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The map label for this gene is tcmR [H]

Identifier: 148663698

GI number: 148663698

Start: 4313502

End: 4314131

Strand: Reverse

Name: tcmR [H]

Synonym: MRA_3870

Alternate gene names: 148663698

Gene position: 4314131-4313502 (Counterclockwise)

Preceding gene: 148663700

Following gene: 148663697

Centisome position: 97.61

GC content: 64.6

Gene sequence:

>630_bases
ATGGTCCGGCCCCCGCAGACGGCGCGCAGCGAACGCACTCGCGAGGCACTGCGCCAGGCCGCCCTGGTGCGATTTCTGGC
CCAGGGCGTCGAGGCTACCTCAGCCGAGCAGATTGCGGAGGACGCCGGGGTGTCGCTGCGTACTTTCTATCGCCACTTCA
GATCCAAGCACGATTTGCTGTTTGCCGACTACGACGCCGGACTGCACTGGTTTCGCGCGGCGCTGGATGCTAGACCGGCC
GACGAATCGATCATCGATTCCGTGCAAGCGGCTATCTTCTCGTTTCCTTATGACGTTGACGCAGTGACGAAGATTGCGTC
GTTGCGGCGCGGCGAGTTGGAGCCGAGCCGGATCGTCCGCCATATGCGCGAGGTGGAAGCCGACTTCGCCGATGCCATCC
AGGCCCAATTGCGGCGACGTAACTGCGATATCGCGGGTGCACCCGATGCCCGATTGCACATCGCCGTCACCGCACGATGC
GTCGCCGCGGCGGTGTTCGGCGCGATGGAAGCCTGGATGCTTGGGAGTGACCGGTCGCTCGGGGAGCTGGCGCGGGTCTG
CCACGTCGCACTGGAGTCGCTGCGCGTCGGCATCTCCGACACCTGGACCACCCTCACAGTTTCGTCATAA

Upstream 100 bases:

>100_bases
AGCGCAGCGTGAACAAGAAGCGACACCATGCGCGCAGTCTCGCCGTGGCCAACAGTTTTGTCAATGTTGACAGAACGAAA
ATTGACGATAGCTTGCAGTC

Downstream 100 bases:

>100_bases
TTGACAAAACATCGAGCGCGTGCGAGCCTGCATTGCTGGAGACGCGTATGACTGGTTATGACGCGATAGTTATCGGCGCC
GGGCACAACGGGCTGACCGC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MVRPPQTARSERTREALRQAALVRFLAQGVEATSAEQIAEDAGVSLRTFYRHFRSKHDLLFADYDAGLHWFRAALDARPA
DESIIDSVQAAIFSFPYDVDAVTKIASLRRGELEPSRIVRHMREVEADFADAIQAQLRRRNCDIAGAPDARLHIAVTARC
VAAAVFGAMEAWMLGSDRSLGELARVCHVALESLRVGISDTWTTLTVSS

Sequences:

>Translated_209_residues
MVRPPQTARSERTREALRQAALVRFLAQGVEATSAEQIAEDAGVSLRTFYRHFRSKHDLLFADYDAGLHWFRAALDARPA
DESIIDSVQAAIFSFPYDVDAVTKIASLRRGELEPSRIVRHMREVEADFADAIQAQLRRRNCDIAGAPDARLHIAVTARC
VAAAVFGAMEAWMLGSDRSLGELARVCHVALESLRVGISDTWTTLTVSS
>Mature_209_residues
MVRPPQTARSERTREALRQAALVRFLAQGVEATSAEQIAEDAGVSLRTFYRHFRSKHDLLFADYDAGLHWFRAALDARPA
DESIIDSVQAAIFSFPYDVDAVTKIASLRRGELEPSRIVRHMREVEADFADAIQAQLRRRNCDIAGAPDARLHIAVTARC
VAAAVFGAMEAWMLGSDRSLGELARVCHVALESLRVGISDTWTTLTVSS

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23124; Mature: 23124

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRPPQTARSERTREALRQAALVRFLAQGVEATSAEQIAEDAGVSLRTFYRHFRSKHDLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCEE
FADYDAGLHWFRAALDARPADESIIDSVQAAIFSFPYDVDAVTKIASLRRGELEPSRIVR
EEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHH
HMREVEADFADAIQAQLRRRNCDIAGAPDARLHIAVTARCVAAAVFGAMEAWMLGSDRSL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCH
GELARVCHVALESLRVGISDTWTTLTVSS
HHHHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MVRPPQTARSERTREALRQAALVRFLAQGVEATSAEQIAEDAGVSLRTFYRHFRSKHDLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCEE
FADYDAGLHWFRAALDARPADESIIDSVQAAIFSFPYDVDAVTKIASLRRGELEPSRIVR
EEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHH
HMREVEADFADAIQAQLRRRNCDIAGAPDARLHIAVTARCVAAAVFGAMEAWMLGSDRSL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCH
GELARVCHVALESLRVGISDTWTTLTVSS
HHHHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]