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The map label for this gene is ppe46

Identifier: 148824208

GI number: 148824208

Start: 3388648

End: 3389952

Strand: Reverse

Name: ppe46

Synonym: TBFG_13033

Alternate gene names: 148824208

Gene position: 3389952-3388648 (Counterclockwise)

Preceding gene: 148824209

Following gene: 148824207

Centisome position: 76.62

GC content: 63.68

Gene sequence:

>1305_bases
GTGACGGCGCCGGTGTGGTTGGCGTCGCCGCCGGAGGTGCATTCGGCGCTGCTAAGTGCTGGTCCGGGGCCGGGTTCGTT
GCAGGCGGCCGCGGCGGGGTGGAGCGCGTTAAGCGCCGAGTACGCCGCTGTGGCGCAAGAGTTGAGCGTGGTGGTGGCCG
CGGTGGGGGCCGGGGTGTGGCAGGGTCCCAGTGCTGAGTTGTTTGTGGCCGCCTATGTGCCGTATGTGGCGTGGTTGGTG
CAGGCCAGTGCGGATAGCGCGGCGGCGGCCGGTGAGCATGAGGCCGCGGCGGCTGGCTATGTTTGTGCGTTGGCGGAGAT
GCCGACGTTGCCGGAGTTGGCGGCCAACCACCTCACGCATGCGGTGTTGGTGGCGACGAATTTCTTTGGGATCAACACGA
TCCCGATCGCGCTCAACGAGGCCGACTATGTGCGGATGTGGGTCCAGGCGGCCACCGTGATGAGCGCCTATGAGGCGGTG
GTGGGTGCCGCGCTGGTGGCCACACCACACACCGGCCCGGCACCGGTCATCGTCAAACCCGGCGCCAATGAAGCCAGCAA
CGCCGTGGCCGCCGCAACCATAACCCCATTCCCATGGCACGAAATTGTACAGTTTTTAGAAGAAACGTTCGCAGCATATG
ACCAGTATCTGTCCGCTTTGCTTTCCGAACTCCCTGCGGTGGCTTGGGTTTGGTTCCAGCTCTTTGTGGATATCCTGGGT
TTCAACATTATTGGGTTCATTATTACGTTGGCATCCAATGCTCAACTATTGACAGAGTTCGCTATCAATGCTTCTTATGT
TGCGGTCGGATTATTGTATGCCATTGCGGGCGTTATAGACATAGTTGTCGAGTGGGTTATTGGGAATCTGTTTGGTGTTG
TTCCCCTTTTGGGGGGGCCGTTGTTGGGGGCGTTGGCCGCTGCTGTGGTTCCGGGTGTAGCTGGGTTGGCCGGGGTGGCG
GGATTGGCCGCTCTGCCGGCGGTGGGTGCGGCTGCTGGCGCGCCGGCGGCGTTGGTGGGCAGTGTGGCGCCGGTGTCGGG
TGGTGTGGTGTCGCCGCAGGCGCGGTTGGTGTCGGCGGTGGAGCCGGCTCCCGCGAGCACGTCGGTGTCGGTGCTGGCTT
CTGATCGGGGTGCTGGGGCGTTGGGGTTTGTTGGGACGGCTGGCAAGGAGTCGGTTGGGCAGCCGGCGGGGTTGACGGTG
TTGGCCGATGAGTTTGGTGATGGTGCGCCGGTGCCGATGCTGCCGGGCAGCTGGGGGCCGGATTTGGTCGGTGTGGCCGG
TGATGGGGGGTTGGTGTCAGTTTGA

Upstream 100 bases:

>100_bases
GCCGCCGCACATTGATTCCGCTAGCGGGTGATCCGGTGTCCTCGCACCGCACGGTCGAGTTCGGTGTCCTGGGCACGTAT
CTGGTTTCGGGTGGGTCGTT

Downstream 100 bases:

>100_bases
CGATCTGACGGCCGTGAACTCGACCAAATTTTCGATCGAAAGAGTGTCTAAAAATCATTGCCCGGAATATTTGAAAGGGA
TTCGTGGTGTCGCAGAGTAT

Product: PPE family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLV
QASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNEADYVRMWVQAATVMSAYEAV
VGAALVATPHTGPAPVIVKPGANEASNAVAAATITPFPWHEIVQFLEETFAAYDQYLSALLSELPAVAWVWFQLFVDILG
FNIIGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIVVEWVIGNLFGVVPLLGGPLLGALAAAVVPGVAGLAGVA
GLAALPAVGAAAGAPAALVGSVAPVSGGVVSPQARLVSAVEPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTV
LADEFGDGAPVPMLPGSWGPDLVGVAGDGGLVSV

