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The map label for this gene is fabH

Identifier: 148827297

GI number: 148827297

Start: 630502

End: 631452

Strand: Reverse

Name: fabH

Synonym: CGSHiGG_03380

Alternate gene names: 148827297

Gene position: 631452-630502 (Counterclockwise)

Preceding gene: 148827298

Following gene: 148827296

Centisome position: 33.46

GC content: 40.59

Gene sequence:

>951_bases
ATGAATAGTAGAATTTTATCCACCGGTAGCTATCTGCCGAGCCATATTCGCACAAATGCGGATTTAGAAAAAATGGTTGA
TACATCAGATGAATGGATTGTCACTCGTTCTGGTATCCGTGAACGTCGTATCGCAGCGGAAGATGAAACTGTTGCAACAA
TGGGATTTGAAGCGGCAAAAAATGCGATCGAAGCTGCTCAAATTAATCCTCAAGATATTGAACTGATTATTGTTGCAACT
ACAAGTCACTCACATGCTTATCCAAGTGCGGCTTGCCAAGTGCAAGGTTTATTAAATATTGATGATGCGATTTCTTTTGA
TTTGGCGGCAGCTTGCACAGGCTTTGTCTATGCTTTGAGCGTAGCTGATCAATTTATTCGTGCAGGCAAAGTGAAAAAAG
CCTTAGTGATAGGCTCAGATCTCAATTCTCGTAAATTAGATGAAACAGATCGCAGCACTGTTGTGCTATTTGGTGATGGT
GCGGGTGCTGTAATTTTAGAAGCGAGTGAACAAGAAGGAATTATCTCCACCCATTTACACGCTTCAGCAGATAAAAATAA
TGCCCTTGTTTTAGCTCAGCCAGAACGTGGTATAGAAAAATCTGGCTATATCGAGATGCAAGGTAACGAAACGTTCAAAT
TGGCAGTTCGTGAACTTTCAAATGTGGTGGAAGAAACACTTTTAGCAAATAATTTAGATAAAAAAGATTTAGACTGGCTT
GTGCCACACCAAGCAAATTTACGTATTATTACAGCGACAGCTAAAAAATTAGAAATGGATATGTCGCAAGTGGTGGTAAC
GTTAGATAAATACGCTAATAACAGTGCAGCAACTGTTCCTGTCGCTTTAGATGAGGCTATTCGAGATGGCCGTATTCAAC
GTGGGCAGTTACTATTATTAGAAGCCTTTGGCGGTGGTTGGACTTGGGGTTCAGCGTTAGTGAGATTTTAG

Upstream 100 bases:

>100_bases
TGCATTCCTTTAACATCGGAAAATAATCCGGTGTGGTCTTATCTCTTACTTGGCGATAGTCCATAGATTTTTTCCTTTTT
AATCGCTTATCTTATTGAGT

Downstream 100 bases:

>100_bases
TTGATTTGATATAATTATTGATGATTTTAAAGTGCGGTAAAAATTGACCGCACTTTTTGTGTTAAATGTCAGGGGTTCGC
CTGACGGCGACTTACTTTCT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNSRILSTGSYLPSHIRTNADLEKMVDTSDEWIVTRSGIRERRIAAEDETVATMGFEAAKNAIEAAQINPQDIELIIVAT
TSHSHAYPSAACQVQGLLNIDDAISFDLAAACTGFVYALSVADQFIRAGKVKKALVIGSDLNSRKLDETDRSTVVLFGDG
AGAVILEASEQEGIISTHLHASADKNNALVLAQPERGIEKSGYIEMQGNETFKLAVRELSNVVEETLLANNLDKKDLDWL
VPHQANLRIITATAKKLEMDMSQVVVTLDKYANNSAATVPVALDEAIRDGRIQRGQLLLLEAFGGGWTWGSALVRF

Sequences:

