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The map label for this gene is ribG

Identifier: 148661200

GI number: 148661200

Start: 1586504

End: 1587523

Strand: Direct

Name: ribG

Synonym: MRA_1418

Alternate gene names: 148661200

Gene position: 1586504-1587523 (Clockwise)

Preceding gene: 148661199

Following gene: 148661203

Centisome position: 35.89

GC content: 67.94

Gene sequence:

>1020_bases
ATGAACGTGGAGCAGGTCAAGAGCATCGACGAGGCTATGGGTCTCGCCATCGAGCACTCCTACCAGGTCAAAGGCACGAC
TTATCCAAAACCCCCAGTGGGGGCCGTCATTGTGGATCCCAACGGTCGGATCGTCGGCGCCGGCGGCACCGAGCCGGCCG
GTGGCGATCATGCCGAGGTGGTGGCGCTGCGCCGGGCCGGCGGATTGGCTGCCGGCGCCATCGTGGTGGTCACCATGGAA
CCCTGTAACCACTACGGCAAGACTCCGCCATGCGTGAACGCTCTGATCGAAGCCAGGGTGGGGACGGTGGTCTACGCCGT
CGCCGACCCGAACGGGATCGCTGGGGGTGGCGCGGGCCGGCTGTCAGCAGCGGGCCTACAGGTGCGGTCCGGGGTGTTGG
CTGAACAGGTGGCGGCCGGACCGCTGCGGGAGTGGCTCCACAAGCAACGCACCGGTCTGCCGCATGTCACCTGGAAGTAC
GCCACCAGCATCGACGGCCGCAGCGCCGCCGCCGACGGCTCCAGCCAGTGGATCTCCAGCGAGGCCGCACGCCTGGATCT
GCATCGCCGCCGCGCCATCGCCGACGCGATCTTGGTCGGCACCGGCACCGTCCTCGCCGACGACCCGGCCCTGACCGCGC
GGCTGGCCGACGGCTCGCTGGCGCCGCAGCAGCCGCTGCGCGTGGTGGTGGGCAAGCGCGACATACCGCCGGAAGCACGG
GTCCTCAACGACGAGGCACGCACCATGATGATCCGCACCCACGAACCTATGGAGGTGCTCAGGGCGTTGTCGGATCGCAC
CGACGTGCTGCTGGAAGGAGGTCCCACCCTCGCCGGCGCCTTCCTACGAGCGGGTGCGATCAACCGGATCCTGGCCTACG
TCGCACCGATCCTGTTGGGCGGTCCGGTTACCGCGGTCGATGACGTCGGGGTGTCCAACATCACCAACGCGTTGCGTTGG
CAGTTCGACAGCGTCGAAAAGGTCGGACCGGATCTGTTGCTGAGCTTGGTGGCTCGTTAG

Upstream 100 bases:

>100_bases
GCTTTGTCGCCGGATCGGCGGTGTACGGCGCCGATGACCCGGCCGCGGCGGTTGCGGCACTACGGCGACAGGCCGGTGCC
GCCTCACTCCACCTGAGCCT

Downstream 100 bases:

>100_bases
AGCGGCTCCACTTGGGGCGCCAGGGTCGGTTGCTCCTGGACTTCCGGTTCATCGGCATGTTCCTTGCGGCCGCTGATCAA
CAGACCTAGCACCGCGCCGA

Product: riboflavin-specific deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIVGAGGTEPAGGDHAEVVALRRAGGLAAGAIVVVTME
PCNHYGKTPPCVNALIEARVGTVVYAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKY
ATSIDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAPQQPLRVVVGKRDIPPEAR
VLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAFLRAGAINRILAYVAPILLGGPVTAVDDVGVSNITNALRW
QFDSVEKVGPDLLLSLVAR

Sequences:

>Translated_339_residues
MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIVGAGGTEPAGGDHAEVVALRRAGGLAAGAIVVVTME
PCNHYGKTPPCVNALIEARVGTVVYAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKY
ATSIDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAPQQPLRVVVGKRDIPPEAR
VLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAFLRAGAINRILAYVAPILLGGPVTAVDDVGVSNITNALRW
QFDSVEKVGPDLLLSLVAR
>Mature_339_residues
MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIVGAGGTEPAGGDHAEVVALRRAGGLAAGAIVVVTME
PCNHYGKTPPCVNALIEARVGTVVYAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKY
ATSIDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAPQQPLRVVVGKRDIPPEAR
VLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAFLRAGAINRILAYVAPILLGGPVTAVDDVGVSNITNALRW
QFDSVEKVGPDLLLSLVAR

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family

Homologues:

Organism=Escherichia coli, GI1786616, Length=364, Percent_Identity=39.5604395604396, Blast_Score=225, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBD_MYCTU (P71677)

Other databases:

- EMBL:   BX842576
- EMBL:   AE000516
- PIR:   F70901
- RefSeq:   NP_215925.1
- RefSeq:   NP_335904.1
- ProteinModelPortal:   P71677
- SMR:   P71677
- EnsemblBacteria:   EBMYCT00000000165
- EnsemblBacteria:   EBMYCT00000069653
- GeneID:   886721
- GeneID:   924519
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT1453
- KEGG:   mtu:Rv1409
- TIGR:   MT1453
- TubercuList:   Rv1409
- GeneTree:   EBGT00050000016519
- HOGENOM:   HBG668075
- OMA:   NPLRVVM
- ProtClustDB:   CLSK791144
- BRENDA:   1.1.1.193
- BRENDA:   3.5.4.26
- GO:   GO:0005829
- GO:   GO:0040007
- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734
- PANTHER:   PTHR11079:SF10
- TIGRFAMs:   TIGR00326
- TIGRFAMs:   TIGR00227

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C; SSF53927 Cytidine_deaminase-like

EC number: =3.5.4.26; =1.1.1.193

Molecular weight: Translated: 35367; Mature: 35367

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: ACT_SITE 59-59 BINDING 161-161 BINDING 175-175 BINDING 177-177 BINDING 191-191 BINDING 203-203 BINDING 207-207 BINDING 211-211 BINDING 214-214 BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIVGAGGTEPAGGDHAEV
CCHHHHHHHHHHHCEEEECCEEECCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCHHHE
VALRRAGGLAAGAIVVVTMEPCNHYGKTPPCVNALIEARVGTVVYAVADPNGIAGGGAGR
EEEHHCCCCEECEEEEEEECCHHCCCCCCHHHHHHHHHHHCEEEEEEECCCCCCCCCCCC
LSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKYATSIDGRSAAADGSSQWISS
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHH
EAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAPQQPLRVVVGKRDIPPEAR
HHHHHHHHHHHHHHHHHEEECCCEEECCCCEEEEECCCCCCCCCCCEEEECCCCCCCHHH
VLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAFLRAGAINRILAYVAPILLG
EECCCHHEEEEECCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
GPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLLSLVAR
CCCCCHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCC
>Mature Secondary Structure
MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIVGAGGTEPAGGDHAEV
CCHHHHHHHHHHHCEEEECCEEECCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCHHHE
VALRRAGGLAAGAIVVVTMEPCNHYGKTPPCVNALIEARVGTVVYAVADPNGIAGGGAGR
EEEHHCCCCEECEEEEEEECCHHCCCCCCHHHHHHHHHHHCEEEEEEECCCCCCCCCCCC
LSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKYATSIDGRSAAADGSSQWISS
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHH
EAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAPQQPLRVVVGKRDIPPEAR
HHHHHHHHHHHHHHHHHEEECCCEEECCCCEEEEECCCCCCCCCCCEEEECCCCCCCHHH
VLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAFLRAGAINRILAYVAPILLG
EECCCHHEEEEECCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
GPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLLSLVAR
CCCCCHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036