Sequences:

>Translated_434_residues
MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLV
QASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNEADYVRMWVQAATVMSAYEAV
VGAALVATPHTGPAPVIVKPGANEASNAVAAATITPFPWHEIVQFLEETFAAYDQYLSALLSELPAVAWVWFQLFVDILG
FNIIGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIVVEWVIGNLFGVVPLLGGPLLGALAAAVVPGVAGLAGVA
GLAALPAVGAAAGAPAALVGSVAPVSGGVVSPQARLVSAVEPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTV
LADEFGDGAPVPMLPGSWGPDLVGVAGDGGLVSV
>Mature_433_residues
TAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQ
ASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNEADYVRMWVQAATVMSAYEAVV
GAALVATPHTGPAPVIVKPGANEASNAVAAATITPFPWHEIVQFLEETFAAYDQYLSALLSELPAVAWVWFQLFVDILGF
NIIGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIVVEWVIGNLFGVVPLLGGPLLGALAAAVVPGVAGLAGVAG
LAALPAVGAAAGAPAALVGSVAPVSGGVVSPQARLVSAVEPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTVL
ADEFGDGAPVPMLPGSWGPDLVGVAGDGGLVSV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPE46_MYCTU (P31500)

Other databases:

- EMBL:   BX842581
- EMBL:   AE000516
- EMBL:   AE000516
- EMBL:   X59271
- PIR:   E70857
- RefSeq:   NP_337613.1
- RefSeq:   NP_337616.1
- RefSeq:   YP_177918.1
- ProteinModelPortal:   P31500
- SMR:   P31500
- EnsemblBacteria:   EBMYCT00000000248
- EnsemblBacteria:   EBMYCT00000072156
- GeneID:   888940
- GeneID:   923197
- GeneID:   926368
- GenomeReviews:   AL123456_GR
- KEGG:   mtu:Rv3018c
- TIGR:   MT3098
- TIGR:   MT3101
- TubercuList:   Rv3018c
- GeneTree:   EBGT00050000014875
- HOGENOM:   HBG572308
- OMA:   MSSHRTP
- ProtClustDB:   CLSK799946
- InterPro:   IPR000030

Pfam domain/function: PF00823 PPE

EC number: NA

Molecular weight: Translated: 43030; Mature: 42898

Theoretical pI: Translated: 3.82; Mature: 3.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSVVVAAVGAGVW
CCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCC
QGPSAELFVAAYVPYVAWLVQASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTH
CCCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
AVLVATNFFGINTIPIALNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKP
HHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEECC
GANEASNAVAAATITPFPWHEIVQFLEETFAAYDQYLSALLSELPAVAWVWFQLFVDILG
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNIIGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIVVEWVIGNLFGVVPLLGGP
HHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LLGALAAAVVPGVAGLAGVAGLAALPAVGAAAGAPAALVGSVAPVSGGVVSPQARLVSAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHC
EPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTVLADEFGDGAPVPMLPGSWGP
CCCCCCCCEEEEECCCCCCCEEECCCCCCHHCCCCCCCEEEECCCCCCCCCCCCCCCCCC
DLVGVAGDGGLVSV
CEEEECCCCCEECC
>Mature Secondary Structure 
TAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSVVVAAVGAGVW
CCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCC
QGPSAELFVAAYVPYVAWLVQASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTH
CCCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
AVLVATNFFGINTIPIALNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKP
HHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEECC
GANEASNAVAAATITPFPWHEIVQFLEETFAAYDQYLSALLSELPAVAWVWFQLFVDILG
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNIIGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIVVEWVIGNLFGVVPLLGGP
HHHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LLGALAAAVVPGVAGLAGVAGLAALPAVGAAAGAPAALVGSVAPVSGGVVSPQARLVSAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHC
EPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTVLADEFGDGAPVPMLPGSWGP
CCCCCCCCEEEEECCCCCCCEEECCCCCCHHCCCCCCCEEEECCCCCCCCCCCCCCCCCC
DLVGVAGDGGLVSV
CEEEECCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036