTGTTGTAAAGAAATTATCATAGCCATATCTTA
ATTATCTCCATTCCCTGAAT

Downstream 100 bases:

>100_bases
TTTTCCGATTTGAAATGGAAAAAGTGCGGTTGAAATTTCCTAAGAATTTTCAACCGCACTTAATAAATATTGATTGTCCA
TTAATGGTGTTGTGATTACT

Product: transcriptional regulatory protein TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTISKFNPQKPFECFIVQSEAMKSAVENAKRFAMFDVPLLIQGETGTGKDLLAKACHYQSLRRDKKFIAVNCAGLPDEDA
ESEMFGRKVGDSETIGFFEYANEGTVLLDGIAELSLGLQAKLLRFLTDGSFRRVGEEKEHYANVRVICTSQVPLHLLVEQ
GKVRADLFHRLNVLTLNVPPLRERMTDIEPLAQGFLQEISEELKIAKPTFDKDFLLYLQKYDWKGNVRELYNTLYRACSL
VQDNHLTIESLNLAPPQSAVISLDEFGNKTLDEIIGSYEAQVLKLFYAEYPSTRKLAQRLGVSHTAIANKLKQYGIGK

Sequences:

>Translated_318_residues
MTISKFNPQKPFECFIVQSEAMKSAVENAKRFAMFDVPLLIQGETGTGKDLLAKACHYQSLRRDKKFIAVNCAGLPDEDA
ESEMFGRKVGDSETIGFFEYANEGTVLLDGIAELSLGLQAKLLRFLTDGSFRRVGEEKEHYANVRVICTSQVPLHLLVEQ
GKVRADLFHRLNVLTLNVPPLRERMTDIEPLAQGFLQEISEELKIAKPTFDKDFLLYLQKYDWKGNVRELYNTLYRACSL
VQDNHLTIESLNLAPPQSAVISLDEFGNKTLDEIIGSYEAQVLKLFYAEYPSTRKLAQRLGVSHTAIANKLKQYGIGK
>Mature_317_residues
TISKFNPQKPFECFIVQSEAMKSAVENAKRFAMFDVPLLIQGETGTGKDLLAKACHYQSLRRDKKFIAVNCAGLPDEDAE
SEMFGRKVGDSETIGFFEYANEGTVLLDGIAELSLGLQAKLLRFLTDGSFRRVGEEKEHYANVRVICTSQVPLHLLVEQG
KVRADLFHRLNVLTLNVPPLRERMTDIEPLAQGFLQEISEELKIAKPTFDKDFLLYLQKYDWKGNVRELYNTLYRACSLV
QDNHLTIESLNLAPPQSAVISLDEFGNKTLDEIIGSYEAQVLKLFYAEYPSTRKLAQRLGVSHTAIANKLKQYGIGK

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport [H]

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=308, Percent_Identity=48.3766233766234, Blast_Score=287, Evalue=8e-79,
Organism=Escherichia coli, GI1788550, Length=315, Percent_Identity=38.4126984126984, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI87082117, Length=319, Percent_Identity=36.6771159874608, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1789087, Length=323, Percent_Identity=34.6749226006192, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789233, Length=328, Percent_Identity=32.3170731707317, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1790299, Length=246, Percent_Identity=39.0243902439024, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI87082152, Length=325, Percent_Identity=34.7692307692308, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1788905, Length=234, Percent_Identity=37.6068376068376, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790437, Length=245, Percent_Identity=36.3265306122449, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI87081872, Length=316, Percent_Identity=31.9620253164557, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1786524, Length=316, Percent_Identity=34.4936708860759, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI87081858, Length=299, Percent_Identity=27.7591973244147, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789828, Length=229, Percent_Identity=28.82096069869, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR002078 [H]

Pfam domain/function: PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 35890; Mature: 35758

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISKFNPQKPFECFIVQSEAMKSAVENAKRFAMFDVPLLIQGETGTGKDLLAKACHYQS
CCCCCCCCCCCCEEEEECHHHHHHHHHHHHHEEEECCCEEEECCCCCCHHHHHHHHHHHH
LRRDKKFIAVNCAGLPDEDAESEMFGRKVGDSETIGFFEYANEGTVLLDGIAELSLGLQA
HHCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHH
KLLRFLTDGSFRRVGEEKEHYANVRVICTSQVPLHLLVEQGKVRADLFHRLNVLTLNVPP
HHHHHHHCCHHHHHCCHHHHHCCEEEEEECCCCEEEHHHCCCHHHHHHHCCEEEEECCCH
LRERMTDIEPLAQGFLQEISEELKIAKPTFDKDFLLYLQKYDWKGNVRELYNTLYRACSL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VQDNHLTIESLNLAPPQSAVISLDEFGNKTLDEIIGSYEAQVLKLFYAEYPSTRKLAQRL
HCCCCEEEEECCCCCCHHHEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GVSHTAIANKLKQYGIGK
CCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TISKFNPQKPFECFIVQSEAMKSAVENAKRFAMFDVPLLIQGETGTGKDLLAKACHYQS
CCCCCCCCCCCEEEEECHHHHHHHHHHHHHEEEECCCEEEECCCCCCHHHHHHHHHHHH
LRRDKKFIAVNCAGLPDEDAESEMFGRKVGDSETIGFFEYANEGTVLLDGIAELSLGLQA
HHCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHH
KLLRFLTDGSFRRVGEEKEHYANVRVICTSQVPLHLLVEQGKVRADLFHRLNVLTLNVPP
HHHHHHHCCHHHHHCCHHHHHCCEEEEEECCCCEEEHHHCCCHHHHHHHCCEEEEECCCH
LRERMTDIEPLAQGFLQEISEELKIAKPTFDKDFLLYLQKYDWKGNVRELYNTLYRACSL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VQDNHLTIESLNLAPPQSAVISLDEFGNKTLDEIIGSYEAQVLKLFYAEYPSTRKLAQRL
HCCCCEEEEECCCCCCHHHEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GVSHTAIANKLKQYGIGK
CCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]