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The map label for this gene is mapA [H]

Identifier: 148660509

GI number: 148660509

Start: 827976

End: 828776

Strand: Direct

Name: mapA [H]

Synonym: MRA_0742

Alternate gene names: 148660509

Gene position: 827976-828776 (Clockwise)

Preceding gene: 148660508

Following gene: 148660510

Centisome position: 18.73

GC content: 68.41

Gene sequence:

>801_bases
ATGCGCCCACTGGCACGGCTGCGGGGTCGCAGGGTCGTGCCGCAGCGCAGTGCCGGCGAACTCGACGCGATGGCCGCGGC
GGGCGCCGTCGTTGCCGCCGCGCTGCGGGCGATCCGTGCGGCAGCGGCTCCCGGCACATCCAGCCTGAGTCTCGACGAGA
TCGCCGAGTCGGTGATCCGCGAATCCGGCGCCACCCCGTCGTTTCTGGGCTATCACGGCTACCCGGCCTCGATCTGCGCG
TCGATCAACGACCGGGTGGTTCATGGCATCCCGTCGACCGCCGAGGTGCTCGCGCCCGGTGATCTGGTATCCATCGACTG
CGGTGCGGTGCTGGACGGTTGGCATGGCGATGCGGCGATCACTTTCGGGGTTGGCGCCCTGAGCGACGCCGACGAAGCGC
TGTCGGAGGCGACAAGGGAATCGCTTCAGGCCGGCATCGCCGCGATGGTGGTCGGCAATCGGTTGACCGACGTCGCGCAT
GCCATCGAAACGGGTACCCGTGCCGCCGAGCTCCGTTATGGACGCTCGTTCGGGATCGTCGCCGGTTACGGGGGCCACGG
CATCGGCCGCCAGATGCATATGGATCCGTTCTTGCCGAACGAGGGTGCGCCGGGGCGCGGTCCGCTGCTGGCTGCCGGCT
CGGTGCTGGCCATCGAACCGATGCTGACCCTCGGTACCACCAAAACGGTGGTGCTCGACGACAAATGGACGGTCACGACC
GCCGATGGGTCACGTGCGGCACACTGGGAACACACCGTGGCGGTAACCGACGACGGGCCCCGAATTCTGACGCTCGGTTA
G

Upstream 100 bases:

>100_bases
CGCTGCTGGAGTACTACCGCGACCAATTGAAGACCGTCGACGCCGTCGGCACCATGGACGAGGTGTTCGCCCGTGCGTTG
CGGGCTCTGGGAAAGTAGTC

Downstream 100 bases:

>100_bases
CGCGGCTGCCGGCGCGGGCAGTGGTGAACCAAACTCTTACTCGACTCGTGTCAGTAAGCGGGAGGTGATCGCGTGGCTCG
TGTGTCGGGCGCCGCGGCCG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MRPLARLRGRRVVPQRSAGELDAMAAAGAVVAAALRAIRAAAAPGTSSLSLDEIAESVIRESGATPSFLGYHGYPASICA
SINDRVVHGIPSTAEVLAPGDLVSIDCGAVLDGWHGDAAITFGVGALSDADEALSEATRESLQAGIAAMVVGNRLTDVAH
AIETGTRAAELRYGRSFGIVAGYGGHGIGRQMHMDPFLPNEGAPGRGPLLAAGSVLAIEPMLTLGTTKTVVLDDKWTVTT
ADGSRAAHWEHTVAVTDDGPRILTLG

Sequences:

>Translated_266_residues
MRPLARLRGRRVVPQRSAGELDAMAAAGAVVAAALRAIRAAAAPGTSSLSLDEIAESVIRESGATPSFLGYHGYPASICA
SINDRVVHGIPSTAEVLAPGDLVSIDCGAVLDGWHGDAAITFGVGALSDADEALSEATRESLQAGIAAMVVGNRLTDVAH
AIETGTRAAELRYGRSFGIVAGYGGHGIGRQMHMDPFLPNEGAPGRGPLLAAGSVLAIEPMLTLGTTKTVVLDDKWTVTT
ADGSRAAHWEHTVAVTDDGPRILTLG
>Mature_266_residues
MRPLARLRGRRVVPQRSAGELDAMAAAGAVVAAALRAIRAAAAPGTSSLSLDEIAESVIRESGATPSFLGYHGYPASICA
SINDRVVHGIPSTAEVLAPGDLVSIDCGAVLDGWHGDAAITFGVGALSDADEALSEATRESLQAGIAAMVVGNRLTDVAH
AIETGTRAAELRYGRSFGIVAGYGGHGIGRQMHMDPFLPNEGAPGRGPLLAAGSVLAIEPMLTLGTTKTVVLDDKWTVTT
ADGSRAAHWEHTVAVTDDGPRILTLG

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=258, Percent_Identity=31.0077519379845, Blast_Score=137, Evalue=9e-33,
Organism=Homo sapiens, GI40385867, Length=219, Percent_Identity=34.2465753424658, Blast_Score=128, Evalue=7e-30,
Organism=Escherichia coli, GI1786364, Length=251, Percent_Identity=37.4501992031873, Blast_Score=173, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI71996291, Length=258, Percent_Identity=32.9457364341085, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323273, Length=267, Percent_Identity=33.7078651685393, Blast_Score=145, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24583427, Length=252, Percent_Identity=36.9047619047619, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=32.6530612244898, Blast_Score=137, Evalue=9e-33,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27277; Mature: 27277

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLARLRGRRVVPQRSAGELDAMAAAGAVVAAALRAIRAAAAPGTSSLSLDEIAESVIR
CCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ESGATPSFLGYHGYPASICASINDRVVHGIPSTAEVLAPGDLVSIDCGAVLDGWHGDAAI
HCCCCCCEEECCCCHHHHHHCCCCCEEECCCCCHHHCCCCCEEEECCCCEECCCCCCEEE
TFGVGALSDADEALSEATRESLQAGIAAMVVGNRLTDVAHAIETGTRAAELRYGRSFGIV
EEECCCCCCHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCCEE
AGYGGHGIGRQMHMDPFLPNEGAPGRGPLLAAGSVLAIEPMLTLGTTKTVVLDDKWTVTT
EECCCCCCCCCEECCCCCCCCCCCCCCCEEECCCEEEECCEEEECCCEEEEECCCEEEEE
ADGSRAAHWEHTVAVTDDGPRILTLG
CCCCCCCCCEEEEEEECCCCEEEEEC
>Mature Secondary Structure
MRPLARLRGRRVVPQRSAGELDAMAAAGAVVAAALRAIRAAAAPGTSSLSLDEIAESVIR
CCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ESGATPSFLGYHGYPASICASINDRVVHGIPSTAEVLAPGDLVSIDCGAVLDGWHGDAAI
HCCCCCCEEECCCCHHHHHHCCCCCEEECCCCCHHHCCCCCEEEECCCCEECCCCCCEEE
TFGVGALSDADEALSEATRESLQAGIAAMVVGNRLTDVAHAIETGTRAAELRYGRSFGIV
EEECCCCCCHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCCEE
AGYGGHGIGRQMHMDPFLPNEGAPGRGPLLAAGSVLAIEPMLTLGTTKTVVLDDKWTVTT
EECCCCCCCCCEECCCCCCCCCCCCCCCEEECCCEEEECCEEEECCCEEEEECCCEEEEE
ADGSRAAHWEHTVAVTDDGPRILTLG
CCCCCCCCCEEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]