Click here to switch to the map view.

The map label for this gene is ilvC

Identifier: 148824191

GI number: 148824191

Start: 3371294

End: 3372295

Strand: Reverse

Name: ilvC

Synonym: TBFG_13016

Alternate gene names: 148824191

Gene position: 3372295-3371294 (Counterclockwise)

Preceding gene: 148824192

Following gene: 148824186

Centisome position: 76.22

GC content: 64.47

Gene sequence:

>1002_bases
ATGTTCTACGACGACGACGCAGACCTGTCGATCATTCAGGGCCGCAAGGTTGGTGTGATCGGCTACGGCAGCCAGGGGCA
CGCGCACTCGCTAAGCCTGCGCGACTCGGGTGTGCAGGTGCGCGTCGGGCTGAAGCAGGGTTCGCGGTCGCGGCCCAAGG
TAGAAGAGCAGGGCCTGGACGTCGACACTCCCGCCGAGGTCGCCAAATGGGCCGATGTGGTCATGGTGTTGGCCCCCGAC
ACCGCCCAGGCCGAGATCTTCGCAGGAGACATCGAACCCAACCTCAAGCCCGGTGACGCGCTGTTCTTCGGTCACGGACT
CAACGTTCACTTCGGCTTGATCAAGCCGCCCGCCGACGTCGCCGTCGCGATGGTCGCCCCGAAGGGACCGGGTCATTTGG
TGCGCCGCCAGTTCGTCGACGGCAAGGGTGTGCCGTGTTTGGTTGCGGTAGAGCAGGATCCGCGAGGCGACGGCTTGGCG
CTGGCGCTGTCGTATGCCAAAGCGATCGGCGGCACCCGGGCCGGCGTCATCAAGACGACGTTCAAAGACGAGACCGAAAC
CGACCTGTTCGGTGAGCAAACGGTGTTGTGCGGCGGCACCGAGGAATTGGTCAAGGCCGGGTTCGAGGTCATGGTCGAAG
CCGGCTACCCCGCGGAATTGGCCTACTTCGAGGTGCTGCACGAGCTGAAGCTGATCGTCGACTTGATGTACGAGGGTGGC
CTGGCGCGGATGTACTACTCGGTGTCGGACACCGCGGAATTCGGCGGCTACCTCTCAGGCCCGCGCGTCATCGATGCCGG
CACCAAGGAGCGGATGCGCGACATCCTGCGGGAGATCCAGGACGGTAGCTTTGTCCACAAGCTGGTCGCCGACGTCGAGG
GCGGCAACAAACAGCTCGAAGAGTTGCGCCGGCAAAACGCCGAGCACCCCATCGAGGTCGTCGGCAAGAAACTCCGCGAC
CTGATGAGCTGGGTGGACCGCCCGATCACCGAGACGGCCTAG

Upstream 100 bases:

>100_bases
ATCGCCCAATCCGGAATGGTGTCGCTGTCCCGCGGTCCGCGCGGCATCGGCACCGCCAAGTAGCTAGCAGGTAAGGAGAG
ATTCAGCGGTGGCACTAGAG

Downstream 100 bases:

>100_bases
CTCCTAGGCCGTCTCGACACTGCAGTGATCGTGACCGGCAACCGCCGTGTGCCACGGGGCAGGTCCGCCCCGTTGTGTCA
CCGGCGTCGCTGCCTTCATC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MFYDDDADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPKVEEQGLDVDTPAEVAKWADVVMVLAPD
TAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADVAVAMVAPKGPGHLVRRQFVDGKGVPCLVAVEQDPRGDGLA
LALSYAKAIGGTRAGVIKTTFKDETETDLFGEQTVLCGGTEELVKAGFEVMVEAGYPAELAYFEVLHELKLIVDLMYEGG
LARMYYSVSDTAEFGGYLSGPRVIDAGTKERMRDILREIQDGSFVHKLVADVEGGNKQLEELRRQNAEHPIEVVGKKLRD
LMSWVDRPITETA