>Translated_316_residues
MNSRILSTGSYLPSHIRTNADLEKMVDTSDEWIVTRSGIRERRIAAEDETVATMGFEAAKNAIEAAQINPQDIELIIVAT
TSHSHAYPSAACQVQGLLNIDDAISFDLAAACTGFVYALSVADQFIRAGKVKKALVIGSDLNSRKLDETDRSTVVLFGDG
AGAVILEASEQEGIISTHLHASADKNNALVLAQPERGIEKSGYIEMQGNETFKLAVRELSNVVEETLLANNLDKKDLDWL
VPHQANLRIITATAKKLEMDMSQVVVTLDKYANNSAATVPVALDEAIRDGRIQRGQLLLLEAFGGGWTWGSALVRF
>Mature_316_residues
MNSRILSTGSYLPSHIRTNADLEKMVDTSDEWIVTRSGIRERRIAAEDETVATMGFEAAKNAIEAAQINPQDIELIIVAT
TSHSHAYPSAACQVQGLLNIDDAISFDLAAACTGFVYALSVADQFIRAGKVKKALVIGSDLNSRKLDETDRSTVVLFGDG
AGAVILEASEQEGIISTHLHASADKNNALVLAQPERGIEKSGYIEMQGNETFKLAVRELSNVVEETLLANNLDKKDLDWL
VPHQANLRIITATAKKLEMDMSQVVVTLDKYANNSAATVPVALDEAIRDGRIQRGQLLLLEAFGGGWTWGSALVRF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=65.9305993690852, Blast_Score=434, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_HAEI8 (Q4QP30)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_247877.1
- HSSP:   P0A6R0
- ProteinModelPortal:   Q4QP30
- SMR:   Q4QP30
- STRING:   Q4QP30
- GeneID:   3429583
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI0247
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- PhylomeDB:   Q4QP30
- ProtClustDB:   PRK09352
- BioCyc:   HINF281310:NTHI0247-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34280; Mature: 34280

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 243-243 ACT_SITE 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSRILSTGSYLPSHIRTNADLEKMVDTSDEWIVTRSGIRERRIAAEDETVATMGFEAAK
CCCEEECCCCCCCHHHCCCCCHHHHHCCCCCEEEECCCCHHHHCCCCCCEEEECCHHHHH
NAIEAAQINPQDIELIIVATTSHSHAYPSAACQVQGLLNIDDAISFDLAAACTGFVYALS
HHHHHHCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
VADQFIRAGKVKKALVIGSDLNSRKLDETDRSTVVLFGDGAGAVILEASEQEGIISTHLH
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEE
ASADKNNALVLAQPERGIEKSGYIEMQGNETFKLAVRELSNVVEETLLANNLDKKDLDWL
CCCCCCCEEEEECCCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VPHQANLRIITATAKKLEMDMSQVVVTLDKYANNSAATVPVALDEAIRDGRIQRGQLLLL
CCCCCCEEEEEEEHHHHHHCHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCCCCCEEEE
EAFGGGWTWGSALVRF
EECCCCEEHHHHHHCC
>Mature Secondary Structure
MNSRILSTGSYLPSHIRTNADLEKMVDTSDEWIVTRSGIRERRIAAEDETVATMGFEAAK
CCCEEECCCCCCCHHHCCCCCHHHHHCCCCCEEEECCCCHHHHCCCCCCEEEECCHHHHH
NAIEAAQINPQDIELIIVATTSHSHAYPSAACQVQGLLNIDDAISFDLAAACTGFVYALS
HHHHHHCCCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
VADQFIRAGKVKKALVIGSDLNSRKLDETDRSTVVLFGDGAGAVILEASEQEGIISTHLH
HHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEE
ASADKNNALVLAQPERGIEKSGYIEMQGNETFKLAVRELSNVVEETLLANNLDKKDLDWL
CCCCCCCEEEEECCCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VPHQANLRIITATAKKLEMDMSQVVVTLDKYANNSAATVPVALDEAIRDGRIQRGQLLLL
CCCCCCEEEEEEEHHHHHHCHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCCCCCEEEE
EAFGGGWTWGSALVRF
EECCCCEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA