Click here to switch to the map view.

The map label for this gene is virS

Identifier: 148824274

GI number: 148824274

Start: 3459168

End: 3460190

Strand: Reverse

Name: virS

Synonym: TBFG_13099

Alternate gene names: 148824274

Gene position: 3460190-3459168 (Counterclockwise)

Preceding gene: 148824284

Following gene: 148824272

Centisome position: 78.21

GC content: 66.86

Gene sequence:

>1023_bases
ATGGAGCTGGGCAGCCTCATCCGCGCCACCAACCTGTGGGGGTACACCGACCTGATGCGCGAGCTCGGCGCGGACCCGCT
GCCGTTTCTGCGGCGCTTCGACATCCCGCCGGGCATCGAACACCAAGAGGACGCGTTCATGTCGCTGGCCGGGTTCGTGC
GCATGCTGGAGGCCAGCGCCGCCGAGCTCGATTGCCCGGACTTCGGACTACGCCTTGCACGCTGGCAGGGCCTGGGCATT
CTCGGCCCGGTAGCGGTGATCGCGCGCAACGCTGCCACCTTGTTCGGCGGGCTGGAGGCGATCGGTCGCTACCTCTACGT
CCATTCGCCCGCCCTGACGCTGACGGTTTCATCAACTACCGCACGGTCCAACGTCCGGTTCGGCTATGAGGTGACCGAAC
CGGGGATTCCCTATCCGCTGCAGGGATACGAGCTGAGCATGGCCAACGCCGCCCGGATGATCCGCCTGCTGGGCGGACCG
CAGGCGCGGGCGCGCGTTTTCTCGTTCCGACATGCGCAACTGGGCACCGACGCCGCCTACCGCGAAGCGTTGGGTTGTAC
CGTTCGGTTCGGCCGGACATGGTGCGGGTTCGAGGTGGACCACCGGCTCGCCGGTAGGCCCATCGACCATGCGGATCCGG
AAACCAAGCGCATCGCCACGAAATATTTGGAATCCCAATACCTTCCGAGCGATGCCACGCTCTCCGAGCGGGTCGTCGGG
TTGGCCCGCCGCCTGCTGCCGACCGGCCAATGCAGCGCCGAGGCCATCGCCGACCAACTCGACATGCACCCACGAACGCT
GCAGCGGCGCTTGGCTGCCGAGGGCCTCCGGTGCCATGACCTCATCGAGCGCGAACGCCGTGCGCAAGCGGCAAGGTACC
TCGCCCAACCGGGGTTGTATCTGAGCCAAATCGCGGTGCTGCTCGGCTATTCCGAGCAGAGCGCGCTCAACCGGTCGTGC
CGGCGCTGGTTTGGGATGACACCCCGGCAGTATCGAGCCTATGGTGGGGTCAGCGGTCGGTGA

Upstream 100 bases:

>100_bases
AGGACGTCGAAATGCTGGTTCATGGCTCCAGCATGGTGGAGGACCCCCGCCACGTATTGACACTTTGCGACAGCCTTTTA
TCATTTTCCGACAGGAGGTG

Downstream 100 bases:

>100_bases
AACGGGTGGTGAAACCCCAGCCCCGACTGACAGAAGCGGTTCGCATTGGGGACGCCCGAATCATGGATAATCCATGACAC
TGGGGTGCTGCGCGCGGCGG

Product: virulence-regulating transcriptional regulator VirS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQEDAFMSLAGFVRMLEASAAELDCPDFGLRLARWQGLGI
LGPVAVIARNAATLFGGLEAIGRYLYVHSPALTLTVSSTTARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGP
QARARVFSFRHAQLGTDAAYREALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRIATKYLESQYLPSDATLSERVVG
LARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGLRCHDLIERERRAQAARYLAQPGLYLSQIAVLLGYSEQSALNRSC
RRWFGMTPRQYRAYGGVSGR

Sequences:

>Translated_340_residues
MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQEDAFMSLAGFVRMLEASAAELDCPDFGLRLARWQGLGI
LGPVAVIARNAATLFGGLEAIGRYLYVHSPALTLTVSSTTARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGP
QARARVFSFRHAQLGTDAAYREALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRIATKYLESQYLPSDATLSERVVG
LARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGLRCHDLIERERRAQAARYLAQPGLYLSQIAVLLGYSEQSALNRSC
RRWFGMTPRQYRAYGGVSGR
>Mature_340_residues
MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQEDAFMSLAGFVRMLEASAAELDCPDFGLRLARWQGLGI
LGPVAVIARNAATLFGGLEAIGRYLYVHSPALTLTVSSTTARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGP
QARARVFSFRHAQLGTDAAYREALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRIATKYLESQYLPSDATLSERVVG
LARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGLRCHDLIERERRAQAARYLAQPGLYLSQIAVLLGYSEQSALNRSC
RRWFGMTPRQYRAYGGVSGR

Specific function: May have a role in the regulation of proteins necessary for virulence

COG id: COG2207

COG function: function code K; AraC-type DNA-binding domain-containing proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): VIRS_MYCTU (Q06861)

Other databases:

- EMBL:   X68281
- EMBL:   BX842581
- EMBL:   AE000516
- PIR:   F70852
- RefSeq:   NP_217598.1
- RefSeq:   NP_337689.1
- ProteinModelPortal:   Q06861
- SMR:   Q06861
- EnsemblBacteria:   EBMYCT00000003711
- EnsemblBacteria:   EBMYCT00000069234
- GeneID:   888657
- GeneID:   926683
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3167
- KEGG:   mtu:Rv3082c
- TIGR:   MT3167
- TubercuList:   Rv3082c
- GeneTree:   EBGT00050000016677
- HOGENOM:   HBG677172
- OMA:   YELAMAN
- ProtClustDB:   CLSK792269
- GO:   GO:0005829
- GO:   GO:0009405
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018060
- Gene3D:   G3DSA:1.10.10.60
- SMART:   SM00342

Pfam domain/function: PF00165 HTH_AraC; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 37790; Mature: 37790

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00041 HTH_ARAC_FAMILY_1; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQEDAFMSLAGFVRMLEASA
CCHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AELDCPDFGLRLARWQGLGILGPVAVIARNAATLFGGLEAIGRYLYVHSPALTLTVSSTT
HCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEEECCC
ARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGPQARARVFSFRHAQLGTDAAY
CCCCCEECEEECCCCCCCCCCCCEECHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHH
REALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRIATKYLESQYLPSDATLSERVVG
HHHHCCEEEECCEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGLRCHDLIERERRAQAARYLAQPGLY
HHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHH
LSQIAVLLGYSEQSALNRSCRRWFGMTPRQYRAYGGVSGR
HHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQEDAFMSLAGFVRMLEASA
CCHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AELDCPDFGLRLARWQGLGILGPVAVIARNAATLFGGLEAIGRYLYVHSPALTLTVSSTT
HCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEEECCC
ARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGPQARARVFSFRHAQLGTDAAY
CCCCCEECEEECCCCCCCCCCCCEECHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHH
REALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRIATKYLESQYLPSDATLSERVVG
HHHHCCEEEECCEECCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGLRCHDLIERERRAQAARYLAQPGLY
HHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHH
LSQIAVLLGYSEQSALNRSCRRWFGMTPRQYRAYGGVSGR
HHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8472958; 9634230; 12218036