Sequences:

>Translated_333_residues
MFYDDDADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPKVEEQGLDVDTPAEVAKWADVVMVLAPD
TAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADVAVAMVAPKGPGHLVRRQFVDGKGVPCLVAVEQDPRGDGLA
LALSYAKAIGGTRAGVIKTTFKDETETDLFGEQTVLCGGTEELVKAGFEVMVEAGYPAELAYFEVLHELKLIVDLMYEGG
LARMYYSVSDTAEFGGYLSGPRVIDAGTKERMRDILREIQDGSFVHKLVADVEGGNKQLEELRRQNAEHPIEVVGKKLRD
LMSWVDRPITETA
>Mature_333_residues
MFYDDDADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPKVEEQGLDVDTPAEVAKWADVVMVLAPD
TAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADVAVAMVAPKGPGHLVRRQFVDGKGVPCLVAVEQDPRGDGLA
LALSYAKAIGGTRAGVIKTTFKDETETDLFGEQTVLCGGTEELVKAGFEVMVEAGYPAELAYFEVLHELKLIVDLMYEGG
LARMYYSVSDTAEFGGYLSGPRVIDAGTKERMRDILREIQDGSFVHKLVADVEGGNKQLEELRRQNAEHPIEVVGKKLRD
LMSWVDRPITETA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=327, Percent_Identity=33.9449541284404, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=305, Percent_Identity=31.4754098360656, Blast_Score=113, Evalue=5e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_MYCBO (P65150)

Other databases:

- EMBL:   BX248344
- RefSeq:   NP_856671.1
- ProteinModelPortal:   P65150
- SMR:   P65150
- EnsemblBacteria:   EBMYCT00000015650
- GeneID:   1093578
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3026c
- GeneTree:   EBGT00050000015910
- HOGENOM:   HBG286525
- OMA:   KDELTAG
- ProtClustDB:   PRK05479
- BioCyc:   MBOV233413:MB3026C-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36091; Mature: 36091

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: ACT_SITE 105-105

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYDDDADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPKVEEQGLD
CCCCCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHCCCC
VDTPAEVAKWADVVMVLAPDTAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADV
CCCHHHHHHHHCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEECCCEEEEEEECCCCCE
AVAMVAPKGPGHLVRRQFVDGKGVPCLVAVEQDPRGDGLALALSYAKAIGGTRAGVIKTT
EEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
FKDETETDLFGEQTVLCGGTEELVKAGFEVMVEAGYPAELAYFEVLHELKLIVDLMYEGG
CCCCCCHHHCCCCEEEECCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
LARMYYSVSDTAEFGGYLSGPRVIDAGTKERMRDILREIQDGSFVHKLVADVEGGNKQLE
EEEEEEECCCHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHH
ELRRQNAEHPIEVVGKKLRDLMSWVDRPITETA
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFYDDDADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPKVEEQGLD
CCCCCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCEEEEEEECCCCCCCCCHHHCCCC
VDTPAEVAKWADVVMVLAPDTAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADV
CCCHHHHHHHHCEEEEECCCCCCCEEEEECCCCCCCCCCEEEEECCCEEEEEEECCCCCE
AVAMVAPKGPGHLVRRQFVDGKGVPCLVAVEQDPRGDGLALALSYAKAIGGTRAGVIKTT
EEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
FKDETETDLFGEQTVLCGGTEELVKAGFEVMVEAGYPAELAYFEVLHELKLIVDLMYEGG
CCCCCCHHHCCCCEEEECCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
LARMYYSVSDTAEFGGYLSGPRVIDAGTKERMRDILREIQDGSFVHKLVADVEGGNKQLE
EEEEEEECCCHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHH
ELRRQNAEHPIEVVGKKLRDLMSWVDRPITETA
HHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972