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The map label for this gene is eccD2

Identifier: 148663754

GI number: 148663754

Start: 4378601

End: 4380130

Strand: Reverse

Name: eccD2

Synonym: MRA_3926

Alternate gene names: 148663754

Gene position: 4380130-4378601 (Counterclockwise)

Preceding gene: 148663755

Following gene: 148663753

Centisome position: 99.1

GC content: 64.9

Gene sequence:

>1530_bases
GTGACTGCGCCGCATAAGGTTGCTTTCCCGGCACGTTGTGCGGTCAACATTTGCTACGACAAGCATCTATGCTCCCAGGT
ATTCCCCGCCGGAATTCCAGTAGAGGGATTCTTCGAAGGAATGGTGGAGTTGTTCGATGCCGATCTGAAGCGCAAAGGTT
TCGACGGGGTTGCGCTGCCGGCGGGTAGCTATGAGCTACACAAGATCAACGGGGTGCGGCTGGACATCAACAAGAGCCTC
GACGAGCTGGGCGTTCAAGACGGTGACACGCTGGTGCTAGTACCCCGGGTTGCTGGCGAGTCGTTTGAGCCACAGTACGA
ATCGCTATCCACCGGGCTGGCGGCCATGGGCAAGTGGCTGGGGCGTGACGGCGGGGATCGGATGTTTGCGCCGGTAACCT
CGCTGACTGCCGCCCACACCGCCATGGCGATTATCGCCATGGCGGTCGGAGTGGTGCTGGCCCTGACGTTGCGGACACGC
ACAATCACCGACAGCCCGGTCCCAGCTGCGATGGCTGGCGGGATTGGTGTGCTCCTGGTGATCGGGGCATTGGTGGTGTG
GTGGGGTTGGCGGGAGCGCCGTGACCTGTTCAGTGGGTTCGGGTGGCTGGCGGTGGTGTTGCTTGCCGTGGCCGCCGCGT
GCGCGCCGCCGGGCGCGCTCGGGGCGGCTCATGCGCTGATCGGGCTCGTGGTGGTGGTTCTGGGTGCGATCACGATCGGC
GTGGCGACCCGCAAGCGGTGGCAGACCGCAGTGGTCACCGCGGTGGTAACGGTGTGCGGGATCCTTGCCGCTGTCGCCGC
CGTCCGAATGTTTAGGCCGGTTTCGATGCAGGTGCTGGCGATTTGCGTGCTGGTAGGGCTGCTTGTCCTGATCAGGATGA
CTCCGACCGTTGCGTTGTGGGTGGCACGGGTACGACCCCCGCACTTCGGATCGATCACCGGCCGGGATCTGTTCGCGCGC
CGTGCGGGAATGCCCGTCGATACGGTGGCTCCGGTCAGCGAAGCCGACGCCGACGATGAGGACAATGAACTGACCGACAT
CACCGCCCGCGGCACCGCGATCGCCGCGTCGGCGCGGCTGGTTAACGCGGTACAGGTGGGTATGTGCGTCGGGGTGTCGC
TCGTACTGCCCGCCGCGGTATGGGGGGTGCTGACGCCACGTCAACCGTGGGCCTGGTTGGCGTTGTTGGTTGCCGGCTTG
ACGGTGGGCCTCTTCATCACCCAGGGCCGCGGGTTCGCCGCCAAATACCAAGCGGTCGCATTGGTGTGCGGGGCGTCCGC
CGCGGTGTGTGCCGGGGTGCTTAAGTACGCCCTCGACACCCCGAAAGGTGTTCAGACCGGGCTGCTTTGGCCTGCGATCT
TCGTCGCGGCTTTCGCCGCATTGGGTTTGGCCGTGGCCCTCGTGGTACCGGCGACGCGGTTTAGGCCGATCATCCGGTTG
ACCGTGGAATGGCTAGAAGTGCTGGCCATGATCGCGTTGTTACCAGCGGCTGCGGCCCTAGGGGGGCTGTTTGCATGGCT
TCGCCACTAA

Upstream 100 bases:

>100_bases
ATACGGTGCATGAATTAAATAAGAAGTCGCGGTTGCGGCTTTTCGAAATCACCGCCGGATTGGCCGACAAATACGTTCCG
GATGCCGAACGGGCGGCGCA

Downstream 100 bases:

>100_bases
ACCGACCTGGCCTGCGGGCCGCGGCCGCGAGCGCCGCCCTCACCCTCGTTGCTTTGTCAGCTAATGTTCCTGCGGCACAG
GCTATCCCACCGCCGTCGGT

Product: putative transmembrane protein

Products: NA

Alternate protein names: ESX conserved component D2; Type VII secretion system protein eccD2; T7SS protein eccD2

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTAPHKVAFPARCAVNICYDKHLCSQVFPAGIPVEGFFEGMVELFDADLKRKGFDGVALPAGSYELHKINGVRLDINKSL
DELGVQDGDTLVLVPRVAGESFEPQYESLSTGLAAMGKWLGRDGGDRMFAPVTSLTAAHTAMAIIAMAVGVVLALTLRTR
TITDSPVPAAMAGGIGVLLVIGALVVWWGWRERRDLFSGFGWLAVVLLAVAAACAPPGALGAAHALIGLVVVVLGAITIG
VATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVSMQVLAICVLVGLLVLIRMTPTVALWVARVRPPHFGSITGRDLFAR
RAGMPVDTVAPVSEADADDEDNELTDITARGTAIAASARLVNAVQVGMCVGVSLVLPAAVWGVLTPRQPWAWLALLVAGL
TVGLFITQGRGFAAKYQAVALVCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVALVVPATRFRPIIRL
TVEWLEVLAMIALLPAAAALGGLFAWLRH

Sequences:

>Translated_509_residues
MTAPHKVAFPARCAVNICYDKHLCSQVFPAGIPVEGFFEGMVELFDADLKRKGFDGVALPAGSYELHKINGVRLDINKSL
DELGVQDGDTLVLVPRVAGESFEPQYESLSTGLAAMGKWLGRDGGDRMFAPVTSLTAAHTAMAIIAMAVGVVLALTLRTR
TITDSPVPAAMAGGIGVLLVIGALVVWWGWRERRDLFSGFGWLAVVLLAVAAACAPPGALGAAHALIGLVVVVLGAITIG
VATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVSMQVLAICVLVGLLVLIRMTPTVALWVARVRPPHFGSITGRDLFAR
RAGMPVDTVAPVSEADADDEDNELTDITARGTAIAASARLVNAVQVGMCVGVSLVLPAAVWGVLTPRQPWAWLALLVAGL
TVGLFITQGRGFAAKYQAVALVCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVALVVPATRFRPIIRL
TVEWLEVLAMIALLPAAAALGGLFAWLRH
>Mature_508_residues
TAPHKVAFPARCAVNICYDKHLCSQVFPAGIPVEGFFEGMVELFDADLKRKGFDGVALPAGSYELHKINGVRLDINKSLD
ELGVQDGDTLVLVPRVAGESFEPQYESLSTGLAAMGKWLGRDGGDRMFAPVTSLTAAHTAMAIIAMAVGVVLALTLRTRT
ITDSPVPAAMAGGIGVLLVIGALVVWWGWRERRDLFSGFGWLAVVLLAVAAACAPPGALGAAHALIGLVVVVLGAITIGV
ATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVSMQVLAICVLVGLLVLIRMTPTVALWVARVRPPHFGSITGRDLFARR
AGMPVDTVAPVSEADADDEDNELTDITARGTAIAASARLVNAVQVGMCVGVSLVLPAAVWGVLTPRQPWAWLALLVAGLT
VGLFITQGRGFAAKYQAVALVCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVALVVPATRFRPIIRLT
VEWLEVLAMIALLPAAAALGGLFAWLRH

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eccD/snm4 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECCD2_MYCTU (O05457)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   H70597
- RefSeq:   NP_218404.1
- RefSeq:   NP_338555.1
- ProteinModelPortal:   O05457
- EnsemblBacteria:   EBMYCT00000002021
- EnsemblBacteria:   EBMYCT00000069769
- GeneID:   886211
- GeneID:   926278
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT4002
- KEGG:   mtu:Rv3887c
- TIGR:   MT4002
- TubercuList:   Rv3887c
- GeneTree:   EBGT00050000016341
- HOGENOM:   HBG564734
- OMA:   EVLAFIV
- ProtClustDB:   CLSK792788
- InterPro:   IPR006707
- TIGRFAMs:   TIGR02958

Pfam domain/function: PF04600 DUF571

EC number: NA

Molecular weight: Translated: 53279; Mature: 53148

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x22980320)-; HASH(0x22d9519c)-; HASH(0x226e91a4)-; HASH(0x22e33ca8)-; HASH(0x22c86518)-; HASH(0x22a21d08)-; HASH(0x22d8f64c)-; HASH(0x22a3d458)-; HASH(0x22e2a560)-; HASH(0x2149c004)-; HASH(0x22b36a04)-;

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPHKVAFPARCAVNICYDKHLCSQVFPAGIPVEGFFEGMVELFDADLKRKGFDGVALP
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECC
AGSYELHKINGVRLDINKSLDELGVQDGDTLVLVPRVAGESFEPQYESLSTGLAAMGKWL
CCCCEEEEECCEEEECCCCHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
GRDGGDRMFAPVTSLTAAHTAMAIIAMAVGVVLALTLRTRTITDSPVPAAMAGGIGVLLV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHH
IGALVVWWGWRERRDLFSGFGWLAVVLLAVAAACAPPGALGAAHALIGLVVVVLGAITIG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
VATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVSMQVLAICVLVGLLVLIRMTPTVALW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHH
VARVRPPHFGSITGRDLFARRAGMPVDTVAPVSEADADDEDNELTDITARGTAIAASARL
HHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHH
VNAVQVGMCVGVSLVLPAAVWGVLTPRQPWAWLALLVAGLTVGLFITQGRGFAAKYQAVA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHH
LVCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVALVVPATRFRPIIRL
HHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
TVEWLEVLAMIALLPAAAALGGLFAWLRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
TAPHKVAFPARCAVNICYDKHLCSQVFPAGIPVEGFFEGMVELFDADLKRKGFDGVALP
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECC
AGSYELHKINGVRLDINKSLDELGVQDGDTLVLVPRVAGESFEPQYESLSTGLAAMGKWL
CCCCEEEEECCEEEECCCCHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHH
GRDGGDRMFAPVTSLTAAHTAMAIIAMAVGVVLALTLRTRTITDSPVPAAMAGGIGVLLV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCHHHHHHH
IGALVVWWGWRERRDLFSGFGWLAVVLLAVAAACAPPGALGAAHALIGLVVVVLGAITIG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
VATRKRWQTAVVTAVVTVCGILAAVAAVRMFRPVSMQVLAICVLVGLLVLIRMTPTVALW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHH
VARVRPPHFGSITGRDLFARRAGMPVDTVAPVSEADADDEDNELTDITARGTAIAASARL
HHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHH
VNAVQVGMCVGVSLVLPAAVWGVLTPRQPWAWLALLVAGLTVGLFITQGRGFAAKYQAVA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHH
LVCGASAAVCAGVLKYALDTPKGVQTGLLWPAIFVAAFAALGLAVALVVPATRFRPIIRL
HHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
TVEWLEVLAMIALLPAAAALGGLFAWLRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036