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The map label for this gene is nanK [H]

Identifier: 148660424

GI number: 148660424

Start: 748343

End: 749251

Strand: Direct

Name: nanK [H]

Synonym: MRA_0661

Alternate gene names: 148660424

Gene position: 748343-749251 (Clockwise)

Preceding gene: 148660423

Following gene: 148660425

Centisome position: 16.93

GC content: 75.14

Gene sequence:

>909_bases
ATGCTCACCCTTTGCCTCGACATCGGCGGCACCAAGATCGCCGCGGGCCTGGCCGACCCGGCCGGCACGTTGGTGCACAC
CGCCCAACGTCCCACCCCGGCGTATGGCGGAGCCGAACAGGTCTGGGCCGCGGTCGCCGAGATGATCGCCGACGCGCTCG
GCGTGGCGGGGGGCGCGGTCGGTGGTGTGGGGATCGCCTCGGCCGGTCCTATCGACCTACACAGCGGCCGCGTCAGCCCG
ATCAACATCGGATCCTGGGGCGGCTTTCCGCTGCGGGATCGGGTCGCCGCCGCGGTCCCGGGGGTTCCGGTGCGGCTGGG
GGGTGACGGGGTGTGCATGGCGCTCGGCGAGCACTGGCTGGGAGCCGGACGGGGTGCGCGCTTTCTGTTGGGTTTGGTGG
TGTCCACCGGGGTGGGCGGCGGGTTGGTGCTCGACGGCGCCCCCTGTCTCGGCCGCACCGGCAACGCCGGTCACGTCGGC
CACGTGGTGGTGGATCCGGATGGCTCGCCGTGCCCGTGCGGGGGGCGTGGCTGTGTGGAGACCATCGCGTCCGGCCCGTC
GCTGGCGCGCTGGGCGCGGGCCAACGGCTGGTCCGCGCCGCCCGGGGCCGGCGCCAAAGAGCTGGCCGAGGCGGCTGGGG
CCGGAGACCCGGTGGCGCTGCGGGCCTTCCGCCGCGGCGCCGCGGCGCTGGCCGCGATGATCGCCTCGGTGGGCGCCGTG
TGCGACTTGGATCTCGCCGTCATCGGCGGCGGCGTGGCCAAGTCGGGTCGCCTGCTGTTCGAGCCGTTACGTGCGGCGCT
AGCCGACCACGCCCGGCTGGACTTTCTGGCCGGCCTGCGGGTGGTGCCTGCCGAGCTGGGCGGCGCCGCCGGCCTGGTGG
GTGCGGCCAGGCTCGCGGCCATCGCATAA

Upstream 100 bases:

>100_bases
GGGTGTGGCTGGACGCGCGCCGGAACGCCCTGGTGGTGCTGGCCCCCGGCTATGAGCACCCCGGCGACCCGCGCCAACCC
GACAACACCCGCCGGCACTG

Downstream 100 bases:

>100_bases
TGCCGATTGTGAATCTGGCGACGCGACACGCCGGTGCGGCGTCGCGGGATTCACACTCGGCGATACGTGTCGCCGTTTTG
GCTGACCGGACCGGGCCAGG

Product: putative glucokinase

Products: NA

Alternate protein names: ManNAc kinase; N-acetyl-D-mannosamine kinase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAGGAVGGVGIASAGPIDLHSGRVSP
INIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGRGARFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVG
HVVVDPDGSPCPCGGRGCVETIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAV
CDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDFLAGLRVVPAELGGAAGLVGAARLAAIA

Sequences:

>Translated_302_residues
MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAGGAVGGVGIASAGPIDLHSGRVSP
INIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGRGARFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVG
HVVVDPDGSPCPCGGRGCVETIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAV
CDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDFLAGLRVVPAELGGAAGLVGAARLAAIA
>Mature_302_residues
MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAGGAVGGVGIASAGPIDLHSGRVSP
INIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGRGARFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVG
HVVVDPDGSPCPCGGRGCVETIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAV
CDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDFLAGLRVVPAELGGAAGLVGAARLAAIA

Specific function: Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family. NanK subfamily [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=270, Percent_Identity=28.5185185185185, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI190014632, Length=270, Percent_Identity=28.5185185185185, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI298566325, Length=270, Percent_Identity=28.5185185185185, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4885285, Length=270, Percent_Identity=28.5185185185185, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787363, Length=306, Percent_Identity=32.3529411764706, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87081733, Length=263, Percent_Identity=32.6996197718631, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786891, Length=273, Percent_Identity=27.1062271062271, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI87082230, Length=256, Percent_Identity=34.765625, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082127, Length=267, Percent_Identity=23.9700374531835, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787878, Length=202, Percent_Identity=28.2178217821782, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.60 [H]

Molecular weight: Translated: 29270; Mature: 29270

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAGGAV
CEEEEEECCCCEEECCCCCCCHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GGVGIASAGPIDLHSGRVSPINIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWL
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEECCCEEEEEHHHHHH
GAGRGARFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVGHVVVDPDGSPCPCGGRGCVE
CCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHH
TIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAV
HHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDFLAGLRVVPAELGGAAGLVGAARLAA
HCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHCCHHHHHHHHHHHH
IA
CC
>Mature Secondary Structure
MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEMIADALGVAGGAV
CEEEEEECCCCEEECCCCCCCHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GGVGIASAGPIDLHSGRVSPINIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWL
CCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEECCCEEEEEHHHHHH
GAGRGARFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVGHVVVDPDGSPCPCGGRGCVE
CCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHH
TIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAV
HHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDFLAGLRVVPAELGGAAGLVGAARLAA
HCCHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHCCHHHHHHHHHHHH
IA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA