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The map label for this gene is xseA [H]

Identifier: 148827600

GI number: 148827600

Start: 943844

End: 944476

Strand: Direct

Name: xseA [H]

Synonym: CGSHiGG_05165

Alternate gene names: 148827600

Gene position: 943844-944476 (Clockwise)

Preceding gene: 148827599

Following gene: 148827601

Centisome position: 50.01

GC content: 40.92

Gene sequence:

>633_bases
ATGTCAGAAATTCAACATTTTAGCCAACAAGATATAGAAATATTGGGCGAACAAACTTTGTATGAAGGTTTTTTCACGCT
TAAACGAATCCAATTTAAACATAAACTTTTTGCTGGGGGACAAAGTGGCGTCGTAACCCGAGAATTACTGATTAAAGGTG
CCGCCTCAGCGGTTATCGCTTATGATCCAAAAGAAGATTCTGTGATTTTAGTCGAACAAGTTCGTATTGGTGCGGCTTAT
CATCCCGAATCTAATCGTTCGCCTTGGTTACTCGAACTAATTGCGGGTATGGTGGAAAAAGGCGAAAAGCCAGAAGACGT
TGCTTTGCGTGAGAGTGAAGAAGAAGCGGGAATTCAAGTCAAAAATTTAACGCATTGTTTAAGTGTGTGGGATAGCCCAG
GTGGCATAGTGGAGCGGATTCATTTATTTGCAGGCGAAGTGGATAGCTCACAAGCAAAAGGTATTCACGGTTTGGCTGAA
GAAAATGAAGATATTCGAGTACAGGTAGTAAAACGTGAACAGGCGTATCAATGGATGTGCGAGGGGAAAATTGATAATGG
CATTGCAGTGATTGGATTGCAGTGGCTTCAATTAAATTATGCTCAGTTACAACAAAGTTGGAAATGTAGTTAG

Upstream 100 bases:

>100_bases
TTTGTGACTCACTTCAAACTCTCAACAAAAAGTGGAAACCTTCTATTTTTTTTGTAGTCTTTTAAGCGTATGATTTTGCG
TGCAGTTTTGGAGAAAACAG

Downstream 100 bases:

>100_bases
GGGCATTAATGAAAAATACGTTTGTTTATCAGGCGGAAAAGCCTGTTATTAAATTATTACAAATTACAGATCCCCATTTA
TTTAAAGATGAAAGTGCGGA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSEIQHFSQQDIEILGEQTLYEGFFTLKRIQFKHKLFAGGQSGVVTRELLIKGAASAVIAYDPKEDSVILVEQVRIGAAY
HPESNRSPWLLELIAGMVEKGEKPEDVALRESEEEAGIQVKNLTHCLSVWDSPGGIVERIHLFAGEVDSSQAKGIHGLAE
ENEDIRVQVVKREQAYQWMCEGKIDNGIAVIGLQWLQLNYAQLQQSWKCS

Sequences:

>Translated_210_residues
MSEIQHFSQQDIEILGEQTLYEGFFTLKRIQFKHKLFAGGQSGVVTRELLIKGAASAVIAYDPKEDSVILVEQVRIGAAY
HPESNRSPWLLELIAGMVEKGEKPEDVALRESEEEAGIQVKNLTHCLSVWDSPGGIVERIHLFAGEVDSSQAKGIHGLAE
ENEDIRVQVVKREQAYQWMCEGKIDNGIAVIGLQWLQLNYAQLQQSWKCS
>Mature_209_residues
SEIQHFSQQDIEILGEQTLYEGFFTLKRIQFKHKLFAGGQSGVVTRELLIKGAASAVIAYDPKEDSVILVEQVRIGAAYH
PESNRSPWLLELIAGMVEKGEKPEDVALRESEEEAGIQVKNLTHCLSVWDSPGGIVERIHLFAGEVDSSQAKGIHGLAEE
NEDIRVQVVKREQAYQWMCEGKIDNGIAVIGLQWLQLNYAQLQQSWKCS

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789412, Length=201, Percent_Identity=53.7313432835821, Blast_Score=222, Evalue=1e-59,
Organism=Escherichia coli, GI1788810, Length=191, Percent_Identity=29.8429319371728, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 23534; Mature: 23403

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIQHFSQQDIEILGEQTLYEGFFTLKRIQFKHKLFAGGQSGVVTRELLIKGAASAVIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEE
YDPKEDSVILVEQVRIGAAYHPESNRSPWLLELIAGMVEKGEKPEDVALRESEEEAGIQV
ECCCCCCEEEEEEEEECEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCEEH
KNLTHCLSVWDSPGGIVERIHLFAGEVDSSQAKGIHGLAEENEDIRVQVVKREQAYQWMC
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHC
EGKIDNGIAVIGLQWLQLNYAQLQQSWKCS
CCCCCCCEEEEEHHHHHCCHHHHHHHCCCC
>Mature Secondary Structure 
SEIQHFSQQDIEILGEQTLYEGFFTLKRIQFKHKLFAGGQSGVVTRELLIKGAASAVIA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEE
YDPKEDSVILVEQVRIGAAYHPESNRSPWLLELIAGMVEKGEKPEDVALRESEEEAGIQV
ECCCCCCEEEEEEEEECEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHCEEH
KNLTHCLSVWDSPGGIVERIHLFAGEVDSSQAKGIHGLAEENEDIRVQVVKREQAYQWMC
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHC
EGKIDNGIAVIGLQWLQLNYAQLQQSWKCS
CCCCCCCEEEEEHHHHHCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10542272 [H]