Click here to switch to the map view.

The map label for this gene is galK [H]

Identifier: 148660392

GI number: 148660392

Start: 714026

End: 715117

Strand: Direct

Name: galK [H]

Synonym: MRA_0629

Alternate gene names: 148660392

Gene position: 714026-715117 (Clockwise)

Preceding gene: 148660391

Following gene: 148660393

Centisome position: 16.15

GC content: 72.53

Gene sequence:

>1092_bases
ATGACGGTCAGCTACGGCGCACCCGGGCGGGTCAACCTGATCGGCGAACACACCGATTACAACCTGGGTTTCGCGCTGCC
GATTGCGTTGCCGCGGCGCACCGTTGTCACGTTCACCCCCGAGCACACCGGCGCGATCACCGCGCGCAGCGACCGCGCCG
ACGGCTCGGCGCGGATCCCGCTCGACACCACGCCGGGGCAGGTGACCGGCTGGGCAGCCTATGCGGCCGGGGCGATCTGG
GCGCTGCGGGGCGCCGGCCACCCGGTGCCCGGCGGGGCGATGTCGATCACCAGCGACGTCGAGATCGGGTCGGGGCTTTC
GTCGTCGGCGGCGCTGATCGGCGCGGTGCTGGGCGCGGTCGGCGCCGCCACCGGCACCCGCATCGACCGTCTCGAGCGGG
CCCGGCTCGCACAGCGAGCCGAGAACGACTACGTCGGTGCCCCAACGGGTTTGCTCGACCACCTGGCCGCGCTGTTCGGA
GCGCCGAAGACCGCGCTGCTGATCGACTTTCGCGACATCACCGTGCGCCCGGTGGCCTTCGACCCGGACGCCTGCGATGT
GGTGCTGCTGTTGATGGATTCTCGAGCCCGACACTGTCACGCCGGCGGGGAGTATGCGCTGCGCCGGGCGTCGTGTGAAC
GGGCGGCCGCCGATCTGGGGGTGTCCTCGTTGCGCGCTGTGCAGGATCGCGGGCTGGCGGCGCTGGGCGCGATCGCCGAT
CCGATCGACGCGCGCCGCGCCCGGCACGTGCTGACCGAGAATCAGCGGGTGCTGGATTTCGCGGCCGCACTGGCTGATTC
GGATTTCACCGCCGCCGGGCAGCTGCTGACCGCGTCGCATGAGTCCATGCGCGAGGACTTCGCCATCACCACCGAGCGGA
TCGATCTGATCGCCGAGAGCGCCGTACGGGCCGGTGCGCTGGGCGCCCGGATGACCGGGGGCGGCTTCGGGGGCGCCGTG
ATCGCACTGGTGCCTGCCGATAGGGCGCGCGACGTGGCCGACACGGTGCGACGGGCGGCGGTCACCGCCGGCTACGACGA
GCCGGCGGTGAGCCGGACCTATGCCGCGCCCGGCGCGGCCGAGTGCCGTTGA

Upstream 100 bases:

>100_bases
CCAAACTGAAATATCTGGCGGCCGCCGAGTCGGCGATGGACGCGTTCATCGCCGACGTTATCCCGGAGAGCGTGGCCACC
CGGCTGCGCGAGCTGGGCCC

Downstream 100 bases:

>100_bases
GCGGGTTGGCGAAGCGTCATGTCCACAGTGAGCAGATCGGTGCGGGTCCGCCACTGCCCTTGACCTCGAAGCCGAACACC
GGCTACGAGACCGCTGCCGC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIPLDTTPGQVTGWAAYAAGAIW
ALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFG
APKTALLIDFRDITVRPVAFDPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIAD
PIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAV
IALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECR

Sequences:

>Translated_363_residues
MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIPLDTTPGQVTGWAAYAAGAIW
ALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFG
APKTALLIDFRDITVRPVAFDPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIAD
PIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAV
IALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECR
>Mature_362_residues
TVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIPLDTTPGQVTGWAAYAAGAIWA
LRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGA
PKTALLIDFRDITVRPVAFDPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIADP
IDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAVI
ALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECR

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=342, Percent_Identity=39.4736842105263, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI1786972, Length=331, Percent_Identity=37.7643504531722, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71989053, Length=384, Percent_Identity=24.21875, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319494, Length=197, Percent_Identity=32.994923857868, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 37573; Mature: 37442

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00106 GALACTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIP
CEECCCCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCEEEECCCCCCCCEECC
LDTTPGQVTGWAAYAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAV
CCCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
GAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDITVRPVAF
HCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCEEEEEEE
DPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIAD
CCCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHCC
PIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAES
CHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRAGALGARMTGGGFGGAVIALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAA
HHHHCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCC
ECR
CCC
>Mature Secondary Structure 
TVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIP
EECCCCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCCCEEEECCCCCCCCEECC
LDTTPGQVTGWAAYAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAV
CCCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHH
GAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDITVRPVAF
HCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCEEEEEEE
DPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIAD
CCCHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHCC
PIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAES
CHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVRAGALGARMTGGGFGGAVIALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAA
HHHHCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCC
ECR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]