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The map label for this gene is pyrC [H]

Identifier: 148661172

GI number: 148661172

Start: 1555498

End: 1556790

Strand: Direct

Name: pyrC [H]

Synonym: MRA_1390

Alternate gene names: 148661172

Gene position: 1555498-1556790 (Clockwise)

Preceding gene: 148661171

Following gene: 148661173

Centisome position: 35.19

GC content: 69.68

Gene sequence:

>1293_bases
GTGAGCGTGCTGATTCGTGGTGTGCGGCCCTACGGCGAGGGGGAGCGGGTCGACGTACTCGTCGATGACGGCCAGATCGC
CCAGATAGGACCGGATCTGGCGATCCCCGATACGGCCGATGTCATTGACGCCACCGGACACGTGCTGCTGCCCGGGTTCG
TCGATCTGCACACCCATCTGCGCGAGCCGGGCCGCGAGTATGCCGAGGACATCGAAACCGGTTCGGCCGCGGCCGCTTTG
GGCGGCTACACCGCGGTGTTCGCGATGGCCAACACCAACCCCGTGGCCGACAGCCCGGTGGTCACCGACCACGTCTGGCA
CCGCGGCCAGCAGGTCGGCCTGGTCGACGTGCACCCCGTCGGCGCGGTCACCGTCGGGCTGGCCGGAGCCGAGCTGACCG
AGATGGGCATGATGAACGCCGGCGCCGCCCAGGTGCGGATGTTCTCCGACGACGGGGTCTGCGTGCATGACCCGCTGATC
ATGCGCCGCGCCCTGGAATATGCCACCGGTTTGGGCGTGCTGATCGCCCAGCACGCCGAGGAGCCCCGGCTGACGGTCGG
CGCCGTCGCGCACGAGGGACCCATGGCGGCGCGGCTGGGCCTGGCGGGATGGCCGCGGGCCGCCGAGGAATCGATCGTCG
CCCGCGACGCCTTGCTGGCCCGTGACGCCGGCGCCCGGGTGCACATCTGTCACGCGTCGGCCGCGGGCACCGTCGAAATC
CTGAAATGGGCTAAGGACCAGGGTATTTCGATCACCGCCGAGGTCACCCCCCACCACCTGTTGCTCGACGATGCCAGATT
GGCCAGCTATGACGGCGTGAACCGGGTCAACCCGCCGCTGCGCGAAGCTTCCGACGCGGTCGCCCTGCGACAGGCGCTGG
CCGACGGGATCATCGACTGTGTGGCCACAGATCACGCCCCGCATGCCGAGCACGAGAAATGCGTCGAATTCGCCGCGGCC
CGGCCCGGCATGCTCGGGTTGCAGACGGCATTGTCGGTGGTGGTGCAGACAATGGTGGCGCCCGGCTTGTTGAGTTGGCG
CGATATCGCGCGGGTGATGAGTGAGAACCCGGCGTGCATCGCACGCTTGCCCGATCAGGGCCGGCCACTGGAGGTGGGGG
AGCCGGCCAACCTGACGGTGGTGGACCCCGACGCCACCTGGACGGTCACCGGCGCCGACCTGGCCAGCCGGTCGGCCAAC
ACGCCGTTTGAGTCGATGAGCCTGCCCGCCACCGTGACCGCGACCCTGCTGCGCGGGAAGGTGACCGCGCGCGACGGGAA
GATCCGGGCATGA

Upstream 100 bases:

>100_bases
CGGCTGTGCTGCAACAGGTTTCCAATGGAGTCCAGGTGCGGATGGCGGTGCTGTTCCATGTGCTGGTGGGAGCGCAGGAT
GCCGGTAAAGAGGGTGCGGC

Downstream 100 bases:

>100_bases
ACTCCGGCACGCTGGCGGGGTCGCTGATCTTCGCGGCGGTGCTCGTCATGCTGATCGCGGTGCTCGCTCGGCTGATGATG
CGCGGCTGGCGGCGCCGTTC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAAL
GGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLI
MRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEI
LKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAA
RPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSAN
TPFESMSLPATVTATLLRGKVTARDGKIRA

Sequences:

>Translated_430_residues
MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAAL
GGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLI
MRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEI
LKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAA
RPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSAN
TPFESMSLPATVTATLLRGKVTARDGKIRA
>Mature_429_residues
SVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALG
GYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIM
RRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEIL
KWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAAR
PGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSANT
PFESMSLPATVTATLLRGKVTARDGKIRA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=406, Percent_Identity=30.7881773399015, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI4503051, Length=451, Percent_Identity=26.3858093126386, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI62422571, Length=450, Percent_Identity=26.4444444444444, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI19923821, Length=466, Percent_Identity=26.1802575107296, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI4503375, Length=465, Percent_Identity=25.8064516129032, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786722, Length=428, Percent_Identity=30.3738317757009, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87082175, Length=442, Percent_Identity=25.3393665158371, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193204318, Length=407, Percent_Identity=29.97542997543, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI86575075, Length=432, Percent_Identity=24.7685185185185, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=398, Percent_Identity=26.3819095477387, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24642586, Length=398, Percent_Identity=31.4070351758794, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17137462, Length=443, Percent_Identity=23.7020316027088, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221377917, Length=449, Percent_Identity=24.7216035634744, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI18859883, Length=413, Percent_Identity=27.6029055690073, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45193; Mature: 45062

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHL
CCEEEECCCCCCCCCEEEEEECCCEEEECCCCCCCCCCHHHHHCCCCEEECCHHHHHHHH
REPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPV
CCCHHHHHHHHCCCCHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHCCCEECEEEECCC
GAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIMRRALEYATGLGVLIAQHAE
CEEEEECCCCHHHHHCCCCCCCEEEEEECCCCEEEECHHHHHHHHHHHHCHHHHEECCCC
EPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEI
CCCEEEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
LKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDC
HHHHCCCCCEEEEECCCCEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACI
HCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEE
ARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSANTPFESMSLPATVTATLLRGK
EECCCCCCCCCCCCCCCEEEECCCCCEEEECHHHHCCCCCCCHHHCCCCHHHHHHHHHCE
VTARDGKIRA
EEECCCCCCC
>Mature Secondary Structure 
SVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHL
CEEEECCCCCCCCCEEEEEECCCEEEECCCCCCCCCCHHHHHCCCCEEECCHHHHHHHH
REPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPV
CCCHHHHHHHHCCCCHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHCCCEECEEEECCC
GAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIMRRALEYATGLGVLIAQHAE
CEEEEECCCCHHHHHCCCCCCCEEEEEECCCCEEEECHHHHHHHHHHHHCHHHHEECCCC
EPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEI
CCCEEEEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
LKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDC
HHHHCCCCCEEEEECCCCEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACI
HCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEE
ARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSANTPFESMSLPATVTATLLRGK
EECCCCCCCCCCCCCCCEEEECCCCCEEEECHHHHCCCCCCCHHHCCCCHHHHHHHHHCE
VTARDGKIRA
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]