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The map label for this gene is serA2 [H]

Identifier: 148660503

GI number: 148660503

Start: 821802

End: 822782

Strand: Reverse

Name: serA2 [H]

Synonym: MRA_0736

Alternate gene names: 148660503

Gene position: 822782-821802 (Counterclockwise)

Preceding gene: 148660506

Following gene: 148660502

Centisome position: 18.62

GC content: 69.62

Gene sequence:

>981_bases
GTGACGCCTCGACCGCGTGCTCTGGTGACGGCTCCATTGCGTGGACCGGGGTTCGCCCAGCTCCGGCGGCTAGCCGACGT
GGTATACGACCCGTGGATCGATCAGCGACCGCTGCGAATCTACAGCGCCGAGCAGCTAGCTGACCGGATCACCGCCGTCG
CCGCCGATGTTCTTGTGGTGGAAAGTGACTCGGTCGGTGGCCCGGTGTTCGAGCGGGGGTTGCGGGTGGTCGCCGCCACC
CGCGGGGATCCCAGCAACGTCGACATCCCCGGCGCCACCGCGGCCGGCATACCGGTGCTGCACACCCCGGCTCGCAACGC
CGACGCTGTCGCCGAGATGACGGTGGCCCTGTTGCTGGCCGTCGCCCGGCACCTGATTCCCGCGGACGCAGATGTGCGGT
CCGGCAACATCTTTCGCGACGGCACCATCCCCTATCAGCGGTTCCGCGGTGCCGAAATCGCCGGGCTGACTGCCGGGCTG
GTGGGCCTGGGTGCCGTCGGTCGCGCGGTGCGCTGGAGGCTGTCCGGGCTGGGCCTGCGGGTCATCGCGCACGATCCTTA
CCGCGACGACGCCGGCCACAGCCTTGACGAGCTGCTGGCCGAGGCTGACATCGTCTCCATGCACGCGGCGGTCACCGACG
ACACGATCGGGATGATCGGTGCCCAGCAGTTCGCGGCCATGCGCGACGGTGCGGTGTTTCTCAACACCGCCCGGTCCCAG
CTGCGCGACACCGATGCGCTCGTCGACGCCCTGCGTGGCGGCAAGCTGGCCGCCGCCGGCCTGGACCACTTCACCGGTGA
ATGGCTGCCGACCGATCACCCTTTGGTGAGCATGCCCAATGTCGTCCTCACCCCCCACATCGGCGGGGCCACCTGGAACA
CCGAGGCCCGGCAGGCGCGGATGGTCGCCGACGACCTGGGCGCACTGCTGTCCGGCAACAGGCCCGCCCATGTCGTCAAC
CCGGAGGTATTGGGCTCATGA

Upstream 100 bases:

>100_bases
CGTCGGCGGCCACCGCTTTGACGGCGGTGGTGCCGATATCGATGCCGATTGTGACGTCGTCGCGTGACACGGGCGCCACC
GTACGCCAGCATTGGCAAAC

Downstream 100 bases:

>100_bases
ACTTCGTTGACGCCCCGGAATCCGCGGTGCTGGCGGCCGCCAAGGACATGTTGCGTCGGGGCCTGGTCGAGGGGACCGCC
GGAAATATCTCAGCCAGGCG

Product: 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVVESDSVGGPVFERGLRVVAAT
RGDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGL
VGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAGHSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARSQ
LRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGGATWNTEARQARMVADDLGALLSGNRPAHVVN
PEVLGS

Sequences:

>Translated_326_residues
MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVVESDSVGGPVFERGLRVVAAT
RGDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGL
VGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAGHSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARSQ
LRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGGATWNTEARQARMVADDLGALLSGNRPAHVVN
PEVLGS
>Mature_325_residues
TPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVVESDSVGGPVFERGLRVVAATR
GDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGLV
GLGAVGRAVRWRLSGLGLRVIAHDPYRDDAGHSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARSQL
RDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGGATWNTEARQARMVADDLGALLSGNRPAHVVNP
EVLGS

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=261, Percent_Identity=31.8007662835249, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI6912396, Length=322, Percent_Identity=30.7453416149068, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4557497, Length=273, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI61743967, Length=273, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI145580578, Length=286, Percent_Identity=28.6713286713287, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4557499, Length=286, Percent_Identity=28.6713286713287, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI145580575, Length=279, Percent_Identity=28.673835125448, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI87082289, Length=280, Percent_Identity=33.5714285714286, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787645, Length=222, Percent_Identity=28.8288288288288, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789279, Length=252, Percent_Identity=30.952380952381, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1788660, Length=269, Percent_Identity=28.6245353159851, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=229, Percent_Identity=31.4410480349345, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25147481, Length=309, Percent_Identity=26.8608414239482, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=258, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6322116, Length=271, Percent_Identity=31.7343173431734, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=304, Percent_Identity=27.6315789473684, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=265, Percent_Identity=22.6415094339623, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=134, Percent_Identity=28.3582089552239, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921140, Length=289, Percent_Identity=31.4878892733564, Blast_Score=130, Evalue=9e-31,
Organism=Drosophila melanogaster, GI28574286, Length=268, Percent_Identity=31.3432835820896, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24585516, Length=255, Percent_Identity=31.3725490196078, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24646446, Length=270, Percent_Identity=31.1111111111111, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646448, Length=270, Percent_Identity=31.1111111111111, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646452, Length=270, Percent_Identity=31.1111111111111, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24646450, Length=270, Percent_Identity=31.1111111111111, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI62472511, Length=270, Percent_Identity=31.1111111111111, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45552429, Length=249, Percent_Identity=29.718875502008, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI45551003, Length=236, Percent_Identity=30.9322033898305, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI28574284, Length=249, Percent_Identity=29.718875502008, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585514, Length=249, Percent_Identity=29.718875502008, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574282, Length=249, Percent_Identity=29.718875502008, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571528, Length=250, Percent_Identity=32.4, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34440; Mature: 34308

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVV
CCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHEEEEE
ESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLA
ECCCCCCHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHH
VARHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLR
HHHHHCCCCCCCCCCCEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VIAHDPYRDDAGHSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARSQ
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEHHHHHH
LRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGGATWNTEARQAR
HHHHHHHHHHHCCCEEEECCCHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHH
MVADDLGALLSGNRPAHVVNPEVLGS
HHHHHHHHHHCCCCCCEEECHHHCCC
>Mature Secondary Structure 
TPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVV
CCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHEEEEE
ESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLA
ECCCCCCHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHH
VARHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLR
HHHHHCCCCCCCCCCCEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VIAHDPYRDDAGHSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARSQ
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEHHHHHH
LRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGGATWNTEARQAR
HHHHHHHHHHHCCCEEEECCCHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHH
MVADDLGALLSGNRPAHVVNPEVLGS
HHHHHHHHHHCCCCCCEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA